Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerSARS-COV-2DengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations Stress granucleNucleoli
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000070366 Gene ID 23293 Accession 17809
Symbol SMG6 Alias EST1A;SMG-6;hEST1A;C17orf31;hSMG5/7a Full Name SMG6 nonsense mediated mRNA decay factor
Status Confidence Length 243943 bases Strand Minus strand
Position 17 : 2059843 - 2303785 RNA binding domain EST1 , PIN_4 , EST1_DNA_bind
Summary This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000263073 EST1_DNA_bind PF10373 8.1e-61 1
ENSP00000263073 EST1 PF10374 5.6e-14 2
ENSP00000263073 PIN_4 PF13638 9.6e-21 3
ENSP00000346977 EST1_DNA_bind PF10373 1.2e-17 1
ENSP00000346977 PIN_4 PF13638 6.1e-21 2
ENSP00000440283 EST1_DNA_bind PF10373 1.2e-17 1
ENSP00000440283 PIN_4 PF13638 6.1e-21 2
ENSP00000459164 EST1_DNA_bind PF10373 2e-13 1
ENSP00000460898 EST1_DNA_bind PF10373 2.3e-13 1
ENSP00000458635 EST1_DNA_bind PF10373 2.5e-13 1
ENSP00000465793 EST1_DNA_bind PF10373 8.2e-09 1
ENSP00000460191 EST1_DNA_bind PF10373 2.9e-08 1
ENSP00000466139 EST1_DNA_bind PF10373 3.5e-07 1
ENSP00000460301 EST1_DNA_bind PF10373 6.1e-07 1
ENSP00000466951 EST1_DNA_bind PF10373 0.0002 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
21965535 N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Yukiko Okada-Katsuhata 2012-02-01 Nucleic acids research
29272451 Nonsense-mediated mRNA decay: a 'nonsense' pathway makes sense in stem cell biology. Xin Han 2018-02-16 Nucleic acids research
25053839 A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD. Pamela Nicholson 2014-08-01 Nucleic acids research
18679436 The multiple lives of NMD factors: balancing roles in gene and genome regulation. Olaf Isken 2008-09-01 Nature reviews. Genetics
28402567 Nonsense-mediated mRNA decay in Tetrahymena is EJC independent and requires a protozoa-specific nuclease. Miao Tian 2017-06-20 Nucleic acids research
33930627 Programmable technologies to manipulate gene expression at the RNA level. Huachun Liu 2021-10-01 Current opinion in chemical biology
29363864 SRR intronic variation inhibits expression of its neighbouring SMG6 gene and protects against temporal lobe epilepsy. Hua Tao 2018-03-01 Journal of cellular and molecular medicine

Transcripts

Name Transcript ID bp Protein Translation ID
SMG6-215 ENST00000574501 2419 No protein -
SMG6-201 ENST00000263073 5974 1419aa ENSP00000263073
SMG6-213 ENST00000573166 4236 No protein -
SMG6-202 ENST00000354901 3473 511aa ENSP00000346977
SMG6-207 ENST00000570756 2426 No protein -
SMG6-220 ENST00000576218 902 No protein -
SMG6-203 ENST00000536871 1865 511aa ENSP00000440283
SMG6-212 ENST00000573153 552 No protein -
SMG6-214 ENST00000573827 601 No protein -
SMG6-218 ENST00000575454 652 208aa ENSP00000460273
SMG6-217 ENST00000575338 546 No protein -
SMG6-208 ENST00000570874 533 No protein -
SMG6-211 ENST00000572369 689 138aa ENSP00000465793
SMG6-216 ENST00000575176 557 124aa ENSP00000466139
SMG6-210 ENST00000572205 551 115aa ENSP00000466951
SMG6-209 ENST00000571442 588 164aa ENSP00000459164
SMG6-205 ENST00000570659 592 163aa ENSP00000460898
SMG6-219 ENST00000575663 574 162aa ENSP00000458635
SMG6-204 ENST00000570606 572 123aa ENSP00000460191
SMG6-206 ENST00000570668 547 119aa ENSP00000460301

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
