Ensembl ID ENSG00000110063 Gene ID 28960 Accession 29812
Gene Symbol DCPS Alias ARS;DCS1;HSL1;HINT5;HINT-5;HSPC015 Full Name decapping enzyme, scavenger
Position 11 : 126304060 - 126350005 Length 45946 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]

ENSG00000110063 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000110063 DCPS 0.55 5.96e-17 BRCA
ENSG00000110063 DCPS 0.75 6.89e-14 COAD
ENSG00000110063 DCPS 1.57 4.74e-12 KICH
ENSG00000110063 DCPS 0.56 4.09e-14 LUSC
ENSG00000110063 DCPS 1.23 8.19e-11 GBM
ENSG00000110063 DCPS 0.68 1.51e-17 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000110063 DCPS Cancer 29533777
ENSG00000110063 DCPS AML 31391371
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000110063 DCPS MESO 0.00031 high
ENSG00000110063 DCPS STAD 0.032 low
ENSG00000110063 DCPS UVM 3e-04 high
ENSG00000110063 DCPS UCEC 0.02 low
ENSG00000110063 DCPS THCA 0.049 low
ENSG00000110063 DCPS LGG 0.014 high
ENSG00000110063 DCPS LUSC 0.045 low
ENSG00000110063 DCPS KIRP 0.012 high
ENSG00000110063 DCPS KICH 0.015 low
ENSG00000110063 DCPS LUAD 0.0061 high
ENSG00000110063 DCPS ESCA 0.035 low
ENSG00000110063 DCPS OV 0.023 low
ENSG00000110063 DCPS KIRC 0.049 high
ENSG00000110063 DCPS PRAD 0.05 high
ENSG00000110063 DCPS BLCA 0.024 low
ENSG00000110063 DCPS LAML 0.015 high
ENSG00000110063 DCPS GBM 0.028 high
ENSG00000110063 DCPS SKCM 0.0096 high
ENSG00000110063 DCPS CESC 5e-04 low
ENSG00000110063 DCPS LIHC 0.03 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000110063 DCPS LUSC Del 3.779803 0.101998 0.357149 0.355289
ENSG00000110063 DCPS LUAD Del 4.790522 0.091690 0.348770 0.228682
ENSG00000110063 DCPS LGG Amp 2.015856 0.063170 0.462211 0.167641
ENSG00000110063 DCPS CESC Del 29.982716 0.320758 0.579464 0.545763
ENSG00000110063 DCPS KIRP Del 3.136243 0.049621 0.562111 0.100694
ENSG00000110063 DCPS SARC Del 9.303728 0.284354 0.565940 0.470817
ENSG00000110063 DCPS ESCA Del 2.307018 0.141215 0.444036 0.429348
ENSG00000110063 DCPS SKCM Del 23.203876 0.260190 0.555427 0.542234
ENSG00000110063 DCPS HNSC Del 12.845139 0.136679 0.434534 0.454023
ENSG00000110063 DCPS LIHC Del 3.186711 0.100950 0.482273 0.256757
ENSG00000110063 DCPS TGCT Del 14.184413 0.269219 0.509275 0.813333
ENSG00000110063 DCPS BLCA Del 2.416722 0.104285 0.405789 0.365196
ENSG00000110063 DCPS BRCA Del 50.884068 0.228760 0.531547 0.485185
ENSG00000110063 DCPS STAD Del 2.004932 0.078560 0.365522 0.206349
ENSG00000110063 DCPS UCEC Del 3.903194 0.080144 0.551801 0.161410
ENSG00000110063 DCPS UVM Del 1.063142 0.073079 0.580201 0.075000
ENSG00000110063 DCPS OV Del 0.705867 0.174084 0.541980 0.326425