Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs snRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000110844 Gene ID 25766 Accession 25031
Symbol PRPF40B Alias HYPC Full Name pre-mRNA processing factor 40 homolog B
Status Confidence Length 76295 bases Strand Plus strand
Position 12 : 49568372 - 49644666 RNA binding domain FF
Summary This gene encodes a WW-domain containing protein similar to yeast splicing factor PRP40. This protein has been shown to interact with Huntingtin and methyl CpG binding protein 2 (MeCP2). Alternative splicing results in different transcript variants. [provided by RefSeq, Aug 2014]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000448073 FF PF01846 9.8e-41 1
ENSP00000448073 FF PF01846 9.8e-41 2
ENSP00000369634 FF PF01846 9.8e-41 1
ENSP00000369634 FF PF01846 9.8e-41 2
ENSP00000261897 FF PF01846 6.8e-40 1
ENSP00000261897 FF PF01846 6.8e-40 2
ENSP00000449485 FF PF01846 9.4e-05 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
25605964 Prp40 pre-mRNA processing factor 40 homolog B (PRPF40B) associates with SF1 and U2AF65 and modulates alternative pre-mRNA splicing in vivo. Soraya Becerra 2015-03-01 RNA (New York, N.Y.)
31088860 Human PRPF40B regulates hundreds of alternative splicing targets and represses a hypoxia expression signature. Alberto Paolo Lorenzini 2019-08-01 RNA (New York, N.Y.)

Transcripts

Name Transcript ID bp Protein Translation ID
PRPF40B-216 ENST00000552301 912 No protein -
PRPF40B-206 ENST00000547764 803 No protein -
PRPF40B-211 ENST00000551063 531 6aa ENSP00000449569
PRPF40B-204 ENST00000527253 742 No protein -
PRPF40B-203 ENST00000508736 1861 No protein -
PRPF40B-215 ENST00000551418 583 No protein -
PRPF40B-202 ENST00000380281 3311 893aa ENSP00000369634
PRPF40B-209 ENST00000548825 3182 892aa ENSP00000448073
PRPF40B-208 ENST00000548436 2059 No protein -
PRPF40B-201 ENST00000261897 3602 858aa ENSP00000261897
PRPF40B-212 ENST00000551111 1061 No protein -
PRPF40B-214 ENST00000551320 455 No protein -
PRPF40B-207 ENST00000548399 455 No protein -
PRPF40B-210 ENST00000549547 697 137aa ENSP00000449485
PRPF40B-205 ENST00000546626 630 No protein -
PRPF40B-213 ENST00000551269 923 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
22678Respiratory Function Tests3.7120000E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000110844homo_sapiensENSP0000044465666.255152.2634homo_sapiensENSP0000044807372.197356.9507

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000110844homo_sapiensENSP0000044807375.672674.2152nomascus_leucogenysENSNLEP0000002365892.592690.8093
ENSG00000110844homo_sapiensENSP0000044807398.206397.9821pan_paniscusENSPPAP0000001034098.316598.092
ENSG00000110844homo_sapiensENSP0000044807391.479890.8072pongo_abeliiENSPPYP0000000512788.025987.3786
ENSG00000110844homo_sapiensENSP0000044807397.533697.5336pan_troglodytesENSPTRP0000005023699.885299.8852
ENSG00000110844homo_sapiensENSP0000044807310099.6637gorilla_gorillaENSGGOP0000000155610099.6637
ENSG00000110844homo_sapiensENSP0000044807363.228756.7265ornithorhynchus_anatinusENSOANP0000003586070.324263.0923
