RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	rRNA
Moonlighting functions	E3 ligase
Localizations	Stress granucleNucleoliNucleoli rim
BulkPerturb-seq	DataSet_01_227 DataSet_01_335

Description

Ensembl ID	ENSG00000105447	Gene ID	83743	Accession	21270
Symbol	GRWD1	Alias	CDW4;GRWD;RRB1;WDR28	Full Name	glutamate rich WD repeat containing 1
Status	Confidence	Length	11182 bases	Strand	Plus strand
Position	19 : 48445841 - 48457022	RNA binding domain	N.A.
Summary	This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hela_human	Hela	Alfredo Castello	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
27453046	RBDmap_PMID_27453046_Hs_HeLa	HeLa	Alfredo Castello	2016 Aug 18	doi: 10.1016/j.molcel.2016.06.029.?Epub 2016 Jul 21
29431736	RICK_PMID29431736_Hs_HeLa.RICK	HeLa	Xichen Bao	2018 Mar	doi: 10.1038/nmeth.4595.?Epub 2018 Feb 12
30352994	eRIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30352994	RIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30528433	XRNAX_PMID30528433_Hs_HEK293	HEK293	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30528433	XRNAX_PMID30528433_Hs_HeLa	HeLa	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6

Showing 1 to 10 of 20 entries

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
GRWD1-201	ENST00000253237	5361	446aa	ENSP00000253237
GRWD1-202	ENST00000598711	881	228aa	ENSP00000468943
GRWD1-203	ENST00000599949	518	No protein	-

Showing 1 to 3 of 3 entries

Gene Model

Click here to download ENSG00000105447's gene model file

Protein-Protein Interaction (PPI)

Click here to download ENSG00000105447's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000105447	homo_sapiens	ENSP00000285873	10.0133	5.37135	homo_sapiens	ENSP00000253237	33.8565	18.1614
ENSG00000105447	homo_sapiens	ENSP00000362592	24.7059	12.7059	homo_sapiens	ENSP00000253237	23.5426	12.1076
ENSG00000105447	homo_sapiens	ENSP00000369427	23.7647	12.2353	homo_sapiens	ENSP00000253237	22.6457	11.6592
ENSG00000105447	homo_sapiens	ENSP00000235090	22.5146	12.2807	homo_sapiens	ENSP00000253237	17.2646	9.41704
ENSG00000105447	homo_sapiens	ENSP00000315680	25.387	16.0991	homo_sapiens	ENSP00000253237	18.3857	11.6592
ENSG00000105447	homo_sapiens	ENSP00000293883	12.7848	6.32911	homo_sapiens	ENSP00000253237	22.6457	11.2108
ENSG00000105447	homo_sapiens	ENSP00000262144	12.115	6.3655	homo_sapiens	ENSP00000253237	26.4574	13.9013
ENSG00000105447	homo_sapiens	ENSP00000387982	21.9577	11.9048	homo_sapiens	ENSP00000253237	18.6099	10.0897
ENSG00000105447	homo_sapiens	ENSP00000501614	34.0909	19.4444	homo_sapiens	ENSP00000253237	30.2691	17.2646

Showing 1 to 9 of 9 entries

Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000105447	homo_sapiens	ENSP00000253237	92.8251	91.2556	nomascus_leucogenys	ENSNLEP00000032862	96.9555	95.3162
ENSG00000105447	homo_sapiens	ENSP00000253237	100	99.5516	pan_paniscus	ENSPPAP00000004924	100	99.5516
ENSG00000105447	homo_sapiens	ENSP00000253237	100	99.7758	pan_paniscus	ENSPPAP00000008614	100	99.7758
ENSG00000105447	homo_sapiens	ENSP00000253237	99.3274	98.4305	pongo_abelii	ENSPPYP00000039736	99.3274	98.4305
ENSG00000105447	homo_sapiens	ENSP00000253237	100	99.7758	pan_troglodytes	ENSPTRP00000019277	100	99.7758
ENSG00000105447	homo_sapiens	ENSP00000253237	99.3274	98.8789	gorilla_gorilla	ENSGGOP00000013118	99.5506	99.1011
ENSG00000105447	homo_sapiens	ENSP00000253237	89.6861	78.0269	ornithorhynchus_anatinus	ENSOANP00000041569	89.8876	78.2022
ENSG00000105447	homo_sapiens	ENSP00000253237	71.3004	62.5561	sarcophilus_harrisii	ENSSHAP00000008495	74.1259	65.035
ENSG00000105447	homo_sapiens	ENSP00000253237	87.2197	78.4753	notamacropus_eugenii	ENSMEUP00000003278	88.4091	79.5455
ENSG00000105447	homo_sapiens	ENSP00000253237	96.6368	93.2735	dasypus_novemcinctus	ENSDNOP00000034597	95.7778	92.4444

Showing 1 to 10 of 180 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005730	is_active_in nucleolus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0006334	involved_in nucleosome assembly	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0003682	enables chromatin binding	1	IDA	Homo_sapiens(9606)	Function
GO:0003688	enables DNA replication origin binding	1	IDA	Homo_sapiens(9606)	Function
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005694	located_in chromosome	1	IEA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component

Showing 1 to 10 of 15 entries

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Expression

Contents

Description
RBPomes
Transcripts
Gene Model
PPI
Paralogs
Orthologs
Gene Ontology
Expression