RBP Type	Canonical_RBPs
Diseases	Cancer Disease
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000110063	Gene ID	28960	Accession	29812
Symbol	DCPS	Alias	ARS;DCS1;HSL1;HINT5;HINT-5;HSPC015	Full Name	decapping enzyme, scavenger
Status	Confidence	Length	45946 bases	Strand	Plus strand
Position	11 : 126304060 - 126350005	RNA binding domain	DcpS , DcpS_C
Summary	This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]