RBP Type
Canonical_RBPs
Diseases
Drug
N.A.
Main interacting RNAs
ncRNA
Moonlighting functions
N.A.
Localizations
N.A.
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000100298 Gene ID
164668 Accession
24100
Symbol
APOBEC3H
Alias
A3H;ARP10;ARP-10
Full Name
apolipoprotein B mRNA editing enzyme catalytic subunit 3H
Status
Confidence
Length
6844 bases
Strand
Plus strand
Position
22 : 39097224 - 39104067
RNA binding domain
APOBEC_N , APOBEC_C
Summary
This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000216123
APOBEC_N
PF08210 9.4e-39
1
ENSP00000216123
APOBEC_C
PF05240 2.2e-24
2
ENSP00000411754
APOBEC_N
PF08210 9.6e-39
1
ENSP00000411754
APOBEC_C
PF05240 2.2e-24
2
ENSP00000385741
APOBEC_N
PF08210 1.3e-38
1
ENSP00000385741
APOBEC_C
PF05240 2.7e-24
2
ENSP00000483689
APOBEC_N
PF08210 1.3e-38
1
ENSP00000483689
APOBEC_C
PF05240 2.7e-24
2
ENSP00000393520
APOBEC_N
PF08210 4.4e-30
1
ENSP00000393520
APOBEC_C
PF05240 1.2e-09
2
ENSP00000482682
APOBEC_N
PF08210 4.4e-30
1
ENSP00000482682
APOBEC_C
PF05240 1.2e-09
2
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
29290613 The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.
M Nadine Shaban
2018-01-04
Molecular cell
36470880 Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G.
Hanjing Yang
2022-12-05
Nature communications
30414963 RNA-Mediated Dimerization of the Human Deoxycytidine Deaminase APOBEC3H Influences Enzyme Activity and Interaction with Nucleic Acids.
Yuqing Feng
2018-12-07
Journal of molecular biology
31578294 Flexibility in Nucleic Acid Binding Is Central to APOBEC3H Antiviral Activity.
A Jennifer Bohn
2019-12-15
Journal of virology
30679582 A panel of eGFP reporters for single base editing by APOBEC-Cas9 editosome complexes.
St A Martin
2019-01-24
Scientific reports
34452478 Special Issue 'APOBECs and Virus Restriction'.
Linda Chelico
2021-08-15
Viruses
23755966 Identification and antiviral activity of common polymorphisms in the APOBEC3 locus in human populations.
K Nisha Duggal
2013-09-01
Virology
29044109 APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA.
A Jennifer Bohn
2017-10-18
Nature communications
Name
Transcript ID
bp
Protein
Translation ID
APOBEC3H-201
ENST00000348946
1046
182aa
ENSP00000216123
APOBEC3H-205
ENST00000474235
338
No protein
-
APOBEC3H-202
ENST00000401756
1023
200aa
ENSP00000385741
APOBEC3H-204
ENST00000442487
1029
183aa
ENSP00000411754
APOBEC3H-207
ENST00000613996
465
154aa
ENSP00000482682
APOBEC3H-206
ENST00000613677
730
200aa
ENSP00000483689
APOBEC3H-203
ENST00000421988
592
154aa
ENSP00000393520
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000100298 homo_sapiens ENSP00000229335 46.9697 29.798 homo_sapiens ENSP00000411754 50.8197 32.2404 ENSG00000100298 homo_sapiens ENSP00000385057 25.5208 16.1458 homo_sapiens ENSP00000411754 53.5519 33.8798 ENSG00000100298 homo_sapiens ENSP00000309749 24.6649 16.8901 homo_sapiens ENSP00000411754 50.2732 34.4262 ENSG00000100298 homo_sapiens ENSP00000216099 23.057 15.8031 homo_sapiens ENSP00000411754 48.6339 33.3333 ENSG00000100298 homo_sapiens ENSP00000355340 46.8421 34.2105 homo_sapiens ENSP00000411754 48.6339 35.5191 ENSG00000100298 homo_sapiens ENSP00000249116 49.7487 30.1508 homo_sapiens ENSP00000411754 54.0984 32.7869 ENSG00000100298 homo_sapiens ENSP00000327459 26.178 14.9215 homo_sapiens ENSP00000411754 54.6448 31.1475 ENSG00000100298 homo_sapiens ENSP00000229304 33.0508 18.2203 homo_sapiens ENSP00000411754 42.623 23.4973 ENSG00000100298 homo_sapiens ENSP00000244669 33.9286 21.4286 homo_sapiens ENSP00000411754 41.5301 26.2295
