Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer
Drug Drug
Main interacting RNAs ncRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000101665 Gene ID 4092 Accession 6773
Symbol SMAD7 Alias CRCS3;MADH7;MADH8 Full Name SMAD family member 7
Status Confidence Length 31113 bases Strand Minus strand
Position 18 : 48919853 - 48950965 RNA binding domain N.A.
Summary The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
35346905 Circular RNA hsa_circ_0000848 Regulates Cardiomyocyte Proliferation and Apoptosis Under Hypoxia via Recruiting ELAVL1 and Stabilizing SMAD7 mRNA. Shuai Cao 2022-03-01 Anatolian journal of cardiology
30374806 Emerging Therapies for Inflammatory Bowel Disease. Roni Weisshof 2018-11-01 Advances in therapy
28838419 Janus Kinase Antagonists and Other Novel Small Molecules for the Treatment of Crohn's Disease. S Brigid Boland 2017-09-01 Gastroenterology clinics of North America
29907872 The current state of the art for biological therapies and new small molecules in inflammatory bowel disease. Sudarshan Paramsothy 2018-11-01 Mucosal immunology
36134711 LncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells. Xiaohui Kong 2022-10-14 Nucleic acids research

Transcripts

Name Transcript ID bp Protein Translation ID
SMAD7-201 ENST00000262158 3341 426aa ENSP00000262158
SMAD7-202 ENST00000545051 2211 No protein -
SMAD7-208 ENST00000591805 1152 211aa ENSP00000466902
SMAD7-207 ENST00000589634 1278 425aa ENSP00000467621
SMAD7-205 ENST00000587336 549 No protein -
SMAD7-203 ENST00000585986 563 No protein -
SMAD7-204 ENST00000586093 574 158aa ENSP00000465590
SMAD7-206 ENST00000588190 401 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
28842monocyte chemoattractant protein 1 (66-77)4.8700000E-005-
65196Schizophrenia3E-626198764
65270Colorectal Neoplasms3E-1124448986
68934Hip3E-725673412
68935Body Mass Index3E-725673412
73449Colorectal Neoplasms4E-2325990418
74769Colorectal Neoplasms1E-721761138
74841Colorectal Neoplasms3E-1526965516
75877Hip9E-1525673412
75878Body Mass Index9E-1525673412
76555Colorectal Neoplasms2E-824836286
76940Colorectal Neoplasms2E-1023266556
77254Longevity2E-727816938
78100Colorectal Neoplasms7E-827207650
81666Colorectal Neoplasms2E-618372905
82729Colorectal Neoplasms2E-1526151821
84760Hip3E-1025673412
84761Body Mass Index3E-1025673412
89801Colorectal Neoplasms8E-2818372901
90990Colorectal Neoplasms2E-826965516
106565Colorectal Neoplasms1E-1217934461

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000101665homo_sapiensENSP0000036915437.04524.4111homo_sapiensENSP0000026215840.610326.7606
ENSG00000101665homo_sapiensENSP0000026216038.115624.4111homo_sapiensENSP0000026215841.78426.7606
ENSG00000101665homo_sapiensENSP0000033297341.176525.6471homo_sapiensENSP0000026215841.079825.5869
ENSG00000101665homo_sapiensENSP0000030576936.774224.5161homo_sapiensENSP0000026215840.140826.7606
ENSG00000101665homo_sapiensENSP0000044195436.774224.3011homo_sapiensENSP0000026215840.140826.5258
ENSG00000101665homo_sapiensENSP0000028884055.241944.9597homo_sapiensENSP0000026215864.319352.3474
ENSG00000101665homo_sapiensENSP0000034155131.884118.6594homo_sapiensENSP0000026215841.314624.1784

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000101665homo_sapiensENSP0000026215887.793487.7934nomascus_leucogenysENSNLEP0000004872599.468199.4681
ENSG00000101665homo_sapiensENSP0000026215849.530549.5305pan_paniscusENSPPAP00000016382100100
ENSG00000101665homo_sapiensENSP0000026215899.530599.5305pongo_abeliiENSPPYP0000001027899.530599.5305
ENSG00000101665homo_sapiensENSP0000026215899.530599.5305pan_troglodytesENSPTRP0000001701686.354486.3544
ENSG00000101665homo_sapiensENSP0000026215849.530549.5305gorilla_gorillaENSGGOP00000010290100100
ENSG00000101665homo_sapiensENSP0000026215848.591547.6526ornithorhynchus_anatinusENSOANP0000001213398.104396.2085
