Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000111331 Gene ID 4940 Accession 8088
Symbol OAS3 Alias p100;p100OAS Full Name 2'-5'-oligoadenylate synthetase 3
Status Confidence Length 38410 bases Strand Plus strand
Position 12 : 112938051 - 112976460 RNA binding domain OAS1_C
Summary This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000505225 OAS1_C PF10421 2.1e-243 1
ENSP00000505225 OAS1_C PF10421 2.1e-243 2
ENSP00000505225 OAS1_C PF10421 2.1e-243 3
ENSP00000505880 OAS1_C PF10421 2.3e-243 1
ENSP00000505880 OAS1_C PF10421 2.3e-243 2
ENSP00000505880 OAS1_C PF10421 2.3e-243 3
ENSP00000505798 OAS1_C PF10421 2.4e-243 1
ENSP00000505798 OAS1_C PF10421 2.4e-243 2
ENSP00000505798 OAS1_C PF10421 2.4e-243 3
ENSP00000228928 OAS1_C PF10421 2.6e-243 1
ENSP00000228928 OAS1_C PF10421 2.6e-243 2
ENSP00000228928 OAS1_C PF10421 2.6e-243 3
ENSP00000505627 OAS1_C PF10421 3e-241 1
ENSP00000505627 OAS1_C PF10421 3e-241 2
ENSP00000505627 OAS1_C PF10421 3e-241 3
ENSP00000506397 OAS1_C PF10421 2.1e-221 1
ENSP00000506397 OAS1_C PF10421 2.1e-221 2
ENSP00000506397 OAS1_C PF10421 2.1e-221 3
ENSP00000505939 OAS1_C PF10421 4e-221 1
ENSP00000505939 OAS1_C PF10421 4e-221 2
ENSP00000505939 OAS1_C PF10421 4e-221 3
ENSP00000506106 OAS1_C PF10421 2.7e-177 1
ENSP00000506106 OAS1_C PF10421 2.7e-177 2
ENSP00000506106 OAS1_C PF10421 2.7e-177 3
ENSP00000506611 OAS1_C PF10421 2.1e-159 1
ENSP00000506611 OAS1_C PF10421 2.1e-159 2
ENSP00000506045 OAS1_C PF10421 2.2e-159 1
ENSP00000506045 OAS1_C PF10421 2.2e-159 2
ENSP00000504871 OAS1_C PF10421 2.3e-159 1
ENSP00000504871 OAS1_C PF10421 2.3e-159 2
ENSP00000505969 OAS1_C PF10421 3.1e-159 1
ENSP00000505969 OAS1_C PF10421 3.1e-159 2
ENSP00000506146 OAS1_C PF10421 3.1e-159 1
ENSP00000506146 OAS1_C PF10421 3.1e-159 2
ENSP00000506335 OAS1_C PF10421 2.9e-137 1
ENSP00000506335 OAS1_C PF10421 2.9e-137 2
ENSP00000505925 OAS1_C PF10421 6.8e-80 1
ENSP00000505154 OAS1_C PF10421 6.9e-80 1
ENSP00000505477 OAS1_C PF10421 7.3e-80 1
ENSP00000505651 OAS1_C PF10421 7.3e-80 1
ENSP00000506365 OAS1_C PF10421 7.3e-80 1
ENSP00000448388 OAS1_C PF10421 4.1e-19 1
ENSP00000505912 OAS1_C PF10421 9.6e-19 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
33408233 Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7. Niluka Goonawardane 2021-01-06 mSphere
30989826 RNA regulation of the antiviral protein 2'-5'-oligoadenylate synthetase. L Samantha Schwartz 2019-07-01 Wiley interdisciplinary reviews. RNA
36851564 Cellular Sensors and Viral Countermeasures: A Molecular Arms Race between Host and SARS-CoV-2. Haoran Sun 2023-01-26 Viruses
35702158 Gene amplification acts as a molecular foothold to facilitate cross-species adaptation and evasion of multiple antiviral pathways. Shefali Banerjee 2022-10-06 bioRxiv : the preprint server for biology

Transcripts

Name Transcript ID bp Protein Translation ID
OAS3-214 ENST00000679812 7017 577aa ENSP00000505154
OAS3-217 ENST00000680090 7007 771aa ENSP00000506611
OAS3-231 ENST00000681346 6898 1120aa ENSP00000505939
OAS3-225 ENST00000681002 6352 971aa ENSP00000506106
OAS3-234 ENST00000681572 2368 219aa ENSP00000505912
OAS3-221 ENST00000680230 1007 114aa ENSP00000505503
OAS3-210 ENST00000679505 6668 114aa ENSP00000506118
OAS3-216 ENST00000680044 6657 1089aa ENSP00000505627
OAS3-224 ENST00000680966 1045 172aa ENSP00000505916
