Ensembl ID ENSG00000088305 Gene ID 1789 Accession 2979
Gene Symbol DNMT3B Alias ICF;ICF1;FSHD4;M.HsaIIIB Full Name DNA methyltransferase 3 beta
Position 20 : 32762385 - 32809359 Length 46975 bases Strand Plus strand
Status Confidence Main interacting RNAsdiverseRBP type Non-canonical_RBPs
Summary CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]

ENSG00000088305 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000088305 DNMT3B 2.31 1.85e-47 HNSC
ENSG00000088305 DNMT3B 2.20 4.09e-15 BLCA
ENSG00000088305 DNMT3B 1.50 2.70e-46 BRCA
ENSG00000088305 DNMT3B 1.60 1.28e-31 COAD
ENSG00000088305 DNMT3B 2.03 2.64e-12 READ
ENSG00000088305 DNMT3B 2.68 3.47e-58 LUSC
ENSG00000088305 DNMT3B 1.52 3.39e-17 KIRP
ENSG00000088305 DNMT3B 1.68 4.38e-25 LIHC
ENSG00000088305 DNMT3B 2.34 2.22e-23 STAD
ENSG00000088305 DNMT3B 2.71 1.23e-53 UCEC
ENSG00000088305 DNMT3B 2.26 7.27e-12 ESCA
ENSG00000088305 DNMT3B 2.05 3.47e-35 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000088305 DNMT3B tumor 10433969
ENSG00000088305 DNMT3B AML 11222358
ENSG00000088305 DNMT3B cancer 12015329
ENSG00000088305 DNMT3B lung cancer 12208751
ENSG00000088305 DNMT3B colorectal cancers 12438232
ENSG00000088305 DNMT3B tumor 12496760
ENSG00000088305 DNMT3B tumor 12507229
ENSG00000088305 DNMT3B tumor 12594811
ENSG00000088305 DNMT3B tumors 12879017
ENSG00000088305 DNMT3B breast cancer 14555514
ENSG00000088305 DNMT3B cancer 14577574
ENSG00000088305 DNMT3B tumor 15148359
ENSG00000088305 DNMT3B breast cancer 15217506
ENSG00000088305 DNMT3B HNSCC 15375549
ENSG00000088305 DNMT3B lung cancer 15528220
ENSG00000088305 DNMT3B breast tumors 15606925
ENSG00000088305 DNMT3B cancers 15661247
ENSG00000088305 DNMT3B cancers 15721400
ENSG00000088305 DNMT3B endometrial cancer 15805266
ENSG00000088305 DNMT3B gastric cancer 16211278
ENSG00000088305 DNMT3B tumor 16318277
ENSG00000088305 DNMT3B ovarian epithelial cancer 16324253
ENSG00000088305 DNMT3B colon cancer 16326863
ENSG00000088305 DNMT3B Cancer 16532039
ENSG00000088305 DNMT3B colonic tumor 16581773
ENSG00000088305 DNMT3B cancer 16722602
ENSG00000088305 DNMT3B non-small cell lung cancer 16773201
ENSG00000088305 DNMT3B AML 16914901
ENSG00000088305 DNMT3B cancers 16920385
ENSG00000088305 DNMT3B non-small cell lung cancer 16951144
ENSG00000088305 DNMT3B cancers 16977793
ENSG00000088305 DNMT3B tumours 17017004
ENSG00000088305 DNMT3B tumours 17071074
ENSG00000088305 DNMT3B tumors 17178860
ENSG00000088305 DNMT3B cancer 17239456
ENSG00000088305 DNMT3B Cancer 17353906
ENSG00000088305 DNMT3B lung cancer 17369845
ENSG00000088305 DNMT3B breast cancer 17532557
ENSG00000088305 DNMT3B tumor 17548962
ENSG00000088305 DNMT3B tumor 17615082
ENSG00000088305 DNMT3B cancer 17965599
ENSG00000088305 DNMT3B tumor 17991895
ENSG00000088305 DNMT3B lung cancer 18006804
ENSG00000088305 DNMT3B cancer 18097598
