Ensembl ID ENSG00000101665 Gene ID 4092 Accession 6773
Gene Symbol SMAD7 Alias CRCS3;MADH7;MADH8 Full Name SMAD family member 7
Position 18 : 48919853 - 48950965 Length 31113 bases Strand Minus strand
Status Confidence Main interacting RNAsncRNARBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

ENSG00000101665 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000101665 SMAD7 -0.9 1.84e-19 COAD
ENSG00000101665 SMAD7 -1.6 6.07e-42 LUSC
ENSG00000101665 SMAD7 -1.1 3.08e-38 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000101665 SMAD7 pancreatic cancer 10498890
ENSG00000101665 SMAD7 germ cell tumors 10706106
ENSG00000101665 SMAD7 tumour 10839991
ENSG00000101665 SMAD7 tumor 10942134
ENSG00000101665 SMAD7 ovarian cancers 11078792
ENSG00000101665 SMAD7 Pancreatic cancers 11135319
ENSG00000101665 SMAD7 pancreatic cancers 11250702
ENSG00000101665 SMAD7 tumor 11313978
ENSG00000101665 SMAD7 colorectal cancer 11391794
ENSG00000101665 SMAD7 tumors 11536370
ENSG00000101665 SMAD7 lung cancer 11719467
ENSG00000101665 SMAD7 lung cancer 12479057
ENSG00000101665 SMAD7 colorectal cancer 12584741
ENSG00000101665 SMAD7 prostate cancer 12589052
ENSG00000101665 SMAD7 colorectal cancer 12866583
ENSG00000101665 SMAD7 cancers 12947087
ENSG00000101665 SMAD7 undifferentiated thyroid tumors 12952364
ENSG00000101665 SMAD7 lung cancer 14579540
ENSG00000101665 SMAD7 tumors 14633701
ENSG00000101665 SMAD7 tumors 15033661
ENSG00000101665 SMAD7 tumor 15086168
ENSG00000101665 SMAD7 pancreatic cancer 15150118
ENSG00000101665 SMAD7 breast tumor 15218362
ENSG00000101665 SMAD7 pancreatic cancer 15300592
ENSG00000101665 SMAD7 breast cancer 15492278
ENSG00000101665 SMAD7 endometrial cancer 15661223
ENSG00000101665 SMAD7 prostate cancer 15684397
ENSG00000101665 SMAD7 prostate cancer 15708859
ENSG00000101665 SMAD7 pancreatic cancers 15811853
ENSG00000101665 SMAD7 cancers 15922743
ENSG00000101665 SMAD7 tumors 16007121
ENSG00000101665 SMAD7 cancers 16333029
ENSG00000101665 SMAD7 pancreatic cancers 16443684
ENSG00000101665 SMAD7 cancer 16596258
ENSG00000101665 SMAD7 pancreatic cancer 16714330
ENSG00000101665 SMAD7 tumor 16883581
ENSG00000101665 SMAD7 tumors 16951165
ENSG00000101665 SMAD7 pancreatic cancer 17224927
ENSG00000101665 SMAD7 tumor 17332363
ENSG00000101665 SMAD7 Wilms tumor 17466922
ENSG00000101665 SMAD7 tumor 17477360
ENSG00000101665 SMAD7 gastric cancer 17909069
ENSG00000101665 SMAD7 tumour 17919240
ENSG00000101665 SMAD7 colorectal cancer 17934461
ENSG00000101665 SMAD7 colorectal cancer 18231913
ENSG00000101665 SMAD7 tumour 18781153
ENSG00000101665 SMAD7 pancreatic cancer 19165547
ENSG00000101665 SMAD7 cervical cancer 19288000