ENSG00000110844homo_sapiensENSP0000044807391.591987.5561sarcophilus_harrisiiENSSHAP0000002417787.755183.8883
ENSG00000110844homo_sapiensENSP0000044807383.408179.4843notamacropus_eugeniiENSMEUP0000000083788.151784.0047
ENSG00000110844homo_sapiensENSP0000044807339.910336.9955choloepus_hoffmanniENSCHOP0000000427241.735138.687
ENSG00000110844homo_sapiensENSP0000044807397.8796.861dasypus_novemcinctusENSDNOP0000003345593.169792.2092
ENSG00000110844homo_sapiensENSP0000044807377.1375.7848erinaceus_europaeusENSEEUP0000000667689.119287.5648
ENSG00000110844homo_sapiensENSP0000044807362.780361.6592echinops_telfairiENSETEP0000001580065.497164.3275
ENSG00000110844homo_sapiensENSP0000044807397.197396.7489callithrix_jacchusENSCJAP0000003908699.312798.8545
ENSG00000110844homo_sapiensENSP0000044807397.197396.9731cercocebus_atysENSCATP0000001710099.540899.3111
ENSG00000110844homo_sapiensENSP0000044807397.197396.9731macaca_fascicularisENSMFAP0000002160299.540899.3111
ENSG00000110844homo_sapiensENSP0000044807399.551699.3274macaca_mulattaENSMMUP0000005737599.551699.3274
ENSG00000110844homo_sapiensENSP0000044807399.663799.4395macaca_nemestrinaENSMNEP0000001894499.663799.4395
ENSG00000110844homo_sapiensENSP0000044807397.197396.9731papio_anubisENSPANP0000000231499.540899.3111
ENSG00000110844homo_sapiensENSP0000044807397.085296.7489mandrillus_leucophaeusENSMLEP0000003972999.425999.0815
ENSG00000110844homo_sapiensENSP0000044807395.964194.2825tursiops_truncatusENSTTRP0000001119298.165196.445
ENSG00000110844homo_sapiensENSP0000044807389.910388.2287vulpes_vulpesENSVVUP0000002977390.826789.128
ENSG00000110844homo_sapiensENSP0000044807395.291593.2735mus_spretusMGP_SPRETEiJ_P004158197.365495.3036
ENSG00000110844homo_sapiensENSP0000044807393.273592.9372equus_asinusENSEASP0000500153998.22997.8749
ENSG00000110844homo_sapiensENSP0000044807394.84393.6099capra_hircusENSCHIP0000002852397.803596.5318
ENSG00000110844homo_sapiensENSP0000044807394.618893.0493loxodonta_africanaENSLAFP0000001230696.900195.2928
ENSG00000110844homo_sapiensENSP0000044807398.094297.0852panthera_leoENSPLOP0000001792498.758597.7427
ENSG00000110844homo_sapiensENSP0000044807398.430597.1973ailuropoda_melanoleucaENSAMEP0000000101898.54197.3064
ENSG00000110844homo_sapiensENSP0000044807396.412695.0673bos_indicus_hybridENSBIXP0000503735492.872691.5767
ENSG00000110844homo_sapiensENSP0000044807392.71390.1345oryctolagus_cuniculusENSOCUP0000004406878.68776.4986
ENSG00000110844homo_sapiensENSP0000044807398.542698.0942equus_caballusENSECAP0000001867196.487496.0483
ENSG00000110844homo_sapiensENSP0000044807398.542697.4215canis_lupus_familiarisENSCAFP0084502684988.164587.1615
ENSG00000110844homo_sapiensENSP0000044807398.094296.9731panthera_pardusENSPPRP0000001682198.758597.6298
ENSG00000110844homo_sapiensENSP0000044807395.739994.7309marmota_marmota_marmotaENSMMMP0000002638897.696.5714
ENSG00000110844homo_sapiensENSP0000044807398.206396.4126balaenoptera_musculusENSBMSP0001002535598.096396.3046
ENSG00000110844homo_sapiensENSP0000044807397.8796.7489cavia_porcellusENSCPOP0000002221898.089996.9663
