RBP Type	Non-canonical_RBPs
Diseases	Cancer Disease
Drug	N.A.
Main interacting RNAs	diverse
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000088305	Gene ID	1789	Accession	2979
Symbol	DNMT3B	Alias	ICF;ICF1;FSHD4;M.HsaIIIB	Full Name	DNA methyltransferase 3 beta
Status	Confidence	Length	46975 bases	Strand	Plus strand
Position	20 : 32762385 - 32809359	RNA binding domain	N.A.
Summary	CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
28334849	ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing.	Sole Gatto	2017-06-02	Nucleic acids research
19270063	The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA.	Isabel I Silanes López	2009-05-01	Nucleic acids research
36443876	Gene body methylation in cancer: molecular mechanisms and clinical applications.	Qi Wang	2022-11-28	Clinical epigenetics
31636039	RETRACTED: lncRNA RMST Enhances DNMT3 Expression through Interaction with HuR.	Wan-Xin Peng	2020-01-08	Molecular therapy : the journal of the American Society of Gene Therapy
36798299	Retrospective identification of intrinsic factors that mark pluripotency potential in rare somatic cells.	Naveen Jain	2023-02-10	bioRxiv : the preprint server for biology
27521372	Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm.	Albert Jeltsch	2016-10-14	Nucleic acids research
31698782	Emerging Roles of Long Non-Coding RNAs as Drivers of Brain Evolution.	Geraldine Zimmer-Bensch	2019-11-06	Cells
31738163	Persistent epigenetic memory impedes rescue of the telomeric phenotype in human ICF iPSCs following DNMT3B correction.	Shir Toubiana	2019-11-20	eLife
24151495	Eradication of HIV and Cure of AIDS, Now and How?	Jielin Zhang	2013-10-18	Frontiers in immunology

Name	Transcript ID	bp	Protein	Translation ID
DNMT3B-207	ENST00000696231	4369	360aa	ENSP00000512497
DNMT3B-202	ENST00000328111	4336	853aa	ENSP00000328547
DNMT3B-208	ENST00000696232	4150	790aa	ENSP00000512498
DNMT3B-203	ENST00000348286	4048	770aa	ENSP00000337764
DNMT3B-204	ENST00000353855	4237	833aa	ENSP00000313397
DNMT3B-209	ENST00000696233	4271	480aa	ENSP00000512499
DNMT3B-210	ENST00000696234	1542	No protein	-
DNMT3B-205	ENST00000443239	2674	728aa	ENSP00000403169
DNMT3B-211	ENST00000696235	1709	332aa	ENSP00000512500
DNMT3B-206	ENST00000456297	2315	694aa	ENSP00000412305
DNMT3B-212	ENST00000696236	1512	318aa	ENSP00000512501
DNMT3B-213	ENST00000696237	766	No protein	-
DNMT3B-201	ENST00000201963	4255	845aa	ENSP00000201963
DNMT3B-214	ENST00000696238	4165	480aa	ENSP00000512502
DNMT3B-215	ENST00000696239	2343	780aa	ENSP00000512503
DNMT3B-216	ENST00000696240	588	No protein	-
DNMT3B-217	ENST00000696241	701	No protein	-
DNMT3B-218	ENST00000696242	706	No protein	-
DNMT3B-219	ENST00000696243	722	No protein	-
DNMT3B-220	ENST00000696244	826	No protein	-
DNMT3B-221	ENST00000696245	2039	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
311	Maximal Midexpiratory Flow Rate	8.63036637993857E-9	17903307
348	Respiratory Function Tests	1.76333591662232E-6	17903307
407	Respiratory Function Tests	1.13134832705717E-6	17903307
12292	Depressive Disorder, Major	6.978E-5	17728769
30480	Eosinophils	5.0990000E-005	-
61056	Inflammatory Bowel Diseases	3E-8	26192919
72872	Colitis, Ulcerative	6E-6	26192919
93305	Inflammatory Bowel Diseases	1E-9	23128233
99807	Attention Deficit Disorder with Hyperactivity	4E-6	23527680
104174	Attention Deficit Disorder with Hyperactivity	4E-6	23527680
105848	Attention Deficit Disorder with Hyperactivity	4E-6	23527680

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000088305	homo_sapiens	ENSP00000306324	25.7627	13.7288	homo_sapiens	ENSP00000328547	17.8195	9.4959
ENSG00000088305	homo_sapiens	ENSP00000324375	58.0044	45.943	homo_sapiens	ENSP00000328547	62.0164	49.1208
ENSG00000088305	homo_sapiens	ENSP00000305151	24.7682	13.1126	homo_sapiens	ENSP00000328547	21.9226	11.6061