OAS3-204 ENST00000548514 1427 223aa ENSP00000448388
OAS3-232 ENST00000681497 9696 1036aa ENSP00000505225
OAS3-206 ENST00000551007 998 177aa ENSP00000449299
OAS3-236 ENST00000681665 2780 No protein -
OAS3-235 ENST00000681594 3223 589aa ENSP00000506365
OAS3-201 ENST00000228928 6599 1087aa ENSP00000228928
OAS3-212 ENST00000679547 6316 97aa ENSP00000506567
OAS3-229 ENST00000681134 6726 928aa ENSP00000506146
OAS3-211 ENST00000679517 6423 182aa ENSP00000506294
OAS3-237 ENST00000681764 6454 724aa ENSP00000506335
OAS3-215 ENST00000679912 6313 846aa ENSP00000504871
OAS3-223 ENST00000680438 3027 928aa ENSP00000505969
OAS3-230 ENST00000681147 949 114aa ENSP00000506513
OAS3-233 ENST00000681527 3905 No protein -
OAS3-226 ENST00000681007 3892 589aa ENSP00000505477
OAS3-207 ENST00000679354 6483 1061aa ENSP00000505880
OAS3-227 ENST00000681085 852 151aa ENSP00000505003
OAS3-219 ENST00000680161 3357 723aa ENSP00000506045
OAS3-220 ENST00000680177 6500 567aa ENSP00000505925
OAS3-208 ENST00000679483 6467 1062aa ENSP00000505798
OAS3-202 ENST00000546638 1536 No protein -
OAS3-213 ENST00000679562 6382 114aa ENSP00000505418
OAS3-209 ENST00000679493 6517 1130aa ENSP00000506397
OAS3-222 ENST00000680293 6544 589aa ENSP00000505651
OAS3-228 ENST00000681105 4217 No protein -
OAS3-218 ENST00000680153 2654 No protein -
OAS3-203 ENST00000546800 588 No protein -
OAS3-205 ENST00000549918 4801 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
63752Alcohol Drinking6E-1721270382
84401Cholesterol, HDL6E-621909109
99513Leukemia, Lymphocytic, Chronic, B-Cell5E-828165464

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000111331homo_sapiensENSP0000037636264.192148.3261homo_sapiensENSP0000022892840.570430.5428
ENSG00000111331homo_sapiensENSP0000020291761.2551.5homo_sapiensENSP0000022892822.539118.9512
ENSG00000111331homo_sapiensENSP0000025757039.688727.0428homo_sapiensENSP0000022892818.767312.7875

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000111331homo_sapiensENSP0000022892894.940293.9282nomascus_leucogenysENSNLEP0000000015496.268795.2425
ENSG00000111331homo_sapiensENSP0000022892897.608197.2401pan_paniscusENSPPAP0000004029398.059297.6895
ENSG00000111331homo_sapiensENSP0000022892898.436197.6081pongo_abeliiENSPPYP0000000568098.436197.6081
ENSG00000111331homo_sapiensENSP0000022892899.35699.356pan_troglodytesENSPTRP0000000929699.35699.356
ENSG00000111331homo_sapiensENSP0000022892899.5499.54gorilla_gorillaENSGGOP0000000795999.5499.54
ENSG00000111331homo_sapiensENSP0000022892810.02767.17571ornithorhynchus_anatinusENSOANP0000004394166.463447.561
ENSG00000111331homo_sapiensENSP0000022892869.917256.0258sarcophilus_harrisiiENSSHAP0000001905071.630557.3987
ENSG00000111331homo_sapiensENSP0000022892842.042334.0386notamacropus_eugeniiENSMEUP0000001104773.709759.6774
ENSG00000111331homo_sapiensENSP0000022892877.736967.9853erinaceus_europaeusENSEEUP0000000428981.800671.5392
ENSG00000111331homo_sapiensENSP0000022892869.457262.7415echinops_telfairiENSETEP0000000885177.435969.9487
ENSG00000111331homo_sapiensENSP0000022892859.797658.0497callithrix_jacchusENSCJAP0000002318959.797658.0497
ENSG00000111331homo_sapiensENSP0000022892896.044293.4683cercocebus_atysENSCATP0000002276395.955993.3824
ENSG00000111331homo_sapiensENSP0000022892895.768293.0083macaca_fascicularisENSMFAP0000004440895.944793.1797