ENSG00000110844homo_sapiensENSP0000044807386.547184.6413felis_catusENSFCAP0000004922685.398283.5177
ENSG00000110844homo_sapiensENSP0000044807320.179418.2735ursus_americanusENSUAMP0000002080364.748258.6331
ENSG00000110844homo_sapiensENSP0000044807398.094296.9731bison_bison_bisonENSBBBP0000001539497.984396.8645
ENSG00000110844homo_sapiensENSP0000044807396.300494.1704monodon_monocerosENSMMNP0001501876579.684677.9221
ENSG00000110844homo_sapiensENSP0000044807395.179494.1704sus_scrofaENSSSCP0000000021597.923996.8858
ENSG00000110844homo_sapiensENSP0000044807398.878998.3184microcebus_murinusENSMICP0000003190398.547597.9888
ENSG00000110844homo_sapiensENSP0000044807315.246615.2466octodon_degusENSODEP00000014776100100
ENSG00000110844homo_sapiensENSP0000044807393.834192.4888jaculus_jaculusENSJJAP0000001152697.212595.8188
ENSG00000110844homo_sapiensENSP0000044807395.515794.1704ovis_aries_rambouilletENSOARP0002000069797.706496.3303
ENSG00000110844homo_sapiensENSP0000044807393.273591.5919ursus_maritimusENSUMAP0000000897392.137390.4762
ENSG00000110844homo_sapiensENSP0000044807392.600989.9103ochotona_princepsENSOPRP0000000422194.616391.8671
ENSG00000110844homo_sapiensENSP0000044807395.403693.722delphinapterus_leucasENSDLEP0000002251598.267996.5358
ENSG00000110844homo_sapiensENSP0000044807398.430596.6368physeter_catodonENSPCTP0000501142298.320396.5286
ENSG00000110844homo_sapiensENSP0000044807395.291593.3857mus_caroliMGP_CAROLIEiJ_P003974797.365495.4181
ENSG00000110844homo_sapiensENSP0000044807395.403693.3857mus_musculusENSMUSP0000011586997.4895.4181
ENSG00000110844homo_sapiensENSP0000044807394.618893.6099dipodomys_ordiiENSDORP0000000025097.011595.977
ENSG00000110844homo_sapiensENSP0000044807395.964194.7309mustela_putorius_furoENSMPUP0000001446798.165196.9037
ENSG00000110844homo_sapiensENSP0000044807399.887999.4395aotus_nancymaaeENSANAP0000002429499.664499.217
ENSG00000110844homo_sapiensENSP0000044807397.085296.861saimiri_boliviensis_boliviensisENSSBOP0000001808699.198298.9691
ENSG00000110844homo_sapiensENSP0000044807399.551699.2152chlorocebus_sabaeusENSCSAP0000000236699.551699.2152
ENSG00000110844homo_sapiensENSP0000044807392.488891.5919tupaia_belangeriENSTBEP0000000627094.501793.5853
ENSG00000110844homo_sapiensENSP0000044807395.964194.2825mesocricetus_auratusENSMAUP0000001206897.605595.8951
ENSG00000110844homo_sapiensENSP0000044807395.964194.2825phocoena_sinusENSPSNP0000001368498.165196.445
ENSG00000110844homo_sapiensENSP0000044807396.86196.0762camelus_dromedariusENSCDRP0000500806281.740881.0785
ENSG00000110844homo_sapiensENSP0000044807397.085296.6368carlito_syrichtaENSTSYP0000001250596.86896.4206
ENSG00000110844homo_sapiensENSP0000044807387.443985.9865panthera_tigris_altaicaENSPTIP0000001516496.654395.0434
ENSG00000110844homo_sapiensENSP0000044807397.421595.4036rattus_norvegicusENSRNOP0000008066697.640495.618
ENSG00000110844homo_sapiensENSP0000044807398.430597.7579prolemur_simusENSPSMP0000002565798.210397.5391
ENSG00000110844homo_sapiensENSP0000044807395.291593.722microtus_ochrogasterENSMOCP0000000114097.25495.6522
