Ensembl ID ENSG00000070366 Gene ID 23293 Accession 17809
Gene Symbol SMG6 Alias EST1A;SMG-6;hEST1A;C17orf31;hSMG5/7a Full Name SMG6 nonsense mediated mRNA decay factor
Position 17 : 2059843 - 2303785 Length 243943 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]

ENSG00000070366 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000070366 SMG6 -0.5 3.44e-13 KIRC
ENSG00000070366 SMG6 -0.5 2.02e-15 BRCA
ENSG00000070366 SMG6 -1.0 7.98e-13 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000070366 SMG6 tumor 19018238
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000070366 SMG6 STAD 0.017 low
ENSG00000070366 SMG6 UVM 0.045 low
ENSG00000070366 SMG6 PAAD 0.027 low
ENSG00000070366 SMG6 UCEC 0.03 low
ENSG00000070366 SMG6 ACC 0.021 low
ENSG00000070366 SMG6 LGG 0.024 high
ENSG00000070366 SMG6 LUSC 0.025 high
ENSG00000070366 SMG6 HNSC 0.011 low
ENSG00000070366 SMG6 KIRP 0.016 high
ENSG00000070366 SMG6 KICH 0.0047 high
ENSG00000070366 SMG6 LUAD 0.035 low
ENSG00000070366 SMG6 BRCA 0.028 high
ENSG00000070366 SMG6 ESCA 0.0088 low
ENSG00000070366 SMG6 BLCA 0.02 high
ENSG00000070366 SMG6 LAML 0.032 low
ENSG00000070366 SMG6 SKCM 0.038 high
ENSG00000070366 SMG6 CESC 0.021 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000070366 SMG6 LUAD Del 2.387901 0.071128 0.368129 0.546512
ENSG00000070366 SMG6 SARC Del 4.849993 0.214002 0.546674 0.350195
ENSG00000070366 SMG6 LIHC Del 6.610724 0.137233 0.645575 0.570270