ENSG00000111331homo_sapiensENSP0000022892895.952293.0083macaca_mulattaENSMMUP0000004252894.646191.7423
ENSG00000111331homo_sapiensENSP0000022892893.376390.3404macaca_nemestrinaENSMNEP0000004420694.330991.2639
ENSG00000111331homo_sapiensENSP0000022892896.228193.5603papio_anubisENSPANP0000001088096.228193.5603
ENSG00000111331homo_sapiensENSP0000022892895.584293.0083mandrillus_leucophaeusENSMLEP0000003296595.496392.9228
ENSG00000111331homo_sapiensENSP0000022892886.016678.1969vulpes_vulpesENSVVUP0000001411886.016678.1969
ENSG00000111331homo_sapiensENSP0000022892879.668870.2852mus_spretusMGP_SPRETEiJ_P007307076.232467.2535
ENSG00000111331homo_sapiensENSP0000022892854.553851.242equus_asinusENSEASP0000505065381.344376.406
ENSG00000111331homo_sapiensENSP0000022892886.752579.6688loxodonta_africanaENSLAFP0000001141787.639480.4833
ENSG00000111331homo_sapiensENSP0000022892887.120579.4848panthera_leoENSPLOP0000002137187.120579.4848
ENSG00000111331homo_sapiensENSP0000022892878.288968.5373oryctolagus_cuniculusENSOCUP0000001776676.0566.5773
ENSG00000111331homo_sapiensENSP0000022892886.384579.8528equus_caballusENSECAP0000003768886.225979.7062
ENSG00000111331homo_sapiensENSP0000022892885.924678.3809canis_lupus_familiarisENSCAFP0084503056981.929874.7368
ENSG00000111331homo_sapiensENSP0000022892886.936579.3928panthera_pardusENSPPRP0000002028786.936579.3928
ENSG00000111331homo_sapiensENSP0000022892882.980773.689marmota_marmota_marmotaENSMMMP000000250638272.8182
ENSG00000111331homo_sapiensENSP0000022892881.876772.3091cavia_porcellusENSCPOP0000000374780.615971.1957
ENSG00000111331homo_sapiensENSP0000022892886.660579.0248felis_catusENSFCAP0000000029386.660579.0248
ENSG00000111331homo_sapiensENSP0000022892886.108677.5529ursus_americanusENSUAMP0000003751083.720975.4025
ENSG00000111331homo_sapiensENSP0000022892873.781158.2337monodelphis_domesticaENSMODP0000004565571.928356.7713
ENSG00000111331homo_sapiensENSP0000022892880.956875.805microcebus_murinusENSMICP0000000776288.978883.3165
ENSG00000111331homo_sapiensENSP0000022892882.152773.4131octodon_degusENSODEP0000001793379.5971.123
ENSG00000111331homo_sapiensENSP0000022892882.152773.873ursus_maritimusENSUMAP0000001373786.614977.8856
ENSG00000111331homo_sapiensENSP0000022892866.789359.3376ochotona_princepsENSOPRP0000001085367.723960.1679
ENSG00000111331homo_sapiensENSP0000022892880.036870.2852mus_caroliMGP_CAROLIEiJ_P007038276.584567.2535
ENSG00000111331homo_sapiensENSP0000022892879.852870.4692mus_musculusENSMUSP0000003558876.274267.3111
ENSG00000111331homo_sapiensENSP0000022892885.832678.3809mustela_putorius_furoENSMPUP0000000251875.853769.2683
ENSG00000111331homo_sapiensENSP0000022892859.981657.7737aotus_nancymaaeENSANAP0000000156161.105958.8566
ENSG00000111331homo_sapiensENSP0000022892858.693756.2098saimiri_boliviensis_boliviensisENSSBOP0000001780658.693756.2098
ENSG00000111331homo_sapiensENSP0000022892860.165658.6937chlorocebus_sabaeusENSCSAP0000001557795.058192.7326
ENSG00000111331homo_sapiensENSP0000022892810.48769.65961mesocricetus_auratusENSMAUP0000001417587.022980.1527
ENSG00000111331homo_sapiensENSP0000022892887.856581.9687carlito_syrichtaENSTSYP0000000847288.262582.3475
ENSG00000111331homo_sapiensENSP0000022892885.832677.3689panthera_tigris_altaicaENSPTIP0000001159163.947957.6422
