Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs diverse
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000101347 Gene ID 25939 Accession 15925
Symbol SAMHD1 Alias DCIP;CHBL2;HDDC1;MOP-5;SBBI88;hSAMHD1 Full Name SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Status Confidence Length 61665 bases Strand Minus strand
Position 20 : 36890229 - 36951893 RNA binding domain N.A.
Summary This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
26101257 SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity. J Kyle Seamon 2015-07-27 Nucleic acids research
25010268 Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility. E Tommy White 2014-07-01 Virology
28229507 A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans. E Tommy White 2017-06-01 Human mutation
23158101 Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1. E Tommy White 2013-02-05 Virology
30336972 SAMHD1 Suppression of Antiviral Immune Responses. Shuliang Chen 2019-03-01 Trends in microbiology
27775344 Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer. J Kyle Seamon 2016-11-08 Biochemistry
37127613 Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells. C Ming-Han Tsai 2023-05-01 Retrovirology
29698322 Lentiviral infection of proliferating brain macrophages in HIV and simian immunodeficiency virus encephalitis despite sterile alpha motif and histidine-aspartate domain-containing protein 1 expression. A Allison Lindgren 2018-05-15 AIDS (London, England)
21740548 SAMHD1: a new insight into HIV-1 restriction in myeloid cells. Corine C St 2011-07-08 Retrovirology
24523981 Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1. Li Wu 2013-07-07 ISRN biochemistry
26733158 Functional organization of human SAMHD1 and mechanisms of HIV-1 restriction. Jinwoo Ahn 2016-04-01 Biological chemistry
27229711 Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle. R F Andreas Sommer 2016-05-27 Scientific reports
23092122 SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells. Benjamin Descours 2012-10-23 Retrovirology
29176984 The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral Response. M Jenna Antonucci 2017-01-01 Frontiers in immunology
31426525 Interplay between Intrinsic and Innate Immunity during HIV Infection. Louis Bergantz 2019-08-17 Cells
29515139 DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1. Paula Jáuregui 2018-03-07 Scientific reports
27482511 Modulation of LINE-1 Retrotransposition by a Human SAMHD1 Polymorphism. E Tommy White 2016-12-01 Virology reports
36899868 Host Cell Restriction Factors Blocking Efficient Vector Transduction: Challenges in Lentiviral and Adeno-Associated Vector Based Gene Therapies. Sofia Ana Coroadinha 2023-02-24 Cells
25755265 A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase. J Kyle Seamon 2015-07-01 Journal of biomolecular screening
26431200 Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction. H Laurence Arnold 2015-10-01 PLoS pathogens
30104243 SAMHD1 Posttranscriptionally Controls the Expression of Foxp3 and Helios in Human T Regulatory Cells. Chan Yong Kim 2018-09-15 Journal of immunology (Baltimore, Md. : 1950)
34697376 HIV-2 Vpx neutralizes host restriction factor SAMHD1 to promote viral pathogenesis. Ahlam Mohamed 2021-10-25 Scientific reports
23601106 The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation. E Tommy White 2013-04-17 Cell host & microbe
24219908 Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1. Alberto Brandariz-Nuñez 2013-11-12 Retrovirology
32244340 SAMHD1 Functions and Human Diseases. A Si'Ana Coggins 2020-03-31 Viruses
35801923 Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics. Benjamin Orris 2022-07-22 Nucleic acids research
31296733 The missing link: allostery and catalysis in the anti-viral protein SAMHD1. R Elizabeth Morris 2019-08-30 Biochemical Society transactions
30254620 Post-translational Modification-Based Regulation of HIV Replication. Lin Chen 2018-01-01 Frontiers in microbiology
24035396 Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1. Ke Zhao 2013-09-26 Cell reports

Transcripts

Name Transcript ID bp Protein Translation ID
SAMHD1-221 ENST00000646673 4649 626aa ENSP00000493536
