RBP Type
Canonical_RBPs
Diseases
Drug
N.A.
Main interacting RNAs
N.A.
Moonlighting functions
Transmemebrane
Localizations
N.A.
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000102109 Gene ID
27344 Accession
17301
Symbol
PCSK1N
Alias
PEN;SAAS;SCG8;BigLEN;SgVIII;PROSAAS
Full Name
proprotein convertase subtilisin/kexin type 1 inhibitor
Status
Confidence
Length
4515 bases
Strand
Minus strand
Position
X : 48831096 - 48835610
RNA binding domain
ProSAAS
Summary
The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000218230
ProSAAS
PF07259 2.9e-46
1
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
Name
Transcript ID
bp
Protein
Translation ID
PCSK1N-201
ENST00000218230
1025
260aa
ENSP00000218230
PCSK1N-202
ENST00000611033
392
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000102109
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000102109 homo_sapiens ENSP00000218230 98.8462 98.0769 nomascus_leucogenys ENSNLEP00000009631 98.8462 98.0769 ENSG00000102109 homo_sapiens ENSP00000218230 85 85 pan_paniscus ENSPPAP00000022288 100 100 ENSG00000102109 homo_sapiens ENSP00000218230 99.2308 99.2308 pongo_abelii ENSPPYP00000022749 99.2308 99.2308 ENSG00000102109 homo_sapiens ENSP00000218230 100 100 pan_troglodytes ENSPTRP00000093601 100 100 ENSG00000102109 homo_sapiens ENSP00000218230 99.2308 99.2308 gorilla_gorilla ENSGGOP00000004447 99.2308 99.2308 ENSG00000102109 homo_sapiens ENSP00000218230 88.8462 85 dasypus_novemcinctus ENSDNOP00000023831 89.8833 85.9922 ENSG00000102109 homo_sapiens ENSP00000218230 64.6154 61.5385 erinaceus_europaeus ENSEEUP00000011890 86.1538 82.0513 ENSG00000102109 homo_sapiens ENSP00000218230 40.3846 35 echinops_telfairi ENSETEP00000004345 37.5 32.5 ENSG00000102109 homo_sapiens ENSP00000218230 78.4615 76.9231 callithrix_jacchus ENSCJAP00000052569 54.2553 53.1915 ENSG00000102109 homo_sapiens ENSP00000218230 99.2308 98.0769 cercocebus_atys ENSCATP00000026882 98.8506 97.7011 ENSG00000102109 homo_sapiens ENSP00000218230 98.8462 97.6923 macaca_mulatta ENSMMUP00000021642 98.4674 97.318 ENSG00000102109 homo_sapiens ENSP00000218230 98.8462 97.6923 macaca_nemestrina ENSMNEP00000024945 98.4674 97.318 ENSG00000102109 homo_sapiens ENSP00000218230 98.8462 97.6923 papio_anubis ENSPANP00000002296 98.4674 97.318 ENSG00000102109 homo_sapiens ENSP00000218230 78.4615 75.7692 tursiops_truncatus ENSTTRP00000004450 92.3077 89.1403 ENSG00000102109 homo_sapiens ENSP00000218230 67.3077 61.9231 vulpes_vulpes ENSVVUP00000024244 59.1216 54.3919 ENSG00000102109 homo_sapiens ENSP00000218230 86.5385 82.3077 mus_spretus MGP_SPRETEiJ_P0094658 87.2093 82.9457 ENSG00000102109 homo_sapiens ENSP00000218230 93.4615 90.7692 equus_asinus ENSEASP00005028307 93.4615 90.7692 ENSG00000102109 homo_sapiens ENSP00000218230 89.6154 86.1538 capra_hircus ENSCHIP00000016498 76.8977 73.9274 ENSG00000102109 homo_sapiens ENSP00000218230 75 68.8462 loxodonta_africana ENSLAFP00000023009 75.8755 69.6498 ENSG00000102109 homo_sapiens ENSP00000218230 88.8462 85 panthera_leo ENSPLOP00000022442 67.9412 65 ENSG00000102109 homo_sapiens ENSP00000218230 91.1538 87.3077 ailuropoda_melanoleuca ENSAMEP00000042678 91.1538 87.3077 ENSG00000102109 homo_sapiens ENSP00000218230 89.2308 86.5385 bos_indicus_hybrid ENSBIXP00005029708 76.5677 74.2574 ENSG00000102109 homo_sapiens ENSP00000218230 82.3077 79.2308 oryctolagus_cuniculus ENSOCUP00000007790 82.3077 79.2308 ENSG00000102109 homo_sapiens ENSP00000218230 93.8462 91.1538 equus_caballus ENSECAP00000035010 93.8462 91.1538 ENSG00000102109 homo_sapiens ENSP00000218230 90.7692 86.9231 