Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000099381 Gene ID 9739 Accession 29010
Symbol SETD1A Alias Set1;EPEDD;EPEO2;KMT2F;Set1A;NEDSID Full Name SET domain containing 1A, histone lysine methyltransferase
Status Confidence Length 26911 bases Strand Plus strand
Position 16 : 30957754 - 30984664 RNA binding domain RRM_1
Summary The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Dec 2016]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000508271 RRM_1 PF00076 2.7e-06 1
ENSP00000262519 RRM_1 PF00076 2.6e-05 1
ENSP00000507683 RRM_1 PF00076 2.6e-05 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
30008910 H3K4me3 and Wdr82 are associated with tumor progression and a favorable prognosis in human colorectal cancer. He Liu 2018-08-01 Oncology letters
34803610 SETD1A Mediated H3K4 Methylation and Its Role in Neurodevelopmental and Neuropsychiatric Disorders. Shan Wang 2021-01-01 Frontiers in molecular neuroscience

Transcripts

Name Transcript ID bp Protein Translation ID
SETD1A-206 ENST00000710314 6451 1707aa ENSP00000518195
SETD1A-201 ENST00000262519 5991 1707aa ENSP00000262519
SETD1A-204 ENST00000682768 1045 289aa ENSP00000508271
SETD1A-205 ENST00000684162 5934 1707aa ENSP00000507683
SETD1A-202 ENST00000452917 315 70aa ENSP00000391408
SETD1A-203 ENST00000640410 718 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000099381homo_sapiensENSP0000047425345.625634.0793homo_sapiensENSP0000026251952.548339.2501
ENSG00000099381homo_sapiensENSP0000032014725.299615.1798homo_sapiensENSP0000026251911.13066.67838
ENSG00000099381homo_sapiensENSP0000048224018.953310.8911homo_sapiensENSP000002625197.850034.51084
ENSG00000099381homo_sapiensENSP0000038675911.97356.43526homo_sapiensENSP0000026251917.98489.66608
ENSG00000099381homo_sapiensENSP0000039883712.11797.99263homo_sapiensENSP0000026251919.273612.7124
ENSG00000099381homo_sapiensENSP0000043678612.10987.40181homo_sapiensENSP0000026251928.178117.2232
ENSG00000099381homo_sapiensENSP0000031398314.4058.28114homo_sapiensENSP0000026251912.12656.97129
ENSG00000099381homo_sapiensENSP0000041798016.48699.09091homo_sapiensENSP0000026251912.53666.91271
ENSG00000099381homo_sapiensENSP000003010679.19275.689homo_sapiensENSP0000026251929.818418.4534
ENSG00000099381homo_sapiensENSP0000040465823.962513.7885homo_sapiensENSP0000026251910.48626.03398
ENSG00000099381homo_sapiensENSP000003959298.234425.0816homo_sapiensENSP0000026251913.00538.02578
ENSG00000099381homo_sapiensENSP0000049740610.33836.39098homo_sapiensENSP000002625199.666085.9754
ENSG00000099381homo_sapiensENSP0000036468717.851210homo_sapiensENSP0000026251912.65387.08846
ENSG00000099381homo_sapiensENSP000003762049.851556.0054homo_sapiensENSP0000026251917.10610.4277
ENSG00000099381homo_sapiensENSP0000042397214.50558.64469homo_sapiensENSP0000026251911.59936.91271
ENSG00000099381homo_sapiensENSP0000026218911.24016.59743homo_sapiensENSP0000026251932.337418.9807
ENSG00000099381homo_sapiensENSP0000034699729.268316.3415homo_sapiensENSP000002625197.029883.92501
ENSG00000099381homo_sapiensENSP0000050942514.78337.66254homo_sapiensENSP0000026251911.18925.79965
ENSG00000099381homo_sapiensENSP0000036587728.883516.9903homo_sapiensENSP000002625196.971294.10076