SAMHD1-217 ENST00000645033 4680 289aa ENSP00000494520
SAMHD1-228 ENST00000682773 3687 626aa ENSP00000507178
SAMHD1-224 ENST00000646904 4672 285aa ENSP00000494823
SAMHD1-214 ENST00000644250 3534 591aa ENSP00000493810
SAMHD1-204 ENST00000642246 4508 127aa ENSP00000494979
SAMHD1-230 ENST00000683766 2618 626aa ENSP00000506877
SAMHD1-225 ENST00000647095 5492 No protein -
SAMHD1-226 ENST00000647163 3440 289aa ENSP00000494313
SAMHD1-201 ENST00000262878 4334 591aa ENSP00000262878
SAMHD1-223 ENST00000646869 3209 626aa ENSP00000495667
SAMHD1-227 ENST00000647459 3146 No protein -
SAMHD1-203 ENST00000642186 3312 289aa ENSP00000494436
SAMHD1-212 ENST00000643918 2967 589aa ENSP00000493928
SAMHD1-213 ENST00000644114 1809 437aa ENSP00000494354
SAMHD1-219 ENST00000646066 1671 556aa ENSP00000495432
SAMHD1-229 ENST00000683720 1919 241aa ENSP00000508219
SAMHD1-202 ENST00000465985 513 104aa ENSP00000496075
SAMHD1-210 ENST00000643825 522 139aa ENSP00000495448
SAMHD1-218 ENST00000645444 4030 289aa ENSP00000495381
SAMHD1-216 ENST00000644688 1700 No protein -
SAMHD1-205 ENST00000642616 1424 156aa ENSP00000494271
SAMHD1-207 ENST00000643078 1395 127aa ENSP00000496474
SAMHD1-208 ENST00000643161 816 No protein -
SAMHD1-222 ENST00000646866 975 129aa ENSP00000495737
SAMHD1-220 ENST00000646121 643 89aa ENSP00000495645
SAMHD1-215 ENST00000644370 527 No protein -
SAMHD1-206 ENST00000643003 546 No protein -
SAMHD1-209 ENST00000643243 1260 No protein -
SAMHD1-211 ENST00000643907 540 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
47136Platelet Function Tests7.5755000E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000101347

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000101347homo_sapiensENSP0000049353697.763695.3674nomascus_leucogenysENSNLEP0000000749797.763695.3674
ENSG00000101347homo_sapiensENSP0000049353699.680599.361pan_paniscusENSPPAP0000003066499.680599.361
ENSG00000101347homo_sapiensENSP0000049353698.083196.1661pongo_abeliiENSPPYP0000003508398.083196.1661
ENSG00000101347homo_sapiensENSP0000049353699.680599.361pan_troglodytesENSPTRP0000002311999.680599.361
ENSG00000101347homo_sapiensENSP0000049353699.520898.8818gorilla_gorillaENSGGOP0000001105499.520898.8818
ENSG00000101347homo_sapiensENSP0000049353677.955366.4537ornithorhynchus_anatinusENSOANP0000004227676.012564.7975
ENSG00000101347homo_sapiensENSP0000049353666.293957.8275sarcophilus_harrisiiENSSHAP0000003648278.007568.0451
ENSG00000101347homo_sapiensENSP0000049353679.872270.1278sarcophilus_harrisiiENSSHAP0000004169580.515370.6924
ENSG00000101347homo_sapiensENSP0000049353645.527238.8179notamacropus_eugeniiENSMEUP0000000086449.651642.3345
ENSG00000101347homo_sapiensENSP0000049353659.424953.9936choloepus_hoffmanniENSCHOP0000000483569.40363.0597
ENSG00000101347homo_sapiensENSP0000049353687.699779.7125dasypus_novemcinctusENSDNOP0000001488587.559879.5853
ENSG00000101347homo_sapiensENSP0000049353676.038367.7316erinaceus_europaeusENSEEUP0000000387876.404568.0578
ENSG00000101347homo_sapiensENSP0000049353669.169360.2236echinops_telfairiENSETEP0000000232769.502460.5136
ENSG00000101347homo_sapiensENSP0000049353692.811587.3802callithrix_jacchusENSCJAP0000000220792.663587.2408
ENSG00000101347homo_sapiensENSP0000049353696.325993.4505cercocebus_atysENSCATP0000000686294.662591.8367
ENSG00000101347homo_sapiensENSP0000049353696.645493.9297macaca_fascicularisENSMFAP0000005100196.645493.9297
ENSG00000101347homo_sapiensENSP0000049353696.485693.77macaca_mulattaENSMMUP0000007443696.485693.77
ENSG00000101347homo_sapiensENSP0000049353691.054387.2204macaca_nemestrinaENSMNEP0000003361195.477491.4573
ENSG00000101347homo_sapiensENSP0000049353696.645493.77papio_anubisENSPANP0000001594596.645493.77
ENSG00000101347homo_sapiensENSP0000049353696.485693.6102mandrillus_leucophaeusENSMLEP0000002542496.485693.6102
ENSG00000101347homo_sapiensENSP0000049353687.220478.5942tursiops_truncatusENSTTRP0000000181287.081378.4689
ENSG00000101347homo_sapiensENSP0000049353688.498477.7955vulpes_vulpesENSVVUP0000004120988.357377.6714
ENSG00000101347homo_sapiensENSP0000049353682.747673.0032mus_spretusMGP_SPRETEiJ_P005790278.723469.4529
ENSG00000101347homo_sapiensENSP0000049353689.776481.9489equus_asinusENSEASP0000500436883.880676.5672
ENSG00000101347homo_sapiensENSP0000049353683.226874.7604capra_hircusENSCHIP0000003352085.973677.2277
ENSG00000101347homo_sapiensENSP0000049353687.060778.115loxodonta_africanaENSLAFP0000000162487.479978.4912
ENSG00000101347homo_sapiensENSP0000049353684.34574.6006panthera_leoENSPLOP0000000240083.544373.8924
ENSG00000101347homo_sapiensENSP0000049353688.658178.4345ailuropoda_melanoleucaENSAMEP0000001314788.516778.3094
ENSG00000101347homo_sapiensENSP0000049353684.185374.7604bos_indicus_hybridENSBIXP0000500612886.677676.9737
ENSG00000101347homo_sapiensENSP0000049353684.185376.0383oryctolagus_cuniculusENSOCUP0000000658185.551977.2727
ENSG00000101347homo_sapiensENSP0000049353689.776482.1086equus_caballusENSECAP0000006917683.880676.7164
ENSG00000101347homo_sapiensENSP0000049353688.338777.7955canis_lupus_familiarisENSCAFP0084503714188.197877.6714
ENSG00000101347homo_sapiensENSP0000049353688.498477.476panthera_pardusENSPPRP0000002749788.357377.3525
ENSG00000101347homo_sapiensENSP0000049353680.191771.885marmota_marmota_marmotaENSMMMP0000002556584.369875.6302
ENSG00000101347homo_sapiensENSP0000049353687.699778.754balaenoptera_musculusENSBMSP0001001710087.420478.5032
ENSG00000101347homo_sapiensENSP0000049353674.121466.9329cavia_porcellusENSCPOP0000000718988.212979.6578
ENSG00000101347homo_sapiensENSP0000049353688.498477.6358felis_catusENSFCAP0000001202588.357377.512
ENSG00000101347homo_sapiensENSP0000049353680.351470.607ursus_americanusENSUAMP0000000940584.254674.0368
ENSG00000101347homo_sapiensENSP0000049353680.511269.4888monodelphis_domesticaENSMODP0000000154081.028969.9357
ENSG00000101347homo_sapiensENSP0000049353684.025674.6006bison_bison_bisonENSBBBP0000002078386.513276.8092
ENSG00000101347homo_sapiensENSP0000049353687.220478.5942monodon_monocerosENSMMNP0001500431986.942778.3439
ENSG00000101347homo_sapiensENSP0000049353688.338780.6709sus_scrofaENSSSCP0000002307088.197880.5423
ENSG00000101347homo_sapiensENSP0000049353689.297182.5879microcebus_murinusENSMICP0000000223589.154782.4561
ENSG00000101347homo_sapiensENSP0000049353682.747673.8019octodon_degusENSODEP0000001869282.747673.8019
ENSG00000101347homo_sapiensENSP0000049353673.322765.016jaculus_jaculusENSJJAP0000001797579.274670.2936
ENSG00000101347homo_sapiensENSP0000049353685.143876.0383ovis_aries_rambouilletENSOARP0002001017387.520578.1609
ENSG00000101347homo_sapiensENSP0000049353688.338778.5942ursus_maritimusENSUMAP0000000512388.197878.4689
ENSG00000101347homo_sapiensENSP0000049353680.511271.885ochotona_princepsENSOPRP0000001123681.159472.4638
ENSG00000101347homo_sapiensENSP0000049353687.380278.9137delphinapterus_leucasENSDLEP0000001851687.101978.6624
ENSG00000101347homo_sapiensENSP0000049353687.220478.4345physeter_catodonENSPCTP0000500778186.942778.1847
ENSG00000101347homo_sapiensENSP0000049353682.587973.0032mus_caroliMGP_CAROLIEiJ_P005574578.571469.4529
ENSG00000101347homo_sapiensENSP0000049353682.747673.0032mus_musculusENSMUSP0000005971778.723469.4529
ENSG00000101347homo_sapiensENSP0000049353664.057556.23dipodomys_ordiiENSDORP0000001161079.721769.9801
ENSG00000101347homo_sapiensENSP0000049353687.220477.476mustela_putorius_furoENSMPUP0000001765787.220477.476
ENSG00000101347homo_sapiensENSP0000049353691.373885.1438aotus_nancymaaeENSANAP0000001215390.793684.6032
ENSG00000101347homo_sapiensENSP0000049353692.651886.901saimiri_boliviensis_boliviensisENSSBOP0000000386687.745882.2995
ENSG00000101347homo_sapiensENSP0000049353681.309971.7252vicugna_pacosENSVPAP0000000333881.701472.0706
ENSG00000101347homo_sapiensENSP0000049353696.166192.9712chlorocebus_sabaeusENSCSAP0000000618796.166192.9712
ENSG00000101347homo_sapiensENSP0000049353652.396248.2428tupaia_belangeriENSTBEP0000000790758.992854.3165
ENSG00000101347homo_sapiensENSP0000049353622.204519.1693mesocricetus_auratusENSMAUP0000002217176.373665.9341
ENSG00000101347homo_sapiensENSP0000049353687.380278.4345phocoena_sinusENSPSNP0000000945387.101978.1847
ENSG00000101347homo_sapiensENSP0000049353688.338779.0735camelus_dromedariusENSCDRP0000502637188.197878.9474
ENSG00000101347homo_sapiensENSP0000049353677.955370.4473carlito_syrichtaENSTSYP0000002085183.70575.6432
ENSG00000101347homo_sapiensENSP0000049353688.338777.3163panthera_tigris_altaicaENSPTIP0000002016188.197877.193
ENSG00000101347homo_sapiensENSP0000049353682.747672.3642rattus_norvegicusENSRNOP0000000896183.548473.0645
ENSG00000101347homo_sapiensENSP0000049353689.776482.9073prolemur_simusENSPSMP0000002648189.633282.7751
ENSG00000101347homo_sapiensENSP0000049353680.351467.4121microtus_ochrogasterENSMOCP0000000864680.095567.1974
ENSG00000101347homo_sapiensENSP0000049353662.619855.4313sorex_araneusENSSARP0000001015767.469959.7246
ENSG00000101347homo_sapiensENSP0000049353680.351470.7668peromyscus_maniculatus_bairdiiENSPEMP0000002195377.029167.8407
ENSG00000101347homo_sapiensENSP0000049353683.865874.2812bos_mutusENSBMUP0000000110486.348776.4803
ENSG00000101347homo_sapiensENSP0000049353682.907372.8435mus_spicilegusENSMSIP0000000179278.875469.3009
ENSG00000101347homo_sapiensENSP0000049353680.351470.7668cricetulus_griseus_chok1gshdENSCGRP0000101284476.560167.4277
ENSG00000101347homo_sapiensENSP0000049353671.565561.6613pteropus_vampyrusENSPVAP0000001014871.337661.465
ENSG00000101347homo_sapiensENSP0000049353677.955366.9329myotis_lucifugusENSMLUP0000000202678.205167.1474
ENSG00000101347homo_sapiensENSP0000049353681.789170.7668vombatus_ursinusENSVURP0001002435882.315171.2219
ENSG00000101347homo_sapiensENSP0000049353683.067173.9617rhinolophus_ferrumequinumENSRFEP0001002082882.802673.7261
ENSG00000101347homo_sapiensENSP0000049353683.546373.8019neovison_visonENSNVIP0000001753483.814174.0385
ENSG00000101347homo_sapiensENSP0000049353680.670971.7252bos_taurusENSBTAP0000004123685.738576.2309
ENSG00000101347homo_sapiensENSP0000049353683.067176.0383heterocephalus_glaber_femaleENSHGLP0000005166587.248379.8658
ENSG00000101347homo_sapiensENSP0000049353697.284394.5687rhinopithecus_bietiENSRBIP0000000013396.974594.2675
ENSG00000101347homo_sapiensENSP0000049353686.26276.1981canis_lupus_dingoENSCAFP0002001483778.947469.7368
ENSG00000101347homo_sapiensENSP0000049353686.26276.3578sciurus_vulgarisENSSVLP0000502315187.237577.2213
ENSG00000101347homo_sapiensENSP0000049353681.150270.4473phascolarctos_cinereusENSPCIP0000001916180.634970
ENSG00000101347homo_sapiensENSP0000049353684.025674.4409bos_grunniensENSBGRP0000000741086.513276.6447
ENSG00000101347homo_sapiensENSP0000049353674.281266.9329chinchilla_lanigeraENSCLAP0000002508186.915978.3178
ENSG00000101347homo_sapiensENSP0000049353684.504874.7604cervus_hanglu_yarkandensisENSCHYP0000002884486.296976.3458
ENSG00000101347homo_sapiensENSP0000049353687.859478.9137catagonus_wagneriENSCWAP0000001724687.719378.7879
ENSG00000101347homo_sapiensENSP0000049353684.664576.1981ictidomys_tridecemlineatusENSSTOP0000001935785.760577.1845
ENSG00000101347homo_sapiensENSP0000049353681.309973.4824otolemur_garnettiiENSOGAP0000000081284.132276.0331
ENSG00000101347homo_sapiensENSP0000049353674.281269.4888cebus_imitatorENSCCAP0000000778491.355685.4617
ENSG00000101347homo_sapiensENSP0000049353684.185375.8786urocitellus_parryiiENSUPAP0001000383985.275176.8608
ENSG00000101347homo_sapiensENSP0000049353684.824375.7188moschus_moschiferusENSMMSP0000000933686.623277.3246
ENSG00000101347homo_sapiensENSP0000049353697.124694.5687rhinopithecus_roxellanaENSRROP0000002124896.815394.2675
ENSG00000101347homo_sapiensENSP0000049353682.587972.524mus_pahariMGP_PahariEiJ_P006672678.571468.997
ENSG00000101347homo_sapiensENSP0000049353657.188553.5144propithecus_coquereliENSPCOP0000000963789.583.75
ENSG00000101347homo_sapiensENSP0000049353643.7727.476caenorhabditis_elegansZK177.8a.146.67829.3015
ENSG00000101347homo_sapiensENSP0000049353630.031918.3706drosophila_melanogasterFBpp030286551.08731.25
ENSG00000101347homo_sapiensENSP0000049353651.118237.6997ciona_intestinalisENSCINP0000002581766.528149.0644
ENSG00000101347homo_sapiensENSP0000049353659.265249.0415petromyzon_marinusENSPMAP0000000443476.337463.1687
ENSG00000101347homo_sapiensENSP0000049353632.108621.7252eptatretus_burgeriENSEBUP0000002175258.430239.5349
ENSG00000101347homo_sapiensENSP0000049353669.648656.5495callorhinchus_miliiENSCMIP0000000521270.209357.0048
ENSG00000101347homo_sapiensENSP0000049353666.613453.8339latimeria_chalumnaeENSLACP0000001139367.585154.6191
ENSG00000101347homo_sapiensENSP0000049353666.613454.7923latimeria_chalumnaeENSLACP0000001044166.190554.4444
ENSG00000101347homo_sapiensENSP0000049353672.52459.1054latimeria_chalumnaeENSLACP0000002084073.107959.5813
ENSG00000101347homo_sapiensENSP0000049353674.440961.3419lepisosteus_oculatusENSLOCP0000000525175.526762.2366
ENSG00000101347homo_sapiensENSP0000049353662.619849.8403clupea_harengusENSCHAP0000000350770.503656.1151
ENSG00000101347homo_sapiensENSP0000049353662.779650.9585clupea_harengusENSCHAP0000000034471.324957.8947
ENSG00000101347homo_sapiensENSP0000049353669.808357.9872clupea_harengusENSCHAP0000000720368.602856.9859
ENSG00000101347homo_sapiensENSP0000049353659.584746.1661clupea_harengusENSCHAP0000000360463.543449.2334
ENSG00000101347homo_sapiensENSP0000049353671.88559.5847danio_rerioENSDARP0000009608772.347359.9678
ENSG00000101347homo_sapiensENSP0000049353671.88560.0639carassius_auratusENSCARP0000005182671.315459.588
ENSG00000101347homo_sapiensENSP0000049353663.578353.3546astyanax_mexicanusENSAMXP0000004914374.392562.4299
ENSG00000101347homo_sapiensENSP0000049353670.766858.4665ictalurus_punctatusENSIPUP0000002130870.766858.4665
ENSG00000101347homo_sapiensENSP0000049353657.50845.0479esox_luciusENSELUP0000000047468.833653.9197
ENSG00000101347homo_sapiensENSP0000049353650.798740.4153esox_luciusENSELUP0000000049065.702552.2727
ENSG00000101347homo_sapiensENSP0000049353649.680539.2971esox_luciusENSELUP0000002624672.663657.4766
ENSG00000101347homo_sapiensENSP0000049353651.597441.2141esox_luciusENSELUP0000000046268.432254.661
ENSG00000101347homo_sapiensENSP0000049353654.472843.77esox_luciusENSELUP0000002623473.809559.3074
ENSG00000101347homo_sapiensENSP0000049353669.648656.3898esox_luciusENSELUP0000005228669.537556.2998
ENSG00000101347homo_sapiensENSP0000049353663.73852.5559esox_luciusENSELUP0000000061471.505458.9606
ENSG00000101347homo_sapiensENSP0000049353671.086359.1054electrophorus_electricusENSEEEP0000000180771.428659.39
ENSG00000101347homo_sapiensENSP0000049353669.648657.508oncorhynchus_kisutchENSOKIP0000510633768.018756.1622
ENSG00000101347homo_sapiensENSP0000049353671.24655.2716oncorhynchus_kisutchENSOKIP0000506574861.34847.5928
ENSG00000101347homo_sapiensENSP0000049353672.044755.5911oncorhynchus_mykissENSOMYP0000008380763.165348.7395
ENSG00000101347homo_sapiensENSP0000049353670.766857.8275oncorhynchus_mykissENSOMYP0000005379174.328960.7383
ENSG00000101347homo_sapiensENSP0000049353666.773253.9936salmo_salarENSSSAP0000006667769.205355.9603
ENSG00000101347homo_sapiensENSP0000049353647.603838.1789salmo_salarENSSSAP0000012290772.860658.4352
ENSG00000101347homo_sapiensENSP0000049353625.399417.4121salmo_salarENSSSAP0000016830563.855443.7751
ENSG00000101347homo_sapiensENSP0000049353671.88558.6262salmo_salarENSSSAP0000013425672.933559.4814
ENSG00000101347homo_sapiensENSP0000049353671.565558.3067salmo_salarENSSSAP0000014316372.609459.1572
ENSG00000101347homo_sapiensENSP0000049353672.364255.7508salmo_salarENSSSAP0000017890972.596255.9295
ENSG00000101347homo_sapiensENSP0000049353672.843559.1054salmo_truttaENSSTUP0000004153967.058854.4118
ENSG00000101347homo_sapiensENSP0000049353668.370652.7157salmo_truttaENSSTUP0000009533867.936552.381
ENSG00000101347homo_sapiensENSP0000049353658.626244.8882salmo_truttaENSSTUP0000009464973.547156.3126
ENSG00000101347homo_sapiensENSP0000049353671.88558.7859gadus_morhuaENSGMOP0000003463673.529460.1307
ENSG00000101347homo_sapiensENSP0000049353653.194943.9297gadus_morhuaENSGMOP0000006574372.707460.0437
ENSG00000101347homo_sapiensENSP0000049353655.910545.3674gadus_morhuaENSGMOP0000000225366.287953.7879
ENSG00000101347homo_sapiensENSP0000049353668.051154.1534fundulus_heteroclitusENSFHEP000000171097559.6831
ENSG00000101347homo_sapiensENSP0000049353672.204558.3067poecilia_reticulataENSPREP0000002738372.089358.2137
ENSG00000101347homo_sapiensENSP0000049353672.683759.2652xiphophorus_maculatusENSXMAP0000000747272.567859.1707
ENSG00000101347homo_sapiensENSP0000049353673.003259.2652oryzias_latipesENSORLP0000003811372.886859.1707
ENSG00000101347homo_sapiensENSP0000049353672.364258.6262cyclopterus_lumpusENSCLMP0000502602571.790858.1616
ENSG00000101347homo_sapiensENSP0000049353672.204557.8275oreochromis_niloticusENSONIP0000004908272.668858.1994
ENSG00000101347homo_sapiensENSP0000049353672.364257.8275haplochromis_burtoniENSHBUP0000000445072.829658.1994
ENSG00000101347homo_sapiensENSP0000049353672.044757.8275astatotilapia_callipteraENSACLP0000003923072.50858.1994
ENSG00000101347homo_sapiensENSP0000049353673.801958.3067sparus_aurataENSSAUP0001003506873.801958.3067
ENSG00000101347homo_sapiensENSP0000049353673.961759.5847lates_calcariferENSLCAP0001004625974.317859.8716
ENSG00000101347homo_sapiensENSP0000049353648.562338.1789lates_calcariferENSLCAP0001002331374.509858.5784
ENSG00000101347homo_sapiensENSP0000049353675.079960.8626xenopus_tropicalisENSXETP0000009242174.603260.4762
ENSG00000101347homo_sapiensENSP0000049353677.635866.7732chrysemys_picta_belliiENSCPBP0000002734077.388566.5605
ENSG00000101347homo_sapiensENSP0000049353675.878664.2173sphenodon_punctatusENSSPUP0000000053976.489564.7343
ENSG00000101347homo_sapiensENSP0000049353673.482462.1406crocodylus_porosusENSCPRP0000502168874.074162.6409
ENSG00000101347homo_sapiensENSP0000049353623.482419.1693laticauda_laticaudataENSLLTP0000001426764.192152.4017
ENSG00000101347homo_sapiensENSP0000049353666.293955.1118pseudonaja_textilisENSPTXP0000000025575.454562.7273
ENSG00000101347homo_sapiensENSP0000049353671.24658.147anas_platyrhynchos_platyrhynchosENSAPLP0000001445877.83663.5253
ENSG00000101347homo_sapiensENSP0000049353672.52459.4249gallus_gallusENSGALP0001003639759.973649.1413
ENSG00000101347homo_sapiensENSP0000049353668.849856.5495meleagris_gallopavoENSMGAP0000000041476.283262.6549
ENSG00000101347homo_sapiensENSP0000049353668.051155.4313serinus_canariaENSSCAP0000001640873.702460.0346
ENSG00000101347homo_sapiensENSP0000049353674.121459.1054parus_majorENSPMJP0000000210076.948661.3599
ENSG00000101347homo_sapiensENSP0000049353675.239662.7796anolis_carolinensisENSACAP0000000692770.50958.8323
ENSG00000101347homo_sapiensENSP0000049353658.466548.5623neolamprologus_brichardiENSNBRP0000001867666.666755.3734
ENSG00000101347homo_sapiensENSP0000049353675.399462.6198naja_najaENSNNAP0000001040173.178360.7752
ENSG00000101347homo_sapiensENSP0000049353655.591143.9297podarcis_muralisENSPMRP0000002855473.728858.2627
ENSG00000101347homo_sapiensENSP0000049353669.808358.3067podarcis_muralisENSPMRP0000002846670.826659.1572
ENSG00000101347homo_sapiensENSP0000049353665.335553.0351podarcis_muralisENSPMRP0000002799873.166459.3918
ENSG00000101347homo_sapiensENSP0000049353667.571955.1118geospiza_fortisENSGFOP0000001093278.917964.3657
ENSG00000101347homo_sapiensENSP0000049353673.003258.7859taeniopygia_guttataENSTGUP0000000339475.537260.8264
ENSG00000101347homo_sapiensENSP0000049353672.204561.1821erpetoichthys_calabaricusENSECRP0000001698771.181160.315
ENSG00000101347homo_sapiensENSP0000049353672.044758.6262kryptolebias_marmoratusENSKMAP0000002508672.275658.8141
ENSG00000101347homo_sapiensENSP0000049353675.079962.6198salvator_merianaeENSSMRP0000000243475.806463.2258
ENSG00000101347homo_sapiensENSP0000049353671.24657.6677oryzias_javanicusENSOJAP0000000333374.457460.2671
ENSG00000101347homo_sapiensENSP0000049353668.690156.5495amphilophus_citrinellusENSACIP0000001208471.906459.1973
ENSG00000101347homo_sapiensENSP0000049353673.801959.9042dicentrarchus_labraxENSDLAP0000503850173.684259.8086
ENSG00000101347homo_sapiensENSP0000049353673.642260.0639amphiprion_perculaENSAPEP0000001061873.642260.0639
ENSG00000101347homo_sapiensENSP0000049353648.72237.5399oryzias_sinensisENSOSIP0000001996566.017350.8658
ENSG00000101347homo_sapiensENSP0000049353674.600663.738pelodiscus_sinensisENSPSIP0000001997383.992871.7626
ENSG00000101347homo_sapiensENSP0000049353674.281263.738gopherus_evgoodeiENSGEVP0000502131578.282867.1717
ENSG00000101347homo_sapiensENSP0000049353671.405860.8626chelonoidis_abingdoniiENSCABP0000002369084.819772.296
ENSG00000101347homo_sapiensENSP0000049353673.801959.4249seriola_dumeriliENSSDUP0000002377873.801959.4249
ENSG00000101347homo_sapiensENSP0000049353673.801959.1054cottoperca_gobioENSCGOP0000005132874.038559.2949
ENSG00000101347homo_sapiensENSP0000049353669.169357.1885struthio_camelus_australisENSSCUP0000001540879.742265.93
ENSG00000101347homo_sapiensENSP0000049353676.038361.8211anser_brachyrhynchusENSABRP0000001950877.398462.9268
ENSG00000101347homo_sapiensENSP0000049353653.035142.6518gasterosteus_aculeatusENSGACP0000000213976.674461.6628
ENSG00000101347homo_sapiensENSP0000049353630.830726.5176gasterosteus_aculeatusENSGACP0000000212782.832671.2446
ENSG00000101347homo_sapiensENSP0000049353671.565556.7093gasterosteus_aculeatusENSGACP0000000213673.563258.2923
ENSG00000101347homo_sapiensENSP0000049353669.96854.9521cynoglossus_semilaevisENSCSEP0000003275073.986558.1081
ENSG00000101347homo_sapiensENSP0000049353672.683758.7859poecilia_formosaENSPFOP0000000899672.567858.6922
ENSG00000101347homo_sapiensENSP0000049353673.482459.5847myripristis_murdjanENSMMDP0000503942373.717959.7756
ENSG00000101347homo_sapiensENSP0000049353673.482457.6677sander_luciopercaENSSLUP0000000524070.552155.3681
ENSG00000101347homo_sapiensENSP0000049353672.364259.1054strigops_habroptilaENSSHBP0000500941376.391262.3946
ENSG00000101347homo_sapiensENSP0000049353673.642260.2236amphiprion_ocellarisENSAOCP0000001497973.642260.2236
ENSG00000101347homo_sapiensENSP0000049353677.795566.9329terrapene_carolina_triunguisENSTMTP0000002554877.547866.7197
ENSG00000101347homo_sapiensENSP0000049353648.881835.9425hucho_huchoENSHHUP0000007870964.421147.3684
ENSG00000101347homo_sapiensENSP0000049353670.127857.0288hucho_huchoENSHHUP0000000393275.171261.1301
ENSG00000101347homo_sapiensENSP0000049353672.364257.0288betta_splendensENSBSLP0000001920872.248856.9378
ENSG00000101347homo_sapiensENSP0000049353670.766857.6677pygocentrus_nattereriENSPNAP0000000469074.579160.7744
ENSG00000101347homo_sapiensENSP0000049353663.578350.9585pygocentrus_nattereriENSPNAP0000000471270.944756.8627
ENSG00000101347homo_sapiensENSP0000049353675.399459.4249anabas_testudineusENSATEP0000003918175.039759.1415
ENSG00000101347homo_sapiensENSP0000049353616.29399.42492ciona_savignyiENSCSAVP0000001064660.35534.9112
ENSG00000101347homo_sapiensENSP0000049353673.642259.1054seriola_lalandi_dorsalisENSSLDP0000003312173.642259.1054
ENSG00000101347homo_sapiensENSP0000049353669.648657.3482labrus_bergyltaENSLBEP0000000662172.425259.6346
ENSG00000101347homo_sapiensENSP0000049353672.204557.9872pundamilia_nyerereiENSPNYP0000000146572.668858.3601
ENSG00000101347homo_sapiensENSP0000049353669.329154.4728mastacembelus_armatusENSMAMP0000005298868.23953.6164
ENSG00000101347homo_sapiensENSP0000049353673.003258.4665stegastes_partitusENSSPAP0000000147973.1258.56
ENSG00000101347homo_sapiensENSP0000049353671.24655.1118oncorhynchus_tshawytschaENSOTSP0000500629959.785546.2467
ENSG00000101347homo_sapiensENSP0000049353671.086357.8275oncorhynchus_tshawytschaENSOTSP0000504761073.920360.1329
ENSG00000101347homo_sapiensENSP0000049353670.127857.8275acanthochromis_polyacanthusENSAPOP0000001354072.682159.9338
ENSG00000101347homo_sapiensENSP0000049353675.718861.5016aquila_chrysaetos_chrysaetosENSACCP0002000510976.823362.3987
ENSG00000101347homo_sapiensENSP0000049353669.96857.0288nothobranchius_furzeriENSNFUP0001502110670.41857.3955
ENSG00000101347homo_sapiensENSP0000049353639.936131.6294cyprinodon_variegatusENSCVAP0000002517463.613250.3817
ENSG00000101347homo_sapiensENSP0000049353642.012831.4696cyprinodon_variegatusENSCVAP0000002840462.028346.4623
ENSG00000101347homo_sapiensENSP0000049353616.134212.7796cyprinodon_variegatusENSCVAP0000000715370.138955.5556
ENSG00000101347homo_sapiensENSP0000049353616.453713.2588cyprinodon_variegatusENSCVAP0000000718963.975251.5528
ENSG00000101347homo_sapiensENSP0000049353668.530354.9521denticeps_clupeoidesENSDCDP0000002552367.136153.8341
ENSG00000101347homo_sapiensENSP0000049353669.169356.3898denticeps_clupeoidesENSDCDP0000002735271.100257.9639
ENSG00000101347homo_sapiensENSP0000049353673.801958.3067larimichthys_croceaENSLCRP0000503526972.413857.21
ENSG00000101347homo_sapiensENSP0000049353668.370654.3131takifugu_rubripesENSTRUP0000000569969.143854.9273
ENSG00000101347homo_sapiensENSP0000049353666.613453.6741ficedula_albicollisENSFALP0000001316775.818261.0909
ENSG00000101347homo_sapiensENSP0000049353670.447355.1118hippocampus_comesENSHCOP0000001678571.12955.6452
ENSG00000101347homo_sapiensENSP0000049353672.683760.5431cyprinus_carpio_carpioENSCCRP0000015964469.785358.1288
ENSG00000101347homo_sapiensENSP0000049353671.88559.4249cyprinus_carpio_carpioENSCCRP0000014318972.697960.0969
ENSG00000101347homo_sapiensENSP0000049353674.920161.1821coturnix_japonicaENSCJPP0000502576876.50962.4796
ENSG00000101347homo_sapiensENSP0000049353672.683758.7859poecilia_latipinnaENSPLAP0000000782872.567858.6922
ENSG00000101347homo_sapiensENSP0000049353673.003260.5431sinocyclocheilus_grahamiENSSGRP0000002303072.886860.4466
ENSG00000101347homo_sapiensENSP0000049353672.044757.6677maylandia_zebraENSMZEP0000503560572.50858.0386
ENSG00000101347homo_sapiensENSP0000049353653.993644.4089tetraodon_nigroviridisENSTNIP0000000888474.449361.2335
ENSG00000101347homo_sapiensENSP0000049353673.961761.9808paramormyrops_kingsleyaeENSPKIP0000001297074.437362.3794
ENSG00000101347homo_sapiensENSP0000049353658.785946.9649paramormyrops_kingsleyaeENSPKIP0000002266166.18752.8777
ENSG00000101347homo_sapiensENSP0000049353664.217349.2013scleropages_formosusENSSFOP0001504810968.835652.7397
ENSG00000101347homo_sapiensENSP0000049353673.961761.0224scleropages_formosusENSSFOP0001503371973.961761.0224
ENSG00000101347homo_sapiensENSP0000049353668.210954.3131scleropages_formosusENSSFOP0001504210268.982254.9273
ENSG00000101347homo_sapiensENSP0000049353622.843519.9681leptobrachium_leishanenseENSLLEP0000003742275.661466.1376
ENSG00000101347homo_sapiensENSP0000049353674.281261.3419leptobrachium_leishanenseENSLLEP0000003602874.638861.6372
ENSG00000101347homo_sapiensENSP0000049353659.105448.5623scophthalmus_maximusENSSMAP000000563207460.8
ENSG00000101347homo_sapiensENSP0000049353668.530356.7093scophthalmus_maximusENSSMAP0000006791471.979959.5638
ENSG00000101347homo_sapiensENSP0000049353672.52459.4249oryzias_melastigmaENSOMEP0000002937672.52459.4249

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000724involved_in double-strand break repair via homologous recombination1IDAHomo_sapiens(9606)Process
GO:0003676enables nucleic acid binding1IDAHomo_sapiens(9606)Function
GO:0003697enables single-stranded DNA binding1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1IDAHomo_sapiens(9606)Function
GO:0004540NOT enables RNA nuclease activity2IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005525enables GTP binding1IEAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0006203involved_in dGTP catabolic process2IBA,IDAHomo_sapiens(9606)Process
GO:0006955involved_in immune response1NASHomo_sapiens(9606)Process
GO:0006974involved_in DNA damage response1IDAHomo_sapiens(9606)Process
GO:0008270enables zinc ion binding1IDAHomo_sapiens(9606)Function
GO:0008832enables dGTPase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0009264involved_in deoxyribonucleotide catabolic process1IDAHomo_sapiens(9606)Process
GO:0016446involved_in somatic hypermutation of immunoglobulin genes1ISSHomo_sapiens(9606)Process
GO:0016793enables triphosphoric monoester hydrolase activity1IDAHomo_sapiens(9606)Function
GO:0032567enables dGTP binding1IDAHomo_sapiens(9606)Function
GO:0035861located_in site of double-strand break1IDAHomo_sapiens(9606)Component
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0045087involved_in innate immune response1IEAHomo_sapiens(9606)Process
GO:0045088involved_in regulation of innate immune response3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0046061involved_in dATP catabolic process1IDAHomo_sapiens(9606)Process
GO:0051289involved_in protein homotetramerization1IDAHomo_sapiens(9606)Process
GO:0051607involved_in defense response to virus3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0060339involved_in negative regulation of type I interferon-mediated signaling pathway1IDAHomo_sapiens(9606)Process
GO:0097197located_in tetraspanin-enriched microdomain1IDAHomo_sapiens(9606)Component
GO:0106375enables deoxynucleoside triphosphate hydrolase activity1IEAHomo_sapiens(9606)Function
GO:0110025involved_in DNA strand resection involved in replication fork processing1IDAHomo_sapiens(9606)Process

Expression