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000100298 homo_sapiens ENSP00000411754 93.9891 87.9781 nomascus_leucogenys ENSNLEP00000018472 81.5166 76.3033 ENSG00000100298 homo_sapiens ENSP00000411754 97.2678 94.5355 pan_paniscus ENSPPAP00000026886 89 86.5 ENSG00000100298 homo_sapiens ENSP00000411754 93.4426 88.5246 pongo_abelii ENSPPYP00000041270 81.0427 76.7773 ENSG00000100298 homo_sapiens ENSP00000411754 97.2678 94.5355 pan_troglodytes ENSPTRP00000083401 89 86.5 ENSG00000100298 homo_sapiens ENSP00000411754 43.7158 26.2295 sarcophilus_harrisii ENSSHAP00000043123 27.7778 16.6667 ENSG00000100298 homo_sapiens ENSP00000411754 79.235 69.3989 callithrix_jacchus ENSCJAP00000073454 70.7317 61.9512 ENSG00000100298 homo_sapiens ENSP00000411754 87.9781 81.9672 cercocebus_atys ENSCATP00000012268 80.9045 75.3769 ENSG00000100298 homo_sapiens ENSP00000411754 89.071 82.5137 macaca_fascicularis ENSMFAP00000017385 77.619 71.9048 ENSG00000100298 homo_sapiens ENSP00000411754 88.5246 82.5137 macaca_mulatta ENSMMUP00000053576 62.3077 58.0769 ENSG00000100298 homo_sapiens ENSP00000411754 89.6175 83.0601 macaca_nemestrina ENSMNEP00000031743 77.7251 72.0379 ENSG00000100298 homo_sapiens ENSP00000411754 74.8634 65.5738 papio_anubis ENSPANP00000048484 56.3786 49.3827 ENSG00000100298 homo_sapiens ENSP00000411754 90.1639 83.6066 mandrillus_leucophaeus ENSMLEP00000018470 78.1991 72.5118 ENSG00000100298 homo_sapiens ENSP00000411754 65.5738 50.2732 tursiops_truncatus ENSTTRP00000001189 67.4157 51.6854 ENSG00000100298 homo_sapiens ENSP00000411754 67.2131 48.6339 vulpes_vulpes ENSVVUP00000019753 40.8638 29.5681 ENSG00000100298 homo_sapiens ENSP00000411754 60.6557 44.8087 mus_spretus MGP_SPRETEiJ_P0040813 25.2273 18.6364 ENSG00000100298 homo_sapiens ENSP00000411754 68.8525 50.8197 equus_asinus ENSEASP00005036918 40.5145 29.9035 ENSG00000100298 homo_sapiens ENSP00000411754 66.1202 49.7268 capra_hircus ENSCHIP00000032712 32.3529 24.3316 ENSG00000100298 homo_sapiens ENSP00000411754 61.2022 48.6339 loxodonta_africana ENSLAFP00000026875 30.4348 24.1848 ENSG00000100298 homo_sapiens ENSP00000411754 65.0273 47.541 ailuropoda_melanoleuca ENSAMEP00000011384 47.6 34.8 ENSG00000100298 homo_sapiens ENSP00000411754 65.5738 48.6339 bos_indicus_hybrid ENSBIXP00005043951 30.303 22.4747 ENSG00000100298 homo_sapiens ENSP00000411754 49.7268 38.7978 oryctolagus_cuniculus ENSOCUP00000035226 17.9134 13.9764 ENSG00000100298 homo_sapiens ENSP00000411754 68.8525 50.8197 equus_caballus ENSECAP00000034895 50.8064 37.5 ENSG00000100298 homo_sapiens ENSP00000411754 66.1202 46.4481 canis_lupus_familiaris ENSCAFP00845030766 48.4 34 ENSG00000100298 homo_sapiens