ENSG00000101665homo_sapiensENSP0000026215892.72390.8451sarcophilus_harrisiiENSSHAP0000002056989.977288.1549
ENSG00000101665homo_sapiensENSP0000026215865.727764.7887notamacropus_eugeniiENSMEUP0000001032995.238193.8775
ENSG00000101665homo_sapiensENSP0000026215897.417897.1831dasypus_novemcinctusENSDNOP0000002892184.349684.1463
ENSG00000101665homo_sapiensENSP0000026215893.66292.9577echinops_telfairiENSETEP0000000084495.683594.964
ENSG00000101665homo_sapiensENSP0000026215899.295899.2958callithrix_jacchusENSCJAP0000006204999.295899.2958
ENSG00000101665homo_sapiensENSP0000026215899.295899.2958cercocebus_atysENSCATP0000002881387.577687.5776
ENSG00000101665homo_sapiensENSP0000026215896.478996.4789macaca_fascicularisENSMFAP0000002263496.478996.4789
ENSG00000101665homo_sapiensENSP0000026215899.765399.7653macaca_mulattaENSMMUP0000006379391.991391.9913
ENSG00000101665homo_sapiensENSP0000026215899.765399.7653macaca_nemestrinaENSMNEP0000003280187.090287.0902
ENSG00000101665homo_sapiensENSP0000026215899.765399.7653papio_anubisENSPANP0000000506699.765399.7653
ENSG00000101665homo_sapiensENSP0000026215849.530549.5305mandrillus_leucophaeusENSMLEP00000029308100100
ENSG00000101665homo_sapiensENSP0000026215899.06198.1221tursiops_truncatusENSTTRP0000000410099.06198.1221
ENSG00000101665homo_sapiensENSP0000026215897.417896.2441vulpes_vulpesENSVVUP0000001941696.736695.5711
ENSG00000101665homo_sapiensENSP0000026215898.356897.8873mus_spretusMGP_SPRETEiJ_P004909698.356897.8873
ENSG00000101665homo_sapiensENSP0000026215898.122197.8873equus_asinusENSEASP0000502367698.122197.8873
ENSG00000101665homo_sapiensENSP0000026215898.591698.1221capra_hircusENSCHIP0000002100198.360797.8923
ENSG00000101665homo_sapiensENSP0000026215882.629180.2817loxodonta_africanaENSLAFP0000002871286.913684.4444
ENSG00000101665homo_sapiensENSP0000026215899.06198.8263panthera_leoENSPLOP0000002009299.06198.8263
ENSG00000101665homo_sapiensENSP0000026215899.06198.5916ailuropoda_melanoleucaENSAMEP0000003779898.82998.3607
ENSG00000101665homo_sapiensENSP0000026215898.591697.8873bos_indicus_hybridENSBIXP0000502477198.591697.8873
ENSG00000101665homo_sapiensENSP0000026215891.549391.5493oryctolagus_cuniculusENSOCUP0000001835371.038371.0383
ENSG00000101665homo_sapiensENSP0000026215897.887397.6526equus_caballusENSECAP0000001807797.887397.6526
ENSG00000101665homo_sapiensENSP0000026215897.887396.7136canis_lupus_familiarisENSCAFP0084502367491.04889.9563
ENSG00000101665homo_sapiensENSP0000026215898.591698.3568panthera_pardusENSPPRP0000000760398.823598.5882
ENSG00000101665homo_sapiensENSP0000026215852.347452.3474marmota_marmota_marmotaENSMMMP0000000692698.237998.2379
ENSG00000101665homo_sapiensENSP0000026215899.06198.1221balaenoptera_musculusENSBMSP0001002966099.06198.1221
ENSG00000101665homo_sapiensENSP0000026215851.877951.8779cavia_porcellusENSCPOP00000024957100100
ENSG00000101665homo_sapiensENSP0000026215899.06198.8263felis_catusENSFCAP0000004287899.06198.8263
ENSG00000101665homo_sapiensENSP0000026215899.06198.5916ursus_americanusENSUAMP0000002717499.06198.5916
ENSG00000101665homo_sapiensENSP0000026215892.72390.3756monodelphis_domesticaENSMODP0000005458786.056683.878
ENSG00000101665homo_sapiensENSP0000026215885.680784.9765bison_bison_bisonENSBBBP0000000132585.680784.9765
ENSG00000101665homo_sapiensENSP0000026215899.06197.8873monodon_monocerosENSMMNP0001500147199.06197.8873
ENSG00000101665homo_sapiensENSP0000026215898.356898.1221sus_scrofaENSSSCP0000000486298.356898.1221
ENSG00000101665homo_sapiensENSP0000026215899.06199.061microcebus_murinusENSMICP0000003322899.294199.2941
ENSG00000101665homo_sapiensENSP0000026215898.122198.1221octodon_degusENSODEP0000002517198.352998.3529
ENSG00000101665homo_sapiensENSP0000026215898.356897.6526jaculus_jaculusENSJJAP0000001506398.588297.8824