ENSG00000088305	homo_sapiens	ENSP00000486001	57.2539	37.0466	homo_sapiens	ENSP00000328547	25.9086	16.7644

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000088305	homo_sapiens	ENSP00000328547	91.3247	91.3247	nomascus_leucogenys	ENSNLEP00000011966	96.7702	96.7702
ENSG00000088305	homo_sapiens	ENSP00000328547	100	100	pan_paniscus	ENSPPAP00000022800	100	100
ENSG00000088305	homo_sapiens	ENSP00000328547	99.6483	99.6483	pongo_abelii	ENSPPYP00000042140	99.6483	99.6483
ENSG00000088305	homo_sapiens	ENSP00000328547	100	100	pan_troglodytes	ENSPTRP00000082164	100	100
ENSG00000088305	homo_sapiens	ENSP00000328547	99.8828	99.8828	gorilla_gorilla	ENSGGOP00000009318	99.8828	99.8828
ENSG00000088305	homo_sapiens	ENSP00000328547	63.7749	56.7409	ornithorhynchus_anatinus	ENSOANP00000019195	78.3862	69.7406
ENSG00000088305	homo_sapiens	ENSP00000328547	79.8359	68.9332	sarcophilus_harrisii	ENSSHAP00000005929	82.2464	71.0145
ENSG00000088305	homo_sapiens	ENSP00000328547	56.3892	54.6307	choloepus_hoffmanni	ENSCHOP00000006063	62.3865	60.441
ENSG00000088305	homo_sapiens	ENSP00000328547	95.1934	92.1454	dasypus_novemcinctus	ENSDNOP00000015956	94.6387	91.6084
ENSG00000088305	homo_sapiens	ENSP00000328547	84.5252	80.1876	erinaceus_europaeus	ENSEEUP00000012038	85.8333	81.4286
ENSG00000088305	homo_sapiens	ENSP00000328547	76.0844	73.5053	echinops_telfairi	ENSETEP00000016503	81.0237	78.2772
ENSG00000088305	homo_sapiens	ENSP00000328547	98.2415	97.4209	callithrix_jacchus	ENSCJAP00000028913	98.2415	97.4209
ENSG00000088305	homo_sapiens	ENSP00000328547	97.1864	97.1864	cercocebus_atys	ENSCATP00000011159	96.1717	96.1717
ENSG00000088305	homo_sapiens	ENSP00000328547	99.4138	99.4138	macaca_fascicularis	ENSMFAP00000044977	99.4138	99.4138
ENSG00000088305	homo_sapiens	ENSP00000328547	96.8347	96.8347	macaca_mulatta	ENSMMUP00000060289	97.7515	97.7515
ENSG00000088305	homo_sapiens	ENSP00000328547	99.4138	99.4138	macaca_nemestrina	ENSMNEP00000031176	99.4138	99.4138
ENSG00000088305	homo_sapiens	ENSP00000328547	99.4138	99.4138	papio_anubis	ENSPANP00000042114	99.4138	99.4138
ENSG00000088305	homo_sapiens	ENSP00000328547	99.5311	99.4138	mandrillus_leucophaeus	ENSMLEP00000012456	99.5311	99.4138
ENSG00000088305	homo_sapiens	ENSP00000328547	95.1934	92.3798	tursiops_truncatus	ENSTTRP00000014038	94.8598	92.0561
ENSG00000088305	homo_sapiens	ENSP00000328547	82.7667	78.898	vulpes_vulpes	ENSVVUP00000006609	75.2665	71.7484
ENSG00000088305	homo_sapiens	ENSP00000328547	59.32	55.4513	mus_spretus	MGP_SPRETEiJ_P0057492	86.3481	80.7167
ENSG00000088305	homo_sapiens	ENSP00000328547	95.8968	93.6694	equus_asinus	ENSEASP00005056106	95.5607	93.3411
ENSG00000088305	homo_sapiens	ENSP00000328547	92.8488	90.3869	capra_hircus	ENSCHIP00000002727	90.8257	88.4174
ENSG00000088305	homo_sapiens	ENSP00000328547	93.7866	90.973	loxodonta_africana	ENSLAFP00000014230	93.5673	90.7602
ENSG00000088305	homo_sapiens	ENSP00000328547	96.1313	93.9039	panthera_leo	ENSPLOP00000019846	95.7944	93.5748
ENSG00000088305	homo_sapiens	ENSP00000328547	95.1934	93.2005	ailuropoda_melanoleuca	ENSAMEP00000042484	94.8598	92.8738
ENSG00000088305	homo_sapiens	ENSP00000328547	94.959	92.3798	bos_indicus_hybrid	ENSBIXP00005024579	93.9675	91.4153
ENSG00000088305	homo_sapiens	ENSP00000328547	95.1934	92.0281	oryctolagus_cuniculus	ENSOCUP00000015318	94.5285	91.3853
ENSG00000088305	homo_sapiens	ENSP00000328547	96.0141	93.9039	equus_caballus	ENSECAP00000010703	95.2326	93.1395
ENSG00000088305	homo_sapiens	ENSP00000328547	95.1934	93.3177	canis_lupus_familiaris	ENSCAFP00845031242	94.8598	92.9907
ENSG00000088305	homo_sapiens	ENSP00000328547	96.1313	93.9039	panthera_pardus	ENSPPRP00000023975	95.7944	93.5748