ENSG00000101665 SMAD7 gastric cancer 19341727
ENSG00000101665 SMAD7 colon cancer 19357349
ENSG00000101665 SMAD7 colorectal cancer 19395656
ENSG00000101665 SMAD7 colorectal cancer 19505925
ENSG00000101665 SMAD7 gastric cancer 19624886
ENSG00000101665 SMAD7 tumor 20012971
ENSG00000101665 SMAD7 colon cancer 20124488
ENSG00000101665 SMAD7 tumor 20165854
ENSG00000101665 SMAD7 tumors 20405019
ENSG00000101665 SMAD7 GBM 20419098
ENSG00000101665 SMAD7 tumors 20462450
ENSG00000101665 SMAD7 cancer 20551054
ENSG00000101665 SMAD7 malignant tumors 20625653
ENSG00000101665 SMAD7 tumors 20738806
ENSG00000101665 SMAD7 Cancer 21075068
ENSG00000101665 SMAD7 cancers 21152263
ENSG00000101665 SMAD7 tumor 21211030
ENSG00000101665 SMAD7 lung cancers 21221812
ENSG00000101665 SMAD7 cancer 21222648
ENSG00000101665 SMAD7 cancer 21269274
ENSG00000101665 SMAD7 invasive breast cancer 21527583
ENSG00000101665 SMAD7 lung cancer 21569311
ENSG00000101665 SMAD7 tumor 21768661
ENSG00000101665 SMAD7 colorectal cancer 21910156
ENSG00000101665 SMAD7 tumor 21944279
ENSG00000101665 SMAD7 cancer 22028324
ENSG00000101665 SMAD7 breast cancer 22033246
ENSG00000101665 SMAD7 tumour 22045186
ENSG00000101665 SMAD7 tumor 22195733
ENSG00000101665 SMAD7 tumor 22204639
ENSG00000101665 SMAD7 breast cancer 22286770
ENSG00000101665 SMAD7 lung cancer 22421218
ENSG00000101665 SMAD7 Colorectal Cancer 22457752
ENSG00000101665 SMAD7 prostate cancer 22496417
ENSG00000101665 SMAD7 HNSCC 22641218
ENSG00000101665 SMAD7 cancer 22669485
ENSG00000101665 SMAD7 tumor 22751114
ENSG00000101665 SMAD7 breast cancer 22841502
ENSG00000101665 SMAD7 colorectal cancer 23019048
ENSG00000101665 SMAD7 cancer 23049692
ENSG00000101665 SMAD7 colorectal cancer 23104301
ENSG00000101665 SMAD7 tumor 23151305
ENSG00000101665 SMAD7 tumor 23244128
ENSG00000101665 SMAD7 tumor 23251254
ENSG00000101665 SMAD7 tumor 23342108
ENSG00000101665 SMAD7 breast cancer 23372687
ENSG00000101665 SMAD7 tumor 23435373
ENSG00000101665 SMAD7 liver cancer 23471579
ENSG00000101665 SMAD7 cancer 23472153
ENSG00000101665 SMAD7 oral cancer 23475202
ENSG00000101665 SMAD7 colorectal cancer 23560096
ENSG00000101665 SMAD7 tumour 23625826
ENSG00000101665 SMAD7 prostate cancer 23643526
ENSG00000101665 SMAD7 tumor 23709694
ENSG00000101665 SMAD7 cancer 23941867
ENSG00000101665 SMAD7 colorectal cancer 23949881
ENSG00000101665 SMAD7 GBM 23951053
ENSG00000101665 SMAD7 cancers 23991075
ENSG00000101665 SMAD7 cancer 23998914
ENSG00000101665 SMAD7 tumor 24004452
ENSG00000101665 SMAD7 tumor 24047375
ENSG00000101665 SMAD7 Colorectal Cancer 24066093
ENSG00000101665 SMAD7 Tumour 24090133
ENSG00000101665 SMAD7 thyroid tumor 24126800