ENSG00000101665homo_sapiensENSP0000026215898.591698.1221ovis_aries_rambouilletENSOARP0002001388798.360797.8923
ENSG00000101665homo_sapiensENSP0000026215846.948445.3052ursus_maritimusENSUMAP0000000319981.967279.0984
ENSG00000101665homo_sapiensENSP0000026215851.877951.4085ochotona_princepsENSOPRP0000000328010099.095
ENSG00000101665homo_sapiensENSP0000026215899.06198.1221delphinapterus_leucasENSDLEP0000000620899.06198.1221
ENSG00000101665homo_sapiensENSP0000026215899.295898.3568physeter_catodonENSPCTP0000503090799.295898.3568
ENSG00000101665homo_sapiensENSP0000026215898.591697.8873mus_caroliMGP_CAROLIEiJ_P004714298.591697.8873
ENSG00000101665homo_sapiensENSP0000026215898.591698.1221mus_musculusENSMUSP0000002699998.591698.1221
ENSG00000101665homo_sapiensENSP0000026215898.591698.1221dipodomys_ordiiENSDORP0000002724198.360797.8923
ENSG00000101665homo_sapiensENSP0000026215898.591698.1221mustela_putorius_furoENSMPUP0000000083898.591698.1221
ENSG00000101665homo_sapiensENSP0000026215895.539995.3052aotus_nancymaaeENSANAP0000002060083.231183.0266
ENSG00000101665homo_sapiensENSP0000026215899.295899.2958saimiri_boliviensis_boliviensisENSSBOP0000002475085.975685.9756
ENSG00000101665homo_sapiensENSP0000026215899.765399.5305chlorocebus_sabaeusENSCSAP0000001404199.765399.5305
ENSG00000101665homo_sapiensENSP0000026215898.591698.1221mesocricetus_auratusENSMAUP0000002307698.360797.8923
ENSG00000101665homo_sapiensENSP0000026215848.826348.8263phocoena_sinusENSPSNP0000001306499.521599.5215
ENSG00000101665homo_sapiensENSP0000026215850.469549.061camelus_dromedariusENSCDRP0000501726892.274789.6996
ENSG00000101665homo_sapiensENSP0000026215847.417844.6009carlito_syrichtaENSTSYP0000002278995.734690.0474
ENSG00000101665homo_sapiensENSP0000026215849.530549.5305panthera_tigris_altaicaENSPTIP00000013440100100
ENSG00000101665homo_sapiensENSP0000026215898.826397.8873rattus_norvegicusENSRNOP0000002483198.826397.8873
ENSG00000101665homo_sapiensENSP0000026215898.826398.8263prolemur_simusENSPSMP0000002670786.270586.2705
ENSG00000101665homo_sapiensENSP0000026215897.652696.9484microtus_ochrogasterENSMOCP0000000163998.113297.4057
ENSG00000101665homo_sapiensENSP0000026215887.793487.7934sorex_araneusENSSARP0000000362287.179587.1795
ENSG00000101665homo_sapiensENSP0000026215898.122197.1831peromyscus_maniculatus_bairdiiENSPEMP0000002468097.435996.5035
ENSG00000101665homo_sapiensENSP0000026215875.586975.1174bos_mutusENSBMUP0000001738475.943475.4717
ENSG00000101665homo_sapiensENSP0000026215898.356897.8873mus_spicilegusENSMSIP0000002255498.356897.8873
ENSG00000101665homo_sapiensENSP0000026215898.356897.8873cricetulus_griseus_chok1gshdENSCGRP0000101776498.126597.6581
ENSG00000101665homo_sapiensENSP0000026215897.652696.7136pteropus_vampyrusENSPVAP0000000185697.652696.7136
ENSG00000101665homo_sapiensENSP0000026215897.417897.1831myotis_lucifugusENSMLUP0000001464497.647197.4118
ENSG00000101665homo_sapiensENSP0000026215893.66291.5493vombatus_ursinusENSVURP0001000037491.935589.8617
ENSG00000101665homo_sapiensENSP0000026215898.826398.1221rhinolophus_ferrumequinumENSRFEP0001002135098.594897.8923
ENSG00000101665homo_sapiensENSP0000026215899.06198.5916neovison_visonENSNVIP0000000183499.06198.5916
ENSG00000101665homo_sapiensENSP0000026215897.417896.4789bos_taurusENSBTAP0000004398796.511695.5814
ENSG00000101665homo_sapiensENSP0000026215855.868553.5211heterocephalus_glaber_femaleENSHGLP0000003620289.473785.7143
ENSG00000101665homo_sapiensENSP0000026215896.713696.2441rhinopithecus_bietiENSRBIP0000002805595.591695.1276
ENSG00000101665homo_sapiensENSP0000026215897.887396.9484canis_lupus_dingoENSCAFP0002003411296.751795.8237
ENSG00000101665homo_sapiensENSP0000026215898.826398.8263sciurus_vulgarisENSSVLP0000502506599.058899.0588