ENSG00000111331homo_sapiensENSP0000022892880.036870.0092rattus_norvegicusENSRNOP0000007306974.168864.8764
ENSG00000111331homo_sapiensENSP0000022892889.420484.0846prolemur_simusENSPSMP0000000180889.420484.0846
ENSG00000111331homo_sapiensENSP0000022892882.428773.2291peromyscus_maniculatus_bairdiiENSPEMP0000001740278.527669.7634
ENSG00000111331homo_sapiensENSP0000022892879.944870.2852mus_spicilegusENSMSIP0000003500876.36267.1353
ENSG00000111331homo_sapiensENSP0000022892881.508771.2971cricetulus_griseus_chok1gshdENSCGRP0000101519078.755668.8889
ENSG00000111331homo_sapiensENSP0000022892879.300872.8611pteropus_vampyrusENSPVAP0000001636079.373872.9282
ENSG00000111331homo_sapiensENSP0000022892881.784774.517myotis_lucifugusENSMLUP0000001437786.647278.9474
ENSG00000111331homo_sapiensENSP0000022892826.678922.0791vombatus_ursinusENSVURP0001000550264.444453.3333
ENSG00000111331homo_sapiensENSP0000022892887.120580.5888rhinolophus_ferrumequinumENSRFEP0001001549487.442380.8864
ENSG00000111331homo_sapiensENSP0000022892885.740678.3809neovison_visonENSNVIP0000001966985.583178.2369
ENSG00000111331homo_sapiensENSP0000022892895.952293.3763rhinopithecus_bietiENSRBIP0000000733895.512892.9487
ENSG00000111331homo_sapiensENSP0000022892886.108678.5649canis_lupus_dingoENSCAFP0002002230186.108678.5649
ENSG00000111331homo_sapiensENSP0000022892882.520773.5051sciurus_vulgarisENSSVLP0000501914882.749173.7085
ENSG00000111331homo_sapiensENSP0000022892827.138923.0911phascolarctos_cinereusENSPCIP0000002498380.821968.7671
ENSG00000111331homo_sapiensENSP0000022892867.341360.3496procavia_capensisENSPCAP0000000897070.861663.5044
ENSG00000111331homo_sapiensENSP0000022892883.072774.701nannospalax_galiliENSNGAP0000000412579.210571.2281
ENSG00000111331homo_sapiensENSP0000022892875.89767.6173ictidomys_tridecemlineatusENSSTOP0000000354883.249274.1675
ENSG00000111331homo_sapiensENSP0000022892887.212582.5207otolemur_garnettiiENSOGAP0000000375286.733882.0677
ENSG00000111331homo_sapiensENSP0000022892851.609949.954cebus_imitatorENSCCAP0000000373156.381954.5729
ENSG00000111331homo_sapiensENSP0000022892883.900674.977urocitellus_parryiiENSUPAP0001001063882.909174.0909
ENSG00000111331homo_sapiensENSP0000022892895.860293.1923rhinopithecus_roxellanaENSRROP0000001110195.421292.7656
ENSG00000111331homo_sapiensENSP0000022892872.401163.2015mus_pahariMGP_PahariEiJ_P005859773.896764.507
ENSG00000111331homo_sapiensENSP0000022892810.57965.88776ciona_intestinalisENSCINP0000003509939.249121.843
ENSG00000111331homo_sapiensENSP0000022892819.319214.7194callorhinchus_miliiENSCMIP0000003990848.387136.8664
ENSG00000111331homo_sapiensENSP0000022892821.803116.9273chrysemys_picta_belliiENSCPBP0000000956766.201151.3966
ENSG00000111331homo_sapiensENSP0000022892823.82719.5032chrysemys_picta_belliiENSCPBP0000000957673.789260.3989
ENSG00000111331homo_sapiensENSP0000022892823.091117.8473sphenodon_punctatusENSSPUP0000001017557.834144.7005
ENSG00000111331homo_sapiensENSP0000022892823.735117.4793laticauda_laticaudataENSLLTP0000000670965.316548.1013
ENSG00000111331homo_sapiensENSP0000022892821.343115.8234notechis_scutatusENSNSUP0000002141464.265947.6454
ENSG00000111331homo_sapiensENSP0000022892821.895116.5593pseudonaja_textilisENSPTXP000000235085642.3529
ENSG00000111331homo_sapiensENSP0000022892816.651312.0515naja_najaENSNNAP0000002444459.73643.2343
