RBP Type	Non-canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	DataSet_01_413

Ensembl ID	ENSG00000087077	Gene ID	7205	Accession	12311
Symbol	TRIP6	Alias	OIP1;OIP-1;ZRP-1;TRIP-6;TRIP6i2	Full Name	thyroid hormone receptor interactor 6
Status	Confidence	Length	6068 bases	Strand	Plus strand
Position	7 : 100867387 - 100873454	RNA binding domain	N.A.
Summary	This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
32585685	Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation.	R Megan Chastney	2020-08-03	The Journal of cell biology

Name	Transcript ID	bp	Protein	Translation ID
TRIP6-208	ENST00000496260	451	No protein	-
TRIP6-202	ENST00000417475	992	106aa	ENSP00000413817
TRIP6-201	ENST00000200457	1693	476aa	ENSP00000200457
TRIP6-206	ENST00000476870	1750	No protein	-
TRIP6-204	ENST00000437505	875	80aa	ENSP00000410736
TRIP6-209	ENST00000619988	1303	80aa	ENSP00000479865
TRIP6-205	ENST00000463125	835	No protein	-
TRIP6-203	ENST00000429658	646	215aa	ENSP00000389194
TRIP6-207	ENST00000488670	615	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
60581	Plasminogen Activator Inhibitor 1	2.1090000E-006	24578379
60586	Plasminogen Activator Inhibitor 1	2.6770000E-009	24578379
60615	Plasminogen Activator Inhibitor 1	3.6140000E-009	24578379

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000087077	homo_sapiens	ENSP00000324422	42.3077	32.6923	homo_sapiens	ENSP00000200457	50.8403	39.2857

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000087077	homo_sapiens	ENSP00000200457	89.2857	88.6555	nomascus_leucogenys	ENSNLEP00000014554	95.0783	94.4072
ENSG00000087077	homo_sapiens	ENSP00000200457	99.1597	98.9496	pan_paniscus	ENSPPAP00000017450	99.1597	98.9496
ENSG00000087077	homo_sapiens	ENSP00000200457	98.5294	98.5294	pongo_abelii	ENSPPYP00000019541	98.5294	98.5294
ENSG00000087077	homo_sapiens	ENSP00000200457	99.3698	99.1597	pan_troglodytes	ENSPTRP00000033404	99.3698	99.1597
ENSG00000087077	homo_sapiens	ENSP00000200457	99.1597	99.1597	gorilla_gorilla	ENSGGOP00000001486	99.1597	99.1597
ENSG00000087077	homo_sapiens	ENSP00000200457	69.3277	63.8655	ornithorhynchus_anatinus	ENSOANP00000052164	71.7391	66.087
ENSG00000087077	homo_sapiens	ENSP00000200457	77.1008	72.6891	sarcophilus_harrisii	ENSSHAP00000024491	78.7554	74.2489
ENSG00000087077	homo_sapiens	ENSP00000200457	76.6807	72.2689	notamacropus_eugenii	ENSMEUP00000015123	83.1435	78.3599
ENSG00000087077	homo_sapiens	ENSP00000200457	91.8067	89.4958	dasypus_novemcinctus	ENSDNOP00000002955	92	89.6842
ENSG00000087077	homo_sapiens	ENSP00000200457	41.8067	38.4454	erinaceus_europaeus	ENSEEUP00000011892	59.9398	55.1205
ENSG00000087077	homo_sapiens	ENSP00000200457	44.5378	43.0672	echinops_telfairi	ENSETEP00000012678	63.6637	61.5616
ENSG00000087077	homo_sapiens	ENSP00000200457	96.4286	96.2185	callithrix_jacchus	ENSCJAP00000027545	96.4286	96.2185
ENSG00000087077	homo_sapiens	ENSP00000200457	98.5294	98.3193	cercocebus_atys	ENSCATP00000040225	98.5294	98.3193
ENSG00000087077	homo_sapiens	ENSP00000200457	61.7647	61.3445	macaca_fascicularis	ENSMFAP00000021328	95.1456	94.4984