ENSG00000101665 SMAD7 cancer 24154973
ENSG00000101665 SMAD7 tumor 24185685
ENSG00000101665 SMAD7 breast cancer 24191129
ENSG00000101665 SMAD7 cancer 24259667
ENSG00000101665 SMAD7 tumors 24317436
ENSG00000101665 SMAD7 tumors 24343358
ENSG00000101665 SMAD7 tumor 24345480
ENSG00000101665 SMAD7 tumour 24394555
ENSG00000101665 SMAD7 colorectal cancer 24448986
ENSG00000101665 SMAD7 colorectal cancer 24480808
ENSG00000101665 SMAD7 tumor 24556688
ENSG00000101665 SMAD7 tumor 24625224
ENSG00000101665 SMAD7 rectal cancer 24643220
ENSG00000101665 SMAD7 tumor 24659668
ENSG00000101665 SMAD7 gastric cancer 24752577
ENSG00000101665 SMAD7 breast cancer 24863656
ENSG00000101665 SMAD7 tumor 24935472
ENSG00000101665 SMAD7 colorectal cancer 24969865
ENSG00000101665 SMAD7 cancer 24970681
ENSG00000101665 SMAD7 tumor 25107916
ENSG00000101665 SMAD7 tumor 25149540
ENSG00000101665 SMAD7 breast cancer 25164015
ENSG00000101665 SMAD7 colorectal cancer 25289133
ENSG00000101665 SMAD7 gastric cancer 25295107
ENSG00000101665 SMAD7 ovarian cancer 25333457
ENSG00000101665 SMAD7 colorectal cancer 25371073
ENSG00000101665 SMAD7 colorectal cancer 25375357
ENSG00000101665 SMAD7 tumors 25501935
ENSG00000101665 SMAD7 tumor 25540364
ENSG00000101665 SMAD7 Esophageal cancer 25554686
ENSG00000101665 SMAD7 tumor 25566830
ENSG00000101665 SMAD7 tumour 25602745
ENSG00000101665 SMAD7 colorectal cancer 25640388
ENSG00000101665 SMAD7 cancers 25664423
ENSG00000101665 SMAD7 tumor 25815272
ENSG00000101665 SMAD7 pancreatic cancer 25867271
ENSG00000101665 SMAD7 tumor 25895132
ENSG00000101665 SMAD7 tumour 25931269
ENSG00000101665 SMAD7 tumor 26015407
ENSG00000101665 SMAD7 colon cancer 26056570
ENSG00000101665 SMAD7 breast cancer 26138318
ENSG00000101665 SMAD7 Cancer 26390174
ENSG00000101665 SMAD7 cancer 26524133
ENSG00000101665 SMAD7 breast cancer 26531758
ENSG00000101665 SMAD7 breast cancer 26563372
ENSG00000101665 SMAD7 Colorectal Cancer 26579801
ENSG00000101665 SMAD7 tumor 26583099
ENSG00000101665 SMAD7 cancer 26608417
ENSG00000101665 SMAD7 tumor 26621452
ENSG00000101665 SMAD7 tumor 26759305
ENSG00000101665 SMAD7 breast cancer 26769181
ENSG00000101665 SMAD7 colorectal cancer 26779637
ENSG00000101665 SMAD7 cancer 26982322
ENSG00000101665 SMAD7 tumor 26989026
ENSG00000101665 SMAD7 cervical cancer 27006642
ENSG00000101665 SMAD7 tumor 27041581
ENSG00000101665 SMAD7 Non-Small Cell Lung Cancer 27185036
ENSG00000101665 SMAD7 breast cancer 27188720
ENSG00000101665 SMAD7 Breast Cancer 27303812
ENSG00000101665 SMAD7 cancer 27440729
ENSG00000101665 SMAD7 cancer 27473228
ENSG00000101665 SMAD7 cancer 27508022
ENSG00000101665 SMAD7 tumor 27536941
