Ensembl ID ENSG00000109819 Gene ID 10891 Accession 9237
Gene Symbol PPARGC1A Alias LEM6;PGC1;PGC1A;PGC-1v;PPARGC1;PGC-1alpha;PGC-1(alpha) Full Name PPARG coactivator 1 alpha
Position 4 : 23792021 - 23890077 Length 98057 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

ENSG00000109819 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000109819 PPARGC1A -1.7 3.88e-21 KIRC
ENSG00000109819 PPARGC1A -3.0 4.40e-26 HNSC
ENSG00000109819 PPARGC1A -1.7 1.21e-18 COAD
ENSG00000109819 PPARGC1A 1.53 3.22e-14 KICH
ENSG00000109819 PPARGC1A -1.7 4.63e-24 PRAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000109819 PPARGC1A tumour 15920699
ENSG00000109819 PPARGC1A familial breast cancer 16704985
ENSG00000109819 PPARGC1A tumour 17047651
ENSG00000109819 PPARGC1A cancer 17053067
ENSG00000109819 PPARGC1A colorectal tumor 17341490
ENSG00000109819 PPARGC1A epithelial ovarian cancer 17372612
ENSG00000109819 PPARGC1A Tumor 17616713
ENSG00000109819 PPARGC1A cancer 17678552
ENSG00000109819 PPARGC1A epithelial ovarian cancer 17785072
ENSG00000109819 PPARGC1A liver cancer 19102936
ENSG00000109819 PPARGC1A tumor 19465495
ENSG00000109819 PPARGC1A cancer 19602572
ENSG00000109819 PPARGC1A tumor 19680556
ENSG00000109819 PPARGC1A tumours 19755984
ENSG00000109819 PPARGC1A endometrial cancer 19861117
ENSG00000109819 PPARGC1A prostate cancer 19884383
ENSG00000109819 PPARGC1A tumour 20211864
ENSG00000109819 PPARGC1A prostate cancer 20477822
ENSG00000109819 PPARGC1A cancer 21069263
ENSG00000109819 PPARGC1A breast cancer 21128112
ENSG00000109819 PPARGC1A brain tumors 21133850
ENSG00000109819 PPARGC1A tumors 21162720
ENSG00000109819 PPARGC1A tumor 21321201
ENSG00000109819 PPARGC1A tumor 21339306
ENSG00000109819 PPARGC1A tumor 21385932
ENSG00000109819 PPARGC1A intestinal cancer 21467224
ENSG00000109819 PPARGC1A tumour 21475674
ENSG00000109819 PPARGC1A colorectal cancer 21862870
ENSG00000109819 PPARGC1A tumor 21914785
ENSG00000109819 PPARGC1A breast cancer 22050908
ENSG00000109819 PPARGC1A tumors 22266114
ENSG00000109819 PPARGC1A cancer 22285815
ENSG00000109819 PPARGC1A liver tumors 22318941
ENSG00000109819 PPARGC1A tumor 22428048
ENSG00000109819 PPARGC1A endometrial cancer 22676897
ENSG00000109819 PPARGC1A breast cancer 22703186
ENSG00000109819 PPARGC1A tumor 22896732
ENSG00000109819 PPARGC1A tumor 22897925
ENSG00000109819 PPARGC1A tumor 23070475
ENSG00000109819 PPARGC1A kidney cancer 23150719
ENSG00000109819 PPARGC1A tumor 23166610
ENSG00000109819 PPARGC1A breast cancer 23172368
ENSG00000109819 PPARGC1A cancer 23216862
ENSG00000109819 PPARGC1A cancer 23231082
ENSG00000109819 PPARGC1A tumour 23335007
ENSG00000109819 PPARGC1A tumors 23416000
ENSG00000109819 PPARGC1A liver cancer 23564453
ENSG00000109819 PPARGC1A prostate cancer 24186207
ENSG00000109819 PPARGC1A breast cancer 24304688
ENSG00000109819 PPARGC1A cancer 24350057
ENSG00000109819 PPARGC1A tumor 24403067
ENSG00000109819 PPARGC1A benign tumors 24472748
ENSG00000109819 PPARGC1A lung cancer 24583643
ENSG00000109819 PPARGC1A cancer 24595460
ENSG00000109819 PPARGC1A tumour 24646150
ENSG00000109819 PPARGC1A tumor 24812272