60689Body Mass Index2E-825673413
62987Body Mass Index9E-825673413
66471Myocardial Infarction3E-626343387
67004Schizophrenia1E-926198764
68138Hydroxyindoleacetic Acid3E-623319000
68655Coronary Disease9E-1021378990
73898Schizophrenia6E-823974872
74605Schizophrenia3E-1025056061
75023Bone Density1E-1822504420
82345Mitral Valve Prolapse2E-826301497
83082Body Mass Index8E-825673413
83083Coronary Artery Disease5E-726343387
84319Coronary Disease1E-921378990
88380Aorta2E-1119584346
89309Carcinoma, Squamous Cell2E-1122960999
89310Esophageal Neoplasms2E-1122960999
99397Schizophrenia7E-626198764
102101Coronary Disease1E-724262325

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000070366

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000070366homo_sapiensENSP0000026307396.758395.3488nomascus_leucogenysENSNLEP0000002087298.211796.7811
ENSG00000070366homo_sapiensENSP0000026307399.224898.1677pan_paniscusENSPPAP0000004137399.224898.1677
ENSG00000070366homo_sapiensENSP0000026307396.687894.926pongo_abeliiENSPPYP0000000877695.145693.4119
ENSG00000070366homo_sapiensENSP0000026307399.224898.3791pan_troglodytesENSPTRP0000001458399.224898.3791
ENSG00000070366homo_sapiensENSP0000026307399.083998.2382gorilla_gorillaENSGGOP0000002016299.083998.2382
ENSG00000070366homo_sapiensENSP0000026307334.601833.6152ornithorhynchus_anatinusENSOANP0000003016096.086193.3464
ENSG00000070366homo_sapiensENSP0000026307390.133983.6505sarcophilus_harrisiiENSSHAP0000001169590.388783.8869
ENSG00000070366homo_sapiensENSP0000026307385.905679.9859notamacropus_eugeniiENSMEUP0000001443788.07882.0087
ENSG00000070366homo_sapiensENSP0000026307346.088843.1994choloepus_hoffmanniENSCHOP0000000445658.497354.8301
ENSG00000070366homo_sapiensENSP0000026307395.489891.8957dasypus_novemcinctusENSDNOP0000002405795.489891.8957
ENSG00000070366homo_sapiensENSP0000026307384.989481.6068erinaceus_europaeusENSEEUP0000000321585.897482.4786
ENSG00000070366homo_sapiensENSP0000026307384.91980.6202echinops_telfairiENSETEP0000001362685.15980.8481
ENSG00000070366homo_sapiensENSP0000026307393.657590.9091callithrix_jacchusENSCJAP0000008087578.176575.8824
ENSG00000070366homo_sapiensENSP0000026307398.167796.6878cercocebus_atysENSCATP0000001603998.167796.6878
ENSG00000070366homo_sapiensENSP0000026307396.405994.8555macaca_fascicularisENSMFAP0000003380098.559196.9741
ENSG00000070366homo_sapiensENSP0000026307398.590696.9697macaca_mulattaENSMMUP0000003048898.590696.9697
ENSG00000070366homo_sapiensENSP0000026307394.362291.8957macaca_nemestrinaENSMNEP0000004396496.539394.0159
ENSG00000070366homo_sapiensENSP0000026307398.379196.8992papio_anubisENSPANP0000001949398.379196.8992
ENSG00000070366homo_sapiensENSP0000026307394.855592.53mandrillus_leucophaeusENSMLEP0000001045297.60795.2139
ENSG00000070366homo_sapiensENSP0000026307383.791480.7611tursiops_truncatusENSTTRP0000000110284.326281.2766
ENSG00000070366homo_sapiensENSP0000026307395.630792.53vulpes_vulpesENSVVUP0000002976596.104892.9887
ENSG00000070366homo_sapiensENSP0000026307395.066990.8386mus_spretusMGP_SPRETEiJ_P002960495.13490.9027
ENSG00000070366homo_sapiensENSP0000026307396.405993.1642equus_asinusENSEASP0000501336396.202592.9677
ENSG00000070366homo_sapiensENSP0000026307395.701292.1071capra_hircusENSCHIP0000002510396.243892.6293
ENSG00000070366homo_sapiensENSP0000026307395.419392.2481loxodonta_africanaENSLAFP0000002064395.28592.1182
