RBP Type	Canonical_RBPs
Diseases	Cancer Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000109819	Gene ID	10891	Accession	9237
Symbol	PPARGC1A	Alias	LEM6;PGC1;PGC1A;PGC-1v;PPARGC1;PGC-1alpha;PGC-1(alpha)	Full Name	PPARG coactivator 1 alpha
Status	Confidence	Length	98057 bases	Strand	Minus strand
Position	4 : 23792021 - 23890077	RNA binding domain	RRM_1
Summary	The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]