Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerSARS-COV-2Dengue
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzymeTransmemebrane
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000100714 Gene ID 4522 Accession 7432
Symbol MTHFD1 Alias CIMAH;MTHFC;MTHFD Full Name methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
Status Confidence Length 75427 bases Strand Plus strand
Position 14 : 64388031 - 64463457 RNA binding domain N.A.
Summary This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
30275950 Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation. Costas Koufaris 2018-01-01 Cancer & metabolism

Transcripts

Name Transcript ID bp Protein Translation ID
MTHFD1-201 ENST00000545908 6814 964aa ENSP00000438588
MTHFD1-211 ENST00000555858 2516 No protein -
MTHFD1-223 ENST00000697166 6522 No protein -
MTHFD1-224 ENST00000697167 2901 392aa ENSP00000513155
MTHFD1-225 ENST00000697168 3038 884aa ENSP00000513156
MTHFD1-226 ENST00000697169 3121 628aa ENSP00000513157
MTHFD1-227 ENST00000697170 4248 No protein -
MTHFD1-228 ENST00000697171 3244 906aa ENSP00000513158
MTHFD1-207 ENST00000554739 688 23aa ENSP00000477359
MTHFD1-208 ENST00000554768 3295 854aa ENSP00000477501
MTHFD1-210 ENST00000555709 2063 161aa ENSP00000450560
MTHFD1-209 ENST00000555252 2053 No protein -
MTHFD1-219 ENST00000652179 3911 854aa ENSP00000498649
MTHFD1-229 ENST00000697172 732 No protein -
MTHFD1-216 ENST00000650853 4528 No protein -
MTHFD1-220 ENST00000652337 3154 935aa ENSP00000498336
MTHFD1-214 ENST00000557370 3082 922aa ENSP00000477199
MTHFD1-230 ENST00000697173 3958 854aa ENSP00000513159
MTHFD1-217 ENST00000651537 3289 935aa ENSP00000498511
MTHFD1-231 ENST00000697174 2897 852aa ENSP00000513160
MTHFD1-232 ENST00000697175 3389 356aa ENSP00000513161
MTHFD1-215 ENST00000557539 3732 854aa ENSP00000476468
MTHFD1-233 ENST00000697176 2908 762aa ENSP00000513162
MTHFD1-221 ENST00000652503 1315 No protein -
MTHFD1-204 ENST00000554057 560 No protein -
MTHFD1-202 ENST00000553391 568 No protein -
MTHFD1-222 ENST00000652509 2183 644aa ENSP00000499176
MTHFD1-206 ENST00000554677 783 No protein -
MTHFD1-234 ENST00000697177 1539 No protein -
MTHFD1-213 ENST00000556771 1780 No protein -
MTHFD1-203 ENST00000553405 833 No protein -
MTHFD1-218 ENST00000651891 1047 No protein -
MTHFD1-212 ENST00000556284 932 No protein -
MTHFD1-205 ENST00000554353 556 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
30475Eosinophils6.4970000E-005-
40221Platelet Function Tests2.3500000E-006-
68782Neuropsychological Tests8E-719734545

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000100714homo_sapiensENSP0000035629072.699458.4867homo_sapiensENSP0000049833676.042861.1765
ENSG00000100714homo_sapiensENSP0000037761754.285735.7143homo_sapiensENSP0000049833620.320913.369
ENSG00000100714homo_sapiensENSP0000032198449.855934.2939homo_sapiensENSP0000049833618.502712.7273

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000100714homo_sapiensENSP0000049833693.155190.3743nomascus_leucogenysENSNLEP0000004491187.979885.3535
ENSG00000100714homo_sapiensENSP0000049833699.572299.3583pan_paniscusENSPPAP0000000198899.572299.3583
ENSG00000100714homo_sapiensENSP0000049833697.967996.6845pongo_abeliiENSPPYP0000000670595.020793.7759
ENSG00000100714homo_sapiensENSP0000049833698.181897.5401pan_troglodytesENSPTRP000000109169089.4118
ENSG00000100714homo_sapiensENSP0000049833694.224692.8342gorilla_gorillaENSGGOP0000001850788.72187.4119
ENSG00000100714homo_sapiensENSP0000049833692.406484.8128ornithorhynchus_anatinusENSOANP0000004614076.595770.3014
ENSG00000100714homo_sapiensENSP0000049833693.796887.3797sarcophilus_harrisiiENSSHAP0000001068893.796887.3797
ENSG00000100714homo_sapiensENSP0000049833661.176556.2567notamacropus_eugeniiENSMEUP0000001500262.857157.8022
ENSG00000100714homo_sapiensENSP0000049833658.609655.9358choloepus_hoffmanniENSCHOP0000000111162.77259.9084
ENSG00000100714homo_sapiensENSP0000049833674.759472.1925dasypus_novemcinctusENSDNOP0000001061094.459591.2162
ENSG00000100714homo_sapiensENSP0000049833678.395775.508erinaceus_europaeusENSEEUP0000000207778.395775.508