ENSG00000088305 DNMT3B esophagus cancer 18407600
ENSG00000088305 DNMT3B cancer 18455294
ENSG00000088305 DNMT3B cancer 18499700
ENSG00000088305 DNMT3B prostate cancer 18637271
ENSG00000088305 DNMT3B colorectal cancer 18662374
ENSG00000088305 DNMT3B tumors 18667590
ENSG00000088305 DNMT3B tumors 19024105
ENSG00000088305 DNMT3B endometrial cancer 19107573
ENSG00000088305 DNMT3B colon cancer 19156137
ENSG00000088305 DNMT3B tumor 19270015
ENSG00000088305 DNMT3B endometrial cancer 19306077
ENSG00000088305 DNMT3B cancer 19417133
ENSG00000088305 DNMT3B cancers 19465161
ENSG00000088305 DNMT3B colorectal cancer 19470733
ENSG00000088305 DNMT3B cancer 19486517
ENSG00000088305 DNMT3B gastric cancer 19517237
ENSG00000088305 DNMT3B cervical cancer 19625766
ENSG00000088305 DNMT3B cancer 19632198
ENSG00000088305 DNMT3B tumor 19680556
ENSG00000088305 DNMT3B colon cancer 19723660
ENSG00000088305 DNMT3B tumor 19825994
ENSG00000088305 DNMT3B tumor 19854132
ENSG00000088305 DNMT3B pancreatic cancer 19932585
ENSG00000088305 DNMT3B tumor 19951990
ENSG00000088305 DNMT3B tumors 20101446
ENSG00000088305 DNMT3B lung cancer 20119531
ENSG00000088305 DNMT3B gastric cancer 20127025
ENSG00000088305 DNMT3B tumours 20128888
ENSG00000088305 DNMT3B tumor 20416177
ENSG00000088305 DNMT3B esophageal cancer 20426865
ENSG00000088305 DNMT3B cancer 20428781
ENSG00000088305 DNMT3B colon cancer 20454457
ENSG00000088305 DNMT3B cancer 20514408
ENSG00000088305 DNMT3B tumors 20587527
ENSG00000088305 DNMT3B tumors 20689651
ENSG00000088305 DNMT3B breast cancer 20830311
ENSG00000088305 DNMT3B tumor 20833755
ENSG00000088305 DNMT3B cancer 20841325
ENSG00000088305 DNMT3B cancer 20847044
ENSG00000088305 DNMT3B tumour 20941790
ENSG00000088305 DNMT3B cancer 20960050
ENSG00000088305 DNMT3B colon cancer 21079786
ENSG00000088305 DNMT3B tumor 21081840
ENSG00000088305 DNMT3B tumors 21147764
ENSG00000088305 DNMT3B skin tumors 21186298
ENSG00000088305 DNMT3B tumors 21229291
ENSG00000088305 DNMT3B tumor 21378119
ENSG00000088305 DNMT3B colon cancer 21408221
ENSG00000088305 DNMT3B acute myeloid leukemia (AML) 21415852
ENSG00000088305 DNMT3B cancer 21484930
ENSG00000088305 DNMT3B colon cancer 21490393
ENSG00000088305 DNMT3B colorectal cancer 21519807
ENSG00000088305 DNMT3B tumors 21521786
ENSG00000088305 DNMT3B colorectal cancer 21526191
ENSG00000088305 DNMT3B tumors 21559209
ENSG00000088305 DNMT3B tumor 21559294
ENSG00000088305 DNMT3B germ cell tumours 21564135
ENSG00000088305 DNMT3B tumor 21610323
ENSG00000088305 DNMT3B tumor 21629434
ENSG00000088305 DNMT3B tumours 21712824
ENSG00000088305 DNMT3B colon cancer 21785137
ENSG00000088305 DNMT3B pancreatic cancer 21854760
ENSG00000088305 DNMT3B cancer 21887463
ENSG00000088305 DNMT3B gastric cancer 21887466
ENSG00000088305 DNMT3B cancer 21938431
ENSG00000088305 DNMT3B cancer 22011581
ENSG00000088305 DNMT3B cancer 22048250