ENSG00000111331homo_sapiensENSP0000022892821.527115.9154naja_najaENSNNAP0000002442966.288949.0085
ENSG00000111331homo_sapiensENSP0000022892821.343115.5474naja_najaENSNNAP0000002507454.079339.3939
ENSG00000111331homo_sapiensENSP0000022892822.355117.2953podarcis_muralisENSPMRP0000002420564.973350.2674
ENSG00000111331homo_sapiensENSP0000022892824.10319.1352pelodiscus_sinensisENSPSIP0000000567262.679449.7608
ENSG00000111331homo_sapiensENSP0000022892821.159216.4673gopherus_evgoodeiENSGEVP0000502162134.277226.6766
ENSG00000111331homo_sapiensENSP0000022892812.87958.64765gopherus_evgoodeiENSGEVP0000501850040.229927.0115
ENSG00000111331homo_sapiensENSP0000022892823.183118.8592chelonoidis_abingdoniiENSCABP0000001673350.50141.0822
ENSG00000111331homo_sapiensENSP0000022892822.447117.9393chelonoidis_abingdoniiENSCABP0000001672154.708543.722
ENSG00000111331homo_sapiensENSP0000022892823.643118.9512struthio_camelus_australisENSSCUP0000001291771.388957.2222
ENSG00000111331homo_sapiensENSP0000022892822.907117.7553terrapene_carolina_triunguisENSTMTP0000000577259.144945.8432

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001730enables 2-5-oligoadenylate synthetase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0003725enables double-stranded RNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IDAHomo_sapiens(9606)Function
GO:0005615located_in extracellular space1HDAHomo_sapiens(9606)Component
GO:0005654is_active_in nucleoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0006139involved_in nucleobase-containing compound metabolic process1TASHomo_sapiens(9606)Process
GO:0009615involved_in response to virus1IDAHomo_sapiens(9606)Process
GO:0016020is_active_in membrane1IBAHomo_sapiens(9606)Component
GO:0032728involved_in positive regulation of interferon-beta production1IMPHomo_sapiens(9606)Process
GO:0032760involved_in positive regulation of tumor necrosis factor production1IMPHomo_sapiens(9606)Process
GO:0035395involved_in negative regulation of chemokine (C-X-C motif) ligand 9 production1IMPHomo_sapiens(9606)Process
GO:0039529involved_in RIG-I signaling pathway1IMPHomo_sapiens(9606)Process
GO:0039530involved_in MDA-5 signaling pathway1IMPHomo_sapiens(9606)Process
GO:0042742involved_in defense response to bacterium1IMPHomo_sapiens(9606)Process
GO:0043231located_in intracellular membrane-bounded organelle1TASHomo_sapiens(9606)Component
GO:0045071involved_in negative regulation of viral genome replication2IBA,IDAHomo_sapiens(9606)Process
GO:0045087involved_in innate immune response1IEAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0051607involved_in defense response to virus2IBA,IDAHomo_sapiens(9606)Process
GO:0060339involved_in negative regulation of type I interferon-mediated signaling pathway1IMPHomo_sapiens(9606)Process
GO:0060700involved_in regulation of ribonuclease activity2IBA,IDAHomo_sapiens(9606)Process
GO:0071639involved_in positive regulation of monocyte chemotactic protein-1 production1IMPHomo_sapiens(9606)Process
GO:0071650involved_in negative regulation of chemokine (C-C motif) ligand 5 production1IMPHomo_sapiens(9606)Process
GO:0071659involved_in negative regulation of IP-10 production1IMPHomo_sapiens(9606)Process
GO:2000342involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production1IMPHomo_sapiens(9606)Process

Expression