ENSG00000101665homo_sapiensENSP0000026215894.366292.2535phascolarctos_cinereusENSPCIP0000004577793.271591.1833
ENSG00000101665homo_sapiensENSP0000026215867.136165.9624procavia_capensisENSPCAP0000001412698.281896.5636
ENSG00000101665homo_sapiensENSP0000026215898.591698.1221nannospalax_galiliENSNGAP0000000397298.591698.1221
ENSG00000101665homo_sapiensENSP0000026215898.591697.8873bos_grunniensENSBGRP0000003613073.684273.1579
ENSG00000101665homo_sapiensENSP0000026215898.122198.1221chinchilla_lanigeraENSCLAP0000001020898.122198.1221
ENSG00000101665homo_sapiensENSP0000026215898.122197.6526cervus_hanglu_yarkandensisENSCHYP0000004056797.892397.4239
ENSG00000101665homo_sapiensENSP0000026215898.591698.1221catagonus_wagneriENSCWAP0000001050098.591698.1221
ENSG00000101665homo_sapiensENSP0000026215899.06199.061ictidomys_tridecemlineatusENSSTOP0000001564799.06199.061
ENSG00000101665homo_sapiensENSP0000026215894.131593.4272otolemur_garnettiiENSOGAP0000001988594.131593.4272
ENSG00000101665homo_sapiensENSP0000026215895.539994.6009cebus_imitatorENSCCAP0000003093584.791783.9583
ENSG00000101665homo_sapiensENSP0000026215899.295899.2958urocitellus_parryiiENSUPAP0001001999599.295899.2958
ENSG00000101665homo_sapiensENSP0000026215898.122197.4178moschus_moschiferusENSMMSP0000000859198.122197.4178
ENSG00000101665homo_sapiensENSP0000026215849.530549.5305rhinopithecus_roxellanaENSRROP00000040471100100
ENSG00000101665homo_sapiensENSP0000026215898.122197.6526mus_pahariMGP_PahariEiJ_P003971098.584998.1132
ENSG00000101665homo_sapiensENSP0000026215898.826398.8263propithecus_coquereliENSPCOP0000000101685.918485.9184
ENSG00000101665homo_sapiensENSP0000026215833.333319.7183caenorhabditis_elegansF37D6.6.134.216920.241
ENSG00000101665homo_sapiensENSP0000026215828.16915.7277caenorhabditis_elegansF01G10.8b.136.253820.2417
ENSG00000101665homo_sapiensENSP0000026215845.539930.2817drosophila_melanogasterFBpp042815329.172919.3985
ENSG00000101665homo_sapiensENSP0000026215844.600930.2817ciona_intestinalisENSCINP0000001831952.631635.7341
ENSG00000101665homo_sapiensENSP0000026215823.004715.2582ciona_intestinalisENSCINP0000001228728.488418.8953
ENSG00000101665homo_sapiensENSP0000026215823.474217.6056petromyzon_marinusENSPMAP0000000414557.471343.1034
ENSG00000101665homo_sapiensENSP0000026215850.93934.7418eptatretus_burgeriENSEBUP0000002117445.974631.3559
ENSG00000101665homo_sapiensENSP0000026215873.004763.615callorhinchus_miliiENSCMIP0000003272872.325663.0233
ENSG00000101665homo_sapiensENSP0000026215881.220775.3521latimeria_chalumnaeENSLACP0000000655191.777285.1459
ENSG00000101665homo_sapiensENSP0000026215839.906138.2629clupea_harengusENSCHAP0000000372093.406689.5604
ENSG00000101665homo_sapiensENSP0000026215875.821670.892danio_rerioENSDARP0000002427786.82881.1828
ENSG00000101665homo_sapiensENSP0000026215875.821670.6573carassius_auratusENSCARP0000001996386.595280.6971
ENSG00000101665homo_sapiensENSP0000026215876.525871.1268carassius_auratusENSCARP0000008405286.472180.3714
ENSG00000101665homo_sapiensENSP0000026215878.16970.892astyanax_mexicanusENSAMXP0000005162085.384677.4359
ENSG00000101665homo_sapiensENSP0000026215875.352168.0751ictalurus_punctatusENSIPUP0000002068083.160675.1295
ENSG00000101665homo_sapiensENSP0000026215876.760670.892esox_luciusENSELUP0000004710586.737480.1061
ENSG00000101665homo_sapiensENSP0000026215875.586967.8404electrophorus_electricusENSEEEP0000000657685.638376.8617
ENSG00000101665homo_sapiensENSP0000026215876.525870.6573oncorhynchus_kisutchENSOKIP0000501631086.472179.8409
ENSG00000101665homo_sapiensENSP0000026215876.056369.0141oncorhynchus_kisutchENSOKIP0000507768985.941677.9841
ENSG00000101665homo_sapiensENSP0000026215876.760670.892oncorhynchus_mykissENSOMYP0000008036586.737480.1061
ENSG00000101665homo_sapiensENSP0000026215875.821669.0141oncorhynchus_mykissENSOMYP0000003615785.676477.9841