ENSP00000411754 62.8415 50.2732 panthera_pardus ENSPPRP00000009485 59.2784 47.4227 ENSG00000100298 homo_sapiens ENSP00000411754 62.2951 47.541 marmota_marmota_marmota ENSMMMP00000015540 49.1379 37.5 ENSG00000100298 homo_sapiens ENSP00000411754 63.9344 49.1803 balaenoptera_musculus ENSBMSP00010013875 65 50 ENSG00000100298 homo_sapiens ENSP00000411754 65.0273 51.3661 cavia_porcellus ENSCPOP00000008311 29.0244 22.9268 ENSG00000100298 homo_sapiens ENSP00000411754 63.388 49.7268 felis_catus ENSFCAP00000059112 36.3636 28.5266 ENSG00000100298 homo_sapiens ENSP00000411754 65.5738 47.541 ursus_americanus ENSUAMP00000004881 54.2986 39.3665 ENSG00000100298 homo_sapiens ENSP00000411754 44.2623 21.3115 monodelphis_domestica ENSMODP00000040505 31.1538 15 ENSG00000100298 homo_sapiens ENSP00000411754 0 0 bison_bison_bison ENSBBBP00000011591 0 0 ENSG00000100298 homo_sapiens ENSP00000411754 65.0273 49.1803 bison_bison_bison ENSBBBP00000011581 67.6136 51.1364 ENSG00000100298 homo_sapiens ENSP00000411754 65.0273 49.1803 monodon_monoceros ENSMMNP00015027558 23.3333 17.6471 ENSG00000100298 homo_sapiens ENSP00000411754 66.6667 50.8197 sus_scrofa ENSSSCP00000049864 50.2058 38.2716 ENSG00000100298 homo_sapiens ENSP00000411754 50.8197 37.1585 jaculus_jaculus ENSJJAP00000014377 25.2033 18.4282 ENSG00000100298 homo_sapiens ENSP00000411754 66.1202 49.1803 ovis_aries_rambouillet ENSOARP00020015068 32.5269 24.1935 ENSG00000100298 homo_sapiens ENSP00000411754 66.1202 48.6339 ursus_maritimus ENSUMAP00000019740 57.346 42.1801 ENSG00000100298 homo_sapiens ENSP00000411754 65.0273 49.1803 delphinapterus_leucas ENSDLEP00000014878 22.2846 16.8539 ENSG00000100298 homo_sapiens ENSP00000411754 66.1202 49.1803 physeter_catodon ENSPCTP00005011753 28.8095 21.4286 ENSG00000100298 homo_sapiens ENSP00000411754 61.2022 46.9945 mus_caroli MGP_CAROLIEiJ_P0039006 25.4545 19.5455 ENSG00000100298 homo_sapiens ENSP00000411754 60.1093 44.8087 mus_musculus ENSMUSP00000135027 25 18.6364 ENSG00000100298 homo_sapiens ENSP00000411754 61.7486 49.7268 dipodomys_ordii ENSDORP00000022770 29.7368 23.9474 ENSG00000100298 homo_sapiens ENSP00000411754 61.7486 48.0874 mustela_putorius_furo ENSMPUP00000013141 29.5039 22.9765 ENSG00000100298 homo_sapiens ENSP00000411754 81.4208 72.1311 aotus_nancymaae ENSANAP00000015030 66.5179 58.9286 ENSG00000100298 homo_sapiens ENSP00000411754 81.4208 69.9454 saimiri_boliviensis_boliviensis ENSSBOP00000027153 62.8692 54.0084 ENSG00000100298 homo_sapiens ENSP00000411754 47.541 36.612 vicugna_pacos ENSVPAP00000010345 68.5039 52.7559 ENSG00000100298 homo_sapiens ENSP00000411754 87.9781 80.8743 chlorocebus_sabaeus ENSCSAP00000002661 76.3033 70.1422 ENSG00000100298 homo_sapiens ENSP00000411754 62.2951 46.4481 tupaia_belangeri ENSTBEP00000001321 68.2635 50.8982 ENSG00000100298 homo_sapiens ENSP00000411754 64.4809 47.541 mesocricetus_auratus ENSMAUP00000010970 28.5714 21.0654 ENSG00000100298 homo_sapiens ENSP00000411754 65.5738 50.2732 phocoena_sinus ENSPSNP00000013086 28.777 22.0623 ENSG00000100298 homo_sapiens ENSP00000411754 61.7486 49.1803 camelus_dromedarius ENSCDRP00005019466 