ENSG00000088305 DNMT3B head and neck cancer 22076708
ENSG00000088305 DNMT3B cancer 22080562
ENSG00000088305 DNMT3B colorectal cancer 22091311
ENSG00000088305 DNMT3B tumor 22133874
ENSG00000088305 DNMT3B colorectal cancer 22244828
ENSG00000088305 DNMT3B tumour 22301400
ENSG00000088305 DNMT3B AML 22303306
ENSG00000088305 DNMT3B cervical cancer 22330137
ENSG00000088305 DNMT3B tumour 22394436
ENSG00000088305 DNMT3B tumor 22399498
ENSG00000088305 DNMT3B HNSCC 22461910
ENSG00000088305 DNMT3B ovarian cancer 22479643
ENSG00000088305 DNMT3B prostate-cancer 22481891
ENSG00000088305 DNMT3B colorectal cancer 22490141
ENSG00000088305 DNMT3B colon cancer 22563479
ENSG00000088305 DNMT3B cancers 22570537
ENSG00000088305 DNMT3B tumor 22641368
ENSG00000088305 DNMT3B tumor 22687754
ENSG00000088305 DNMT3B tumors 22815530
ENSG00000088305 DNMT3B tumor 22819380
ENSG00000088305 DNMT3B Pancreatic Cancer 22919364
ENSG00000088305 DNMT3B cervical cancer 22964322
ENSG00000088305 DNMT3B Pancreatic Cancer 22966223
ENSG00000088305 DNMT3B lung cancer 22969923
ENSG00000088305 DNMT3B lung cancer 23056009
ENSG00000088305 DNMT3B breast cancer 23079992
ENSG00000088305 DNMT3B cancer 23081874
ENSG00000088305 DNMT3B tumors 23100393
ENSG00000088305 DNMT3B AML 23178755
ENSG00000088305 DNMT3B pancreatic cancer 23213320
ENSG00000088305 DNMT3B cancer 23251566
ENSG00000088305 DNMT3B tumor 23284304
ENSG00000088305 DNMT3B cancers 23312906
ENSG00000088305 DNMT3B tumor 23315164
ENSG00000088305 DNMT3B Tumor 23368921
ENSG00000088305 DNMT3B cancer 23474979
ENSG00000088305 DNMT3B tumor 23517596
ENSG00000088305 DNMT3B gastric cancer 23549984
ENSG00000088305 DNMT3B tumor 23591808
ENSG00000088305 DNMT3B cancer 23636939
ENSG00000088305 DNMT3B breast cancer 23638630
ENSG00000088305 DNMT3B ovarian cancer 23666104
ENSG00000088305 DNMT3B cervical cancer 23677709
ENSG00000088305 DNMT3B cancer 23686312
ENSG00000088305 DNMT3B cancers 23788674
ENSG00000088305 DNMT3B lung cancer 23936390
ENSG00000088305 DNMT3B tumor 23939044
ENSG00000088305 DNMT3B breast cancer 23961262
ENSG00000088305 DNMT3B prostate cancer 24001151
ENSG00000088305 DNMT3B tumors 24019826
ENSG00000088305 DNMT3B AML 24069326
ENSG00000088305 DNMT3B lung cancer 24098518
ENSG00000088305 DNMT3B cancer 24260492
ENSG00000088305 DNMT3B brain tumor 24316981
ENSG00000088305 DNMT3B cancer 24360954
ENSG00000088305 DNMT3B head and neck cancer 24362509
ENSG00000088305 DNMT3B tumors 24386123
ENSG00000088305 DNMT3B cancer 24603304
ENSG00000088305 DNMT3B cancer 24643999
ENSG00000088305 DNMT3B tumor 24648923
ENSG00000088305 DNMT3B cancer 24649027
ENSG00000088305 DNMT3B tumor 24822169
ENSG00000088305 DNMT3B cancer 24832164
ENSG00000088305 DNMT3B tumor 24839957
ENSG00000088305 DNMT3B cancer 24850984
ENSG00000088305 DNMT3B lung cancer 25122426
ENSG00000088305 DNMT3B Cancer 25198254