ENSG00000101665homo_sapiensENSP0000026215876.525870.892salmo_salarENSSSAP0000017690286.472180.1061
ENSG00000101665homo_sapiensENSP0000026215876.056369.2488salmo_salarENSSSAP0000014302585.941678.2493
ENSG00000101665homo_sapiensENSP0000026215835.680829.3427salmo_truttaENSSTUP0000003356574.146360.9756
ENSG00000101665homo_sapiensENSP0000026215876.525870.892salmo_truttaENSSTUP0000000621986.472180.1061
ENSG00000101665homo_sapiensENSP0000026215875.352168.5446gadus_morhuaENSGMOP0000000363285.372377.6596
ENSG00000101665homo_sapiensENSP0000026215877.934371.1268fundulus_heteroclitusENSFHEP0000002339587.830780.1587
ENSG00000101665homo_sapiensENSP0000026215878.16971.5962poecilia_reticulataENSPREP0000002572088.095280.6878
ENSG00000101665homo_sapiensENSP0000026215877.934371.3615xiphophorus_maculatusENSXMAP0000003737287.830780.4233
ENSG00000101665homo_sapiensENSP0000026215877.699571.1268oryzias_latipesENSORLP0000004421588.266780.8
ENSG00000101665homo_sapiensENSP0000026215875.117468.7793cyclopterus_lumpusENSCLMP0000501884886.720979.4038
ENSG00000101665homo_sapiensENSP0000026215878.16971.3615oreochromis_niloticusENSONIP0000000976288.563880.8511
ENSG00000101665homo_sapiensENSP0000026215878.16971.3615haplochromis_burtoniENSHBUP0000001612388.563880.8511
ENSG00000101665homo_sapiensENSP0000026215877.934371.1268astatotilapia_callipteraENSACLP0000000873788.297980.5851
ENSG00000101665homo_sapiensENSP0000026215878.16971.831sparus_aurataENSSAUP0001003184288.563881.383
ENSG00000101665homo_sapiensENSP0000026215878.16971.3615lates_calcariferENSLCAP0001001118088.563880.8511
ENSG00000101665homo_sapiensENSP0000026215879.342776.2911xenopus_tropicalisENSXETP0000004382988.481785.0785
ENSG00000101665homo_sapiensENSP0000026215879.10874.4131chrysemys_picta_belliiENSCPBP0000003697692.837587.3278
ENSG00000101665homo_sapiensENSP0000026215848.122146.7136sphenodon_punctatusENSSPUP0000001987297.156494.3128
ENSG00000101665homo_sapiensENSP0000026215884.741880.7512crocodylus_porosusENSCPRP0000502116594.010489.5833
ENSG00000101665homo_sapiensENSP0000026215881.220774.8826laticauda_laticaudataENSLLTP0000001832375.217469.3478
ENSG00000101665homo_sapiensENSP0000026215876.525870.892notechis_scutatusENSNSUP0000001764288.828382.2888
ENSG00000101665homo_sapiensENSP0000026215880.751274.6479pseudonaja_textilisENSPTXP0000000915674.458968.8312
ENSG00000101665homo_sapiensENSP0000026215880.04777.23anas_platyrhynchos_platyrhynchosENSAPLP0000000068592.411989.1599
ENSG00000101665homo_sapiensENSP0000026215875.352169.4836gallus_gallusENSGALP0001001714979.652673.4491
ENSG00000101665homo_sapiensENSP0000026215878.873273.9437gallus_gallusENSGALP0001001357486.597981.1856
ENSG00000101665homo_sapiensENSP0000026215845.539943.1925serinus_canariaENSSCAP0000002262487.782883.2579
ENSG00000101665homo_sapiensENSP0000026215882.394479.3427parus_majorENSPMJP0000000330289.540886.2245
ENSG00000101665homo_sapiensENSP0000026215848.122147.1831anolis_carolinensisENSACAP0000003511497.156495.2607
ENSG00000101665homo_sapiensENSP0000026215878.16971.3615neolamprologus_brichardiENSNBRP0000001116188.563880.8511
ENSG00000101665homo_sapiensENSP0000026215876.995371.5962naja_najaENSNNAP0000002160989.130482.8804
ENSG00000101665homo_sapiensENSP0000026215884.037679.5775podarcis_muralisENSPMRP0000001426978.33774.1794
ENSG00000101665homo_sapiensENSP0000026215848.122146.9484geospiza_fortisENSGFOP0000001938897.156494.7867
ENSG00000101665homo_sapiensENSP0000026215882.394479.3427taeniopygia_guttataENSTGUP0000000003389.540886.2245
ENSG00000101665homo_sapiensENSP0000026215880.04774.4131erpetoichthys_calabaricusENSECRP0000001201790.691584.3085
ENSG00000101665homo_sapiensENSP0000026215869.718364.0845kryptolebias_marmoratusENSKMAP0000001965587.352980.2941
ENSG00000101665homo_sapiensENSP0000026215884.272379.3427salvator_merianaeENSSMRP0000002130274.791770.4167
