Ensembl ID ENSG00000100714 Gene ID 4522 Accession 7432
Gene Symbol MTHFD1 Alias CIMAH;MTHFC;MTHFD Full Name methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
Position 14 : 64388031 - 64463457 Length 75427 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008]

ENSG00000100714 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000100714 MTHFD1 -0.4 5.61e-16 BRCA
ENSG00000100714 MTHFD1 0.68 2.15e-18 COAD
ENSG00000100714 MTHFD1 0.77 2.68e-18 LUSC
ENSG00000100714 MTHFD1 -1.2 1.47e-13 LIHC
ENSG00000100714 MTHFD1 0.73 3.15e-14 UCEC
ENSG00000100714 MTHFD1 -3.4 3.00e-46 CHOL
ENSG00000100714 MTHFD1 0.57 1.73e-13 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000100714 MTHFD1 gastric cancer 17438114
ENSG00000100714 MTHFD1 lung cancer 17533396
ENSG00000100714 MTHFD1 tumour 19501504
ENSG00000100714 MTHFD1 larynx cancer 19649727
ENSG00000100714 MTHFD1 breast cancer 19946345
ENSG00000100714 MTHFD1 tumor 21055808
ENSG00000100714 MTHFD1 cancer 21090237
ENSG00000100714 MTHFD1 breast cancer 21105050
ENSG00000100714 MTHFD1 cervical cancer 21349258
ENSG00000100714 MTHFD1 rectal tumor 21537397
ENSG00000100714 MTHFD1 head and neck cancer 21537707
ENSG00000100714 MTHFD1 head and neck cancer 21630102
ENSG00000100714 MTHFD1 HNSCC 22051736
ENSG00000100714 MTHFD1 ovarian cancer 22183302
ENSG00000100714 MTHFD1 colorectal cancer 22202336
ENSG00000100714 MTHFD1 breast cancer 23296054
ENSG00000100714 MTHFD1 cancer 23894459
ENSG00000100714 MTHFD1 prostate cancer 24197977
ENSG00000100714 MTHFD1 ovarian cancer 24287951
ENSG00000100714 MTHFD1 breast cancer 24399849
ENSG00000100714 MTHFD1 tumors 26466563
ENSG00000100714 MTHFD1 colorectal tumors 27597531
ENSG00000100714 MTHFD1 primary liver cancer 27936032
ENSG00000100714 MTHFD1 cancer 28265077
ENSG00000100714 MTHFD1 tumor 28417167
ENSG00000100714 MTHFD1 cancer 28968444
ENSG00000100714 MTHFD1 cancer 29142318
ENSG00000100714 MTHFD1 esophageal cancer 29171320
ENSG00000100714 MTHFD1 cancers 29321536
ENSG00000100714 MTHFD1 lung tumor 30343310
ENSG00000100714 MTHFD1 tumor 30459299
ENSG00000100714 MTHFD1 tumor 30534944
ENSG00000100714 MTHFD1 cancer 31133746
ENSG00000100714 MTHFD1 cancer 31377316
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000100714 MTHFD1 SARC 0.0072 high
ENSG00000100714 MTHFD1 STAD 0.028 low
ENSG00000100714 MTHFD1 CHOL 0.034 high
ENSG00000100714 MTHFD1 UVM 0.00071 high
ENSG00000100714 MTHFD1 PAAD 0.001 high
ENSG00000100714 MTHFD1 UCEC 0.045 high
ENSG00000100714 MTHFD1 ACC 0.00072 high
ENSG00000100714 MTHFD1 LGG 0.00099 high
ENSG00000100714 MTHFD1 HNSC 0.018 low
ENSG00000100714 MTHFD1 KICH 0.016 high
ENSG00000100714 MTHFD1 PCPG 0.005 high
ENSG00000100714 MTHFD1 THYM 0.014 low
ENSG00000100714 MTHFD1 BRCA 0.0087 low
ENSG00000100714 MTHFD1 ESCA 0.0096 high
ENSG00000100714 MTHFD1 OV 0.037 low
ENSG00000100714 MTHFD1 PRAD 0.013 low
ENSG00000100714 MTHFD1 BLCA 0.024 high
ENSG00000100714 MTHFD1 LAML 0.019 high
ENSG00000100714 MTHFD1 CESC 0.0057 low
ENSG00000100714 MTHFD1 LIHC 0.0099 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000100714 MTHFD1 CHOL Del 1.613733 0.285699 0.599587 0.555556
ENSG00000100714 MTHFD1 LGG Del 12.224917 0.116074 0.546562 0.237817
ENSG00000100714 MTHFD1 GBM Del 2.013592 0.067361 0.590692 0.296360
ENSG00000100714 MTHFD1 LIHC Del 2.606864 0.093635 0.513890 0.340541
ENSG00000100714 MTHFD1 BRCA Del 3.432776 0.084006 0.414036 0.312963
ENSG00000100714 MTHFD1 KIRC Del 0.693182 0.024196 0.427995 0.426136
ENSG00000100714 MTHFD1 OV Del 6.249392 0.261407 0.544769 0.528497