ENSG00000088305 DNMT3B cancer 25204569
ENSG00000088305 DNMT3B tumors 25219500
ENSG00000088305 DNMT3B cancer 25231211
ENSG00000088305 DNMT3B Tumor 25309923
ENSG00000088305 DNMT3B cancer 25333769
ENSG00000088305 DNMT3B cancer 25433949
ENSG00000088305 DNMT3B colon cancer 25454821
ENSG00000088305 DNMT3B cancer 25515408
ENSG00000088305 DNMT3B tumor 25550796
ENSG00000088305 DNMT3B gastric cancer 25574460
ENSG00000088305 DNMT3B prostate cancer 25597172
ENSG00000088305 DNMT3B cancer 25607950
ENSG00000088305 DNMT3B tumor 25639876
ENSG00000088305 DNMT3B tumor 25746661
ENSG00000088305 DNMT3B cancers 25769449
ENSG00000088305 DNMT3B cancer 25788984
ENSG00000088305 DNMT3B AML 25924238
ENSG00000088305 DNMT3B tumor 25948775
ENSG00000088305 DNMT3B tumor 25949795
ENSG00000088305 DNMT3B AML 25996952
ENSG00000088305 DNMT3B breast cancer 26070560
ENSG00000088305 DNMT3B tumor 26112163
ENSG00000088305 DNMT3B Tumor 26161119
ENSG00000088305 DNMT3B gastric tumors 26172537
ENSG00000088305 DNMT3B lung cancer 26273407
ENSG00000088305 DNMT3B tumor 26298164
ENSG00000088305 DNMT3B tumor 26305882
ENSG00000088305 DNMT3B tumors 26350239
ENSG00000088305 DNMT3B tumor 26404322
ENSG00000088305 DNMT3B cancer 26406961
ENSG00000088305 DNMT3B tumors 26453442
ENSG00000088305 DNMT3B breast cancer 26459286
ENSG00000088305 DNMT3B colorectal cancers 26485042
ENSG00000088305 DNMT3B colorectal cancer 26497367
ENSG00000088305 DNMT3B cancer 26505438
ENSG00000088305 DNMT3B AML 26506237
ENSG00000088305 DNMT3B cancer 26550225
ENSG00000088305 DNMT3B breast cancer 26618174
ENSG00000088305 DNMT3B tumors 26629503
ENSG00000088305 DNMT3B tumors 26629529
ENSG00000088305 DNMT3B cancer 26667181
ENSG00000088305 DNMT3B mammary cancer 26672991
ENSG00000088305 DNMT3B tumor 26703582
ENSG00000088305 DNMT3B tumors 26795243
ENSG00000088305 DNMT3B tumor 26840292
ENSG00000088305 DNMT3B GBMs 26892683
ENSG00000088305 DNMT3B cancer 26923591
ENSG00000088305 DNMT3B lung cancer 26942697
ENSG00000088305 DNMT3B acute myeloid leukemia (AML) 27013212
ENSG00000088305 DNMT3B cancer 27062459
ENSG00000088305 DNMT3B cancer 27121154
ENSG00000088305 DNMT3B tumors 27129173
ENSG00000088305 DNMT3B tumor 27133822
ENSG00000088305 DNMT3B tumor 27158195
ENSG00000088305 DNMT3B colon cancer 27198154
ENSG00000088305 DNMT3B breast cancer 27207652
ENSG00000088305 DNMT3B Colorectal Cancer 27356727
ENSG00000088305 DNMT3B cancer 27449289
ENSG00000088305 DNMT3B cancers 27462454
ENSG00000088305 DNMT3B breast cancer 27554481
ENSG00000088305 DNMT3B cancer 27555773
ENSG00000088305 DNMT3B tumor 27563627
ENSG00000088305 DNMT3B Cancer 27623253
ENSG00000088305 DNMT3B AML 27636548
ENSG00000088305 DNMT3B colon cancer 27668319
ENSG00000088305 DNMT3B AML 27686215
ENSG00000088305 DNMT3B tumor 27752157
ENSG00000088305 DNMT3B tumour 27764816
ENSG00000088305 DNMT3B Gastric Cancer 27789275
ENSG00000088305 DNMT3B tumors 27863398