ENSG00000088305	homo_sapiens	ENSP00000328547	90.973	87.2216	marmota_marmota_marmota	ENSMMMP00000027115	94.0606	90.1818
ENSG00000088305	homo_sapiens	ENSP00000328547	94.959	92.6143	balaenoptera_musculus	ENSBMSP00010022421	94.7368	92.3977
ENSG00000088305	homo_sapiens	ENSP00000328547	54.7479	53.1067	cavia_porcellus	ENSCPOP00000018434	97.0894	94.1788
ENSG00000088305	homo_sapiens	ENSP00000328547	96.1313	93.9039	felis_catus	ENSFCAP00000048862	95.7944	93.5748
ENSG00000088305	homo_sapiens	ENSP00000328547	94.2556	91.5592	ursus_americanus	ENSUAMP00000030593	93.2715	90.6032
ENSG00000088305	homo_sapiens	ENSP00000328547	79.3669	68.6987	monodelphis_domestica	ENSMODP00000024261	79.5535	68.8602
ENSG00000088305	homo_sapiens	ENSP00000328547	94.8417	92.2626	bison_bison_bison	ENSBBBP00000000926	94.5093	91.9393
ENSG00000088305	homo_sapiens	ENSP00000328547	95.4279	92.7315	monodon_monoceros	ENSMMNP00015004266	95.0935	92.4065
ENSG00000088305	homo_sapiens	ENSP00000328547	95.3107	92.7315	sus_scrofa	ENSSSCP00000041398	94.9766	92.4065
ENSG00000088305	homo_sapiens	ENSP00000328547	96.0141	94.0211	microcebus_murinus	ENSMICP00000006096	96.0141	94.0211
ENSG00000088305	homo_sapiens	ENSP00000328547	93.5522	89.6835	octodon_degus	ENSODEP00000015956	93.8824	90
ENSG00000088305	homo_sapiens	ENSP00000328547	87.5733	81.1254	jaculus_jaculus	ENSJJAP00000000957	88.8228	82.283
ENSG00000088305	homo_sapiens	ENSP00000328547	84.2907	78.0774	ovis_aries_rambouillet	ENSOARP00020009817	71.9	66.6
ENSG00000088305	homo_sapiens	ENSP00000328547	94.2556	91.5592	ursus_maritimus	ENSUMAP00000033540	93.2715	90.6032
ENSG00000088305	homo_sapiens	ENSP00000328547	90.7386	88.2767	ochotona_princeps	ENSOPRP00000006129	90.5263	88.0702
ENSG00000088305	homo_sapiens	ENSP00000328547	86.1665	82.0633	delphinapterus_leucas	ENSDLEP00000025624	90.1841	85.8896
ENSG00000088305	homo_sapiens	ENSP00000328547	95.0762	92.1454	physeter_catodon	ENSPCTP00005018198	94.8538	91.9298
ENSG00000088305	homo_sapiens	ENSP00000328547	83.2356	77.2567	mus_caroli	MGP_CAROLIEiJ_P0055352	89.0841	82.6851
ENSG00000088305	homo_sapiens	ENSP00000328547	90.3869	83.939	mus_musculus	ENSMUSP00000051830	89.6512	83.2558
ENSG00000088305	homo_sapiens	ENSP00000328547	73.6225	67.1747	mus_musculus	ENSMUSP00000153622	84.8649	77.4324
ENSG00000088305	homo_sapiens	ENSP00000328547	92.0281	87.2216	dipodomys_ordii	ENSDORP00000012072	93.4524	88.5714
ENSG00000088305	homo_sapiens	ENSP00000328547	93.5522	91.5592	mustela_putorius_furo	ENSMPUP00000017757	94.1038	92.0991
ENSG00000088305	homo_sapiens	ENSP00000328547	83.7046	81.5944	aotus_nancymaae	ENSANAP00000003208	92.0103	89.6907
ENSG00000088305	homo_sapiens	ENSP00000328547	98.476	97.5381	aotus_nancymaae	ENSANAP00000015022	98.476	97.5381
ENSG00000088305	homo_sapiens	ENSP00000328547	94.3728	93.6694	saimiri_boliviensis_boliviensis	ENSSBOP00000028874	98.2906	97.558
ENSG00000088305	homo_sapiens	ENSP00000328547	62.6026	60.2579	vicugna_pacos	ENSVPAP00000009529	63.6472	61.2634
ENSG00000088305	homo_sapiens	ENSP00000328547	99.2966	98.5932	chlorocebus_sabaeus	ENSCSAP00000008720	98.9486	98.2477
ENSG00000088305	homo_sapiens	ENSP00000328547	83.1184	80.891	tupaia_belangeri	ENSTBEP00000009499	82.8271	80.6075
ENSG00000088305	homo_sapiens	ENSP00000328547	95.4279	92.4971	phocoena_sinus	ENSPSNP00000007411	95.0935	92.1729
ENSG00000088305	homo_sapiens	ENSP00000328547	95.0762	92.4971	camelus_dromedarius	ENSCDRP00005028847	94.6324	92.0653
ENSG00000088305	homo_sapiens	ENSP00000328547	94.959	92.0281	carlito_syrichta	ENSTSYP00000001852	94.959	92.0281
ENSG00000088305	homo_sapiens	ENSP00000328547	96.0141	93.7866	panthera_tigris_altaica	ENSPTIP00000017077	95.6776	93.4579
ENSG00000088305	homo_sapiens	ENSP00000328547	90.6213	84.408	rattus_norvegicus	ENSRNOP00000015482	89.8837	83.7209