ENSG00000087077	homo_sapiens	ENSP00000200457	37.605	34.4538	macaca_mulatta	ENSMMUP00000073815	58.8816	53.9474
ENSG00000087077	homo_sapiens	ENSP00000200457	98.5294	98.3193	macaca_mulatta	ENSMMUP00000027988	98.5294	98.3193
ENSG00000087077	homo_sapiens	ENSP00000200457	97.8992	97.6891	macaca_nemestrina	ENSMNEP00000033231	97.8992	97.6891
ENSG00000087077	homo_sapiens	ENSP00000200457	98.3193	98.1092	papio_anubis	ENSPANP00000015856	98.3193	98.1092
ENSG00000087077	homo_sapiens	ENSP00000200457	98.5294	98.3193	mandrillus_leucophaeus	ENSMLEP00000036214	98.5294	98.3193
ENSG00000087077	homo_sapiens	ENSP00000200457	74.5798	72.479	tursiops_truncatus	ENSTTRP00000010527	74.7368	72.6316
ENSG00000087077	homo_sapiens	ENSP00000200457	90.7563	86.9748	vulpes_vulpes	ENSVVUP00000032516	89.2562	85.5372
ENSG00000087077	homo_sapiens	ENSP00000200457	90.7563	87.1849	mus_spretus	MGP_SPRETEiJ_P0074299	90	86.4583
ENSG00000087077	homo_sapiens	ENSP00000200457	84.4538	80.042	equus_asinus	ENSEASP00005053301	64.7343	61.3527
ENSG00000087077	homo_sapiens	ENSP00000200457	93.6975	90.7563	capra_hircus	ENSCHIP00000011483	92.7235	89.8129
ENSG00000087077	homo_sapiens	ENSP00000200457	92.6471	90.5462	loxodonta_africana	ENSLAFP00000018827	91.875	89.7917
ENSG00000087077	homo_sapiens	ENSP00000200457	92.437	89.7059	panthera_leo	ENSPLOP00000020172	92.0502	89.3305
ENSG00000087077	homo_sapiens	ENSP00000200457	93.2773	90.5462	ailuropoda_melanoleuca	ENSAMEP00000015314	94.0678	91.3136
ENSG00000087077	homo_sapiens	ENSP00000200457	57.9832	55.2521	bos_indicus_hybrid	ENSBIXP00005015853	88.1789	84.0256
ENSG00000087077	homo_sapiens	ENSP00000200457	93.6975	91.1765	bos_indicus_hybrid	ENSBIXP00005006325	87.2798	84.9315
ENSG00000087077	homo_sapiens	ENSP00000200457	84.6639	80.2521	equus_caballus	ENSECAP00000074072	64.8953	61.5137
ENSG00000087077	homo_sapiens	ENSP00000200457	92.437	89.2857	canis_lupus_familiaris	ENSCAFP00845000955	92.0502	88.9121
ENSG00000087077	homo_sapiens	ENSP00000200457	92.2269	89.2857	panthera_pardus	ENSPPRP00000020533	93.2059	90.2335
ENSG00000087077	homo_sapiens	ENSP00000200457	93.6975	91.3866	marmota_marmota_marmota	ENSMMMP00000013234	92.1488	89.876
ENSG00000087077	homo_sapiens	ENSP00000200457	94.7479	92.6471	balaenoptera_musculus	ENSBMSP00010015044	93.763	91.684
ENSG00000087077	homo_sapiens	ENSP00000200457	92.2269	90.1261	cavia_porcellus	ENSCPOP00000001568	91.4583	89.375
ENSG00000087077	homo_sapiens	ENSP00000200457	92.437	89.7059	felis_catus	ENSFCAP00000006363	92.0502	89.3305
ENSG00000087077	homo_sapiens	ENSP00000200457	92.6471	89.916	ursus_americanus	ENSUAMP00000036971	92.2594	89.5397
ENSG00000087077	homo_sapiens	ENSP00000200457	72.479	67.0168	monodelphis_domestica	ENSMODP00000055213	69.4165	64.1851
ENSG00000087077	homo_sapiens	ENSP00000200457	94.1176	92.0168	monodon_monoceros	ENSMMNP00015011972	92.7536	90.6832
ENSG00000087077	homo_sapiens	ENSP00000200457	93.2773	90.7563	sus_scrofa	ENSSSCP00000021756	92.3077	89.8129
ENSG00000087077	homo_sapiens	ENSP00000200457	94.7479	93.0672	microcebus_murinus	ENSMICP00000008607	93.9583	92.2917