ENSG00000109819 PPARGC1A tumor 24892905
ENSG00000109819 PPARGC1A Tumour 24898700
ENSG00000109819 PPARGC1A breast cancer 24904222
ENSG00000109819 PPARGC1A cancers 24947365
ENSG00000109819 PPARGC1A pancreatic cancer 25051362
ENSG00000109819 PPARGC1A tumor 25141867
ENSG00000109819 PPARGC1A tumor 25204433
ENSG00000109819 PPARGC1A breast cancer 25212524
ENSG00000109819 PPARGC1A tumor 25241037
ENSG00000109819 PPARGC1A tumour 25243473
ENSG00000109819 PPARGC1A tumors 25297634
ENSG00000109819 PPARGC1A Tumour 25307264
ENSG00000109819 PPARGC1A cancers 25490445
ENSG00000109819 PPARGC1A breast cancer 25516445
ENSG00000109819 PPARGC1A tumor 25522631
ENSG00000109819 PPARGC1A cancer 25688484
ENSG00000109819 PPARGC1A tumor 25736869
ENSG00000109819 PPARGC1A Colon Cancer 25779952
ENSG00000109819 PPARGC1A tumors 25791281
ENSG00000109819 PPARGC1A endometrial cancer 25914546
ENSG00000109819 PPARGC1A cancers 25918410
ENSG00000109819 PPARGC1A tumor 26119730
ENSG00000109819 PPARGC1A cancer 26136192
ENSG00000109819 PPARGC1A tumour 26136413
ENSG00000109819 PPARGC1A cancer 26334087
ENSG00000109819 PPARGC1A Pancreatic Cancer 26365176
ENSG00000109819 PPARGC1A cancer 26438876
ENSG00000109819 PPARGC1A liver cancer 26442469
ENSG00000109819 PPARGC1A breast cancer 26492917
ENSG00000109819 PPARGC1A tumor 26636649
ENSG00000109819 PPARGC1A cancer 26775698
ENSG00000109819 PPARGC1A Breast Cancer 26804918
ENSG00000109819 PPARGC1A cancer 26812134
ENSG00000109819 PPARGC1A breast cancer 27010860
ENSG00000109819 PPARGC1A tumor 27081083
ENSG00000109819 PPARGC1A tumor 27086599
ENSG00000109819 PPARGC1A breast cancer 27102200
ENSG00000109819 PPARGC1A tumors 27134168
ENSG00000109819 PPARGC1A endometrial cancer 27153547
ENSG00000109819 PPARGC1A Cancer 27197257
ENSG00000109819 PPARGC1A tumours 27214280
ENSG00000109819 PPARGC1A cancer 27228792
ENSG00000109819 PPARGC1A prostate cancer 27230528
ENSG00000109819 PPARGC1A primary cancer 27308459
ENSG00000109819 PPARGC1A tumors 27308473
ENSG00000109819 PPARGC1A endometrial cancer 27418839
ENSG00000109819 PPARGC1A tumor 27496732
ENSG00000109819 PPARGC1A colorectal cancer 27531262
ENSG00000109819 PPARGC1A cancer 27551487
ENSG00000109819 PPARGC1A cancer 27563641
ENSG00000109819 PPARGC1A Cancer 27589085
ENSG00000109819 PPARGC1A endometrial cancer 27601924
ENSG00000109819 PPARGC1A tumor 27626695
ENSG00000109819 PPARGC1A cancer 27721378
ENSG00000109819 PPARGC1A tumors 27726115
ENSG00000109819 PPARGC1A breast cancer 27746856
ENSG00000109819 PPARGC1A benign breast tumor 27780920
ENSG00000109819 PPARGC1A tumor 27878239
ENSG00000109819 PPARGC1A breast cancer 27916422
ENSG00000109819 PPARGC1A tumor 27929420
ENSG00000109819 PPARGC1A colon cancer 28007957
ENSG00000109819 PPARGC1A colorectal cancer 28051997
ENSG00000109819 PPARGC1A tumor 28076790
ENSG00000109819 PPARGC1A Prostate Cancer 28093148
ENSG00000109819 PPARGC1A tumor 28096382
ENSG00000109819 PPARGC1A tumor 28250388
ENSG00000109819 PPARGC1A cancer 28352611
ENSG00000109819 PPARGC1A breast cancer 28357294
ENSG00000109819 PPARGC1A cancer 28370295
ENSG00000109819 PPARGC1A tumor 28381162