ENSG00000088305 DNMT3B lung cancer 27876061
ENSG00000088305 DNMT3B AML 27916548
ENSG00000088305 DNMT3B cancers 27994704
ENSG00000088305 DNMT3B tumor 27999265
ENSG00000088305 DNMT3B tumors 28036297
ENSG00000088305 DNMT3B cancers 28092669
ENSG00000088305 DNMT3B cancer 28123849
ENSG00000088305 DNMT3B breast tumors 28127428
ENSG00000088305 DNMT3B cancers 28160561
ENSG00000088305 DNMT3B Cancer 28217009
ENSG00000088305 DNMT3B tumor 28220037
ENSG00000088305 DNMT3B Gastric Cancer 28220295
ENSG00000088305 DNMT3B cancer 28225755
ENSG00000088305 DNMT3B Bladder Cancer 28278502
ENSG00000088305 DNMT3B colorectal cancer 28300471
ENSG00000088305 DNMT3B cancers 28396701
ENSG00000088305 DNMT3B tumor 28425913
ENSG00000088305 DNMT3B tumor 28440439
ENSG00000088305 DNMT3B cervical cancer 28459195
ENSG00000088305 DNMT3B cancer 28459462
ENSG00000088305 DNMT3B breast cancer 28534825
ENSG00000088305 DNMT3B tumour 28587163
ENSG00000088305 DNMT3B tumor 28594926
ENSG00000088305 DNMT3B colorectal cancer 28607593
ENSG00000088305 DNMT3B tumors 28629431
ENSG00000088305 DNMT3B cancers 28656064
ENSG00000088305 DNMT3B cancer 28730333
ENSG00000088305 DNMT3B penile cancer 28751665
ENSG00000088305 DNMT3B pediatric AML 28892045
ENSG00000088305 DNMT3B breast cancer 28912888
ENSG00000088305 DNMT3B acute myeloid leukemia (AML) 28959968
ENSG00000088305 DNMT3B lung cancer 28972577
ENSG00000088305 DNMT3B breast cancer 28979331
ENSG00000088305 DNMT3B gastric cancer 29027179
ENSG00000088305 DNMT3B lung cancer 29072397
ENSG00000088305 DNMT3B Cancer 29073069
ENSG00000088305 DNMT3B tumor 29100357
ENSG00000088305 DNMT3B endometrial cancer 29228451
ENSG00000088305 DNMT3B cancer 29277888
ENSG00000088305 DNMT3B tumors 29305580
ENSG00000088305 DNMT3B Gastric Cancer 29332452
ENSG00000088305 DNMT3B tumor 29364483
ENSG00000088305 DNMT3B tumor 29383100
ENSG00000088305 DNMT3B tumor 29394925
ENSG00000088305 DNMT3B lung cancer 29416619
ENSG00000088305 DNMT3B tumor 29432024
ENSG00000088305 DNMT3B tumor 29439669
ENSG00000088305 DNMT3B tumor 29449903
ENSG00000088305 DNMT3B breast cancer 29574992
ENSG00000088305 DNMT3B colon cancer 29598829
ENSG00000088305 DNMT3B cervical cancer 29664054
ENSG00000088305 DNMT3B tumour 29717263
ENSG00000088305 DNMT3B tumor 29759938
ENSG00000088305 DNMT3B breast cancer 29796115
ENSG00000088305 DNMT3B tumors 29845195
ENSG00000088305 DNMT3B pediatric AML 29928480
ENSG00000088305 DNMT3B tumor 30002361
ENSG00000088305 DNMT3B cancer 30017965
ENSG00000088305 DNMT3B breast cancer 30103729
ENSG00000088305 DNMT3B tumor 30105866
ENSG00000088305 DNMT3B breast cancer 30139210
ENSG00000088305 DNMT3B tumors 30249036
ENSG00000088305 DNMT3B prostate cancer 30341411
ENSG00000088305 DNMT3B cancer 30405408
ENSG00000088305 DNMT3B tumors 30406101
ENSG00000088305 DNMT3B cancer 30416311
ENSG00000088305 DNMT3B cancer 30465505