ENSG00000070366homo_sapiensENSP0000026307396.758393.8689panthera_leoENSPLOP0000001640497.169194.2675
ENSG00000070366homo_sapiensENSP0000026307396.053692.9528ailuropoda_melanoleucaENSAMEP0000000805896.598293.4798
ENSG00000070366homo_sapiensENSP0000026307395.771792.1071bos_indicus_hybridENSBIXP0000500748786.560583.2484
ENSG00000070366homo_sapiensENSP0000026307394.785191.1205oryctolagus_cuniculusENSOCUP0000004946793.728290.1045
ENSG00000070366homo_sapiensENSP0000026307396.405992.8823equus_caballusENSECAP0000000493096.202592.6864
ENSG00000070366homo_sapiensENSP0000026307395.771792.6709canis_lupus_familiarisENSCAFP0084501970796.246593.1303
ENSG00000070366homo_sapiensENSP0000026307396.758393.9394panthera_pardusENSPPRP0000002431597.169194.3383
ENSG00000070366homo_sapiensENSP0000026307396.617393.5166marmota_marmota_marmotaENSMMMP0000002760096.685593.5825
ENSG00000070366homo_sapiensENSP0000026307395.912692.8823balaenoptera_musculusENSBMSP0001002710096.456493.4089
ENSG00000070366homo_sapiensENSP0000026307394.92690.3453cavia_porcellusENSCPOP0000001340694.859290.2817
ENSG00000070366homo_sapiensENSP0000026307396.758393.8689felis_catusENSFCAP0000002330597.169194.2675
ENSG00000070366homo_sapiensENSP0000026307396.12493.1642ursus_americanusENSUAMP0000003298296.463993.4936
ENSG00000070366homo_sapiensENSP0000026307335.236134.2495monodelphis_domesticaENSMODP0000001330597.847495.1076
ENSG00000070366homo_sapiensENSP0000026307395.771792.1776bison_bison_bisonENSBBBP0000002664996.314792.7002
ENSG00000070366homo_sapiensENSP0000026307395.630792.3185monodon_monocerosENSMMNP0001502762796.172992.842
ENSG00000070366homo_sapiensENSP0000026307395.489891.8252sus_scrofaENSSSCP0000001888695.963292.2805
ENSG00000070366homo_sapiensENSP0000026307397.322194.5032microcebus_murinusENSMICP0000001177297.390794.5698
ENSG00000070366homo_sapiensENSP0000026307391.0586.8922octodon_degusENSODEP0000001078895.069990.7285
ENSG00000070366homo_sapiensENSP0000026307377.237571.3178jaculus_jaculusENSJJAP0000001230090.803683.8442
ENSG00000070366homo_sapiensENSP0000026307395.701292.1071ovis_aries_rambouilletENSOARP0002002855896.243892.6293
ENSG00000070366homo_sapiensENSP0000026307394.221391.191ursus_maritimusENSUMAP0000001251796.884193.7681
ENSG00000070366homo_sapiensENSP0000026307353.981752.0789ochotona_princepsENSOPRP0000000053279.708676.8991
ENSG00000070366homo_sapiensENSP0000026307395.348892.0366delphinapterus_leucasENSDLEP0000001654695.889492.5585
ENSG00000070366homo_sapiensENSP0000026307376.744272.8682physeter_catodonENSPCTP0000500962194.613489.8349
ENSG00000070366homo_sapiensENSP0000026307395.207990.9091mus_caroliMGP_CAROLIEiJ_P002821395.27590.9732
ENSG00000070366homo_sapiensENSP0000026307395.207990.8386mus_musculusENSMUSP0000004355595.27590.9027
ENSG00000070366homo_sapiensENSP0000026307393.234788.654dipodomys_ordiiENSDORP0000002144693.763389.1566
ENSG00000070366homo_sapiensENSP0000026307395.842192.8823mustela_putorius_furoENSMPUP0000001294796.249193.2767
ENSG00000070366homo_sapiensENSP0000026307396.899295.2079aotus_nancymaaeENSANAP0000003659096.899295.2079
ENSG00000070366homo_sapiensENSP0000026307396.758395.0669saimiri_boliviensis_boliviensisENSSBOP0000001157685.866284.3652
ENSG00000070366homo_sapiensENSP0000026307375.052971.5997vicugna_pacosENSVPAP0000000020779.241175.5952