ENSG00000101665homo_sapiensENSP0000026215877.934371.1268oryzias_javanicusENSOJAP0000000773988.533380.8
ENSG00000101665homo_sapiensENSP0000026215873.708967.3709amphilophus_citrinellusENSACIP0000002196889.204581.5341
ENSG00000101665homo_sapiensENSP0000026215877.934371.5962dicentrarchus_labraxENSDLAP0000504082388.297981.117
ENSG00000101665homo_sapiensENSP0000026215877.934371.1268amphiprion_perculaENSAPEP0000002389388.297980.5851
ENSG00000101665homo_sapiensENSP0000026215877.934371.1268oryzias_sinensisENSOSIP0000003196788.533380.8
ENSG00000101665homo_sapiensENSP0000026215884.50779.3427pelodiscus_sinensisENSPSIP0000000681793.023387.3385
ENSG00000101665homo_sapiensENSP0000026215884.741880.047gopherus_evgoodeiENSGEVP0000502816893.041287.8866
ENSG00000101665homo_sapiensENSP0000026215884.50780.047chelonoidis_abingdoniiENSCABP0000002158492.783587.8866
ENSG00000101665homo_sapiensENSP0000026215878.16971.3615seriola_dumeriliENSSDUP0000002217888.328980.6366
ENSG00000101665homo_sapiensENSP0000026215877.934371.831cottoperca_gobioENSCGOP0000004415388.297981.383
ENSG00000101665homo_sapiensENSP0000026215848.356847.4178struthio_camelus_australisENSSCUP0000000208797.630395.7346
ENSG00000101665homo_sapiensENSP0000026215848.356847.1831anser_brachyrhynchusENSABRP0000000147597.630395.2607
ENSG00000101665homo_sapiensENSP0000026215878.403872.0657gasterosteus_aculeatusENSGACP0000002180188.829881.6489
ENSG00000101665homo_sapiensENSP0000026215877.699570.4225cynoglossus_semilaevisENSCSEP0000003101488.031979.7872
ENSG00000101665homo_sapiensENSP0000026215878.16971.5962poecilia_formosaENSPFOP0000000917488.095280.6878
ENSG00000101665homo_sapiensENSP0000026215877.934371.1268myripristis_murdjanENSMMDP0000503008088.297980.5851
ENSG00000101665homo_sapiensENSP0000026215878.16971.831sander_luciopercaENSSLUP0000001718988.563881.383
ENSG00000101665homo_sapiensENSP0000026215881.220777.23strigops_habroptilaENSSHBP0000501255989.870185.4545
ENSG00000101665homo_sapiensENSP0000026215877.934371.1268amphiprion_ocellarisENSAOCP0000001010288.297980.5851
ENSG00000101665homo_sapiensENSP0000026215884.50780.047terrapene_carolina_triunguisENSTMTP0000000187192.783587.8866
ENSG00000101665homo_sapiensENSP0000026215841.079834.2723hucho_huchoENSHHUP0000002416768.627457.2549
ENSG00000101665homo_sapiensENSP0000026215876.291170.6573hucho_huchoENSHHUP0000006862086.206979.8409
ENSG00000101665homo_sapiensENSP0000026215878.403871.3615betta_splendensENSBSLP0000001292688.829880.8511
ENSG00000101665homo_sapiensENSP0000026215877.2370.4225pygocentrus_nattereriENSPNAP0000002193584.35976.9231
ENSG00000101665homo_sapiensENSP0000026215878.16970.892anabas_testudineusENSATEP0000002409488.563880.3191
ENSG00000101665homo_sapiensENSP0000026215844.131529.8122ciona_savignyiENSCSAVP0000001893252.222235.2778
ENSG00000101665homo_sapiensENSP0000026215878.16971.3615seriola_lalandi_dorsalisENSSLDP0000000915088.328980.6366
ENSG00000101665homo_sapiensENSP0000026215877.934370.892labrus_bergyltaENSLBEP0000002378788.297980.3191
ENSG00000101665homo_sapiensENSP0000026215878.16971.3615pundamilia_nyerereiENSPNYP0000001031688.563880.8511
ENSG00000101665homo_sapiensENSP0000026215877.934370.892mastacembelus_armatusENSMAMP0000002207988.297980.3191
ENSG00000101665homo_sapiensENSP0000026215875.117468.7793stegastes_partitusENSSPAP0000000812088.397880.9392
ENSG00000101665homo_sapiensENSP0000026215835.915529.3427oncorhynchus_tshawytschaENSOTSP0000502814276.562.5
ENSG00000101665homo_sapiensENSP0000026215876.525870.6573oncorhynchus_tshawytschaENSOTSP0000507440986.472179.8409
ENSG00000101665homo_sapiensENSP0000026215877.934371.1268acanthochromis_polyacanthusENSAPOP0000001706988.297980.5851
ENSG00000101665homo_sapiensENSP0000026215883.098679.8122aquila_chrysaetos_chrysaetosENSACCP0002002409789.847786.2944
