RBP Type	Non-canonical_RBPs
Diseases	CancerSARS-COV-2Dengue
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzymeTransmemebrane
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000100714	Gene ID	4522	Accession	7432
Symbol	MTHFD1	Alias	CIMAH;MTHFC;MTHFD	Full Name	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
Status	Confidence	Length	75427 bases	Strand	Plus strand
Position	14 : 64388031 - 64463457	RNA binding domain	N.A.
Summary	This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008]