ENSG00000109819 PPARGC1A cancer 28405929
ENSG00000109819 PPARGC1A tumors 28423551
ENSG00000109819 PPARGC1A tumor 28447025
ENSG00000109819 PPARGC1A prostate cancer 28453464
ENSG00000109819 PPARGC1A tumor 28473727
ENSG00000109819 PPARGC1A tumor 28484465
ENSG00000109819 PPARGC1A breast cancer 28525844
ENSG00000109819 PPARGC1A Cancer 28596418
ENSG00000109819 PPARGC1A tumor 28599408
ENSG00000109819 PPARGC1A cancer 28620312
ENSG00000109819 PPARGC1A tumor 28785374
ENSG00000109819 PPARGC1A lung cancer 28803067
ENSG00000109819 PPARGC1A breast cancer 28821609
ENSG00000109819 PPARGC1A tumor 28825045
ENSG00000109819 PPARGC1A tumor 28915557
ENSG00000109819 PPARGC1A tumor 28932704
ENSG00000109819 PPARGC1A cancer 28947972
ENSG00000109819 PPARGC1A tumors 28978917
ENSG00000109819 PPARGC1A Breast Cancer 28988825
ENSG00000109819 PPARGC1A tumor 28991225
ENSG00000109819 PPARGC1A cancer 29017115
ENSG00000109819 PPARGC1A tumor 29038164
ENSG00000109819 PPARGC1A cancers 29115599
ENSG00000109819 PPARGC1A colorectal cancer 29121859
ENSG00000109819 PPARGC1A colorectal cancer 29130104
ENSG00000109819 PPARGC1A Prostate Cancer 29144947
ENSG00000109819 PPARGC1A ovarian cancer 29163365
ENSG00000109819 PPARGC1A prostate cancer 29181019
ENSG00000109819 PPARGC1A tumor 29192176
ENSG00000109819 PPARGC1A breast cancer 29200866
ENSG00000109819 PPARGC1A AML 29229602
ENSG00000109819 PPARGC1A cancer 29306792
ENSG00000109819 PPARGC1A tumor 29323298
ENSG00000109819 PPARGC1A cancer 29340100
ENSG00000109819 PPARGC1A cancer 29354634
ENSG00000109819 PPARGC1A Cancer 29361779
ENSG00000109819 PPARGC1A liver cancer 29436167
ENSG00000109819 PPARGC1A tumor 29453741
ENSG00000109819 PPARGC1A tumor 29463573
ENSG00000109819 PPARGC1A tumor 29511066
ENSG00000109819 PPARGC1A cancer 29548774
ENSG00000109819 PPARGC1A colorectal cancer 29566941
ENSG00000109819 PPARGC1A Cancer 29599799
ENSG00000109819 PPARGC1A tumor 29629336
ENSG00000109819 PPARGC1A cancer 29654866
ENSG00000109819 PPARGC1A tumors 29700317
ENSG00000109819 PPARGC1A cancer 29717261
ENSG00000109819 PPARGC1A tumour 29739810
ENSG00000109819 PPARGC1A tumor 29740540
ENSG00000109819 PPARGC1A cancer 29743249
ENSG00000109819 PPARGC1A tumor 29785246
ENSG00000109819 PPARGC1A Colorectal Cancer 29789344
ENSG00000109819 PPARGC1A cancer 29865240
ENSG00000109819 PPARGC1A cancer 29888964
ENSG00000109819 PPARGC1A cancer 29915539
ENSG00000109819 PPARGC1A Breast Cancer 29930100
ENSG00000109819 PPARGC1A tumor 29966675
ENSG00000109819 PPARGC1A cancer 30016403
ENSG00000109819 PPARGC1A prostate cancer 30042415
ENSG00000109819 PPARGC1A tumor 30054562
ENSG00000109819 PPARGC1A cancer 30122956
ENSG00000109819 PPARGC1A tumor 30143538
ENSG00000109819 PPARGC1A Breast Cancer 30178342
ENSG00000109819 PPARGC1A cancer 30186229
ENSG00000109819 PPARGC1A tumor 30242145
ENSG00000109819 PPARGC1A tumors 30244973
ENSG00000109819 PPARGC1A cancer 30254608
ENSG00000109819 PPARGC1A tumors 30310055
ENSG00000109819 PPARGC1A cancer 30318520
ENSG00000109819 PPARGC1A tumor 30374329
ENSG00000109819 PPARGC1A tumor 30391585
ENSG00000109819 PPARGC1A cancer 30400212