ENSG00000101665homo_sapiensENSP0000026215871.596265.0235nothobranchius_furzeriENSNFUP0001500190383.791276.0989
ENSG00000101665homo_sapiensENSP0000026215875.352168.5446cyprinodon_variegatusENSCVAP0000001448387.704979.7814
ENSG00000101665homo_sapiensENSP0000026215878.638572.0657denticeps_clupeoidesENSDCDP0000001908889.095781.6489
ENSG00000101665homo_sapiensENSP0000026215878.16971.5962larimichthys_croceaENSLCRP0000500793488.563881.117
ENSG00000101665homo_sapiensENSP0000026215875.352168.3099takifugu_rubripesENSTRUP0000002571586.05978.0161
ENSG00000101665homo_sapiensENSP0000026215848.122146.9484ficedula_albicollisENSFALP0000000933497.156494.7867
ENSG00000101665homo_sapiensENSP0000026215878.403871.5962hippocampus_comesENSHCOP0000002333856.323851.4334
ENSG00000101665homo_sapiensENSP0000026215876.056370.892cyprinus_carpio_carpioENSCCRP0000018142886.863380.9651
ENSG00000101665homo_sapiensENSP0000026215876.760671.5962cyprinus_carpio_carpioENSCCRP0000010477786.737480.9019
ENSG00000101665homo_sapiensENSP0000026215878.638573.7089coturnix_japonicaENSCJPP0000500509186.340280.9278
ENSG00000101665homo_sapiensENSP0000026215875.117469.0141poecilia_latipinnaENSPLAP0000000486687.912180.7692
ENSG00000101665homo_sapiensENSP0000026215875.586970.6573sinocyclocheilus_grahamiENSSGRP0000009420786.792481.1321
ENSG00000101665homo_sapiensENSP0000026215838.967137.0892sinocyclocheilus_grahamiENSSGRP0000005020191.208886.8132
ENSG00000101665homo_sapiensENSP0000026215877.934371.1268maylandia_zebraENSMZEP0000502651088.297980.5851
ENSG00000101665homo_sapiensENSP0000026215877.2370.4225tetraodon_nigroviridisENSTNIP0000002194587.579.7872
ENSG00000101665homo_sapiensENSP0000026215876.525869.7183paramormyrops_kingsleyaeENSPKIP0000002242487.165879.4118
ENSG00000101665homo_sapiensENSP0000026215876.525870.4225paramormyrops_kingsleyaeENSPKIP0000003038479.126272.8155
ENSG00000101665homo_sapiensENSP0000026215877.699572.3005scleropages_formosusENSSFOP0001501599488.031981.9149
ENSG00000101665homo_sapiensENSP0000026215871.83165.493scleropages_formosusENSSFOP0001503550986.685679.0368
ENSG00000101665homo_sapiensENSP0000026215878.873274.4131leptobrachium_leishanenseENSLLEP0000000683525.358523.9245
ENSG00000101665homo_sapiensENSP0000026215878.873271.1268scophthalmus_maximusENSSMAP0000000944489.361780.5851
ENSG00000101665homo_sapiensENSP0000026215877.934371.1268oryzias_melastigmaENSOMEP0000000679588.533380.8

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0000785part_of chromatin1ISAHomo_sapiens(9606)Component
GO:0001650located_in fibrillar center1IDAHomo_sapiens(9606)Component
GO:0001657involved_in ureteric bud development1IEAHomo_sapiens(9606)Process
GO:0002725involved_in negative regulation of T cell cytokine production1ISSHomo_sapiens(9606)Process
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005518enables collagen binding1IEAHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005813located_in centrosome1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0005912colocalizes_with adherens junction1IDAHomo_sapiens(9606)Component
GO:0006357involved_in regulation of transcription by RNA polymerase II1IBAHomo_sapiens(9606)Process
GO:0007179involved_in transforming growth factor beta receptor signaling pathway1IBAHomo_sapiens(9606)Process
GO:0008013enables beta-catenin binding1IPIHomo_sapiens(9606)Function
GO:0009653involved_in anatomical structure morphogenesis1IBAHomo_sapiens(9606)Process
GO:0010717involved_in regulation of epithelial to mesenchymal transition1IMPHomo_sapiens(9606)Process
GO:0010719involved_in negative regulation of epithelial to mesenchymal transition2IC,TASHomo_sapiens(9606)Process
GO:0010801involved_in negative regulation of peptidyl-threonine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0010944involved_in negative regulation of transcription by competitive promoter binding1IDAHomo_sapiens(9606)Process