ENSG00000070366homo_sapiensENSP0000026307398.590697.0402chlorocebus_sabaeusENSCSAP0000000995398.590697.0402
ENSG00000070366homo_sapiensENSP0000026307391.543388.3721tupaia_belangeriENSTBEP0000000990691.997288.8102
ENSG00000070366homo_sapiensENSP0000026307315.644815.081mesocricetus_auratusENSMAUP0000001871896.103992.6407
ENSG00000070366homo_sapiensENSP0000026307395.489891.9662phocoena_sinusENSPSNP0000002843796.031292.4876
ENSG00000070366homo_sapiensENSP0000026307395.983192.53camelus_dromedariusENSCDRP0000501321396.527393.0546
ENSG00000070366homo_sapiensENSP0000026307396.12493.0233carlito_syrichtaENSTSYP0000000313496.12493.0233
ENSG00000070366homo_sapiensENSP0000026307394.785191.9662panthera_tigris_altaicaENSPTIP0000000725795.187592.3567
ENSG00000070366homo_sapiensENSP0000026307395.419391.3319rattus_norvegicusENSRNOP0000000405891.983788.0435
ENSG00000070366homo_sapiensENSP0000026307315.856215.2925microtus_ochrogasterENSMOCP0000002310796.153892.735
ENSG00000070366homo_sapiensENSP0000026307395.489891.5433peromyscus_maniculatus_bairdiiENSPEMP0000002376295.624691.6725
ENSG00000070366homo_sapiensENSP0000026307390.979687.1036bos_mutusENSBMUP0000002821695.985191.8959
ENSG00000070366homo_sapiensENSP0000026307395.137490.8386mus_spicilegusENSMSIP0000002826186.151982.2591
ENSG00000070366homo_sapiensENSP0000026307352.431348.7667cricetulus_griseus_chok1gshdENSCGRP0000102043093.350186.8256
ENSG00000070366homo_sapiensENSP0000026307379.70477.4489pteropus_vampyrusENSPVAP0000000204079.929377.6678
ENSG00000070366homo_sapiensENSP0000026307396.12492.1776myotis_lucifugusENSMLUP0000000525396.737692.766
ENSG00000070366homo_sapiensENSP0000026307391.613884.9894vombatus_ursinusENSVURP0001001024992.395285.7143
ENSG00000070366homo_sapiensENSP0000026307396.335492.9528rhinolophus_ferrumequinumENSRFEP0001001074496.881693.4798
ENSG00000070366homo_sapiensENSP0000026307394.503291.05neovison_visonENSNVIP0000001483294.303890.8579
ENSG00000070366homo_sapiensENSP0000026307395.771792.1776bos_taurusENSBTAP0000000033396.314792.7002
ENSG00000070366homo_sapiensENSP0000026307395.630791.4729heterocephalus_glaber_femaleENSHGLP0000001798195.42991.2799
ENSG00000070366homo_sapiensENSP0000026307398.520196.8992rhinopithecus_bietiENSRBIP0000000567098.520196.8992
ENSG00000070366homo_sapiensENSP0000026307395.771792.6709canis_lupus_dingoENSCAFP0002001215496.246593.1303
ENSG00000070366homo_sapiensENSP0000026307335.729435.5884sciurus_vulgarisENSSVLP0000502881699.217298.8258
ENSG00000070366homo_sapiensENSP0000026307334.954233.6152phascolarctos_cinereusENSPCIP0000004240497.064693.3464
ENSG00000070366homo_sapiensENSP0000026307392.177687.7378procavia_capensisENSPCAP0000000055692.503588.0481
ENSG00000070366homo_sapiensENSP0000026307392.459588.2311nannospalax_galiliENSNGAP0000000522194.592690.2668
ENSG00000070366homo_sapiensENSP0000026307391.543387.3855bos_grunniensENSBGRP0000003921988.790284.7573
ENSG00000070366homo_sapiensENSP0000026307395.701291.8957chinchilla_lanigeraENSCLAP0000000973795.701291.8957
ENSG00000070366homo_sapiensENSP0000026307395.912692.6004cervus_hanglu_yarkandensisENSCHYP0000001976396.456493.1254
ENSG00000070366homo_sapiensENSP0000026307395.630791.8957catagonus_wagneriENSCWAP0000000149096.172992.4167
ENSG00000070366homo_sapiensENSP0000026307396.687893.4461ictidomys_tridecemlineatusENSSTOP0000002396796.75693.512