canis_lupus_familiaris ENSCAFP00845043249 68.6047 65.6977 ENSG00000102109 homo_sapiens ENSP00000218230 88.8462 85 panthera_pardus ENSPPRP00000018601 90.2344 86.3281 ENSG00000102109 homo_sapiens ENSP00000218230 81.1538 76.9231 marmota_marmota_marmota ENSMMMP00000013634 82.7451 78.4314 ENSG00000102109 homo_sapiens ENSP00000218230 91.9231 89.2308 balaenoptera_musculus ENSBMSP00010019805 70.5015 68.4366 ENSG00000102109 homo_sapiens ENSP00000218230 88.0769 83.0769 cavia_porcellus ENSCPOP00000006824 87.7395 82.7586 ENSG00000102109 homo_sapiens ENSP00000218230 90.3846 86.5385 felis_catus ENSFCAP00000010425 90.3846 86.5385 ENSG00000102109 homo_sapiens ENSP00000218230 91.5385 88.8462 monodon_monoceros ENSMMNP00015018478 91.8919 89.1892 ENSG00000102109 homo_sapiens ENSP00000218230 80.3846 76.5385 sus_scrofa ENSSSCP00000068857 87.8151 83.6134 ENSG00000102109 homo_sapiens ENSP00000218230 90 86.9231 microcebus_murinus ENSMICP00000031593 90 86.9231 ENSG00000102109 homo_sapiens ENSP00000218230 87.6923 84.6154 octodon_degus ENSODEP00000014236 87.3563 84.2912 ENSG00000102109 homo_sapiens ENSP00000218230 89.2308 85.3846 jaculus_jaculus ENSJJAP00000000166 89.2308 85.3846 ENSG00000102109 homo_sapiens ENSP00000218230 89.6154 85.7692 ovis_aries_rambouillet ENSOARP00020024723 76.8977 73.5974 ENSG00000102109 homo_sapiens ENSP00000218230 73.0769 70 ochotona_princeps ENSOPRP00000011360 80.8511 77.4468 ENSG00000102109 homo_sapiens ENSP00000218230 76.5385 72.3077 delphinapterus_leucas ENSDLEP00000020900 66.5552 62.8763 ENSG00000102109 homo_sapiens ENSP00000218230 91.5385 88.8462 physeter_catodon ENSPCTP00005009332 91.8919 89.1892 ENSG00000102109 homo_sapiens ENSP00000218230 86.9231 83.0769 mus_caroli MGP_CAROLIEiJ_P0090916 87.5969 83.7209 ENSG00000102109 homo_sapiens ENSP00000218230 86.5385 82.6923 mus_musculus ENSMUSP00000040342 87.2093 83.3333 ENSG00000102109 homo_sapiens ENSP00000218230 88.4615 85.3846 dipodomys_ordii ENSDORP00000007464 88.4615 85.3846 ENSG00000102109 homo_sapiens ENSP00000218230 89.2308 84.2308 mustela_putorius_furo ENSMPUP00000013566 89.2308 84.2308 ENSG00000102109 homo_sapiens ENSP00000218230 98.0769 96.1538 aotus_nancymaae ENSANAP00000026834 98.0769 96.1538 ENSG00000102109 homo_sapiens ENSP00000218230 98.0769 96.5385 saimiri_boliviensis_boliviensis ENSSBOP00000037846 98.0769 96.5385 ENSG00000102109 homo_sapiens ENSP00000218230 98.8462 97.6923 chlorocebus_sabaeus ENSCSAP00000009350 98.8462 97.6923 ENSG00000102109 homo_sapiens ENSP00000218230 60 59.6154 tupaia_belangeri ENSTBEP00000009708 64.1975 63.786 ENSG00000102109 homo_sapiens ENSP00000218230 88.0769 84.2308 mesocricetus_auratus ENSMAUP00000016762 88.7597 84.8837 ENSG00000102109 homo_sapiens ENSP00000218230 91.1538 88.4615 phocoena_sinus ENSPSNP00000030207 91.5058 88.8031 ENSG00000102109 homo_sapiens ENSP00000218230 90 86.9231 camelus_dromedarius ENSCDRP00005025428 91.4062 88.2812 ENSG00000102109 homo_sapiens ENSP00000218230 63.8462 61.9231 carlito_syrichta ENSTSYP00000023242 84.6939 82.1429 ENSG00000102109 homo_sapiens ENSP00000218230 86.9231 83.8462 rattus_norvegicus ENSRNOP00000066891 86.9231 83.8462 ENSG00000102109 homo_sapiens ENSP00000218230 91.9231 89.2308 prolemur_simus ENSPSMP00000024166 91.9231 89.2308 ENSG00000102109 homo_sapiens ENSP00000218230 87.3077 82.6923 microtus_ochrogaster ENSMOCP00000017974 87.9845 83.3333 ENSG00000102109 homo_sapiens ENSP00000218230 89.2308 85.7692 peromyscus_maniculatus_bairdii ENSPEMP00000018696 89.9225 86.4341 ENSG00000102109 homo_sapiens ENSP00000218230 76.9231 71.5385 mus_spicilegus ENSMSIP00000023167 81.3008 75.6098 