GO:0017015involved_in regulation of transforming growth factor beta receptor signaling pathway1ICHomo_sapiens(9606)Process
GO:0022409involved_in positive regulation of cell-cell adhesion1IDAHomo_sapiens(9606)Process
GO:0030154involved_in cell differentiation1IBAHomo_sapiens(9606)Process
GO:0030279involved_in negative regulation of ossification1IEAHomo_sapiens(9606)Process
GO:0030336involved_in negative regulation of cell migration1TASHomo_sapiens(9606)Process
GO:0030512involved_in negative regulation of transforming growth factor beta receptor signaling pathway1IDAHomo_sapiens(9606)Process
GO:0030514involved_in negative regulation of BMP signaling pathway1IDAHomo_sapiens(9606)Process
GO:0031397involved_in negative regulation of protein ubiquitination1IDAHomo_sapiens(9606)Process
GO:0031398involved_in positive regulation of protein ubiquitination1IDAHomo_sapiens(9606)Process
GO:0031503involved_in protein-containing complex localization1IDAHomo_sapiens(9606)Process
GO:0031625enables ubiquitin protein ligase binding1IPIHomo_sapiens(9606)Function
GO:0032436involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process1IDAHomo_sapiens(9606)Process
GO:0032925involved_in regulation of activin receptor signaling pathway1IDAHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0033137involved_in negative regulation of peptidyl-serine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0034333involved_in adherens junction assembly1IMPHomo_sapiens(9606)Process
GO:0034616involved_in response to laminar fluid shear stress1IEPHomo_sapiens(9606)Process
GO:0034713enables type I transforming growth factor beta receptor binding1IPIHomo_sapiens(9606)Function
GO:0043433involved_in negative regulation of DNA-binding transcription factor activity1IDAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0048185enables activin binding1IPIHomo_sapiens(9606)Function
GO:0048844involved_in artery morphogenesis1ISSHomo_sapiens(9606)Process
GO:0050821involved_in protein stabilization1IDAHomo_sapiens(9606)Process
GO:0051444involved_in negative regulation of ubiquitin-protein transferase activity1IDAHomo_sapiens(9606)Process
GO:0055010involved_in ventricular cardiac muscle tissue morphogenesis1ISSHomo_sapiens(9606)Process
GO:0055117involved_in regulation of cardiac muscle contraction1ISSHomo_sapiens(9606)Process
GO:0060373involved_in regulation of ventricular cardiac muscle cell membrane depolarization1ICHomo_sapiens(9606)Process
GO:0060389involved_in pathway-restricted SMAD protein phosphorylation1ISSHomo_sapiens(9606)Process
GO:0060394involved_in negative regulation of pathway-restricted SMAD protein phosphorylation2IDA,TASHomo_sapiens(9606)Process
GO:0060395involved_in SMAD protein signal transduction1IBAHomo_sapiens(9606)Process
GO:0060412involved_in ventricular septum morphogenesis1ISSHomo_sapiens(9606)Process
GO:0070411enables I-SMAD binding2IBA,IPIHomo_sapiens(9606)Function
GO:0071144part_of heteromeric SMAD protein complex1IBAHomo_sapiens(9606)Component
GO:0071560involved_in cellular response to transforming growth factor beta stimulus1IMPHomo_sapiens(9606)Process
GO:0140416enables transcription regulator inhibitor activity2IBA,IDAHomo_sapiens(9606)Function
GO:1902731involved_in negative regulation of chondrocyte proliferation1IEAHomo_sapiens(9606)Process
GO:1903043involved_in positive regulation of chondrocyte hypertrophy1IEAHomo_sapiens(9606)Process
GO:1990830involved_in cellular response to leukemia inhibitory factor1IEAHomo_sapiens(9606)Process
GO:2000317involved_in negative regulation of T-helper 17 type immune response1ISSHomo_sapiens(9606)Process
GO:2000320involved_in negative regulation of T-helper 17 cell differentiation1ISSHomo_sapiens(9606)Process

Expression