ENSG00000070366homo_sapiensENSP0000026307396.828894.0099otolemur_garnettiiENSOGAP0000000400396.760693.9437
ENSG00000070366homo_sapiensENSP0000026307397.040295.4898cebus_imitatorENSCCAP0000003578697.040295.4898
ENSG00000070366homo_sapiensENSP0000026307396.617393.3756urocitellus_parryiiENSUPAP0001002250096.685593.4415
ENSG00000070366homo_sapiensENSP0000026307395.348891.4024moschus_moschiferusENSMMSP0000000841496.025692.0511
ENSG00000070366homo_sapiensENSP0000026307398.520196.8992rhinopithecus_roxellanaENSRROP0000001223898.520196.8992
ENSG00000070366homo_sapiensENSP0000026307394.92690.4158mus_pahariMGP_PahariEiJ_P003495495.0690.5434
ENSG00000070366homo_sapiensENSP0000026307397.251694.2918propithecus_coquereliENSPCOP0000001811197.251694.2918
ENSG00000070366homo_sapiensENSP0000026307335.799918.5342caenorhabditis_elegansY54F10AL.2a.140.934721.1926
ENSG00000070366homo_sapiensENSP0000026307332.276317.8295drosophila_melanogasterFBpp008417148.312226.6878
ENSG00000070366homo_sapiensENSP000002630738.668085.84919ciona_intestinalisENSCINP0000003647569.886447.1591
ENSG00000070366homo_sapiensENSP0000026307318.745612.3326ciona_intestinalisENSCINP0000002021954.845436.0825
ENSG00000070366homo_sapiensENSP0000026307357.575841.3672eptatretus_burgeriENSEBUP0000000776651.97237.341
ENSG00000070366homo_sapiensENSP0000026307377.730865.1163callorhinchus_miliiENSCMIP0000002954374.577462.4746
ENSG00000070366homo_sapiensENSP0000026307329.739326.2156latimeria_chalumnaeENSLACP0000000368190.752780
ENSG00000070366homo_sapiensENSP0000026307338.477832.5581latimeria_chalumnaeENSLACP0000000089667.99557.5342
ENSG00000070366homo_sapiensENSP0000026307365.327753.9112lepisosteus_oculatusENSLOCP0000000780167.812755.962
ENSG00000070366homo_sapiensENSP0000026307365.468650.8104clupea_harengusENSCHAP0000002150054.169142.0408
ENSG00000070366homo_sapiensENSP0000026307367.230453.136danio_rerioENSDARP0000014075261.787648.8342
ENSG00000070366homo_sapiensENSP0000026307367.582853.2065carassius_auratusENSCARP0000005767161.395648.3355
ENSG00000070366homo_sapiensENSP0000026307364.763949.8943astyanax_mexicanusENSAMXP0000001793767.623352.0971
ENSG00000070366homo_sapiensENSP0000026307365.609651.3742ictalurus_punctatusENSIPUP0000001837957.970145.3923
ENSG00000070366homo_sapiensENSP0000026307367.371453.277esox_luciusENSELUP0000000482452.934741.8605
ENSG00000070366homo_sapiensENSP0000026307366.173452.4313electrophorus_electricusENSEEEP0000003637259.61947.2381
ENSG00000070366homo_sapiensENSP0000026307361.874649.7533oncorhynchus_kisutchENSOKIP0000509272857.273346.0535
ENSG00000070366homo_sapiensENSP0000026307368.498954.6864oncorhynchus_kisutchENSOKIP0000509593249.290139.3509
ENSG00000070366homo_sapiensENSP0000026307359.267145.525oncorhynchus_mykissENSOMYP0000013223948.810237.4927
ENSG00000070366homo_sapiensENSP0000026307368.35854.5455oncorhynchus_mykissENSOMYP0000013348948.524338.7194
ENSG00000070366homo_sapiensENSP0000026307368.217154.2636salmo_salarENSSSAP0000012621749.312339.2257
ENSG00000070366homo_sapiensENSP0000026307367.723753.8407salmo_salarENSSSAP0000018129155.166543.8576
ENSG00000070366homo_sapiensENSP0000026307343.199433.4038salmo_truttaENSSTUP0000004205845.780435.3996
ENSG00000070366homo_sapiensENSP0000026307368.35854.4045salmo_truttaENSSTUP0000007910351.377140.8898
ENSG00000070366homo_sapiensENSP0000026307364.904951.2333fundulus_heteroclitusENSFHEP0000002889457.027945.0155