ENSG00000101665 SMAD7 colorectal cancers 27537386
ENSG00000101665 SMAD7 tumor 27628042
ENSG00000101665 SMAD7 tumor 27662660
ENSG00000101665 SMAD7 Colon Cancer 27730400
ENSG00000101665 SMAD7 osteosarcoma tumor 27827889
ENSG00000101665 SMAD7 cancer 27830743
ENSG00000101665 SMAD7 tumour 27861825
ENSG00000101665 SMAD7 cancer 27974675
ENSG00000101665 SMAD7 cancer 27996004
ENSG00000101665 SMAD7 colorectal cancer 28070019
ENSG00000101665 SMAD7 tumor 28095858
ENSG00000101665 SMAD7 tumor 28134936
ENSG00000101665 SMAD7 cancer 28163383
ENSG00000101665 SMAD7 tumors 28178600
ENSG00000101665 SMAD7 tumor 28192402
ENSG00000101665 SMAD7 colorectal cancer 28218435
ENSG00000101665 SMAD7 colon cancer 28300830
ENSG00000101665 SMAD7 colorectal cancer 28374902
ENSG00000101665 SMAD7 GBM 28381482
ENSG00000101665 SMAD7 Tumor 28388926
ENSG00000101665 SMAD7 gastric cancer 28400336
ENSG00000101665 SMAD7 tumor 28439009
ENSG00000101665 SMAD7 breast cancer 28445989
ENSG00000101665 SMAD7 colorectal cancer 28467803
ENSG00000101665 SMAD7 tumor 28494854
ENSG00000101665 SMAD7 lung cancer 28601662
ENSG00000101665 SMAD7 triple-negative breast cancer 28674186
ENSG00000101665 SMAD7 tumor 28732737
ENSG00000101665 SMAD7 liver tumor 28734833
ENSG00000101665 SMAD7 GBM 28735518
ENSG00000101665 SMAD7 cancer 28874583
ENSG00000101665 SMAD7 colorectal cancer 28928094
ENSG00000101665 SMAD7 cancer 28967304
ENSG00000101665 SMAD7 mammary cancer 29066540
ENSG00000101665 SMAD7 colorectal cancer 29084532
ENSG00000101665 SMAD7 rectal cancer 29119627
ENSG00000101665 SMAD7 prostate cancer 29156807
ENSG00000101665 SMAD7 oral cancer 29199336
ENSG00000101665 SMAD7 Breast cancer 29235476
ENSG00000101665 SMAD7 prostate cancer 29278879
ENSG00000101665 SMAD7 breast cancer 29423331
ENSG00000101665 SMAD7 tumor 29441724
ENSG00000101665 SMAD7 tumor 29465312
ENSG00000101665 SMAD7 Papillary Thyroid Cancer 29610597
ENSG00000101665 SMAD7 colorectal cancer 29698419
ENSG00000101665 SMAD7 tumor 29799477
ENSG00000101665 SMAD7 breast cancers 29799499
ENSG00000101665 SMAD7 breast cancer 29893810
ENSG00000101665 SMAD7 Cancer 29973939
ENSG00000101665 SMAD7 cancer 30017880
ENSG00000101665 SMAD7 tumor 30036733
ENSG00000101665 SMAD7 lung cancer 30072581
ENSG00000101665 SMAD7 cancer 30130141
ENSG00000101665 SMAD7 gastric cancer 30147341
ENSG00000101665 SMAD7 cancer 30154401
ENSG00000101665 SMAD7 tumours 30158641
ENSG00000101665 SMAD7 Oral Cancer 30185419
ENSG00000101665 SMAD7 tumor 30195786
ENSG00000101665 SMAD7 tumor 30219864
ENSG00000101665 SMAD7 tumor 30250517
ENSG00000101665 SMAD7 Colorectal Cancer 30275229
ENSG00000101665 SMAD7 tumors 30342000
ENSG00000101665 SMAD7 renal cancer 30419914