ENSG00000088305	homo_sapiens	ENSP00000328547	72.9191	66.4713	rattus_norvegicus	ENSRNOP00000083712	84.1678	76.7253
ENSG00000088305	homo_sapiens	ENSP00000328547	96.0141	94.2556	prolemur_simus	ENSPSMP00000007003	96.0141	94.2556
ENSG00000088305	homo_sapiens	ENSP00000328547	88.1594	82.2978	microtus_ochrogaster	ENSMOCP00000016373	88.6792	82.783
ENSG00000088305	homo_sapiens	ENSP00000328547	90.3869	85.8148	sorex_araneus	ENSSARP00000009334	92.446	87.7698
ENSG00000088305	homo_sapiens	ENSP00000328547	72.9191	67.0574	peromyscus_maniculatus_bairdii	ENSPEMP00000004141	85.5571	78.6795
ENSG00000088305	homo_sapiens	ENSP00000328547	64.7128	57.2098	peromyscus_maniculatus_bairdii	ENSPEMP00000026954	74.4939	65.8569
ENSG00000088305	homo_sapiens	ENSP00000328547	94.6073	92.0281	bos_mutus	ENSBMUP00000019136	94.2757	91.7056
ENSG00000088305	homo_sapiens	ENSP00000328547	90.6213	84.1735	mus_spicilegus	ENSMSIP00000022060	89.7793	83.3914
ENSG00000088305	homo_sapiens	ENSP00000328547	69.7538	63.6577	cricetulus_griseus_chok1gshd	ENSCGRP00001007508	83.921	76.5867
ENSG00000088305	homo_sapiens	ENSP00000328547	90.8558	85.2286	cricetulus_griseus_chok1gshd	ENSCGRP00001010194	89.4919	83.9492
ENSG00000088305	homo_sapiens	ENSP00000328547	85.8148	84.1735	pteropus_vampyrus	ENSPVAP00000014988	91.0448	89.3035
ENSG00000088305	homo_sapiens	ENSP00000328547	92.4971	89.0973	myotis_lucifugus	ENSMLUP00000014940	91.6376	88.2695
ENSG00000088305	homo_sapiens	ENSP00000328547	61.5475	55.803	vombatus_ursinus	ENSVURP00010018110	87.3544	79.2013
ENSG00000088305	homo_sapiens	ENSP00000328547	94.6073	92.7315	rhinolophus_ferrumequinum	ENSRFEP00010015852	94.2757	92.4065
ENSG00000088305	homo_sapiens	ENSP00000328547	95.6624	93.6694	neovison_vison	ENSNVIP00000023941	95.3271	93.3411
ENSG00000088305	homo_sapiens	ENSP00000328547	92.8488	90.5041	bos_taurus	ENSBTAP00000059458	94.0618	91.6865
ENSG00000088305	homo_sapiens	ENSP00000328547	61.8992	58.7339	heterocephalus_glaber_female	ENSHGLP00000046190	83.2808	79.0221
ENSG00000088305	homo_sapiens	ENSP00000328547	84.408	83.3529	rhinopithecus_bieti	ENSRBIP00000019555	96.9044	95.6931
ENSG00000088305	homo_sapiens	ENSP00000328547	94.1383	93.6694	rhinopithecus_bieti	ENSRBIP00000032856	96.283	95.8034
ENSG00000088305	homo_sapiens	ENSP00000328547	94.2556	91.6764	canis_lupus_dingo	ENSCAFP00020005825	93.2715	90.7193
ENSG00000088305	homo_sapiens	ENSP00000328547	81.8288	77.374	sciurus_vulgaris	ENSSVLP00005018972	89.8327	84.9421
ENSG00000088305	homo_sapiens	ENSP00000328547	96.2485	93.4349	sciurus_vulgaris	ENSSVLP00005002856	96.0234	93.2164
ENSG00000088305	homo_sapiens	ENSP00000328547	66.5885	59.4373	phascolarctos_cinereus	ENSPCIP00000034833	86.8502	77.5229
ENSG00000088305	homo_sapiens	ENSP00000328547	83.5873	80.422	procavia_capensis	ENSPCAP00000000802	83.6854	80.5164
ENSG00000088305	homo_sapiens	ENSP00000328547	89.449	85.5803	nannospalax_galili	ENSNGAP00000022707	90.9416	87.0083
ENSG00000088305	homo_sapiens	ENSP00000328547	94.959	92.3798	bos_grunniens	ENSBGRP00000007328	94.6262	92.0561
ENSG00000088305	homo_sapiens	ENSP00000328547	92.7315	89.449	chinchilla_lanigera	ENSCLAP00000024822	91.3395	88.1062
ENSG00000088305	homo_sapiens	ENSP00000328547	84.9941	79.1325	cervus_hanglu_yarkandensis	ENSCHYP00000024662	72.5	67.5
ENSG00000088305	homo_sapiens	ENSP00000328547	95.3107	92.7315	catagonus_wagneri	ENSCWAP00000011072	94.9766	92.4065
ENSG00000088305	homo_sapiens	ENSP00000328547	91.3247	87.6905	ictidomys_tridecemlineatus	ENSSTOP00000005971	93.5174	89.7959
ENSG00000088305	homo_sapiens	ENSP00000328547	35.8734	32.8253	ictidomys_tridecemlineatus	ENSSTOP00000029242	88.4393	80.9249
ENSG00000088305	homo_sapiens	ENSP00000328547	95.0762	92.7315	otolemur_garnettii	ENSOGAP00000004221	94.5221	92.1911
ENSG00000088305	homo_sapiens	ENSP00000328547	88.1594	87.1043	cebus_imitator	ENSCCAP00000019758	95.0695	93.9317