ENSG00000070366homo_sapiensENSP0000026307365.468650.9514poecilia_reticulataENSPREP0000001490257.809644.9907
ENSG00000070366homo_sapiensENSP0000026307366.032451.4447xiphophorus_maculatusENSXMAP0000001034357.91145.1174
ENSG00000070366homo_sapiensENSP0000026307366.455350.8104oryzias_latipesENSORLP0000000412357.46543.9366
ENSG00000070366homo_sapiensENSP0000026307364.129750.8104cyclopterus_lumpusENSCLMP0000502427559.129346.8486
ENSG00000070366homo_sapiensENSP0000026307366.666752.6427oreochromis_niloticusENSONIP0000000703957.368145.3002
ENSG00000070366homo_sapiensENSP0000026307366.525752.4313haplochromis_burtoniENSHBUP0000003403257.525945.3382
ENSG00000070366homo_sapiensENSP0000026307366.666752.4313astatotilapia_callipteraENSACLP0000000781657.402945.1456
ENSG00000070366homo_sapiensENSP0000026307366.384852.9246sparus_aurataENSSAUP0001000712056.987345.4325
ENSG00000070366homo_sapiensENSP0000026307366.455352.4313lates_calcariferENSLCAP0001005189556.602644.6579
ENSG00000070366homo_sapiensENSP0000026307372.938760.8175xenopus_tropicalisENSXETP0000005132474.783262.3555
ENSG00000070366homo_sapiensENSP0000026307383.509572.5863chrysemys_picta_belliiENSCPBP0000002887783.274872.3823
ENSG00000070366homo_sapiensENSP0000026307380.549769.9789sphenodon_punctatusENSSPUP0000000918981.063870.4255
ENSG00000070366homo_sapiensENSP0000026307377.942268.9218crocodylus_porosusENSCPRP0000502278084.556674.7706
ENSG00000070366homo_sapiensENSP0000026307355.179746.4412laticauda_laticaudataENSLLTP0000000140870.035858.9445
ENSG00000070366homo_sapiensENSP0000026307380.620270.5426gallus_gallusENSGALP0001004381169.671160.9622
ENSG00000070366homo_sapiensENSP0000026307371.529260.2537meleagris_gallopavoENSMGAP0000000532472.036960.6813
ENSG00000070366homo_sapiensENSP0000026307380.549770.4017serinus_canariaENSSCAP0000000940973.175463.9565
ENSG00000070366homo_sapiensENSP0000026307381.747771.3883parus_majorENSPMJP0000002604178.857968.8647
ENSG00000070366homo_sapiensENSP0000026307361.733650.9514anolis_carolinensisENSACAP0000003259268.277556.3523
ENSG00000070366homo_sapiensENSP0000026307363.213550.3876neolamprologus_brichardiENSNBRP0000001228958.781146.8545
ENSG00000070366homo_sapiensENSP0000026307371.599761.4517naja_najaENSNNAP0000000148975.877565.1232
ENSG00000070366homo_sapiensENSP0000026307375.96965.9619podarcis_muralisENSPMRP0000002754777.55467.3381
ENSG00000070366homo_sapiensENSP0000026307380.338370.1198geospiza_fortisENSGFOP0000000632582.310571.8412
ENSG00000070366homo_sapiensENSP0000026307381.324971.3178taeniopygia_guttataENSTGUP0000000602281.439771.4185
ENSG00000070366homo_sapiensENSP0000026307370.542658.6328erpetoichthys_calabaricusENSECRP0000001296068.048956.5602
ENSG00000070366homo_sapiensENSP0000026307365.891550.9514kryptolebias_marmoratusENSKMAP0000000029457.151644.1932
ENSG00000070366homo_sapiensENSP0000026307375.616665.1868salvator_merianaeENSSMRP0000000860577.41766.7388
ENSG00000070366homo_sapiensENSP0000026307362.790750.3171amphilophus_citrinellusENSACIP0000001672460.902348.8038
ENSG00000070366homo_sapiensENSP0000026307365.327752.1494dicentrarchus_labraxENSDLAP0000505736659.499447.4968
ENSG00000070366homo_sapiensENSP0000026307366.314352.2199amphiprion_perculaENSAPEP0000002687257.134244.9909
ENSG00000070366homo_sapiensENSP0000026307365.750551.0923oryzias_sinensisENSOSIP0000001247256.855644.1804