ENSG00000101665 SMAD7 tumors 30423327
ENSG00000101665 SMAD7 Colorectal Cancer 30498395
ENSG00000101665 SMAD7 breast cancer 30545440
ENSG00000101665 SMAD7 non-small-cell lung cancer 30568467
ENSG00000101665 SMAD7 pancreatic cancer 30588176
ENSG00000101665 SMAD7 breast cancer 30594253
ENSG00000101665 SMAD7 tumor 30611100
ENSG00000101665 SMAD7 tumor 30662328
ENSG00000101665 SMAD7 tumor 30862693
ENSG00000101665 SMAD7 tumor 30973065
ENSG00000101665 SMAD7 breast cancer 30989460
ENSG00000101665 SMAD7 tumors 31039140
ENSG00000101665 SMAD7 lung cancer 31041568
ENSG00000101665 SMAD7 tumor 31052449
ENSG00000101665 SMAD7 prostate cancer 31097718
ENSG00000101665 SMAD7 gastric cancer 31146975
ENSG00000101665 SMAD7 triple-negative breast cancer 31147529
ENSG00000101665 SMAD7 tumor 31243343
ENSG00000101665 SMAD7 ovarian cancer 31298312
ENSG00000101665 SMAD7 cancers 31383035
ENSG00000101665 SMAD7 tumour 31388092
ENSG00000101665 SMAD7 tumor 31434255
ENSG00000101665 SMAD7 esophageal cancer 31534563
ENSG00000101665 SMAD7 tumor 31547867
ENSG00000101665 SMAD7 tumor 31554487
ENSG00000101665 SMAD7 liver cancer 31614569
ENSG00000101665 SMAD7 tumor 31681406
ENSG00000101665 SMAD7 liver cancer 31711043
ENSG00000101665 SMAD7 lung cancer 31767934
ENSG00000101665 SMAD7 cervical cancer 31815762
ENSG00000101665 SMAD7 breast cancer 31941699
ENSG00000101665 SMAD7 lung cancer 9712726
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000101665 SMAD7 MESO 0.0026 high
ENSG00000101665 SMAD7 SARC 0.022 high
ENSG00000101665 SMAD7 UCEC 0.001 high
ENSG00000101665 SMAD7 THCA 0.011 high
ENSG00000101665 SMAD7 ACC 0.037 high
ENSG00000101665 SMAD7 LUSC 0.0051 high
ENSG00000101665 SMAD7 READ 0.039 low
ENSG00000101665 SMAD7 KIRP 0.038 low
ENSG00000101665 SMAD7 KICH 0.00034 low
ENSG00000101665 SMAD7 LUAD 0.024 low
ENSG00000101665 SMAD7 PCPG 0.014 low
ENSG00000101665 SMAD7 OV 0.033 low
ENSG00000101665 SMAD7 KIRC 0.033 low
ENSG00000101665 SMAD7 LAML 0.031 low
ENSG00000101665 SMAD7 CESC 0.015 high
ENSG00000101665 SMAD7 LIHC 0.0098 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000101665 SMAD7 LUAD Del 2.633470 0.073436 0.372800 0.478682
ENSG00000101665 SMAD7 READ Del 1.757501 0.099079 0.632871 0.854545
ENSG00000101665 SMAD7 COAD Del 1.860723 0.054733 0.612147 0.605322
ENSG00000101665 SMAD7 PAAD Del 2.663135 0.081199 0.399866 0.679348
ENSG00000101665 SMAD7 ESCA Del 3.342221 0.164751 0.480540 0.614130
ENSG00000101665 SMAD7 HNSC Del 1.162489 0.059732 0.402438 0.484674
ENSG00000101665 SMAD7 LIHC Del 0.914995 0.069056 0.527259 0.251351
ENSG00000101665 SMAD7 STAD Del 8.607256 0.136497 0.424752 0.430839
ENSG00000101665 SMAD7 OV Del 2.361677 0.209051 0.621488 0.559585