ENSG00000110844homo_sapiensENSP0000044807358.183956.8386sorex_araneusENSSARP0000001083166.967765.4194
ENSG00000110844homo_sapiensENSP0000044807349.439549.1031sorex_araneusENSSARP0000001177096.923196.2637
ENSG00000110844homo_sapiensENSP0000044807395.515793.4978peromyscus_maniculatus_bairdiiENSPEMP0000001703197.149495.0969
ENSG00000110844homo_sapiensENSP0000044807394.058392.8251bos_mutusENSBMUP0000003140898.128796.8421
ENSG00000110844homo_sapiensENSP0000044807395.403693.3857mus_spicilegusENSMSIP0000000339197.928695.8573
ENSG00000110844homo_sapiensENSP0000044807398.206396.6368cricetulus_griseus_chok1gshdENSCGRP0000100499697.877196.3129
ENSG00000110844homo_sapiensENSP0000044807391.479890.583pteropus_vampyrusENSPVAP0000001497394.226393.3025
ENSG00000110844homo_sapiensENSP0000044807396.412695.0673myotis_lucifugusENSMLUP0000000582496.95695.6032
ENSG00000110844homo_sapiensENSP0000044807388.901384.8655vombatus_ursinusENSVURP0001000870188.801884.7704
ENSG00000110844homo_sapiensENSP0000044807397.085295.9641rhinolophus_ferrumequinumENSRFEP0001001907597.303496.1798
ENSG00000110844homo_sapiensENSP0000044807395.291594.0583neovison_visonENSNVIP0000000797389.947188.7831
ENSG00000110844homo_sapiensENSP0000044807396.076294.6188bos_taurusENSBTAP0000005756789.363988.0083
ENSG00000110844homo_sapiensENSP0000044807397.085295.7399heterocephalus_glaber_femaleENSHGLP0000000563996.54495.2062
ENSG00000110844homo_sapiensENSP0000044807396.412695.9641rhinopithecus_bietiENSRBIP0000001186096.629296.1798
ENSG00000110844homo_sapiensENSP0000044807392.488890.583canis_lupus_dingoENSCAFP0002001706095.155793.1949
ENSG00000110844homo_sapiensENSP0000044807398.318497.4215sciurus_vulgarisENSSVLP0000501978898.208397.3124
ENSG00000110844homo_sapiensENSP0000044807388.789284.6413phascolarctos_cinereusENSPCIP000000363679085.7955
ENSG00000110844homo_sapiensENSP0000044807379.932778.8117procavia_capensisENSPCAP0000001248881.672480.5269
ENSG00000110844homo_sapiensENSP0000044807394.84393.0493nannospalax_galiliENSNGAP0000002058196.685794.8571
ENSG00000110844homo_sapiensENSP0000044807398.206397.0852bos_grunniensENSBGRP0000000327798.096396.9765
ENSG00000110844homo_sapiensENSP0000044807394.84393.3857chinchilla_lanigeraENSCLAP0000000229797.803596.3006
ENSG00000110844homo_sapiensENSP0000044807398.094296.7489catagonus_wagneriENSCWAP0000002414597.874796.5324
ENSG00000110844homo_sapiensENSP0000044807398.430597.5336ictidomys_tridecemlineatusENSSTOP0000002906296.166595.2903
ENSG00000110844homo_sapiensENSP0000044807395.964195.1794otolemur_garnettiiENSOGAP0000000458898.052797.2509
ENSG00000110844homo_sapiensENSP0000044807397.197396.861cebus_imitatorENSCCAP0000002472399.312798.9691
ENSG00000110844homo_sapiensENSP0000044807393.385792.0404urocitellus_parryiiENSUPAP0001001201295.637294.2595
ENSG00000110844homo_sapiensENSP0000044807395.179493.8341moschus_moschiferusENSMMSP0000002026897.362495.9862
ENSG00000110844homo_sapiensENSP0000044807399.327499.2152rhinopithecus_roxellanaENSRROP0000002877399.327499.2152
ENSG00000110844homo_sapiensENSP0000044807395.291593.1614mus_pahariMGP_PahariEiJ_P004309897.365495.189