ENSG00000070366homo_sapiensENSP0000026307373.784463.5659pelodiscus_sinensisENSPSIP0000000721580.168569.0658
ENSG00000070366homo_sapiensENSP0000026307382.945771.9521gopherus_evgoodeiENSGEVP0000501246882.654571.6994
ENSG00000070366homo_sapiensENSP0000026307381.113570.4722chelonoidis_abingdoniiENSCABP0000002829482.746271.8907
ENSG00000070366homo_sapiensENSP0000026307366.596252.3608seriola_dumeriliENSSDUP0000002254556.893444.7321
ENSG00000070366homo_sapiensENSP0000026307366.384851.7266cottoperca_gobioENSCGOP0000000457656.610644.1106
ENSG00000070366homo_sapiensENSP0000026307381.465871.5292struthio_camelus_australisENSSCUP0000000011982.986472.8643
ENSG00000070366homo_sapiensENSP0000026307381.395370.895anser_brachyrhynchusENSABRP0000001275279.710169.4272
ENSG00000070366homo_sapiensENSP0000026307362.08649.7533gasterosteus_aculeatusENSGACP0000002713468.188954.644
ENSG00000070366homo_sapiensENSP0000026307365.257251.0218cynoglossus_semilaevisENSCSEP0000002002656.566944.2272
ENSG00000070366homo_sapiensENSP0000026307365.891551.5152poecilia_formosaENSPFOP0000001219858.146845.4602
ENSG00000070366homo_sapiensENSP0000026307367.1653.0655myripristis_murdjanENSMMDP0000500782156.895544.9552
ENSG00000070366homo_sapiensENSP0000026307366.596252.2199sander_luciopercaENSSLUP0000001985256.82544.558
ENSG00000070366homo_sapiensENSP0000026307381.959171.5292strigops_habroptilaENSSHBP0000500716882.482371.9858
ENSG00000070366homo_sapiensENSP0000026307366.243852.1494amphiprion_ocellarisENSAOCP0000002352957.073544.9302
ENSG00000070366homo_sapiensENSP0000026307381.677271.3178terrapene_carolina_triunguisENSTMTP0000001332083.381372.8058
ENSG00000070366homo_sapiensENSP0000026307324.453817.4771hucho_huchoENSHHUP0000000778136.183525.8603
ENSG00000070366homo_sapiensENSP0000026307363.495450.0352hucho_huchoENSHHUP0000005769151.841240.8516
ENSG00000070366homo_sapiensENSP000002630736.694865.074hucho_huchoENSHHUP0000000779268.345351.7986
ENSG00000070366homo_sapiensENSP0000026307366.243852.2199betta_splendensENSBSLP0000000985157.073544.9909
ENSG00000070366homo_sapiensENSP0000026307362.861249.6124pygocentrus_nattereriENSPNAP0000000993159.34846.8397
ENSG00000070366homo_sapiensENSP0000026307367.01952.6427anabas_testudineusENSATEP0000000920757.048644.811
ENSG00000070366homo_sapiensENSP0000026307310.64136.90627ciona_savignyiENSCSAVP0000001300657.19737.1212
ENSG00000070366homo_sapiensENSP000002630735.003523.31219ciona_savignyiENSCSAVP0000001298978.888952.2222
ENSG00000070366homo_sapiensENSP0000026307362.649849.26seriola_lalandi_dorsalisENSSLDP0000002668657.764845.4191
ENSG00000070366homo_sapiensENSP0000026307366.102951.6561labrus_bergyltaENSLBEP0000000277256.302543.9976
ENSG00000070366homo_sapiensENSP0000026307363.706850.8104pundamilia_nyerereiENSPNYP0000003200861.246648.8482
ENSG00000070366homo_sapiensENSP0000026307366.948653.136mastacembelus_armatusENSMAMP0000002983457.332545.5039
ENSG00000070366homo_sapiensENSP0000026307366.173451.938stegastes_partitusENSSPAP0000002072457.012744.748
ENSG00000070366homo_sapiensENSP0000026307366.384852.5722acanthochromis_polyacanthusENSAPOP0000001633657.194945.2945
ENSG00000070366homo_sapiensENSP0000026307381.324971.1064aquila_chrysaetos_chrysaetosENSACCP0002000796181.497271.2571
ENSG00000070366homo_sapiensENSP0000026307364.834450.74nothobranchius_furzeriENSNFUP0001501130156.097643.9024