ENSG00000102109 homo_sapiens ENSP00000218230 88.0769 85 cricetulus_griseus_chok1gshd ENSCGRP00001012068 88.7597 85.6589 ENSG00000102109 homo_sapiens ENSP00000218230 88.0769 82.6923 pteropus_vampyrus ENSPVAP00000007215 90.1575 84.6457 ENSG00000102109 homo_sapiens ENSP00000218230 61.1538 56.9231 myotis_lucifugus ENSMLUP00000008314 80.7107 75.1269 ENSG00000102109 homo_sapiens ENSP00000218230 91.1538 86.1538 rhinolophus_ferrumequinum ENSRFEP00010000797 91.8605 86.8217 ENSG00000102109 homo_sapiens ENSP00000218230 89.2308 86.5385 bos_taurus ENSBTAP00000042463 76.5677 74.2574 ENSG00000102109 homo_sapiens ENSP00000218230 86.5385 84.2308 heterocephalus_glaber_female ENSHGLP00000004039 76.7918 74.744 ENSG00000102109 homo_sapiens ENSP00000218230 83.8462 82.6923 rhinopithecus_bieti ENSRBIP00000018274 98.1982 96.8468 ENSG00000102109 homo_sapiens ENSP00000218230 90.7692 87.3077 canis_lupus_dingo ENSCAFP00020025850 90.7692 87.3077 ENSG00000102109 homo_sapiens ENSP00000218230 89.6154 87.3077 sciurus_vulgaris ENSSVLP00005026353 89.6154 87.3077 ENSG00000102109 homo_sapiens ENSP00000218230 88.4615 85 nannospalax_galili ENSNGAP00000012966 88.8031 85.3282 ENSG00000102109 homo_sapiens ENSP00000218230 89.2308 86.5385 bos_grunniens ENSBGRP00000028458 76.5677 74.2574 ENSG00000102109 homo_sapiens ENSP00000218230 54.2308 52.3077 chinchilla_lanigera ENSCLAP00000004776 83.9286 80.9524 ENSG00000102109 homo_sapiens ENSP00000218230 81.1538 76.9231 cervus_hanglu_yarkandensis ENSCHYP00000016439 68.5065 64.9351 ENSG00000102109 homo_sapiens ENSP00000218230 82.3077 79.2308 catagonus_wagneri ENSCWAP00000015159 89.916 86.5546 ENSG00000102109 homo_sapiens ENSP00000218230 89.6154 87.6923 ictidomys_tridecemlineatus ENSSTOP00000023433 89.272 87.3563 ENSG00000102109 homo_sapiens ENSP00000218230 91.5385 88.0769 otolemur_garnettii ENSOGAP00000017142 91.5385 88.0769 ENSG00000102109 homo_sapiens ENSP00000218230 96.9231 95 cebus_imitator ENSCCAP00000028183 96.9231 95 ENSG00000102109 homo_sapiens ENSP00000218230 89.6154 87.6923 urocitellus_parryii ENSUPAP00010003557 89.272 87.3563 ENSG00000102109 homo_sapiens ENSP00000218230 89.2308 86.1538 moschus_moschiferus ENSMMSP00000019482 89.5753 86.4865 ENSG00000102109 homo_sapiens ENSP00000218230 85.7692 83.4615 rhinopithecus_roxellana ENSRROP00000037740 95.7082 93.133 ENSG00000102109 homo_sapiens ENSP00000218230 86.5385 82.6923 mus_pahari MGP_PahariEiJ_P0088555 87.2093 83.3333 ENSG00000102109 homo_sapiens ENSP00000218230 93.8462 91.1538 propithecus_coquereli ENSPCOP00000004550 93.8462 91.1538
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0002021 involved_in response to dietary excess 1 IEA Homo_sapiens(9606) Process GO:0004866 enables endopeptidase inhibitor activity 1 IBA Homo_sapiens(9606) Function GO:0004867 enables serine-type endopeptidase inhibitor activity 1 IEA Homo_sapiens(9606) Function GO:0005102 enables signaling receptor binding 1 TAS Homo_sapiens(9606) Function GO:0005615 is_active_in extracellular space 1 IBA Homo_sapiens(9606) Component GO:0005802 located_in trans-Golgi network 1 IEA Homo_sapiens(9606) Component GO:0007218 involved_in neuropeptide signaling pathway 1 IEA Homo_sapiens(9606) Process GO:0009409 involved_in response to cold 1 IEA Homo_sapiens(9606) Process GO:0010951 involved_in negative regulation of endopeptidase activity 1 IEA Homo_sapiens(9606) Process GO:0016486 involved_in peptide hormone processing 1 IEA Homo_sapiens(9606) Process GO:0030141 located_in secretory granule 1 IEA Homo_sapiens(9606) Component
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