ENSG00000088305	homo_sapiens	ENSP00000328547	41.0317	38.9215	cebus_imitator	ENSCCAP00000009946	95.1087	90.2174
ENSG00000088305	homo_sapiens	ENSP00000328547	98.3587	97.5381	cebus_imitator	ENSCCAP00000005259	98.3587	97.5381
ENSG00000088305	homo_sapiens	ENSP00000328547	90.3869	86.6354	urocitellus_parryii	ENSUPAP00010024722	93.1159	89.2512
ENSG00000088305	homo_sapiens	ENSP00000328547	94.8417	91.5592	moschus_moschiferus	ENSMMSP00000019673	94.5093	91.2383
ENSG00000088305	homo_sapiens	ENSP00000328547	32.9426	32.5909	rhinopithecus_roxellana	ENSRROP00000005961	95.5782	94.5578
ENSG00000088305	homo_sapiens	ENSP00000328547	99.6483	99.6483	rhinopithecus_roxellana	ENSRROP00000000291	99.6483	99.6483
ENSG00000088305	homo_sapiens	ENSP00000328547	69.2849	64.2438	mus_pahari	MGP_PahariEiJ_P0066324	87.1681	80.826
ENSG00000088305	homo_sapiens	ENSP00000328547	96.9519	95.0762	propithecus_coquereli	ENSPCOP00000025886	96.7251	94.8538
ENSG00000088305	homo_sapiens	ENSP00000328547	21.8054	13.7163	eptatretus_burgeri	ENSEBUP00000011100	31	19.5
ENSG00000088305	homo_sapiens	ENSP00000328547	59.789	50.0586	callorhinchus_milii	ENSCMIP00000040176	77.39	64.7951
ENSG00000088305	homo_sapiens	ENSP00000328547	61.4302	49.1208	latimeria_chalumnae	ENSLACP00000009510	70.6199	56.469
ENSG00000088305	homo_sapiens	ENSP00000328547	67.6436	55.0996	lepisosteus_oculatus	ENSLOCP00000006885	69.4344	56.5584
ENSG00000088305	homo_sapiens	ENSP00000328547	66.9402	54.6307	clupea_harengus	ENSCHAP00000043708	69.7192	56.8987
ENSG00000088305	homo_sapiens	ENSP00000328547	66.0023	53.3411	danio_rerio	ENSDARP00000053417	68.9951	55.7598
ENSG00000088305	homo_sapiens	ENSP00000328547	65.6506	53.9273	carassius_auratus	ENSCARP00000011279	67.8788	55.7576
ENSG00000088305	homo_sapiens	ENSP00000328547	65.8851	53.6928	carassius_auratus	ENSCARP00000117062	69.6406	56.7534
ENSG00000088305	homo_sapiens	ENSP00000328547	64.2438	52.4033	carassius_auratus	ENSCARP00000078067	66.5049	54.2476
ENSG00000088305	homo_sapiens	ENSP00000328547	63.5404	51.6999	astyanax_mexicanus	ENSAMXP00000029071	67.4129	54.8507
ENSG00000088305	homo_sapiens	ENSP00000328547	65.1817	53.3411	ictalurus_punctatus	ENSIPUP00000016461	68.7268	56.2423
ENSG00000088305	homo_sapiens	ENSP00000328547	65.7679	53.6928	esox_lucius	ENSELUP00000026874	67.5904	55.1807
ENSG00000088305	homo_sapiens	ENSP00000328547	63.4232	51.5826	electrophorus_electricus	ENSEEEP00000013654	66.9554	54.4554
ENSG00000088305	homo_sapiens	ENSP00000328547	65.6506	53.3411	oncorhynchus_kisutch	ENSOKIP00005101023	67.0659	54.491
ENSG00000088305	homo_sapiens	ENSP00000328547	65.4162	53.4584	oncorhynchus_kisutch	ENSOKIP00005033456	67.7184	55.3398
ENSG00000088305	homo_sapiens	ENSP00000328547	62.837	50.9965	oncorhynchus_mykiss	ENSOMYP00000058836	67.1679	54.5113
ENSG00000088305	homo_sapiens	ENSP00000328547	65.5334	53.4584	oncorhynchus_mykiss	ENSOMYP00000058621	65	53.0233
ENSG00000088305	homo_sapiens	ENSP00000328547	65.6506	53.8101	salmo_salar	ENSSSAP00000097901	67.4699	55.3012
ENSG00000088305	homo_sapiens	ENSP00000328547	65.7679	53.3411	salmo_salar	ENSSSAP00000097806	68.0825	55.2184
ENSG00000088305	homo_sapiens	ENSP00000328547	65.4162	53.5756	salmo_trutta	ENSSTUP00000075459	67.31	55.1267
ENSG00000088305	homo_sapiens	ENSP00000328547	66.354	53.4584	salmo_trutta	ENSSTUP00000092845	68.6893	55.3398
ENSG00000088305	homo_sapiens	ENSP00000328547	64.0094	52.286	gadus_morhua	ENSGMOP00000030913	66.9939	54.7239
ENSG00000088305	homo_sapiens	ENSP00000328547	66.0023	54.279	fundulus_heteroclitus	ENSFHEP00000014801	61.0629	50.2169
ENSG00000088305	homo_sapiens	ENSP00000328547	48.8863	40.5627	poecilia_reticulata	ENSPREP00000029271	74.1993	61.5658
ENSG00000088305	homo_sapiens	ENSP00000328547	65.1817	52.6377	xiphophorus_maculatus	ENSXMAP00000037273	68.9826	55.7072