ENSG00000070366homo_sapiensENSP0000026307365.186850.9514cyprinodon_variegatusENSCVAP0000001063156.923144.4923
ENSG00000070366homo_sapiensENSP0000026307367.371453.136denticeps_clupeoidesENSDCDP0000000424357.348545.231
ENSG00000070366homo_sapiensENSP0000026307366.666752.5018larimichthys_croceaENSLCRP0000500385355.451343.6694
ENSG00000070366homo_sapiensENSP0000026307365.398252.0789takifugu_rubripesENSTRUP0000007741857.639845.9006
ENSG00000070366homo_sapiensENSP0000026307380.197370.4017ficedula_albicollisENSFALP0000000681882.106872.0779
ENSG00000070366homo_sapiensENSP0000026307357.434845.3841hippocampus_comesENSHCOP0000000686768.200853.8912
ENSG00000070366homo_sapiensENSP0000026307367.653353.4179cyprinus_carpio_carpioENSCCRP0000014594660.682747.914
ENSG00000070366homo_sapiensENSP0000026307366.666752.3608cyprinus_carpio_carpioENSCCRP0000012693158.794346.1777
ENSG00000070366homo_sapiensENSP0000026307381.536371.7407coturnix_japonicaENSCJPP0000501349681.13671.3885
ENSG00000070366homo_sapiensENSP0000026307365.82151.2333poecilia_latipinnaENSPLAP0000002834858.084645.2114
ENSG00000070366homo_sapiensENSP0000026307366.596252.5722sinocyclocheilus_grahamiENSSGRP0000004716061.046548.1912
ENSG00000070366homo_sapiensENSP0000026307367.371453.4179sinocyclocheilus_grahamiENSSGRP0000006393460.85348.2495
ENSG00000070366homo_sapiensENSP0000026307366.596252.3608maylandia_zebraENSMZEP0000503315757.37745.1123
ENSG00000070366homo_sapiensENSP0000026307364.059250.9514tetraodon_nigroviridisENSTNIP0000001925562.474249.6907
ENSG00000070366homo_sapiensENSP0000026307367.230453.6293scleropages_formosusENSSFOP0001500830154.985643.8617
ENSG00000070366homo_sapiensENSP0000026307373.009259.9013leptobrachium_leishanenseENSLLEP0000001763374.371961.0194
ENSG00000070366homo_sapiensENSP0000026307365.468651.938scophthalmus_maximusENSSMAP0000003227555.829344.2909
ENSG00000070366homo_sapiensENSP0000026307366.455350.8809oryzias_melastigmaENSOMEP0000000961858.209944.5679

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000184involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay3IBA,IMP,TASHomo_sapiens(9606)Process
GO:0000781located_in chromosome, telomeric region1IEAHomo_sapiens(9606)Component
GO:0003723enables RNA binding1IPIHomo_sapiens(9606)Function
GO:0004521enables RNA endonuclease activity3IDA,IMP,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005697part_of telomerase holoenzyme complex2IBA,TASHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0006406involved_in mRNA export from nucleus1TASHomo_sapiens(9606)Process
GO:0032204involved_in regulation of telomere maintenance1IMPHomo_sapiens(9606)Process
GO:0032210involved_in regulation of telomere maintenance via telomerase2IC,TASHomo_sapiens(9606)Process
GO:0035303involved_in regulation of dephosphorylation1TASHomo_sapiens(9606)Process
GO:0042162enables telomeric DNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0043021enables ribonucleoprotein complex binding1IPIHomo_sapiens(9606)Function
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0051972involved_in regulation of telomerase activity1ICHomo_sapiens(9606)Process
GO:0070034enables telomerase RNA binding2IBA,IPIHomo_sapiens(9606)Function
GO:0070182enables DNA polymerase binding1IPIHomo_sapiens(9606)Function
GO:1904354involved_in negative regulation of telomere capping1IDAHomo_sapiens(9606)Process

Expression