26.7139 21.2766 ENSG00000100298 homo_sapiens ENSP00000411754 63.9344 49.1803 carlito_syrichta ENSTSYP00000023224 64.6409 49.7238 ENSG00000100298 homo_sapiens ENSP00000411754 62.8415 50.2732 panthera_tigris_altaica ENSPTIP00000009121 59.2784 47.4227 ENSG00000100298 homo_sapiens ENSP00000411754 63.388 49.1803 rattus_norvegicus ENSRNOP00000095626 26.1261 20.2703 ENSG00000100298 homo_sapiens ENSP00000411754 63.9344 48.0874 microtus_ochrogaster ENSMOCP00000025473 27.8571 20.9524 ENSG00000100298 homo_sapiens ENSP00000411754 61.2022 43.7158 peromyscus_maniculatus_bairdii ENSPEMP00000000666 25.6293 18.3066 ENSG00000100298 homo_sapiens ENSP00000411754 66.6667 49.7268 bos_mutus ENSBMUP00000000416 31.6883 23.6364 ENSG00000100298 homo_sapiens ENSP00000411754 60.6557 45.3552 mus_spicilegus ENSMSIP00000034718 25.2273 18.8636 ENSG00000100298 homo_sapiens ENSP00000411754 64.4809 49.1803 cricetulus_griseus_chok1gshd ENSCGRP00001025355 28.5714 21.7918 ENSG00000100298 homo_sapiens ENSP00000411754 65.5738 49.7268 pteropus_vampyrus ENSPVAP00000008916 68.1818 51.7045 ENSG00000100298 homo_sapiens ENSP00000411754 44.2623 25.1366 vombatus_ursinus ENSVURP00010031524 27.1812 15.4362 ENSG00000100298 homo_sapiens ENSP00000411754 66.6667 49.1803 rhinolophus_ferrumequinum ENSRFEP00010002311 57.0093 42.0561 ENSG00000100298 homo_sapiens ENSP00000411754 61.7486 46.4481 neovison_vison ENSNVIP00000001830 55.3922 41.6667 ENSG00000100298 homo_sapiens ENSP00000411754 66.1202 48.6339 bos_taurus ENSBTAP00000003115 31.4286 23.1169 ENSG00000100298 homo_sapiens ENSP00000411754 63.388 51.3661 heterocephalus_glaber_female ENSHGLP00000024290 56.0386 45.4106 ENSG00000100298 homo_sapiens ENSP00000411754 86.3388 81.9672 rhinopithecus_bieti ENSRBIP00000010473 74.8815 71.09 ENSG00000100298 homo_sapiens ENSP00000411754 66.1202 45.9016 canis_lupus_dingo ENSCAFP00020003085 56.8075 39.4366 ENSG00000100298 homo_sapiens ENSP00000411754 56.8306 44.2623 sciurus_vulgaris ENSSVLP00005019455 22.6087 17.6087 ENSG00000100298 homo_sapiens ENSP00000411754 45.3552 25.1366 phascolarctos_cinereus ENSPCIP00000049844 31.9231 17.6923 ENSG00000100298 homo_sapiens ENSP00000411754 55.1913 40.9836 procavia_capensis ENSPCAP00000014600 58.046 43.1034 ENSG00000100298 homo_sapiens ENSP00000411754 63.388 46.9945 nannospalax_galili ENSNGAP00000019083 27.685 20.5251 ENSG00000100298 homo_sapiens ENSP00000411754 65.5738 49.1803 bos_grunniens ENSBGRP00000004947 48.9796 36.7347 ENSG00000100298 homo_sapiens ENSP00000411754 62.8415 51.9126 chinchilla_lanigera ENSCLAP00000024206 56.9307 47.0297 ENSG00000100298 homo_sapiens ENSP00000411754 65.0273 50.8197 cervus_hanglu_yarkandensis ENSCHYP00000021689 25.1055 19.6203 ENSG00000100298 homo_sapiens ENSP00000411754 61.7486 50.8197 catagonus_wagneri ENSCWAP00000020400 28.392 23.3668 ENSG00000100298 homo_sapiens ENSP00000411754 63.9344 50.2732 ictidomys_tridecemlineatus ENSSTOP00000006364 56.25 44.2308 ENSG00000100298 homo_sapiens ENSP00000411754 84.6995 73.7705 cebus_imitator ENSCCAP00000001319 72.77 63.3803 ENSG00000100298 homo_sapiens ENSP00000411754 52.459 38.2514 urocitellus_parryii