ENSG00000088305	homo_sapiens	ENSP00000328547	65.6506	53.2239	oryzias_latipes	ENSORLP00000036522	62.5	50.6696
ENSG00000088305	homo_sapiens	ENSP00000328547	65.5334	52.286	cyclopterus_lumpus	ENSCLMP00005029550	66.7861	53.2855
ENSG00000088305	homo_sapiens	ENSP00000328547	65.5334	53.6928	oreochromis_niloticus	ENSONIP00000018687	71.301	58.4184
ENSG00000088305	homo_sapiens	ENSP00000328547	65.5334	53.1067	haplochromis_burtoni	ENSHBUP00000011553	67.6755	54.8426
ENSG00000088305	homo_sapiens	ENSP00000328547	65.7679	53.4584	astatotilapia_calliptera	ENSACLP00000013682	68.4982	55.6777
ENSG00000088305	homo_sapiens	ENSP00000328547	64.9472	53.2239	sparus_aurata	ENSSAUP00010068754	67.4787	55.2984
ENSG00000088305	homo_sapiens	ENSP00000328547	65.1817	53.5756	lates_calcarifer	ENSLCAP00010042806	67.5577	55.5286
ENSG00000088305	homo_sapiens	ENSP00000328547	31.5358	26.3775	chrysemys_picta_bellii	ENSCPBP00000015629	49.2674	41.2088
ENSG00000088305	homo_sapiens	ENSP00000328547	62.3681	54.9824	chrysemys_picta_bellii	ENSCPBP00000039909	83.7795	73.8583
ENSG00000088305	homo_sapiens	ENSP00000328547	57.0926	50.0586	sphenodon_punctatus	ENSSPUP00000024706	69.7708	61.1748
ENSG00000088305	homo_sapiens	ENSP00000328547	71.7468	62.1336	crocodylus_porosus	ENSCPRP00005011142	72.255	62.5738
ENSG00000088305	homo_sapiens	ENSP00000328547	61.4302	50.6448	laticauda_laticaudata	ENSLLTP00000002464	68.6763	56.6186
ENSG00000088305	homo_sapiens	ENSP00000328547	56.1547	46.7761	notechis_scutatus	ENSNSUP00000014835	76.1526	63.434
ENSG00000088305	homo_sapiens	ENSP00000328547	47.3623	37.163	pseudonaja_textilis	ENSPTXP00000016942	70.2609	55.1304
ENSG00000088305	homo_sapiens	ENSP00000328547	61.6647	52.0516	anas_platyrhynchos_platyrhynchos	ENSAPLP00000018469	51.3672	43.3594
ENSG00000088305	homo_sapiens	ENSP00000328547	64.1266	53.2239	gallus_gallus	ENSGALP00010019054	65.1967	54.112
ENSG00000088305	homo_sapiens	ENSP00000328547	60.2579	48.5346	meleagris_gallopavo	ENSMGAP00000019746	63.0675	50.7975
ENSG00000088305	homo_sapiens	ENSP00000328547	60.2579	50.2931	serinus_canaria	ENSSCAP00000019679	65.3944	54.5802
ENSG00000088305	homo_sapiens	ENSP00000328547	61.1958	50.4103	parus_major	ENSPMJP00000007350	66.1597	54.4994
ENSG00000088305	homo_sapiens	ENSP00000328547	37.163	33.4115	anolis_carolinensis	ENSACAP00000041275	82.9843	74.6073
ENSG00000088305	homo_sapiens	ENSP00000328547	61.313	48.4174	neolamprologus_brichardi	ENSNBRP00000011763	66.0354	52.1465
ENSG00000088305	homo_sapiens	ENSP00000328547	66.0023	54.1618	naja_naja	ENSNNAP00000001620	68.1598	55.9322
ENSG00000088305	homo_sapiens	ENSP00000328547	60.4924	51.6999	podarcis_muralis	ENSPMRP00000010010	75.4386	64.4737
ENSG00000088305	homo_sapiens	ENSP00000328547	60.6096	49.5897	geospiza_fortis	ENSGFOP00000002354	62.4396	51.087
ENSG00000088305	homo_sapiens	ENSP00000328547	61.8992	50.4103	taeniopygia_guttata	ENSTGUP00000020744	64	52.1212
ENSG00000088305	homo_sapiens	ENSP00000328547	57.9132	48.7691	erpetoichthys_calabaricus	ENSECRP00000016768	78.2884	65.9271
ENSG00000088305	homo_sapiens	ENSP00000328547	67.7608	55.6858	salvator_merianae	ENSSMRP00000025264	70.3163	57.7859
ENSG00000088305	homo_sapiens	ENSP00000328547	65.7679	52.9894	oryzias_javanicus	ENSOJAP00000002145	66.548	53.618
ENSG00000088305	homo_sapiens	ENSP00000328547	65.6506	54.0445	amphilophus_citrinellus	ENSACIP00000011587	72.2581	59.4839
ENSG00000088305	homo_sapiens	ENSP00000328547	65.1817	53.3411	dicentrarchus_labrax	ENSDLAP00005013494	67.6399	55.3528
ENSG00000088305	homo_sapiens	ENSP00000328547	59.4373	50.4103	amphiprion_percula	ENSAPEP00000030321	80.9904	68.6901
ENSG00000088305	homo_sapiens	ENSP00000328547	66.1196	53.5756	oryzias_sinensis	ENSOSIP00000046742	62.9464	51.0045
ENSG00000088305	homo_sapiens	ENSP00000328547	56.5064	48.6518	pelodiscus_sinensis	ENSPSIP00000007469	75.7862	65.2516
ENSG00000088305	homo_sapiens	ENSP00000328547	48.7691	43.728	gopherus_evgoodei	ENSGEVP00005010538	84.0404	75.3535
ENSG00000088305	homo_sapiens	ENSP00000328547	15.0059	10.7855	gopherus_evgoodei	ENSGEVP00005011539	44.2907	31.8339
ENSG00000088305	homo_sapiens	ENSP00000328547	62.9543	55.4513	chelonoidis_abingdonii	ENSCABP00000005254	67.4623	59.4221
ENSG00000088305	homo_sapiens	ENSP00000328547	15.592	11.7233	chelonoidis_abingdonii	ENSCABP00000012681	50.5703	38.0228
ENSG00000088305	homo_sapiens	ENSP00000328547	65.5334	53.5756	seriola_dumerili	ENSSDUP00000010000	67.9222	55.5286
ENSG00000088305	homo_sapiens	ENSP00000328547	64.7128	52.4033	cottoperca_gobio	ENSCGOP00000026175	67.8133	54.914
ENSG00000088305	homo_sapiens	ENSP00000328547	57.5615	48.4174	struthio_camelus_australis	ENSSCUP00000002860	64.7757	54.4855
ENSG00000088305	homo_sapiens	ENSP00000328547	58.6166	49.0035	anser_brachyrhynchus	ENSABRP00000024899	57.2738	47.8809
ENSG00000088305	homo_sapiens	ENSP00000328547	65.4162	52.9894	gasterosteus_aculeatus	ENSGACP00000013579	69.4894	56.2889
ENSG00000088305	homo_sapiens	ENSP00000328547	64.4783	53.1067	cynoglossus_semilaevis	ENSCSEP00000013908	66.8287	55.0425
ENSG00000088305	homo_sapiens	ENSP00000328547	45.4865	37.163	cynoglossus_semilaevis	ENSCSEP00000028552	75.9296	62.0352
ENSG00000088305	homo_sapiens	ENSP00000328547	64.83	52.8722	poecilia_formosa	ENSPFOP00000011431	68.1034	55.5419
ENSG00000088305	homo_sapiens	ENSP00000328547	66.5885	54.5135	myripristis_murdjan	ENSMMDP00005023770	68.8485	56.3636
ENSG00000088305	homo_sapiens	ENSP00000328547	65.4162	52.9894	sander_lucioperca	ENSSLUP00000030015	68.0488	55.122
ENSG00000088305	homo_sapiens	ENSP00000328547	63.8921	53.5756	strigops_habroptila	ENSSHBP00005006298	65.1914	54.6651
ENSG00000088305	homo_sapiens	ENSP00000328547	44.197	37.6319	amphiprion_ocellaris	ENSAOCP00000010112	80.2128	68.2979
ENSG00000088305	homo_sapiens	ENSP00000328547	15.4748	12.1923	terrapene_carolina_triunguis	ENSTMTP00000004452	52.1739	41.1067
ENSG00000088305	homo_sapiens	ENSP00000328547	61.313	52.755	terrapene_carolina_triunguis	ENSTMTP00000014358	65.212	56.1097
ENSG00000088305	homo_sapiens	ENSP00000328547	63.0715	51.8171	hucho_hucho	ENSHHUP00000070177	69.8701	57.4026
ENSG00000088305	homo_sapiens	ENSP00000328547	60.2579	49.3552	hucho_hucho	ENSHHUP00000031961	70.2186	57.5137
ENSG00000088305	homo_sapiens	ENSP00000328547	65.0645	52.6377	betta_splendens	ENSBSLP00000045951	67.9315	54.9572
ENSG00000088305	homo_sapiens	ENSP00000328547	64.5955	53.8101	pygocentrus_nattereri	ENSPNAP00000010283	68.2776	56.8773
ENSG00000088305	homo_sapiens	ENSP00000328547	65.1817	53.8101	anabas_testudineus	ENSATEP00000036088	66.9073	55.2347
ENSG00000088305	homo_sapiens	ENSP00000328547	41.0317	30.2462	ciona_savignyi	ENSCSAVP00000020042	55.5556	40.9524
ENSG00000088305	homo_sapiens	ENSP00000328547	21.6882	16.6471	ciona_savignyi	ENSCSAVP00000005338	67.2727	51.6364
ENSG00000088305	homo_sapiens	ENSP00000328547	65.5334	53.4584	seriola_lalandi_dorsalis	ENSSLDP00000000753	71.5749	58.3867
ENSG00000088305	homo_sapiens	ENSP00000328547	10.0821	9.37866	labrus_bergylta	ENSLBEP00000013750	80.3738	74.7664
ENSG00000088305	homo_sapiens	ENSP00000328547	64.3611	52.5205	pundamilia_nyererei	ENSPNYP00000031627	69.9363	57.0701
ENSG00000088305	homo_sapiens	ENSP00000328547	65.5334	54.0445	mastacembelus_armatus	ENSMAMP00000011809	67.7576	55.8788
ENSG00000088305	homo_sapiens	ENSP00000328547	53.9273	42.7902	stegastes_partitus	ENSSPAP00000027602	65.2482	51.773
ENSG00000088305	homo_sapiens	ENSP00000328547	64.3611	52.4033	oncorhynchus_tshawytscha	ENSOTSP00005072793	70.0255	57.0153