ENSG00000100714homo_sapiensENSP0000049833681.604378.1818echinops_telfairiENSETEP0000000504981.779278.3494
ENSG00000100714homo_sapiensENSP0000049833697.967995.4011callithrix_jacchusENSCJAP0000008125293.852591.3934
ENSG00000100714homo_sapiensENSP0000049833692.834290.3743cercocebus_atysENSCATP0000000416888.752686.4008
ENSG00000100714homo_sapiensENSP0000049833698.609697.0053macaca_fascicularisENSMFAP0000003179498.715297.1092
ENSG00000100714homo_sapiensENSP0000049833698.609697.1123macaca_mulattaENSMMUP0000004663680.877279.6491
ENSG00000100714homo_sapiensENSP0000049833692.513489.8396macaca_nemestrinaENSMNEP0000002102788.900386.3309
ENSG00000100714homo_sapiensENSP0000049833672.192569.6257papio_anubisENSPANP0000003680486.872683.7838
ENSG00000100714homo_sapiensENSP0000049833693.796891.6578papio_anubisENSPANP0000005603092.608290.4963
ENSG00000100714homo_sapiensENSP0000049833651.871749.3048papio_anubisENSPANP0000005009886.917682.6165
ENSG00000100714homo_sapiensENSP0000049833681.283478.3957mandrillus_leucophaeusENSMLEP0000000883786.75883.6758
ENSG00000100714homo_sapiensENSP0000049833688.98486.2032tursiops_truncatusENSTTRP0000000049288.888986.1111
ENSG00000100714homo_sapiensENSP0000049833651.764750.3743vulpes_vulpesENSVVUP0000003925997.580694.9597
ENSG00000100714homo_sapiensENSP0000049833678.716674.7594vulpes_vulpesENSVVUP0000001938292.929388.2576
ENSG00000100714homo_sapiensENSP0000049833697.540192.7273mus_spretusMGP_SPRETEiJ_P003409597.540192.7273
ENSG00000100714homo_sapiensENSP0000049833695.294190.9091equus_asinusENSEASP0000501229392.427488.1743
ENSG00000100714homo_sapiensENSP0000049833696.256791.8717capra_hircusENSCHIP0000000130796.256791.8717
ENSG00000100714homo_sapiensENSP0000049833692.406488.7701loxodonta_africanaENSLAFP0000001813192.406488.7701
ENSG00000100714homo_sapiensENSP0000049833697.219393.5829panthera_leoENSPLOP0000001514597.219393.5829
ENSG00000100714homo_sapiensENSP0000049833695.401190.9091ailuropoda_melanoleucaENSAMEP0000000414093.110688.7265
ENSG00000100714homo_sapiensENSP0000049833696.256791.9786bos_indicus_hybridENSBIXP0000502880596.256791.9786
ENSG00000100714homo_sapiensENSP0000049833697.326292.2995oryctolagus_cuniculusENSOCUP0000001008197.326292.2995
ENSG00000100714homo_sapiensENSP0000049833694.973391.016equus_caballusENSECAP0000007883794.367790.4357
ENSG00000100714homo_sapiensENSP0000049833610.05358.98396canis_lupus_familiarisENSCAFP0084500926785.454576.3636
ENSG00000100714homo_sapiensENSP0000049833697.219393.9037canis_lupus_familiarisENSCAFP0084500279597.219393.9037
ENSG00000100714homo_sapiensENSP0000049833695.61591.4438panthera_pardusENSPPRP0000002242690.30386.3636
ENSG00000100714homo_sapiensENSP0000049833697.219394.5455marmota_marmota_marmotaENSMMMP0000002388997.219394.5455
ENSG00000100714homo_sapiensENSP0000049833696.684593.4759balaenoptera_musculusENSBMSP0001000039296.684593.4759
ENSG00000100714homo_sapiensENSP0000049833694.973391.016cavia_porcellusENSCPOP0000001180295.689791.7026
ENSG00000100714homo_sapiensENSP0000049833697.005393.5829felis_catusENSFCAP0000000723997.005393.5829
ENSG00000100714homo_sapiensENSP0000049833695.294190.6952ursus_americanusENSUAMP0000002784089.818685.4839
ENSG00000100714homo_sapiensENSP0000049833694.010787.8075monodelphis_domesticaENSMODP0000003232594.010787.8075
ENSG00000100714homo_sapiensENSP0000049833696.363691.7647bison_bison_bisonENSBBBP0000001501396.363691.7647
ENSG00000100714homo_sapiensENSP0000049833696.363693.369monodon_monocerosENSMMNP0001501629596.363693.369
ENSG00000100714homo_sapiensENSP0000049833696.791491.8717sus_scrofaENSSSCP0000000246496.791491.8717
ENSG00000100714homo_sapiensENSP0000049833683.422579.0374microcebus_murinusENSMICP0000001737884.233379.8056
ENSG00000100714homo_sapiensENSP0000049833693.36988.7701microcebus_murinusENSMICP0000001885992.773688.204
ENSG00000100714homo_sapiensENSP0000049833688.770183.9572microcebus_murinusENSMICP0000003731886.368481.6857
ENSG00000100714homo_sapiensENSP0000049833693.155188.2353microcebus_murinusENSMICP0000002403988.696584.0122
ENSG00000100714homo_sapiensENSP0000049833677.005371.5508microcebus_murinusENSMICP0000002866486.538580.4087
ENSG00000100714homo_sapiensENSP0000049833679.037473.6898microcebus_murinusENSMICP0000004751885.040379.2865