ENSG00000088305 DNMT3B cancer 30468428
ENSG00000088305 DNMT3B tumour 30621801
ENSG00000088305 DNMT3B ovarian cancer 30675199
ENSG00000088305 DNMT3B tumors 30692513
ENSG00000088305 DNMT3B tumor 30718452
ENSG00000088305 DNMT3B tumors 30760837
ENSG00000088305 DNMT3B cancers 30788428
ENSG00000088305 DNMT3B cancers 30813436
ENSG00000088305 DNMT3B breast cancer 30851420
ENSG00000088305 DNMT3B cancer 30925862
ENSG00000088305 DNMT3B tumor 30948928
ENSG00000088305 DNMT3B tumor 30950914
ENSG00000088305 DNMT3B tumor 30979371
ENSG00000088305 DNMT3B tumor 31024853
ENSG00000088305 DNMT3B liver tumors 31061957
ENSG00000088305 DNMT3B cancer 31090214
ENSG00000088305 DNMT3B tumour 31105426
ENSG00000088305 DNMT3B tumor 31119097
ENSG00000088305 DNMT3B tumor 31126316
ENSG00000088305 DNMT3B tumors 31144406
ENSG00000088305 DNMT3B tumor 31168296
ENSG00000088305 DNMT3B oral cancer 31253192
ENSG00000088305 DNMT3B tumor 31266538
ENSG00000088305 DNMT3B Cancer 31284662
ENSG00000088305 DNMT3B AML 31331399
ENSG00000088305 DNMT3B breast cancer 31340867
ENSG00000088305 DNMT3B tumour 31364725
ENSG00000088305 DNMT3B cancer 31370354
ENSG00000088305 DNMT3B breast cancer 31413588
ENSG00000088305 DNMT3B tumor 31534549
ENSG00000088305 DNMT3B cancers 31565203
ENSG00000088305 DNMT3B bladder cancer 31572524
ENSG00000088305 DNMT3B ovarian cancer 31615043
ENSG00000088305 DNMT3B oral cancer 31624299
ENSG00000088305 DNMT3B tumors 31637008
ENSG00000088305 DNMT3B breast cancer 31659695
ENSG00000088305 DNMT3B breast cancer 31660998
ENSG00000088305 DNMT3B cancer 31675998
ENSG00000088305 DNMT3B cancer 31828117
ENSG00000088305 DNMT3B prostate cancer 31864524
ENSG00000088305 DNMT3B breast cancer 31880901
ENSG00000088305 DNMT3B tumor 31894272
ENSG00000088305 DNMT3B tumor 31907153
ENSG00000088305 DNMT3B bladder cancer 31971654
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000088305 DNMT3B UVM 0.027 high
ENSG00000088305 DNMT3B UCEC 0.00041 high
ENSG00000088305 DNMT3B THCA 0.039 high
ENSG00000088305 DNMT3B KICH 0.0074 high
ENSG00000088305 DNMT3B LUAD 0.03 high
ENSG00000088305 DNMT3B THYM 0.0051 low
ENSG00000088305 DNMT3B BRCA 0.0059 high
ENSG00000088305 DNMT3B COAD 0.022 high
ENSG00000088305 DNMT3B ESCA 0.00084 high
ENSG00000088305 DNMT3B LAML 0.00099 high
ENSG00000088305 DNMT3B CESC 0.0028 high
ENSG00000088305 DNMT3B LIHC 0.00036 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000088305 DNMT3B LUSC Amp 1.119820 0.208343 0.526120 0.584830
ENSG00000088305 DNMT3B CESC Amp 3.431056 0.223965 0.729207 0.440678
ENSG00000088305 DNMT3B READ Amp 19.573267 0.665386 1.302593 0.884848
ENSG00000088305 DNMT3B COAD Amp 31.651043 0.425266 1.154486 0.713969
ENSG00000088305 DNMT3B UCS Amp 2.064893 0.699201 0.860661 0.767857
ENSG00000088305 DNMT3B HNSC Amp 2.728454 0.162564 0.555795 0.440613
ENSG00000088305 DNMT3B BLCA Amp 4.156575 0.269360 0.593660 0.627451