ENSG00000088305	homo_sapiens	ENSP00000328547	65.4162	53.3411	oncorhynchus_tshawytscha	ENSOTSP00005096442	67.31	54.8854
ENSG00000088305	homo_sapiens	ENSP00000328547	64.3611	52.4033	oncorhynchus_tshawytscha	ENSOTSP00005089814	70.0255	57.0153
ENSG00000088305	homo_sapiens	ENSP00000328547	58.7339	47.9484	acanthochromis_polyacanthus	ENSAPOP00000026996	67.2483	54.8993
ENSG00000088305	homo_sapiens	ENSP00000328547	64.3611	53.8101	aquila_chrysaetos_chrysaetos	ENSACCP00020009560	66.3043	55.4348
ENSG00000088305	homo_sapiens	ENSP00000328547	62.2509	51.1137	cyprinodon_variegatus	ENSCVAP00000005326	65.7993	54.0273
ENSG00000088305	homo_sapiens	ENSP00000328547	66.2368	53.9273	denticeps_clupeoides	ENSDCDP00000040230	69.2402	56.3725
ENSG00000088305	homo_sapiens	ENSP00000328547	65.2989	53.1067	larimichthys_crocea	ENSLCRP00005029333	67.5971	54.9757
ENSG00000088305	homo_sapiens	ENSP00000328547	57.6788	48.8863	takifugu_rubripes	ENSTRUP00000086209	74.2081	62.8959
ENSG00000088305	homo_sapiens	ENSP00000328547	60.6096	49.7069	ficedula_albicollis	ENSFALP00000005597	63.9061	52.4104
ENSG00000088305	homo_sapiens	ENSP00000328547	65.0645	53.1067	hippocampus_comes	ENSHCOP00000003229	71.4286	58.3012
ENSG00000088305	homo_sapiens	ENSP00000328547	66.0023	53.4584	cyprinus_carpio_carpio	ENSCCRP00000004519	68.8264	55.7457
ENSG00000088305	homo_sapiens	ENSP00000328547	64.1266	53.3411	coturnix_japonica	ENSCJPP00005005546	64.5809	53.719
ENSG00000088305	homo_sapiens	ENSP00000328547	64.5955	53.2239	poecilia_latipinna	ENSPLAP00000022022	71.1886	58.6563
ENSG00000088305	homo_sapiens	ENSP00000328547	65.4162	53.2239	sinocyclocheilus_grahami	ENSSGRP00000080252	68.0488	55.3659
ENSG00000088305	homo_sapiens	ENSP00000328547	65.6506	53.3411	sinocyclocheilus_grahami	ENSSGRP00000068485	68.4597	55.6235
ENSG00000088305	homo_sapiens	ENSP00000328547	65.6506	53.4584	maylandia_zebra	ENSMZEP00005035959	68.3761	55.6777
ENSG00000088305	homo_sapiens	ENSP00000328547	29.4256	26.9637	tetraodon_nigroviridis	ENSTNIP00000009616	92.963	85.1852
ENSG00000088305	homo_sapiens	ENSP00000328547	65.1817	53.3411	tetraodon_nigroviridis	ENSTNIP00000009615	72.0207	58.9378
ENSG00000088305	homo_sapiens	ENSP00000328547	64.0094	53.4584	paramormyrops_kingsleyae	ENSPKIP00000019203	70.9091	59.2208
ENSG00000088305	homo_sapiens	ENSP00000328547	66.2368	53.2239	paramormyrops_kingsleyae	ENSPKIP00000020047	68.6513	55.164
ENSG00000088305	homo_sapiens	ENSP00000328547	66.1196	54.6307	scleropages_formosus	ENSSFOP00015001158	70.0621	57.8882
ENSG00000088305	homo_sapiens	ENSP00000328547	64.83	52.1688	scleropages_formosus	ENSSFOP00015073415	68.1874	54.8705
ENSG00000088305	homo_sapiens	ENSP00000328547	64.9472	53.3411	scophthalmus_maximus	ENSSMAP00000027596	66.747	54.8193
ENSG00000088305	homo_sapiens	ENSP00000328547	66.0023	53.4584	oryzias_melastigma	ENSOMEP00000026318	68.5749	55.542

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0003677	enables DNA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0003714	enables transcription corepressor activity	2	IDA,IMP	Homo_sapiens(9606)	Function
GO:0003886	enables DNA (cytosine-5-)-methyltransferase activity	3	IDA,NAS,TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	3	IBA,IDA,NAS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006306	involved_in DNA methylation	2	NAS,TAS	Homo_sapiens(9606)	Process
GO:0009008	enables DNA-methyltransferase activity	1	NAS	Homo_sapiens(9606)	Function
GO:0010628	involved_in positive regulation of gene expression	1	IMP	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0051718	enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	1	IBA	Homo_sapiens(9606)	Function
GO:0090116	involved_in C-5 methylation of cytosine	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:1902494	part_of catalytic complex	1	IPI	Homo_sapiens(9606)	Component