ENSG00000100714homo_sapiensENSP0000049833696.256791.4438octodon_degusENSODEP0000001959196.256791.4438
ENSG00000100714homo_sapiensENSP0000049833697.112392.0856jaculus_jaculusENSJJAP0000001804997.112392.0856
ENSG00000100714homo_sapiensENSP0000049833694.224689.3048ovis_aries_rambouilletENSOARP0002001876293.723488.8298
ENSG00000100714homo_sapiensENSP0000049833696.577592.6203ursus_maritimusENSUMAP0000001835596.577592.6203
ENSG00000100714homo_sapiensENSP0000049833695.935890.4813ochotona_princepsENSOPRP0000000484396.141590.6752
ENSG00000100714homo_sapiensENSP0000049833696.363693.262delphinapterus_leucasENSDLEP0000001743396.363693.262
ENSG00000100714homo_sapiensENSP0000049833696.577593.262physeter_catodonENSPCTP0000501676996.577593.262
ENSG00000100714homo_sapiensENSP0000049833697.433292.9412mus_caroliMGP_CAROLIEiJ_P003258197.433292.9412
ENSG00000100714homo_sapiensENSP0000049833697.433292.7273mus_musculusENSMUSP0000002144397.433292.7273
ENSG00000100714homo_sapiensENSP0000049833696.470692.8342dipodomys_ordiiENSDORP0000001429296.16292.5373
ENSG00000100714homo_sapiensENSP0000049833697.005393.1551mustela_putorius_furoENSMPUP0000000665397.005393.1551
ENSG00000100714homo_sapiensENSP0000049833697.433294.4385aotus_nancymaaeENSANAP0000001848189.842287.0809
ENSG00000100714homo_sapiensENSP0000049833695.828993.262saimiri_boliviensis_boliviensisENSSBOP0000003045091.056988.6179
ENSG00000100714homo_sapiensENSP0000049833658.074955.1872vicugna_pacosENSVPAP0000000451671.635968.0739
ENSG00000100714homo_sapiensENSP0000049833698.395796.7914chlorocebus_sabaeusENSCSAP0000000996188.291786.8522
ENSG00000100714homo_sapiensENSP0000049833683.850380tupaia_belangeriENSTBEP0000001169283.850380
ENSG00000100714homo_sapiensENSP0000049833692.513486.4171mesocricetus_auratusENSMAUP0000000917994.329388.1134
ENSG00000100714homo_sapiensENSP0000049833696.470693.1551phocoena_sinusENSPSNP0000001941896.470693.1551
ENSG00000100714homo_sapiensENSP0000049833696.577591.9786camelus_dromedariusENSCDRP0000500162096.577591.9786
ENSG00000100714homo_sapiensENSP0000049833695.401191.6578carlito_syrichtaENSTSYP0000001244096.536892.7489
ENSG00000100714homo_sapiensENSP0000049833683.850378.1818carlito_syrichtaENSTSYP0000002234983.315677.6833
ENSG00000100714homo_sapiensENSP0000049833695.294191.7647panthera_tigris_altaicaENSPTIP0000000163296.953293.3624
ENSG00000100714homo_sapiensENSP0000049833696.149792.1925rattus_norvegicusENSRNOP0000007779195.536791.6047
ENSG00000100714homo_sapiensENSP0000049833695.50891.4438prolemur_simusENSPSMP0000003176994.397590.3805
ENSG00000100714homo_sapiensENSP0000049833697.75493.0481microtus_ochrogasterENSMOCP0000002231297.75493.0481
ENSG00000100714homo_sapiensENSP0000049833674.438571.2299sorex_araneusENSSARP0000001075974.678171.4592
ENSG00000100714homo_sapiensENSP0000049833697.219392.6203peromyscus_maniculatus_bairdiiENSPEMP0000000260197.219392.6203
ENSG00000100714homo_sapiensENSP0000049833696.470692.1925bos_mutusENSBMUP0000001764296.470692.1925
ENSG00000100714homo_sapiensENSP0000049833697.433292.7273mus_spicilegusENSMSIP0000001233197.433292.7273
ENSG00000100714homo_sapiensENSP0000049833695.828990.4813cricetulus_griseus_chok1gshdENSCGRP0000101177595.726590.3846
ENSG00000100714homo_sapiensENSP0000049833692.727389.0909pteropus_vampyrusENSPVAP0000001658292.430788.806
ENSG00000100714homo_sapiensENSP0000049833694.331690.3743myotis_lucifugusENSMLUP0000001507995.973991.9478
ENSG00000100714homo_sapiensENSP0000049833651.871747.5936vombatus_ursinusENSVURP0001002575589.483482.1033
ENSG00000100714homo_sapiensENSP0000049833680.106972.4064vombatus_ursinusENSVURP0001003092983.968675.8969
ENSG00000100714homo_sapiensENSP0000049833693.903789.8396rhinolophus_ferrumequinumENSRFEP0001000262393.205989.172
ENSG00000100714homo_sapiensENSP0000049833697.005393.262neovison_visonENSNVIP0000001011097.005393.262
ENSG00000100714homo_sapiensENSP0000049833696.256791.9786bos_taurusENSBTAP0000001270496.256791.9786
ENSG00000100714homo_sapiensENSP0000049833696.256792.2995heterocephalus_glaber_femaleENSHGLP0000003899789.197285.5302
ENSG00000100714homo_sapiensENSP0000049833695.080292.7273rhinopithecus_bietiENSRBIP0000001383490.162387.931
ENSG00000100714homo_sapiensENSP0000049833610.05358.98396canis_lupus_dingoENSCAFP0002002913985.454576.3636
ENSG00000100714homo_sapiensENSP0000049833691.336987.1658canis_lupus_dingoENSCAFP0002000885893.231488.9738
ENSG00000100714homo_sapiensENSP0000049833697.112394.1176sciurus_vulgarisENSSVLP0000500075397.112394.1176
ENSG00000100714homo_sapiensENSP0000049833694.545587.8075phascolarctos_cinereusENSPCIP0000003931794.545587.8075
ENSG00000100714homo_sapiensENSP0000049833683.422579.7861procavia_capensisENSPCAP0000000780883.333379.7009
ENSG00000100714homo_sapiensENSP0000049833688.449283.3155nannospalax_galiliENSNGAP0000001931090.481485.2298
ENSG00000100714homo_sapiensENSP0000049833696.470692.1925bos_grunniensENSBGRP0000002084296.470692.1925
ENSG00000100714homo_sapiensENSP0000049833695.935891.5508chinchilla_lanigeraENSCLAP0000000562995.935891.5508
ENSG00000100714homo_sapiensENSP0000049833696.577592.4064cervus_hanglu_yarkandensisENSCHYP0000001818396.577592.4064
ENSG00000100714homo_sapiensENSP0000049833696.791492.1925catagonus_wagneriENSCWAP0000002941991.78587.4239
ENSG00000100714homo_sapiensENSP0000049833696.791494.1176ictidomys_tridecemlineatusENSSTOP0000001390196.791494.1176
ENSG00000100714homo_sapiensENSP0000049833695.50891.016otolemur_garnettiiENSOGAP0000000469995.815591.309
ENSG00000100714homo_sapiensENSP0000049833699.037497.2193cebus_imitatorENSCCAP0000000947999.037497.2193
ENSG00000100714homo_sapiensENSP0000049833697.112394.1176urocitellus_parryiiENSUPAP0001001411297.112394.1176
ENSG00000100714homo_sapiensENSP0000049833696.363692.0856moschus_moschiferusENSMMSP0000001729696.363692.0856
ENSG00000100714homo_sapiensENSP0000049833694.759492.1925rhinopithecus_roxellanaENSRROP0000004439690.040687.6016
ENSG00000100714homo_sapiensENSP0000049833697.647193.1551mus_pahariMGP_PahariEiJ_P008269497.647193.1551
ENSG00000100714homo_sapiensENSP0000049833687.379783.5294propithecus_coquereliENSPCOP0000000084487.286383.4402
ENSG00000100714homo_sapiensENSP0000049833636.577531.123eptatretus_burgeriENSEBUP0000000019581.622969.4511
ENSG00000100714homo_sapiensENSP0000049833688.128378.3957callorhinchus_miliiENSCMIP0000001343286.736877.1579
ENSG00000100714homo_sapiensENSP0000049833681.604369.9465latimeria_chalumnaeENSLACP0000001876982.04370.3226
ENSG00000100714homo_sapiensENSP0000049833689.197979.4652lepisosteus_oculatusENSLOCP0000001588289.197979.4652
ENSG00000100714homo_sapiensENSP0000049833687.700577.0053clupea_harengusENSCHAP0000005854687.048876.4331
ENSG00000100714homo_sapiensENSP0000049833673.26257.861clupea_harengusENSCHAP0000000694775.523759.6472
ENSG00000100714homo_sapiensENSP0000049833687.593676.1497danio_rerioENSDARP0000002077087.687476.2313
ENSG00000100714homo_sapiensENSP0000049833673.26255.8289danio_rerioENSDARP0000015079274.537556.8009
ENSG00000100714homo_sapiensENSP0000049833672.727357.9679carassius_auratusENSCARP0000011174271.428656.9328
ENSG00000100714homo_sapiensENSP0000049833674.010759.0374carassius_auratusENSCARP0000010164475.545960.262
ENSG00000100714homo_sapiensENSP0000049833682.24671.5508carassius_auratusENSCARP0000005168276.441466.501
ENSG00000100714homo_sapiensENSP0000049833688.663178.0749astyanax_mexicanusENSAMXP0000001293788.75878.1585
ENSG00000100714homo_sapiensENSP0000049833670.695254.8663astyanax_mexicanusENSAMXP0000000745672.319556.1269
ENSG00000100714homo_sapiensENSP0000049833668.021451.123ictalurus_punctatusENSIPUP0000002769570.198752.7594
ENSG00000100714homo_sapiensENSP0000049833687.914477.9679ictalurus_punctatusENSIPUP0000002979088.008678.0514
ENSG00000100714homo_sapiensENSP0000049833666.524152.5134esox_luciusENSELUP0000001690573.090557.6968
ENSG00000100714homo_sapiensENSP0000049833688.770177.1123esox_luciusENSELUP0000002770687.002175.5765
ENSG00000100714homo_sapiensENSP0000049833687.272777.0053electrophorus_electricusENSEEEP0000000723884.823374.8441
ENSG00000100714homo_sapiensENSP0000049833668.663153.262electrophorus_electricusENSEEEP0000002534771.651855.5804
ENSG00000100714homo_sapiensENSP0000049833665.454556.1497oncorhynchus_kisutchENSOKIP0000503286376.691765.7895
ENSG00000100714homo_sapiensENSP0000049833676.149762.246oncorhynchus_kisutchENSOKIP0000504160074.47760.8787
ENSG00000100714homo_sapiensENSP0000049833688.342277.6471oncorhynchus_kisutchENSOKIP0000504754988.436877.7302
ENSG00000100714homo_sapiensENSP0000049833660.855650.1604oncorhynchus_mykissENSOMYP0000005672875.06661.8734
ENSG00000100714homo_sapiensENSP0000049833688.128377.5401oncorhynchus_mykissENSOMYP0000006493186.828276.3962
ENSG00000100714homo_sapiensENSP0000049833675.61561.7112oncorhynchus_mykissENSOMYP0000003873976.515262.4459
ENSG00000100714homo_sapiensENSP0000049833688.128377.5401salmo_salarENSSSAP0000001431287.473576.9639
ENSG00000100714homo_sapiensENSP0000049833676.042862.4599salmo_salarENSSSAP0000001642673.678860.5181
ENSG00000100714homo_sapiensENSP0000049833675.294164.5989salmo_salarENSSSAP0000000555080.457169.0286
ENSG00000100714homo_sapiensENSP0000049833688.128377.5401salmo_truttaENSSTUP0000004621787.473576.9639
ENSG00000100714homo_sapiensENSP0000049833674.652460.8556salmo_truttaENSSTUP0000009788672.406659.0249
ENSG00000100714homo_sapiensENSP0000049833689.090977.6471gadus_morhuaENSGMOP0000002460589.186377.7302
ENSG00000100714homo_sapiensENSP0000049833688.235377.3262fundulus_heteroclitusENSFHEP0000001567388.329877.409
ENSG00000100714homo_sapiensENSP0000049833616.149712.9412fundulus_heteroclitusENSFHEP0000000969972.248857.8947
ENSG00000100714homo_sapiensENSP0000049833687.700577.5401poecilia_reticulataENSPREP0000003228487.794477.6231
ENSG00000100714homo_sapiensENSP0000049833688.235377.6471xiphophorus_maculatusENSXMAP0000002738988.329877.7302
ENSG00000100714homo_sapiensENSP0000049833616.577512.2995xiphophorus_maculatusENSXMAP0000000967172.7753.9906
ENSG00000100714homo_sapiensENSP0000049833617.219313.262oryzias_latipesENSORLP0000004033458.974445.4212
ENSG00000100714homo_sapiensENSP0000049833611.65788.34225oryzias_latipesENSORLP0000001968677.30555.3191
ENSG00000100714homo_sapiensENSP0000049833684.278174.1176oryzias_latipesENSORLP0000002141689.443878.6606
ENSG00000100714homo_sapiensENSP0000049833687.914477.6471cyclopterus_lumpusENSCLMP0000503079488.102977.8135
ENSG00000100714homo_sapiensENSP0000049833614.224610.0535cyclopterus_lumpusENSCLMP0000501329367.171747.4747
ENSG00000100714homo_sapiensENSP0000049833685.561574.6524oreochromis_niloticusENSONIP0000007175782.389371.8847
ENSG00000100714homo_sapiensENSP0000049833687.593676.5775haplochromis_burtoniENSHBUP0000003049887.687476.6595
ENSG00000100714homo_sapiensENSP000004983368.128346.09626astatotilapia_callipteraENSACLP0000002347062.295146.7213
ENSG00000100714homo_sapiensENSP0000049833687.593676.4706astatotilapia_callipteraENSACLP0000000535487.687476.5525
ENSG00000100714homo_sapiensENSP0000049833688.128377.4332sparus_aurataENSSAUP0001004924288.034277.3504
ENSG00000100714homo_sapiensENSP000004983368.770056.84492sparus_aurataENSSAUP0001000639463.076949.2308
ENSG00000100714homo_sapiensENSP0000049833687.807577.3262lates_calcariferENSLCAP0001002404288.469877.9095
ENSG00000100714homo_sapiensENSP0000049833691.657881.8182xenopus_tropicalisENSXETP0000008848891.755981.9058
ENSG00000100714homo_sapiensENSP0000049833689.197979.5722chrysemys_picta_belliiENSCPBP0000003181591.749281.8482
ENSG00000100714homo_sapiensENSP0000049833688.98479.7861sphenodon_punctatusENSSPUP0000000513788.98479.7861
ENSG00000100714homo_sapiensENSP0000049833685.561575.8289crocodylus_porosusENSCPRP0000502382485.470175.7479
ENSG00000100714homo_sapiensENSP0000049833669.839661.3904laticauda_laticaudataENSLLTP0000001922188.482477.7778
ENSG00000100714homo_sapiensENSP0000049833671.550859.893notechis_scutatusENSNSUP0000002633279.642966.6667
ENSG00000100714homo_sapiensENSP0000049833690.695279.3583pseudonaja_textilisENSPTXP0000002162590.695279.3583
ENSG00000100714homo_sapiensENSP0000049833691.12380.6417anas_platyrhynchos_platyrhynchosENSAPLP0000002102291.12380.6417
ENSG00000100714homo_sapiensENSP0000049833690.053579.8931gallus_gallusENSGALP0001002501189.861379.7225
ENSG00000100714homo_sapiensENSP0000049833691.12380.7487meleagris_gallopavoENSMGAP000000196718070.892
ENSG00000100714homo_sapiensENSP0000049833690.588279.6791serinus_canariaENSSCAP0000000799290.588279.6791
ENSG00000100714homo_sapiensENSP0000049833690.374380.1069parus_majorENSPMJP0000000184090.374380.1069
ENSG00000100714homo_sapiensENSP0000049833689.946579.3583anolis_carolinensisENSACAP0000001552987.240776.971
ENSG00000100714homo_sapiensENSP0000049833684.38573.1551neolamprologus_brichardiENSNBRP0000000068084.115172.9211
ENSG00000100714homo_sapiensENSP0000049833622.24617.6471neolamprologus_brichardiENSNBRP0000000472080.308963.7066
ENSG00000100714homo_sapiensENSP0000049833686.844975.508naja_najaENSNNAP0000001389288.069476.5727
ENSG00000100714homo_sapiensENSP0000049833690.588278.8235podarcis_muralisENSPMRP0000000773577.777867.6768
ENSG00000100714homo_sapiensENSP0000049833678.930569.5187geospiza_fortisENSGFOP0000000084887.648577.1972
ENSG00000100714homo_sapiensENSP0000049833690.053579.7861taeniopygia_guttataENSTGUP0000003737390.053579.7861
ENSG00000100714homo_sapiensENSP0000049833689.518779.2513erpetoichthys_calabaricusENSECRP0000002535189.903379.5918
ENSG00000100714homo_sapiensENSP0000049833688.663177.5401kryptolebias_marmoratusENSKMAP0000002024288.75877.6231
ENSG00000100714homo_sapiensENSP0000049833622.24616.8984kryptolebias_marmoratusENSKMAP000000287806549.375
ENSG00000100714homo_sapiensENSP0000049833690.802179.2513salvator_merianaeENSSMRP0000001740590.802179.2513
ENSG00000100714homo_sapiensENSP0000049833688.556277.1123oryzias_javanicusENSOJAP0000004059988.65177.1949
ENSG00000100714homo_sapiensENSP000004983366.737974.91979oryzias_javanicusENSOJAP0000001452674.117654.1176
ENSG00000100714homo_sapiensENSP0000049833682.994772.7273amphilophus_citrinellusENSACIP0000001945388.990877.9817
ENSG00000100714homo_sapiensENSP0000049833686.844976.1497dicentrarchus_labraxENSDLAP0000501862084.05873.706
ENSG00000100714homo_sapiensENSP0000049833688.87777.4332amphiprion_perculaENSAPEP0000003039488.972277.5161
ENSG00000100714homo_sapiensENSP000004983366.631025.34759amphiprion_perculaENSAPEP0000002534971.264457.4713
ENSG00000100714homo_sapiensENSP0000049833688.449277.2193oryzias_sinensisENSOSIP0000002812088.260477.0544
ENSG00000100714homo_sapiensENSP0000049833689.518779.4652pelodiscus_sinensisENSPSIP0000000354692.079281.7382
ENSG00000100714homo_sapiensENSP0000049833691.01681.3904gopherus_evgoodeiENSGEVP0000500241291.01681.3904
ENSG00000100714homo_sapiensENSP0000049833689.304879.6791chelonoidis_abingdoniiENSCABP0000001535091.859281.9582
ENSG00000100714homo_sapiensENSP000004983368.342256.31016seriola_dumeriliENSSDUP0000002204060.937546.0938
ENSG00000100714homo_sapiensENSP0000049833688.87777.754seriola_dumeriliENSSDUP0000001454388.972277.8373
ENSG00000100714homo_sapiensENSP0000049833685.989375.615cottoperca_gobioENSCGOP0000004950685.259874.9735
ENSG00000100714homo_sapiensENSP0000049833620.10715.8289cottoperca_gobioENSCGOP0000004976384.304966.3677
ENSG00000100714homo_sapiensENSP0000049833690.160479.3583struthio_camelus_australisENSSCUP0000001291889.96879.1889
ENSG00000100714homo_sapiensENSP0000049833690.695280.5348anser_brachyrhynchusENSABRP0000001027288.795878.8482
ENSG00000100714homo_sapiensENSP0000049833625.775419.893gasterosteus_aculeatusENSGACP0000001819774.844757.764
ENSG00000100714homo_sapiensENSP0000049833688.449277.6471gasterosteus_aculeatusENSGACP0000000858988.449277.6471
ENSG00000100714homo_sapiensENSP0000049833688.021478.3957cynoglossus_semilaevisENSCSEP0000000023088.115678.4797
ENSG00000100714homo_sapiensENSP0000049833624.49218.3957poecilia_formosaENSPFOP0000001623571.562553.75
ENSG00000100714homo_sapiensENSP0000049833685.133775.615poecilia_formosaENSPFOP0000000884688.740278.8183
ENSG00000100714homo_sapiensENSP0000049833620.320914.2246myripristis_murdjanENSMMDP0000503984670.63249.4424
ENSG00000100714homo_sapiensENSP0000049833686.524175.615myripristis_murdjanENSMMDP0000504433283.834273.2643
ENSG00000100714homo_sapiensENSP0000049833688.342278.0749sander_luciopercaENSSLUP0000000630287.965977.7423
ENSG00000100714homo_sapiensENSP0000049833690.802180.6417strigops_habroptilaENSSHBP0000501230690.802180.6417
ENSG00000100714homo_sapiensENSP0000049833688.87777.5401amphiprion_ocellarisENSAOCP0000001382188.972277.6231
ENSG00000100714homo_sapiensENSP000004983367.058825.34759amphiprion_ocellarisENSAOCP0000002629466.666750.5051
ENSG00000100714homo_sapiensENSP000004983366.844925.5615amphiprion_ocellarisENSAOCP0000000826068.817255.914
ENSG00000100714homo_sapiensENSP0000049833691.12381.3904terrapene_carolina_triunguisENSTMTP0000002102591.12381.3904
ENSG00000100714homo_sapiensENSP0000049833619.465216.6845hucho_huchoENSHHUP0000006551672.862.4
ENSG00000100714homo_sapiensENSP0000049833688.770177.754betta_splendensENSBSLP0000002948988.865177.8373
ENSG00000100714homo_sapiensENSP0000049833672.299556.0428pygocentrus_nattereriENSPNAP0000000333273.160256.71
ENSG00000100714homo_sapiensENSP0000049833688.449278.2888pygocentrus_nattereriENSPNAP0000001523088.543978.3726
ENSG00000100714homo_sapiensENSP0000049833688.770178.0749anabas_testudineusENSATEP0000003892888.865178.1585
ENSG00000100714homo_sapiensENSP0000049833620.641716.3636anabas_testudineusENSATEP0000004893879.752163.2231
ENSG00000100714homo_sapiensENSP0000049833688.770177.4332seriola_lalandi_dorsalisENSSLDP0000000415488.865177.5161
ENSG00000100714homo_sapiensENSP000004983368.235296.20321seriola_lalandi_dorsalisENSSLDP0000001468875.490256.8627
ENSG00000100714homo_sapiensENSP0000049833688.556277.754labrus_bergyltaENSLBEP0000003400088.65177.8373
ENSG00000100714homo_sapiensENSP0000049833687.486676.3636pundamilia_nyerereiENSPNYP0000000173387.580376.4454
ENSG00000100714homo_sapiensENSP0000049833688.449277.9679mastacembelus_armatusENSMAMP0000003986588.543978.0514
ENSG00000100714homo_sapiensENSP0000049833620.641716.3636mastacembelus_armatusENSMAMP0000005702880.753164.0167
ENSG00000100714homo_sapiensENSP0000049833688.449277.1123stegastes_partitusENSSPAP0000002747988.543977.1949
ENSG00000100714homo_sapiensENSP0000049833688.128377.4332oncorhynchus_tshawytschaENSOTSP0000501532186.828276.2908
ENSG00000100714homo_sapiensENSP0000049833668.128358.6096oncorhynchus_tshawytschaENSOTSP0000500950279.032367.9901
ENSG00000100714homo_sapiensENSP0000049833669.839656.2567oncorhynchus_tshawytschaENSOTSP0000501907774.71460.1831
ENSG00000100714homo_sapiensENSP0000049833619.144415.1872acanthochromis_polyacanthusENSAPOP0000003435674.583359.1667
ENSG00000100714homo_sapiensENSP0000049833636.363632.0856acanthochromis_polyacanthusENSAPOP0000000978392.896281.9672
ENSG00000100714homo_sapiensENSP0000049833688.770177.0053acanthochromis_polyacanthusENSAPOP0000000898584.521473.3198
ENSG00000100714homo_sapiensENSP0000049833690.909180.2139aquila_chrysaetos_chrysaetosENSACCP0002002048790.909180.2139
ENSG00000100714homo_sapiensENSP0000049833685.775475.1872nothobranchius_furzeriENSNFUP0001504885985.4174.8669
ENSG00000100714homo_sapiensENSP0000049833688.663177.6471cyprinodon_variegatusENSCVAP0000001080888.75877.7302
ENSG00000100714homo_sapiensENSP0000049833618.823514.5455cyprinodon_variegatusENSCVAP0000002021970.682754.6185
ENSG00000100714homo_sapiensENSP0000049833665.989351.4439denticeps_clupeoidesENSDCDP0000004128774.516958.0918
ENSG00000100714homo_sapiensENSP0000049833686.096375.7219denticeps_clupeoidesENSDCDP0000003146483.333373.2919
ENSG00000100714homo_sapiensENSP000004983366.951875.24064larimichthys_croceaENSLCRP0000500346373.863655.6818
ENSG00000100714homo_sapiensENSP0000049833685.240674.8663larimichthys_croceaENSLCRP0000505422584.160573.9176
ENSG00000100714homo_sapiensENSP0000049833688.87777.5401takifugu_rubripesENSTRUP0000005729388.972277.6231
ENSG00000100714homo_sapiensENSP0000049833619.358314.4385takifugu_rubripesENSTRUP0000008057665.579748.913
ENSG00000100714homo_sapiensENSP0000049833690.267479.8931ficedula_albicollisENSFALP0000000337090.267479.8931
ENSG00000100714homo_sapiensENSP0000049833688.663177.861hippocampus_comesENSHCOP0000001151588.75877.9443
ENSG00000100714homo_sapiensENSP000004983369.732626.84492hippocampus_comesENSHCOP0000000543669.465748.855
ENSG00000100714homo_sapiensENSP0000049833618.930513.262cyprinus_carpio_carpioENSCCRP0000017231372.54150.8197
ENSG00000100714homo_sapiensENSP0000049833687.272775.9358cyprinus_carpio_carpioENSCCRP0000002213987.366276.0171
ENSG00000100714homo_sapiensENSP0000049833673.048157.861cyprinus_carpio_carpioENSCCRP0000014037576.057960.245
ENSG00000100714homo_sapiensENSP0000049833687.593676.8984coturnix_japonicaENSCJPP0000500470388.925178.0673
ENSG00000100714homo_sapiensENSP0000049833623.422517.3262poecilia_latipinnaENSPLAP0000002906266.768349.3902
ENSG00000100714homo_sapiensENSP0000049833687.914477.4332poecilia_latipinnaENSPLAP0000000855888.008677.5161
ENSG00000100714homo_sapiensENSP0000049833687.165875.8289sinocyclocheilus_grahamiENSSGRP0000006144785.699374.5531
ENSG00000100714homo_sapiensENSP0000049833650.802138.7166sinocyclocheilus_grahamiENSSGRP0000007145773.529456.0372
ENSG00000100714homo_sapiensENSP0000049833673.048157.9679sinocyclocheilus_grahamiENSSGRP0000009993576.741660.8989
ENSG00000100714homo_sapiensENSP0000049833687.593676.4706maylandia_zebraENSMZEP0000503624087.687476.5525
ENSG00000100714homo_sapiensENSP0000049833688.128376.6845tetraodon_nigroviridisENSTNIP0000002060888.034276.6026
ENSG00000100714homo_sapiensENSP0000049833624.812819.4652tetraodon_nigroviridisENSTNIP0000000745172.049756.5217
ENSG00000100714homo_sapiensENSP0000049833689.090977.4332paramormyrops_kingsleyaeENSPKIP0000001953289.186377.5161
ENSG00000100714homo_sapiensENSP0000049833622.032115.7219paramormyrops_kingsleyaeENSPKIP0000003852163.190245.092
ENSG00000100714homo_sapiensENSP0000049833686.63175.615scleropages_formosusENSSFOP0001507591284.287273.5692
ENSG00000100714homo_sapiensENSP0000049833690.160480.4278leptobrachium_leishanenseENSLLEP0000001489990.25780.5139
ENSG00000100714homo_sapiensENSP0000049833620.855616.5775leptobrachium_leishanenseENSLLEP0000003751860.747748.2866
ENSG00000100714homo_sapiensENSP0000049833688.663177.9679scophthalmus_maximusENSSMAP0000001153088.75878.0514
ENSG00000100714homo_sapiensENSP0000049833620.10715.508scophthalmus_maximusENSSMAP0000006221083.928664.7321
ENSG00000100714homo_sapiensENSP0000049833620.534815.9358oryzias_melastigmaENSOMEP0000001236682.051363.6752
ENSG00000100714homo_sapiensENSP0000049833688.235377.3262oryzias_melastigmaENSOMEP0000003221388.329877.409

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000105involved_in histidine biosynthetic process1IEAHomo_sapiens(9606)Process
GO:0001780involved_in neutrophil homeostasis1IEAHomo_sapiens(9606)Process
GO:0001843involved_in neural tube closure1ISSHomo_sapiens(9606)Process
GO:0004329enables formate-tetrahydrofolate ligase activity2IDA,ISSHomo_sapiens(9606)Function
GO:0004477enables methenyltetrahydrofolate cyclohydrolase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0004486enables methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity1IDAHomo_sapiens(9606)Function
GO:0004487enables methylenetetrahydrofolate dehydrogenase (NAD+) activity1ISSHomo_sapiens(9606)Function
GO:0004488enables methylenetetrahydrofolate dehydrogenase (NADP+) activity2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005739located_in mitochondrion1TASHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol2IBA,TASHomo_sapiens(9606)Component
GO:0006164acts_upstream_of purine nucleotide biosynthetic process2IMP,ISSHomo_sapiens(9606)Process
GO:0006555involved_in methionine metabolic process1ISSHomo_sapiens(9606)Process
GO:0006730involved_in one-carbon metabolic process1IMPHomo_sapiens(9606)Process
GO:0007507involved_in heart development1ISSHomo_sapiens(9606)Process
GO:0009069involved_in serine family amino acid metabolic process1ISSHomo_sapiens(9606)Process
GO:0009070involved_in serine family amino acid biosynthetic process1IMPHomo_sapiens(9606)Process
GO:0009086involved_in methionine biosynthetic process1IMPHomo_sapiens(9606)Process
GO:0009152involved_in purine ribonucleotide biosynthetic process1IEAHomo_sapiens(9606)Process
GO:0009257involved_in 10-formyltetrahydrofolate biosynthetic process2IDA,ISSHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0019346involved_in transsulfuration1IEAHomo_sapiens(9606)Process
GO:0035999involved_in tetrahydrofolate interconversion4IBA,IDA,IEA,ISSHomo_sapiens(9606)Process
GO:0048702involved_in embryonic neurocranium morphogenesis1ISSHomo_sapiens(9606)Process
GO:0048703involved_in embryonic viscerocranium morphogenesis1ISSHomo_sapiens(9606)Process
GO:0061053involved_in somite development1ISSHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component

Expression