ENSG00000109819 PPARGC1A cancer 30527740
ENSG00000109819 PPARGC1A tumor 30578297
ENSG00000109819 PPARGC1A cancers 30594485
ENSG00000109819 PPARGC1A tumor 30610087
ENSG00000109819 PPARGC1A breast cancer 30616060
ENSG00000109819 PPARGC1A tumour 30648791
ENSG00000109819 PPARGC1A tumor 30684287
ENSG00000109819 PPARGC1A primary cancer 30691108
ENSG00000109819 PPARGC1A tumour 30767037
ENSG00000109819 PPARGC1A cancer 30771209
ENSG00000109819 PPARGC1A cancer 30848477
ENSG00000109819 PPARGC1A tumor 30867900
ENSG00000109819 PPARGC1A tumors 30880247
ENSG00000109819 PPARGC1A cancer 30906622
ENSG00000109819 PPARGC1A cancer 30911677
ENSG00000109819 PPARGC1A cancer 30920960
ENSG00000109819 PPARGC1A tumor 30931098
ENSG00000109819 PPARGC1A cancer 30936458
ENSG00000109819 PPARGC1A tumor 30945396
ENSG00000109819 PPARGC1A Colorectal Cancer 30959809
ENSG00000109819 PPARGC1A tumor 30967773
ENSG00000109819 PPARGC1A tumor 30997670
ENSG00000109819 PPARGC1A rectal cancer 31028741
ENSG00000109819 PPARGC1A cancer 31040369
ENSG00000109819 PPARGC1A breast cancer 31052256
ENSG00000109819 PPARGC1A tumor 31060333
ENSG00000109819 PPARGC1A Prostate Cancer 31064849
ENSG00000109819 PPARGC1A tumor 31066170
ENSG00000109819 PPARGC1A tumor 31097683
ENSG00000109819 PPARGC1A breast cancer 31154462
ENSG00000109819 PPARGC1A breast cancers 31221959
ENSG00000109819 PPARGC1A colorectal cancer 31258845
ENSG00000109819 PPARGC1A ovarian cancer 31313989
ENSG00000109819 PPARGC1A thyroid cancer 31333799
ENSG00000109819 PPARGC1A tumor 31383001
ENSG00000109819 PPARGC1A tumor 31451071
ENSG00000109819 PPARGC1A tumors 31452510
ENSG00000109819 PPARGC1A tumor 31469445
ENSG00000109819 PPARGC1A tumor 31493764
ENSG00000109819 PPARGC1A Colorectal Cancer 31519589
ENSG00000109819 PPARGC1A cancer 31519688
ENSG00000109819 PPARGC1A tumor 31547367
ENSG00000109819 PPARGC1A tumor 31588240
ENSG00000109819 PPARGC1A Prostate Cancer 31594836
ENSG00000109819 PPARGC1A cancer 31600993
ENSG00000109819 PPARGC1A cancer 31614775
ENSG00000109819 PPARGC1A liver cancer 31623280
ENSG00000109819 PPARGC1A tumor 31629659
ENSG00000109819 PPARGC1A ovarian cancer 31657115
ENSG00000109819 PPARGC1A non-small cell lung cancer 31663688
ENSG00000109819 PPARGC1A tumour 31664147
ENSG00000109819 PPARGC1A tumor 31694905
ENSG00000109819 PPARGC1A Malignant Tumours 31702508
ENSG00000109819 PPARGC1A AML 31709192
ENSG00000109819 PPARGC1A non-small-cell lung cancer 31713888
ENSG00000109819 PPARGC1A tumor 31926622
ENSG00000109819 PPARGC1A tumor 31929186
ENSG00000109819 PPARGC1A tumor 31968688
ENSG00000109819 PPARGC1A kidney cancer 31982456
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000109819 PPARGC1A UVM 0.01 low
ENSG00000109819 PPARGC1A THCA 0.00022 high
ENSG00000109819 PPARGC1A LUAD 0.025 high
ENSG00000109819 PPARGC1A PCPG 0.0079 high
ENSG00000109819 PPARGC1A THYM 0.011 high
ENSG00000109819 PPARGC1A ESCA 0.05 low
ENSG00000109819 PPARGC1A DLBC 0.015 high
ENSG00000109819 PPARGC1A BLCA 0.0034 high
ENSG00000109819 PPARGC1A GBM 0.02 low
ENSG00000109819 PPARGC1A SKCM 0.02 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency