Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerSARS-COV-2
Drug N.A.
Main interacting RNAs tRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000101391 Gene ID 51654 Accession 15880
Symbol CDK5RAP1 Alias C42;CGI-05;HSPC167;C20orf34 Full Name CDK5 regulatory subunit associated protein 1
Status Confidence Length 42723 bases Strand Minus strand
Position 20 : 33358839 - 33401561 RNA binding domain N.A.
Summary This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
33061813 S-adenosylmethionine tRNA modification: unexpected/unsuspected implications of former/new players. Raffaella Adami 2020-01-01 International journal of biological sciences

Transcripts

Name Transcript ID bp Protein Translation ID
CDK5RAP1-204 ENST00000427097 974 256aa ENSP00000409474
CDK5RAP1-212 ENST00000481964 945 No protein -
CDK5RAP1-213 ENST00000482967 840 No protein -
CDK5RAP1-210 ENST00000473997 1930 497aa ENSP00000476857
CDK5RAP1-202 ENST00000346416 2080 587aa ENSP00000217372
CDK5RAP1-201 ENST00000339269 1891 510aa ENSP00000341840
CDK5RAP1-203 ENST00000357886 2164 601aa ENSP00000350558
CDK5RAP1-207 ENST00000461710 2650 No protein -
CDK5RAP1-216 ENST00000498525 777 No protein -
CDK5RAP1-215 ENST00000496381 858 No protein -
CDK5RAP1-205 ENST00000460043 535 No protein -
CDK5RAP1-208 ENST00000471264 763 No protein -
CDK5RAP1-209 ENST00000473791 740 No protein -
CDK5RAP1-211 ENST00000477105 979 No protein -
CDK5RAP1-206 ENST00000461356 758 No protein -
CDK5RAP1-214 ENST00000488723 708 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
14162Iron2.4700000E-00419880490
83691Hair Color2E-1520585627

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000101391homo_sapiensENSP0000027469542.141623.4888homo_sapiensENSP0000021737241.567323.1687

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000101391homo_sapiensENSP0000021737298.977997.9557nomascus_leucogenysENSNLEP0000001214096.672295.6739
ENSG00000101391homo_sapiensENSP0000021737299.829699.4889pan_paniscusENSPPAP0000000203499.829699.4889
ENSG00000101391homo_sapiensENSP0000021737299.148297.7853pongo_abeliiENSPPYP0000001219996.838695.5075
ENSG00000101391homo_sapiensENSP0000021737299.659399.1482pan_troglodytesENSPTRP0000008761297.597
ENSG00000101391homo_sapiensENSP0000021737268.994968.8245gorilla_gorillaENSGGOP0000000320410099.7531
ENSG00000101391homo_sapiensENSP0000021737276.831368.1431ornithorhynchus_anatinusENSOANP0000003762177.22668.4931
ENSG00000101391homo_sapiensENSP0000021737280.068169.3356sarcophilus_harrisiiENSSHAP0000000486487.198575.5102
ENSG00000101391homo_sapiensENSP0000021737278.534968.4838notamacropus_eugeniiENSMEUP0000000930576.578166.7774
ENSG00000101391homo_sapiensENSP0000021737286.882582.9642choloepus_hoffmanniENSCHOP0000000873384.717680.897
ENSG00000101391homo_sapiensENSP0000021737293.35688.4157dasypus_novemcinctusENSDNOP0000001181293.03988.1154
ENSG00000101391homo_sapiensENSP0000021737265.928561.6695erinaceus_europaeusENSEEUP0000001293877.555172.5451
ENSG00000101391homo_sapiensENSP0000021737278.875675.4685echinops_telfairiENSETEP0000001256076.528973.2231
ENSG00000101391homo_sapiensENSP0000021737297.785395.0596callithrix_jacchusENSCJAP0000008664592.28389.7106
ENSG00000101391homo_sapiensENSP0000021737297.785396.2521cercocebus_atysENSCATP0000003313597.453395.9253
ENSG00000101391homo_sapiensENSP0000021737298.637197.4446macaca_fascicularisENSMFAP0000000069398.637197.4446
ENSG00000101391homo_sapiensENSP0000021737298.466897.4446macaca_mulattaENSMMUP0000001111098.466897.4446
ENSG00000101391homo_sapiensENSP0000021737298.637197.4446macaca_nemestrinaENSMNEP0000004621898.637197.4446
ENSG00000101391homo_sapiensENSP0000021737298.296497.2743papio_anubisENSPANP0000001682996.006795.0083
ENSG00000101391homo_sapiensENSP0000021737255.877355.1959mandrillus_leucophaeusENSMLEP0000000971694.252993.1034
ENSG00000101391homo_sapiensENSP0000021737259.795656.0477tursiops_truncatusENSTTRP0000001030659.592555.8574
ENSG00000101391homo_sapiensENSP0000021737285.689981.0903vulpes_vulpesENSVVUP0000000626984.113779.5987
ENSG00000101391homo_sapiensENSP0000021737292.674687.5639mus_spretusMGP_SPRETEiJ_P005753492.51787.415
ENSG00000101391homo_sapiensENSP0000021737295.911490.46equus_asinusENSEASP0000501226395.585790.1528
ENSG00000101391homo_sapiensENSP0000021737295.059690.2896capra_hircusENSCHIP0000003185094.736889.983
ENSG00000101391homo_sapiensENSP0000021737293.185788.586loxodonta_africanaENSLAFP0000000098890.713186.2355
ENSG00000101391homo_sapiensENSP0000021737294.207890.6303panthera_leoENSPLOP0000002215994.854291.2521
ENSG00000101391homo_sapiensENSP0000021737286.712183.3049ailuropoda_melanoleucaENSAMEP0000001373395.497291.7448
ENSG00000101391homo_sapiensENSP0000021737294.889389.7785bos_indicus_hybridENSBIXP0000502550292.371587.3964
ENSG00000101391homo_sapiensENSP0000021737291.482187.0528oryctolagus_cuniculusENSOCUP0000004418183.775479.7192
ENSG00000101391homo_sapiensENSP0000021737295.741190.2896equus_caballusENSECAP0000000857495.41689.983
ENSG00000101391homo_sapiensENSP0000021737294.889390.46canis_lupus_familiarisENSCAFP0084503348195.540391.0806
ENSG00000101391homo_sapiensENSP0000021737294.378290.971panthera_pardusENSPPRP0000001458495.025791.5952
ENSG00000101391homo_sapiensENSP0000021737295.400391.6525marmota_marmota_marmotaENSMMMP0000002704895.238191.4966
ENSG00000101391homo_sapiensENSP0000021737288.58682.6235balaenoptera_musculusENSBMSP0001002062488.58682.6235
ENSG00000101391homo_sapiensENSP0000021737294.207889.4378cavia_porcellusENSCPOP0000000600194.207889.4378
ENSG00000101391homo_sapiensENSP0000021737294.548690.971felis_catusENSFCAP0000001409795.197391.5952
ENSG00000101391homo_sapiensENSP0000021737270.357767.121ursus_americanusENSUAMP0000003371144.408642.3656
ENSG00000101391homo_sapiensENSP0000021737288.756476.4906monodelphis_domesticaENSMODP0000000020288.305176.1017
ENSG00000101391homo_sapiensENSP0000021737295.059690.1192bison_bison_bisonENSBBBP0000001015294.736889.8132
ENSG00000101391homo_sapiensENSP0000021737295.2390.2896monodon_monocerosENSMMNP0001500282494.906689.983
ENSG00000101391homo_sapiensENSP0000021737295.2390.1192sus_scrofaENSSSCP0000000773694.906689.8132
ENSG00000101391homo_sapiensENSP0000021737296.422593.6968microcebus_murinusENSMICP0000000400296.258593.5374
ENSG00000101391homo_sapiensENSP0000021737294.037589.4378octodon_degusENSODEP0000001788293.877589.2857
ENSG00000101391homo_sapiensENSP0000021737292.504387.5639ovis_aries_rambouilletENSOARP0002001331290.049885.2405
ENSG00000101391homo_sapiensENSP0000021737294.718991.1414ursus_maritimusENSUMAP0000003348355.323453.2338
ENSG00000101391homo_sapiensENSP0000021737289.778584.3271ochotona_princepsENSOPRP0000000628390.239784.7603
ENSG00000101391homo_sapiensENSP0000021737295.2390.1192delphinapterus_leucasENSDLEP0000002543494.906689.8132
ENSG00000101391homo_sapiensENSP0000021737224.020421.6354delphinapterus_leucasENSDLEP0000002540381.034572.9885
ENSG00000101391homo_sapiensENSP0000021737295.570790.2896physeter_catodonENSPCTP0000501453195.246289.983
ENSG00000101391homo_sapiensENSP0000021737228.10926.4055mus_caroliMGP_CAROLIEiJ_P005539586.842181.5789
ENSG00000101391homo_sapiensENSP0000021737293.015387.7342mus_musculusENSMUSP0000010535392.857187.585
ENSG00000101391homo_sapiensENSP0000021737293.015386.5417dipodomys_ordiiENSDORP0000000432793.174186.6894
ENSG00000101391homo_sapiensENSP000002173729.710398.68825mustela_putorius_furoENSMPUP0000001772479.166770.8333
ENSG00000101391homo_sapiensENSP0000021737212.436111.414mustela_putorius_furoENSMPUP0000001772586.904879.7619
ENSG00000101391homo_sapiensENSP0000021737212.947211.925mustela_putorius_furoENSMPUP0000001772689.411882.3529
ENSG00000101391homo_sapiensENSP0000021737296.592893.8671aotus_nancymaaeENSANAP0000003835496.428693.7075
ENSG00000101391homo_sapiensENSP0000021737297.444694.8893saimiri_boliviensis_boliviensisENSSBOP0000003757497.444694.8893
ENSG00000101391homo_sapiensENSP0000021737290.630386.5417vicugna_pacosENSVPAP0000000902190.476286.3946
ENSG00000101391homo_sapiensENSP0000021737297.955796.7632chlorocebus_sabaeusENSCSAP0000000848097.955796.7632
ENSG00000101391homo_sapiensENSP0000021737280.579277.0017tupaia_belangeriENSTBEP0000000520978.571475.0831
ENSG00000101391homo_sapiensENSP0000021737275.298171.891mesocricetus_auratusENSMAUP0000000131990.946586.8313
ENSG00000101391homo_sapiensENSP0000021737295.2389.9489phocoena_sinusENSPSNP0000000642794.906689.6435
ENSG00000101391homo_sapiensENSP0000021737295.059691.1414camelus_dromedariusENSCDRP0000501539194.89890.9864
ENSG00000101391homo_sapiensENSP0000021737293.015389.6082carlito_syrichtaENSTSYP0000003470990.697787.3754
ENSG00000101391homo_sapiensENSP0000021737294.378290.8007panthera_tigris_altaicaENSPTIP0000001856395.025791.4237
ENSG00000101391homo_sapiensENSP0000021737227.086925.3833rattus_norvegicusENSRNOP0000008048084.574579.2553
ENSG00000101391homo_sapiensENSP0000021737229.98328.7905prolemur_simusENSPSMP0000002551093.61789.8936
ENSG00000101391homo_sapiensENSP0000021737286.20180.0681microtus_ochrogasterENSMOCP0000000356890.196183.779
ENSG00000101391homo_sapiensENSP0000021737277.172172.2317sorex_araneusENSSARP0000000145975.249270.4319
ENSG00000101391homo_sapiensENSP0000021737293.35688.7564peromyscus_maniculatus_bairdiiENSPEMP0000001847392.724288.1557
ENSG00000101391homo_sapiensENSP0000021737294.718989.9489bos_mutusENSBMUP0000003312892.205687.5622
ENSG00000101391homo_sapiensENSP0000021737292.674687.3935mus_spicilegusENSMSIP0000000108492.51787.2449
ENSG00000101391homo_sapiensENSP0000021737294.207889.2675cricetulus_griseus_chok1gshdENSCGRP0000102201493.570288.6633
ENSG00000101391homo_sapiensENSP0000021737294.548690.8007pteropus_vampyrusENSPVAP0000000969691.887488.245
ENSG00000101391homo_sapiensENSP0000021737295.400391.9932myotis_lucifugusENSMLUP0000000514994.754791.3706
ENSG00000101391homo_sapiensENSP0000021737289.097178.8756vombatus_ursinusENSVURP0001001738088.644178.4746
ENSG00000101391homo_sapiensENSP0000021737294.889389.9489rhinolophus_ferrumequinumENSRFEP0001001276294.567189.6435
ENSG00000101391homo_sapiensENSP0000021737289.948985.8603neovison_visonENSNVIP0000002312394.285790
ENSG00000101391homo_sapiensENSP0000021737291.822886.7121bos_taurusENSBTAP0000007381890.284885.2596
ENSG00000101391homo_sapiensENSP0000021737294.718990.46heterocephalus_glaber_femaleENSHGLP0000000704694.557890.3061
ENSG00000101391homo_sapiensENSP0000021737298.637197.2743rhinopithecus_bietiENSRBIP0000003575496.339495.0083
ENSG00000101391homo_sapiensENSP0000021737294.889390.46canis_lupus_dingoENSCAFP0002000599895.540391.0806
ENSG00000101391homo_sapiensENSP0000021737294.889390.46sciurus_vulgarisENSSVLP0000500349594.889390.46
ENSG00000101391homo_sapiensENSP0000021737289.437879.046phascolarctos_cinereusENSPCIP0000001660488.98378.6441
ENSG00000101391homo_sapiensENSP0000021737275.127871.891procavia_capensisENSPCAP000000051317571.7687
ENSG00000101391homo_sapiensENSP0000021737266.439561.4991nannospalax_galiliENSNGAP0000001616985.339278.9934
ENSG00000101391homo_sapiensENSP0000021737294.718989.9489bos_grunniensENSBGRP0000000951194.397389.6435
ENSG00000101391homo_sapiensENSP0000021737294.207890.46chinchilla_lanigeraENSCLAP0000002253494.047690.3061
ENSG00000101391homo_sapiensENSP0000021737292.504387.5639cervus_hanglu_yarkandensisENSCHYP0000002975389.900785.0993
ENSG00000101391homo_sapiensENSP0000021737295.059690.6303catagonus_wagneriENSCWAP0000000893694.736890.3226
ENSG00000101391homo_sapiensENSP0000021737295.570791.6525ictidomys_tridecemlineatusENSSTOP0000000491795.570791.6525
ENSG00000101391homo_sapiensENSP0000021737290.119285.0085otolemur_garnettiiENSOGAP0000000963687.43882.4793
ENSG00000101391homo_sapiensENSP0000021737297.955795.0596cebus_imitatorENSCCAP0000002687197.955795.0596
ENSG00000101391homo_sapiensENSP0000021737295.2391.4821urocitellus_parryiiENSUPAP0001000616195.2391.4821
ENSG00000101391homo_sapiensENSP0000021737294.378289.6082moschus_moschiferusENSMMSP0000001653194.057789.3039
ENSG00000101391homo_sapiensENSP0000021737298.637197.2743rhinopithecus_roxellanaENSRROP0000002752396.339495.0083
ENSG00000101391homo_sapiensENSP0000021737292.333987.2232mus_pahariMGP_PahariEiJ_P006636492.491587.372
ENSG00000101391homo_sapiensENSP0000021737283.645778.5349propithecus_coquereliENSPCOP0000002409588.468583.0631
ENSG00000101391homo_sapiensENSP0000021737270.187459.2845callorhinchus_miliiENSCMIP0000003337079.536767.1815
ENSG00000101391homo_sapiensENSP0000021737280.068166.7802latimeria_chalumnaeENSLACP0000001437080.068166.7802
ENSG00000101391homo_sapiensENSP0000021737276.320366.6099lepisosteus_oculatusENSLOCP0000000174076.843967.0669
ENSG00000101391homo_sapiensENSP0000021737276.831364.2249clupea_harengusENSCHAP0000000738874.299862.1087
ENSG00000101391homo_sapiensENSP0000021737274.616762.6917astyanax_mexicanusENSAMXP000000503227563.0137
ENSG00000101391homo_sapiensENSP0000021737276.320365.5877esox_luciusENSELUP0000002585874.172263.7417
ENSG00000101391homo_sapiensENSP0000021737276.66165.7581oncorhynchus_kisutchENSOKIP0000509920674.257463.6964
ENSG00000101391homo_sapiensENSP0000021737275.298163.8842salmo_salarENSSSAP0000010819374.915363.5593
ENSG00000101391homo_sapiensENSP0000021737277.172166.4395salmo_truttaENSSTUP0000010044675.374464.8918
ENSG00000101391homo_sapiensENSP0000021737212.43619.88075oreochromis_niloticusENSONIP0000003837569.523855.2381
ENSG00000101391homo_sapiensENSP0000021737277.001764.9063oreochromis_niloticusENSONIP0000005258852.19443.9954
ENSG00000101391homo_sapiensENSP0000021737219.591115.1618astatotilapia_callipteraENSACLP0000003520764.971750.2825
ENSG00000101391homo_sapiensENSP0000021737282.964274.1056chrysemys_picta_belliiENSCPBP0000003987076.692968.5039
ENSG00000101391homo_sapiensENSP0000021737280.749669.6763sphenodon_punctatusENSSPUP0000002474975.477765.1274
ENSG00000101391homo_sapiensENSP0000021737274.616762.862laticauda_laticaudataENSLLTP0000000193576.977164.8506
ENSG00000101391homo_sapiensENSP0000021737265.417454.3441notechis_scutatusENSNSUP0000001216874.563161.9417
ENSG00000101391homo_sapiensENSP0000021737271.039259.9659pseudonaja_textilisENSPTXP0000001898079.127166.7932
ENSG00000101391homo_sapiensENSP0000021737271.550360.3066pseudonaja_textilisENSPTXP0000001865774.074162.4339
ENSG00000101391homo_sapiensENSP0000021737271.720664.0545anas_platyrhynchos_platyrhynchosENSAPLP0000003231781.274172.5869
ENSG00000101391homo_sapiensENSP0000021737279.557170.8688gallus_gallusENSGALP0001002114654.239348.3159
ENSG00000101391homo_sapiensENSP0000021737277.172169.8467meleagris_gallopavoENSMGAP0000002522649.616644.9069
ENSG00000101391homo_sapiensENSP0000021737276.831368.4838serinus_canariaENSSCAP0000001954076.440768.1356
ENSG00000101391homo_sapiensENSP0000021737274.957466.4395parus_majorENSPMJP0000000717974.074165.6566
ENSG00000101391homo_sapiensENSP0000021737280.068167.121anolis_carolinensisENSACAP0000000435979.526266.6667
ENSG00000101391homo_sapiensENSP0000021737261.669552.2998naja_najaENSNNAP0000001956682.837570.2517
ENSG00000101391homo_sapiensENSP0000021737280.749669.506podarcis_muralisENSPMRP0000001023178.737567.7741
ENSG00000101391homo_sapiensENSP0000021737270.868863.2027geospiza_fortisENSGFOP0000000282477.902669.4757
ENSG00000101391homo_sapiensENSP0000021737278.194268.8245taeniopygia_guttataENSTGUP0000003800381.095471.3781
ENSG00000101391homo_sapiensENSP0000021737271.379960.3066erpetoichthys_calabaricusENSECRP0000001919482.806369.9605
ENSG00000101391homo_sapiensENSP0000021737254.344145.3152salvator_merianaeENSSMRP0000001328376.498863.789
ENSG00000101391homo_sapiensENSP0000021737281.942172.5724gopherus_evgoodeiENSGEVP0000501037082.36372.9452
ENSG00000101391homo_sapiensENSP0000021737282.964273.5946chelonoidis_abingdoniiENSCABP0000000564267.921960.251
ENSG00000101391homo_sapiensENSP0000021737277.001768.1431struthio_camelus_australisENSSCUP0000000300384.328474.6269
ENSG00000101391homo_sapiensENSP0000021737277.172169.1652anser_brachyrhynchusENSABRP0000002461461.632755.2381
ENSG00000101391homo_sapiensENSP0000021737274.27663.7138gasterosteus_aculeatusENSGACP0000001419875.04364.3718
ENSG00000101391homo_sapiensENSP0000021737278.875671.0392strigops_habroptilaENSSHBP0000500665282.826574.5975
ENSG00000101391homo_sapiensENSP0000021737283.304973.7649terrapene_carolina_triunguisENSTMTP0000001411778.617469.6142
ENSG00000101391homo_sapiensENSP0000021737277.001766.2692hucho_huchoENSHHUP0000001166774.958564.5108
ENSG00000101391homo_sapiensENSP0000021737273.935362.0102pygocentrus_nattereriENSPNAP0000000792873.187261.3828
ENSG00000101391homo_sapiensENSP0000021737279.216470.8688aquila_chrysaetos_chrysaetosENSACCP0002000927982.887774.1533
ENSG00000101391homo_sapiensENSP0000021737274.27664.3952denticeps_clupeoidesENSDCDP0000004972176.090865.9686
ENSG00000101391homo_sapiensENSP0000021737278.364669.3356ficedula_albicollisENSFALP0000002088073.665.12
ENSG00000101391homo_sapiensENSP0000021737276.320367.632coturnix_japonicaENSCJPP0000500471481.306772.0508
ENSG00000101391homo_sapiensENSP0000021737219.591115.1618maylandia_zebraENSMZEP0000501084964.971750.2825
ENSG00000101391homo_sapiensENSP0000021737275.979665.247scleropages_formosusENSSFOP0001502406675.850365.1361
ENSG00000101391homo_sapiensENSP0000021737277.512866.4395leptobrachium_leishanenseENSLLEP0000003412778.583867.3575

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0005575is_active_in cellular_component1NDHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005739is_active_in mitochondrion2IBA,IDAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol2IBA,IDAHomo_sapiens(9606)Component
GO:0007420involved_in brain development1NASHomo_sapiens(9606)Process
GO:0019901enables protein kinase binding1NASHomo_sapiens(9606)Function
GO:0035597enables N6-isopentenyladenosine methylthiotransferase activity1IBAHomo_sapiens(9606)Function
GO:0035600involved_in tRNA methylthiolation1IEAHomo_sapiens(9606)Process
GO:0045664involved_in regulation of neuron differentiation1NASHomo_sapiens(9606)Process
GO:0045736involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity3IBA,IDA,TASHomo_sapiens(9606)Process
GO:0045903involved_in positive regulation of translational fidelity1IEAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0051539enables 4 iron, 4 sulfur cluster binding1IEAHomo_sapiens(9606)Function
GO:0070131involved_in positive regulation of mitochondrial translation1IEAHomo_sapiens(9606)Process
GO:0070900involved_in mitochondrial tRNA modification1IEAHomo_sapiens(9606)Process

Expression