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000099381homo_sapiensENSP0000026251998.886998.6526pongo_abeliiENSPPYP0000000824499.002998.7683
ENSG00000099381homo_sapiensENSP0000026251999.531399.5313pan_troglodytesENSPTRP0000001370699.531399.5313
ENSG00000099381homo_sapiensENSP0000026251997.773997.7153gorilla_gorillaENSGGOP0000001566597.888697.8299
ENSG00000099381homo_sapiensENSP0000026251998.242597.7739cercocebus_atysENSCATP0000002375198.127697.6594
ENSG00000099381homo_sapiensENSP0000026251998.301197.7739papio_anubisENSPANP0000001256698.128797.6023
ENSG00000099381homo_sapiensENSP0000026251997.949697.481mandrillus_leucophaeusENSMLEP0000001205597.83597.3669
ENSG00000099381homo_sapiensENSP0000026251994.961993.0287tursiops_truncatusENSTTRP0000001468195.690793.7426
ENSG00000099381homo_sapiensENSP0000026251994.083291.9742equus_asinusENSEASP0000501613895.142293.0095
ENSG00000099381homo_sapiensENSP0000026251994.258992.3257capra_hircusENSCHIP0000003163894.203892.2717
ENSG00000099381homo_sapiensENSP0000026251992.735890.744loxodonta_africanaENSLAFP0000001745693.613291.6026
ENSG00000099381homo_sapiensENSP0000026251995.782194.1418panthera_leoENSPLOP0000002077295.61493.9766
ENSG00000099381homo_sapiensENSP0000026251994.610492.6772bos_indicus_hybridENSBIXP0000504311694.55592.6229
ENSG00000099381homo_sapiensENSP0000026251995.606393.6145equus_caballusENSECAP0000001284295.606393.6145
ENSG00000099381homo_sapiensENSP0000026251995.37293.4974canis_lupus_familiarisENSCAFP0084501801095.037993.1699
ENSG00000099381homo_sapiensENSP0000026251991.857190.3339panthera_pardusENSPPRP0000002211895.435293.8527
ENSG00000099381homo_sapiensENSP0000026251996.07594.4933marmota_marmota_marmotaENSMMMP0000000037595.962694.3827
ENSG00000099381homo_sapiensENSP0000026251995.196393.0287balaenoptera_musculusENSBMSP0001002598395.53293.3568
ENSG00000099381homo_sapiensENSP0000026251994.434792.2671cavia_porcellusENSCPOP0000001426394.712192.5382
ENSG00000099381homo_sapiensENSP0000026251995.723594.0246felis_catusENSFCAP0000000238695.723594.0246
ENSG00000099381homo_sapiensENSP0000026251957.293556.1804ursus_americanusENSUAMP0000001832793.678291.8582
ENSG00000099381homo_sapiensENSP0000026251985.588883.8313bison_bison_bisonENSBBBP0000000783987.48585.6886
ENSG00000099381homo_sapiensENSP0000026251994.961993.0287monodon_monocerosENSMMNP0001500885395.409193.4667
ENSG00000099381homo_sapiensENSP0000026251995.020593.2045sus_scrofaENSSSCP0000000831095.243793.4234
ENSG00000099381homo_sapiensENSP0000026251995.547794.1418microcebus_murinusENSMICP0000003057695.603894.197
ENSG00000099381homo_sapiensENSP0000026251944.229642.7651jaculus_jaculusENSJJAP0000001554490.419287.4251
ENSG00000099381homo_sapiensENSP0000026251994.258992.3257ovis_aries_rambouilletENSOARP0002002984394.203892.2717
ENSG00000099381homo_sapiensENSP0000026251995.196393.2045delphinapterus_leucasENSDLEP0000002129395.53293.5332
ENSG00000099381homo_sapiensENSP0000026251945.869944.9326dipodomys_ordiiENSDORP0000002259592.772590.8768
ENSG00000099381homo_sapiensENSP0000026251997.363896.075saimiri_boliviensis_boliviensisENSSBOP0000000688397.306896.0187
ENSG00000099381homo_sapiensENSP0000026251998.418397.891chlorocebus_sabaeusENSCSAP0000000208598.360797.8337
ENSG00000099381homo_sapiensENSP0000026251995.313493.263phocoena_sinusENSPSNP0000001401395.649693.592
ENSG00000099381homo_sapiensENSP0000026251993.321690.744rattus_norvegicusENSRNOP0000007393792.778190.2155
ENSG00000099381homo_sapiensENSP0000026251992.794490.1582microtus_ochrogasterENSMOCP0000001241792.415489.79
ENSG00000099381homo_sapiensENSP0000026251992.735890.3925peromyscus_maniculatus_bairdiiENSPEMP0000002881692.681590.3396
ENSG00000099381homo_sapiensENSP0000026251985.061583.4798bos_mutusENSBMUP0000003415085.714384.1204
ENSG00000099381homo_sapiensENSP0000026251993.321690.5682cricetulus_griseus_chok1gshdENSCGRP0000102455192.45589.7272
ENSG00000099381homo_sapiensENSP0000026251989.513887.0533neovison_visonENSNVIP0000003237789.618887.1554
ENSG00000099381homo_sapiensENSP0000026251994.551892.6186bos_taurusENSBTAP0000006888994.496592.5644
ENSG00000099381homo_sapiensENSP0000026251993.96692.15canis_lupus_dingoENSCAFP0002002291593.473291.6667
ENSG00000099381homo_sapiensENSP0000026251995.840794.3175sciurus_vulgarisENSSVLP0000503238496.178794.6502
ENSG00000099381homo_sapiensENSP0000026251945.518543.9953nannospalax_galiliENSNGAP0000001775591.411888.3529
ENSG00000099381homo_sapiensENSP0000026251993.497491.2712chinchilla_lanigeraENSCLAP0000001688393.937691.701
ENSG00000099381homo_sapiensENSP0000026251994.727692.6772cervus_hanglu_yarkandensisENSCHYP0000000300594.838792.7859
ENSG00000099381homo_sapiensENSP0000026251995.957894.4347ictidomys_tridecemlineatusENSSTOP0000000484395.901694.3794
ENSG00000099381homo_sapiensENSP0000026251947.100246.1629otolemur_garnettiiENSOGAP0000001807493.925292.0561
ENSG00000099381homo_sapiensENSP0000026251997.539596.1336cebus_imitatorENSCCAP0000001566597.482496.0773
ENSG00000099381homo_sapiensENSP0000026251995.899294.3175urocitellus_parryiiENSUPAP0001002489493.329591.7902
ENSG00000099381homo_sapiensENSP0000026251994.317592.2085moschus_moschiferusENSMMSP0000001960894.594692.4794
ENSG00000099381homo_sapiensENSP0000026251994.610493.2045propithecus_coquereliENSPCOP0000001806594.665993.2591
ENSG00000099381homo_sapiensENSP000002625196.268314.33509caenorhabditis_elegansK09F5.5.127.506419.0231
ENSG00000099381homo_sapiensENSP000002625194.803752.75337caenorhabditis_elegansF34D6.4.129.496416.9065
ENSG00000099381homo_sapiensENSP000002625196.444053.39777caenorhabditis_elegansK12H6.11.127.363214.4279
ENSG00000099381homo_sapiensENSP0000026251911.24786.38547caenorhabditis_elegansW01C8.3.120.146911.4376
ENSG00000099381homo_sapiensENSP0000026251911.71656.26831caenorhabditis_elegansC43E11.3a.112.46886.67082
ENSG00000099381homo_sapiensENSP000002625197.264213.9836caenorhabditis_elegansF02D10.7.130.466816.7076
ENSG00000099381homo_sapiensENSP000002625196.912713.69069caenorhabditis_elegansR11E3.4.219.312610.311
ENSG00000099381homo_sapiensENSP000002625198.728764.628caenorhabditis_elegansC49F5.2.121.045211.1582
ENSG00000099381homo_sapiensENSP000002625195.799652.81195caenorhabditis_elegansC41G7.4.119.14899.28433
ENSG00000099381homo_sapiensENSP000002625196.736973.39777caenorhabditis_elegansY24D9A.2.120.246510.2113
ENSG00000099381homo_sapiensENSP0000026251915.11429.6075drosophila_melanogasterFBpp007361010.92296.94327
ENSG00000099381homo_sapiensENSP0000026251910.54485.79965drosophila_melanogasterFBpp030520710.8635.97465
ENSG00000099381homo_sapiensENSP000002625195.038082.92912drosophila_melanogasterFBpp011212831.970318.5874
ENSG00000099381homo_sapiensENSP000002625196.092565.68248eptatretus_burgeriENSEBUP0000002614090.434884.3478
ENSG00000099381homo_sapiensENSP0000026251914.411210.9549ciona_savignyiENSCSAVP0000001250855.782342.4036
ENSG00000099381homo_sapiensENSP0000026251961.687253.6614leptobrachium_leishanenseENSLLEP0000003715161.54353.5359