ENSG00000110844homo_sapiensENSP0000044807398.878998.4305propithecus_coquereliENSPCOP0000002999198.657798.2103
ENSG00000110844homo_sapiensENSP0000044807345.515728.9238caenorhabditis_elegansZK1098.1a.156.077335.6354
ENSG00000110844homo_sapiensENSP0000044807354.372238.3408drosophila_melanogasterFBpp007733360.173742.4318
ENSG00000110844homo_sapiensENSP0000044807354.372240.0224ciona_intestinalisENSCINP0000001682659.509243.8037
ENSG00000110844homo_sapiensENSP0000044807371.973157.5112petromyzon_marinusENSPMAP0000000335772.297357.7703
ENSG00000110844homo_sapiensENSP0000044807344.506736.2108eptatretus_burgeriENSEBUP0000000554972.84459.2661
ENSG00000110844homo_sapiensENSP0000044807374.215262.4439latimeria_chalumnaeENSLACP0000002175974.049262.3042
ENSG00000110844homo_sapiensENSP0000044807378.026966.1435xenopus_tropicalisENSXETP0000007048974.438563.1016
ENSG00000110844homo_sapiensENSP0000044807364.57456.7265chrysemys_picta_belliiENSCPBP0000002778871.375562.7014
ENSG00000110844homo_sapiensENSP0000044807329.372225.7848sphenodon_punctatusENSSPUP0000002127079.878170.1219
ENSG00000110844homo_sapiensENSP0000044807368.834160.426crocodylus_porosusENSCPRP0000500266973.886964.8616
ENSG00000110844homo_sapiensENSP0000044807354.484347.7578notechis_scutatusENSNSUP0000002528483.937873.5751
ENSG00000110844homo_sapiensENSP0000044807353.363247.1973pseudonaja_textilisENSPTXP0000000861681.646772.2127
ENSG00000110844homo_sapiensENSP0000044807354.14847.9821anolis_carolinensisENSACAP0000002678777.156568.3706
ENSG00000110844homo_sapiensENSP0000044807353.13947.4215naja_najaENSNNAP0000001370683.597974.6032
ENSG00000110844homo_sapiensENSP0000044807354.708548.5426podarcis_muralisENSPMRP0000003436982.711973.3898
ENSG00000110844homo_sapiensENSP0000044807354.260144.0583erpetoichthys_calabaricusENSECRP0000001619368.458355.587
ENSG00000110844homo_sapiensENSP0000044807375.560564.7982salvator_merianaeENSSMRP0000001182376.590965.6818
ENSG00000110844homo_sapiensENSP0000044807375.448467.0404gopherus_evgoodeiENSGEVP0000501347377.713669.0531
ENSG00000110844homo_sapiensENSP0000044807362.892455.0448chelonoidis_abingdoniiENSCABP0000001202666.077757.8327
ENSG00000110844homo_sapiensENSP0000044807363.004555.6054terrapene_carolina_triunguisENSTMTP0000003048771.410463.0241
ENSG00000110844homo_sapiensENSP0000044807314.349810.3139ciona_savignyiENSCSAVP0000001383667.015748.1675
ENSG00000110844homo_sapiensENSP0000044807330.044815.583saccharomyces_cerevisiaeYKL012W45.969123.8422
ENSG00000110844homo_sapiensENSP0000044807367.600956.1659leptobrachium_leishanenseENSLLEP0000000686865.048554.0453

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000398involved_in mRNA splicing, via spliceosome1IBAHomo_sapiens(9606)Process
GO:0003723enables RNA binding1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005685part_of U1 snRNP1IBAHomo_sapiens(9606)Component
GO:0016607located_in nuclear speck1IEAHomo_sapiens(9606)Component
GO:0045292involved_in mRNA cis splicing, via spliceosome1IEAHomo_sapiens(9606)Process
GO:0071004part_of U2-type prespliceosome1IBAHomo_sapiens(9606)Component

Expression