ENSG00000087077	homo_sapiens	ENSP00000200457	92.437	89.916	octodon_degus	ENSODEP00000022803	91.4761	88.9813
ENSG00000087077	homo_sapiens	ENSP00000200457	77.1008	73.1092	jaculus_jaculus	ENSJJAP00000023342	88.2212	83.6538
ENSG00000087077	homo_sapiens	ENSP00000200457	93.4874	90.9664	ovis_aries_rambouillet	ENSOARP00020019083	92.5156	90.0208
ENSG00000087077	homo_sapiens	ENSP00000200457	92.6471	89.916	ursus_maritimus	ENSUMAP00000015387	92.2594	89.5397
ENSG00000087077	homo_sapiens	ENSP00000200457	69.958	66.8067	ochotona_princeps	ENSOPRP00000001780	69.375	66.25
ENSG00000087077	homo_sapiens	ENSP00000200457	82.9832	81.3025	delphinapterus_leucas	ENSDLEP00000011402	79	77.4
ENSG00000087077	homo_sapiens	ENSP00000200457	92.6471	90.1261	physeter_catodon	ENSPCTP00005029053	90.3689	87.9098
ENSG00000087077	homo_sapiens	ENSP00000200457	90.5462	86.7647	mus_caroli	MGP_CAROLIEiJ_P0071485	89.7917	86.0417
ENSG00000087077	homo_sapiens	ENSP00000200457	90.7563	87.1849	mus_musculus	ENSMUSP00000024119	90	86.4583
ENSG00000087077	homo_sapiens	ENSP00000200457	91.5966	88.8655	dipodomys_ordii	ENSDORP00000005222	90.4564	87.7593
ENSG00000087077	homo_sapiens	ENSP00000200457	96.4286	96.2185	aotus_nancymaae	ENSANAP00000030340	96.4286	96.2185
ENSG00000087077	homo_sapiens	ENSP00000200457	97.0588	96.6387	saimiri_boliviensis_boliviensis	ENSSBOP00000039710	97.0588	96.6387
ENSG00000087077	homo_sapiens	ENSP00000200457	98.7395	98.5294	chlorocebus_sabaeus	ENSCSAP00000014010	98.7395	98.5294
ENSG00000087077	homo_sapiens	ENSP00000200457	63.6555	61.7647	tupaia_belangeri	ENSTBEP00000004280	63.522	61.6352
ENSG00000087077	homo_sapiens	ENSP00000200457	91.5966	87.605	mesocricetus_auratus	ENSMAUP00000015168	90.8333	86.875
ENSG00000087077	homo_sapiens	ENSP00000200457	94.1176	92.0168	phocoena_sinus	ENSPSNP00000010477	92.7536	90.6832
ENSG00000087077	homo_sapiens	ENSP00000200457	92.437	90.1261	camelus_dromedarius	ENSCDRP00005021745	91.4761	89.1892
ENSG00000087077	homo_sapiens	ENSP00000200457	94.1176	91.8067	carlito_syrichta	ENSTSYP00000021011	94.3158	92
ENSG00000087077	homo_sapiens	ENSP00000200457	91.5966	88.8655	panthera_tigris_altaica	ENSPTIP00000015892	92.569	89.8089
ENSG00000087077	homo_sapiens	ENSP00000200457	84.6639	81.5126	rattus_norvegicus	ENSRNOP00000084948	83.0928	80
ENSG00000087077	homo_sapiens	ENSP00000200457	94.958	93.4874	prolemur_simus	ENSPSMP00000027427	94.1667	92.7083
ENSG00000087077	homo_sapiens	ENSP00000200457	92.6471	89.0756	microtus_ochrogaster	ENSMOCP00000004257	91.875	88.3333
ENSG00000087077	homo_sapiens	ENSP00000200457	50.6303	46.8487	sorex_araneus	ENSSARP00000010333	74.8447	69.2547
ENSG00000087077	homo_sapiens	ENSP00000200457	92.6471	88.6555	peromyscus_maniculatus_bairdii	ENSPEMP00000007574	91.684	87.7339
ENSG00000087077	homo_sapiens	ENSP00000200457	92.6471	89.0756	bos_mutus	ENSBMUP00000024664	92.6471	89.0756
ENSG00000087077	homo_sapiens	ENSP00000200457	90.1261	86.5546	mus_spicilegus	ENSMSIP00000011392	89.375	85.8333
ENSG00000087077	homo_sapiens	ENSP00000200457	92.437	88.6555	cricetulus_griseus_chok1gshd	ENSCGRP00001019674	91.6667	87.9167
ENSG00000087077	homo_sapiens	ENSP00000200457	71.4286	68.2773	pteropus_vampyrus	ENSPVAP00000014402	70.9812	67.8497
ENSG00000087077	homo_sapiens	ENSP00000200457	90.9664	87.1849	myotis_lucifugus	ENSMLUP00000009069	89.4628	85.7438
ENSG00000087077	homo_sapiens	ENSP00000200457	78.1513	74.1597	vombatus_ursinus	ENSVURP00010001310	80.1724	76.0776
ENSG00000087077	homo_sapiens	ENSP00000200457	92.6471	90.1261	rhinolophus_ferrumequinum	ENSRFEP00010005785	91.4938	89.0042
ENSG00000087077	homo_sapiens	ENSP00000200457	92.6471	89.916	neovison_vison	ENSNVIP00000001935	92.2594	89.5397
ENSG00000087077	homo_sapiens	ENSP00000200457	93.6975	91.1765	bos_taurus	ENSBTAP00000001503	92.7235	90.2287
ENSG00000087077	homo_sapiens	ENSP00000200457	67.2269	65.3361	heterocephalus_glaber_female	ENSHGLP00000054259	70.7965	68.8053
ENSG00000087077	homo_sapiens	ENSP00000200457	98.5294	98.1092	rhinopithecus_bieti	ENSRBIP00000008948	98.5294	98.1092
ENSG00000087077	homo_sapiens	ENSP00000200457	92.437	89.2857	canis_lupus_dingo	ENSCAFP00020017234	92.0502	88.9121
ENSG00000087077	homo_sapiens	ENSP00000200457	94.1176	92.0168	sciurus_vulgaris	ENSSVLP00005021585	92.562	90.4959
ENSG00000087077	homo_sapiens	ENSP00000200457	74.7899	70.3782	phascolarctos_cinereus	ENSPCIP00000054583	67.0433	63.0885
ENSG00000087077	homo_sapiens	ENSP00000200457	91.3866	88.6555	procavia_capensis	ENSPCAP00000001474	90.8142	88.1002
ENSG00000087077	homo_sapiens	ENSP00000200457	87.8151	84.2437	nannospalax_galili	ENSNGAP00000022245	86.722	83.195
ENSG00000087077	homo_sapiens	ENSP00000200457	88.4454	85.5042	bos_grunniens	ENSBGRP00000029288	85.0505	82.2222
ENSG00000087077	homo_sapiens	ENSP00000200457	93.0672	90.1261	chinchilla_lanigera	ENSCLAP00000002488	92.2917	89.375
ENSG00000087077	homo_sapiens	ENSP00000200457	93.6975	90.5462	cervus_hanglu_yarkandensis	ENSCHYP00000022730	92.7235	89.605
ENSG00000087077	homo_sapiens	ENSP00000200457	92.8571	90.7563	catagonus_wagneri	ENSCWAP00000021331	91.134	89.0722
ENSG00000087077	homo_sapiens	ENSP00000200457	93.4874	91.1765	ictidomys_tridecemlineatus	ENSSTOP00000020280	91.9421	89.6694
ENSG00000087077	homo_sapiens	ENSP00000200457	93.6975	91.5966	otolemur_garnettii	ENSOGAP00000012266	92.9167	90.8333
ENSG00000087077	homo_sapiens	ENSP00000200457	96.6387	96.4286	cebus_imitator	ENSCCAP00000038108	96.6387	96.4286
ENSG00000087077	homo_sapiens	ENSP00000200457	93.4874	90.9664	urocitellus_parryii	ENSUPAP00010022044	92.7083	90.2083
ENSG00000087077	homo_sapiens	ENSP00000200457	93.6975	90.7563	moschus_moschiferus	ENSMMSP00000014873	82.4399	79.8521
ENSG00000087077	homo_sapiens	ENSP00000200457	98.3193	97.8992	rhinopithecus_roxellana	ENSRROP00000014498	98.3193	97.8992
ENSG00000087077	homo_sapiens	ENSP00000200457	90.9664	86.9748	mus_pahari	MGP_PahariEiJ_P0059776	90.2083	86.25
ENSG00000087077	homo_sapiens	ENSP00000200457	94.7479	92.8571	propithecus_coquereli	ENSPCOP00000003030	93.9583	92.0833
ENSG00000087077	homo_sapiens	ENSP00000200457	24.5798	15.9664	caenorhabditis_elegans	F09B9.2b.1	18.3099	11.8936
ENSG00000087077	homo_sapiens	ENSP00000200457	37.605	27.3109	eptatretus_burgeri	ENSEBUP00000004620	40.0447	29.0828
ENSG00000087077	homo_sapiens	ENSP00000200457	65.9664	53.1513	danio_rerio	ENSDARP00000142895	54.9912	44.3082
ENSG00000087077	homo_sapiens	ENSP00000200457	65.5462	52.1008	carassius_auratus	ENSCARP00000118998	53.9792	42.9066
ENSG00000087077	homo_sapiens	ENSP00000200457	65.9664	53.5714	oncorhynchus_mykiss	ENSOMYP00000026898	57.0909	46.3636
ENSG00000087077	homo_sapiens	ENSP00000200457	60.7143	47.479	oncorhynchus_mykiss	ENSOMYP00000071337	50.0867	39.1681
ENSG00000087077	homo_sapiens	ENSP00000200457	53.7815	42.8571	oncorhynchus_mykiss	ENSOMYP00000122282	59.8131	47.6636
ENSG00000087077	homo_sapiens	ENSP00000200457	65.9664	53.5714	oncorhynchus_mykiss	ENSOMYP00000026884	57.0909	46.3636
ENSG00000087077	homo_sapiens	ENSP00000200457	61.3445	46.8487	salmo_salar	ENSSSAP00000114676	50.9599	38.918
ENSG00000087077	homo_sapiens	ENSP00000200457	31.7227	21.4286	haplochromis_burtoni	ENSHBUP00000020992	37.5622	25.3731
ENSG00000087077	homo_sapiens	ENSP00000200457	61.5546	48.3193	hucho_hucho	ENSHHUP00000041757	46.5819	36.566
ENSG00000087077	homo_sapiens	ENSP00000200457	31.9328	20.3782	anabas_testudineus	ENSATEP00000010916	39.1753	25
ENSG00000087077	homo_sapiens	ENSP00000200457	32.7731	21.6387	labrus_bergylta	ENSLBEP00000027562	31.7719	20.9776
ENSG00000087077	homo_sapiens	ENSP00000200457	61.3445	48.1092	oncorhynchus_tshawytscha	ENSOTSP00005101305	50.4318	39.5509
ENSG00000087077	homo_sapiens	ENSP00000200457	65.3361	52.3109	cyprinus_carpio_carpio	ENSCCRP00000053257	53.8062	43.0796
ENSG00000087077	homo_sapiens	ENSP00000200457	65.3361	53.1513	cyprinus_carpio_carpio	ENSCCRP00000086411	54.1812	44.0767
ENSG00000087077	homo_sapiens	ENSP00000200457	32.3529	22.8992	scleropages_formosus	ENSSFOP00015015963	38.1188	26.9802
ENSG00000087077	homo_sapiens	ENSP00000200457	65.1261	53.1513	scophthalmus_maximus	ENSSMAP00000013894	53.913	44

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001725	is_active_in stress fiber	1	IBA	Homo_sapiens(9606)	Component
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0005149	enables interleukin-1 receptor binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0005856	located_in cytoskeleton	1	IDA	Homo_sapiens(9606)	Component
GO:0005886	located_in plasma membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0005925	located_in focal adhesion	3	HDA,IBA,IDA	Homo_sapiens(9606)	Component
GO:0007165	involved_in signal transduction	1	IBA	Homo_sapiens(9606)	Process
GO:0019900	enables kinase binding	1	IPI	Homo_sapiens(9606)	Function
GO:0030335	involved_in positive regulation of cell migration	1	IMP	Homo_sapiens(9606)	Process
GO:0043009	involved_in chordate embryonic development	1	IEA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0046966	enables nuclear thyroid hormone receptor binding	1	NAS	Homo_sapiens(9606)	Function
GO:0048041	involved_in focal adhesion assembly	1	NAS	Homo_sapiens(9606)	Process
GO:1901224	involved_in positive regulation of NIK/NF-kappaB signaling	2	IBA,IDA	Homo_sapiens(9606)	Process