RBP Type	Canonical_RBPs
Diseases	CancerSARS-COV-2
Drug	N.A.
Main interacting RNAs	rRNA
Moonlighting functions	N.A.
Localizations	P-bodyNucleoliNucleoli rim
BulkPerturb-seq	DataSet_01_129 DataSet_01_31

Ensembl ID	ENSG00000100029	Gene ID	23481	Accession	8848
Symbol	PES1	Alias	PES;NOP7	Full Name	pescadillo ribosomal biogenesis factor 1
Status	Confidence	Length	30459 bases	Strand	Minus strand
Position	22 : 30576625 - 30607083	RNA binding domain	Pescadillo_N
Summary	This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]