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000785part_of chromatin1IDAHomo_sapiens(9606)Component
GO:0003723enables RNA binding1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus2IDA,IMPHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0006338involved_in chromatin remodeling1IEAHomo_sapiens(9606)Process
GO:0006974involved_in DNA damage response1IEAHomo_sapiens(9606)Process
GO:0007420involved_in brain development1IMPHomo_sapiens(9606)Process
GO:0008013enables beta-catenin binding1IPIHomo_sapiens(9606)Function
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0035097part_of histone methyltransferase complex1IDAHomo_sapiens(9606)Component
GO:0042800enables histone H3K4 methyltransferase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0048188part_of Set1C/COMPASS complex4IBA,IDA,IPI,TASHomo_sapiens(9606)Component
GO:0051568involved_in histone H3-K4 methylation2IBA,NASHomo_sapiens(9606)Process
GO:0061629enables RNA polymerase II-specific DNA-binding transcription factor binding1IPIHomo_sapiens(9606)Function
GO:0140945enables histone H3K4 monomethyltransferase activity1IEAHomo_sapiens(9606)Function
GO:0140999enables histone H3K4 trimethyltransferase activity1IEAHomo_sapiens(9606)Function
GO:1902036involved_in regulation of hematopoietic stem cell differentiation1IDAHomo_sapiens(9606)Process
GO:1902275involved_in regulation of chromatin organization1IDAHomo_sapiens(9606)Process

Expression