ENSUPAP00010028216 44.6512 32.5581 ENSG00000100298 homo_sapiens ENSP00000411754 67.2131 50.8197 moschus_moschiferus ENSMMSP00000021032 33.0645 25 ENSG00000100298 homo_sapiens ENSP00000411754 86.8852 81.4208 rhinopithecus_roxellana ENSRROP00000006181 69.1304 64.7826 ENSG00000100298 homo_sapiens ENSP00000411754 63.9344 47.541 mus_pahari MGP_PahariEiJ_P0042359 26.4108 19.6388 ENSG00000100298 homo_sapiens ENSP00000411754 46.4481 24.5902 callorhinchus_milii ENSCMIP00000004961 40.4762 21.4286 ENSG00000100298 homo_sapiens ENSP00000411754 41.5301 22.9508 latimeria_chalumnae ENSLACP00000018020 22.093 12.2093 ENSG00000100298 homo_sapiens ENSP00000411754 43.1694 25.6831 lepisosteus_oculatus ENSLOCP00000004258 28.9377 17.2161 ENSG00000100298 homo_sapiens ENSP00000411754 45.3552 21.3115 xenopus_tropicalis ENSXETP00000073758 37.3874 17.5676 ENSG00000100298 homo_sapiens ENSP00000411754 44.8087 24.0437 anolis_carolinensis ENSACAP00000018261 30.4833 16.3569 ENSG00000100298 homo_sapiens ENSP00000411754 37.1585 17.4863 podarcis_muralis ENSPMRP00000035742 32.381 15.2381 ENSG00000100298 homo_sapiens ENSP00000411754 45.3552 25.6831 erpetoichthys_calabaricus ENSECRP00000021015 31.8008 18.0077 ENSG00000100298 homo_sapiens ENSP00000411754 39.3443 26.776 paramormyrops_kingsleyae ENSPKIP00000029857 34.7826 23.6715 ENSG00000100298 homo_sapiens ENSP00000411754 45.3552 28.4153 scleropages_formosus ENSSFOP00015009596 41.9192 26.2626
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000932 is_active_in P-body 2 IBA,IDA Homo_sapiens(9606) Component GO:0003723 enables RNA binding 1 IBA Homo_sapiens(9606) Function GO:0004126 enables cytidine deaminase activity 2 IBA,IDA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005634 is_active_in nucleus 2 IBA,IDA Homo_sapiens(9606) Component GO:0005654 located_in nucleoplasm 1 IDA Homo_sapiens(9606) Component GO:0005737 is_active_in cytoplasm 2 IBA,IDA Homo_sapiens(9606) Component GO:0005829 located_in cytosol 1 IDA Homo_sapiens(9606) Component GO:0008270 enables zinc ion binding 1 IEA Homo_sapiens(9606) Function GO:0009972 involved_in cytidine deamination 1 IEA Homo_sapiens(9606) Process GO:0010526 involved_in retrotransposon silencing 2 IDA,IMP Homo_sapiens(9606) Process GO:0016554 involved_in cytidine to uridine editing 1 IBA Homo_sapiens(9606) Process GO:0044355 involved_in clearance of foreign intracellular DNA 1 IDA Homo_sapiens(9606) Process GO:0044828 involved_in negative regulation by host of viral genome replication 1 IMP Homo_sapiens(9606) Process GO:0045087 involved_in innate immune response 1 IEA Homo_sapiens(9606) Process GO:0045869 involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 2 IBA,IDA Homo_sapiens(9606) Process GO:0047844 enables deoxycytidine deaminase activity 1 IBA Homo_sapiens(9606) Function GO:0051607 involved_in defense response to virus 2 IBA,IDA Homo_sapiens(9606) Process GO:0070383 involved_in DNA cytosine deamination 2 IBA,IDA Homo_sapiens(9606) Process GO:0080111 involved_in DNA demethylation 1 IBA Homo_sapiens(9606) Process
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