Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs rRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000266472 Gene ID 54460 Accession 14046
Symbol MRPS21 Alias bS21m;MDS016;RPMS21;MRP-S21 Full Name mitochondrial ribosomal protein S21
Status Confidence Length 15119 bases Strand Plus strand
Position 1 : 150293861 - 150308979 RNA binding domain Ribosomal_S21
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000461930 Ribosomal_S21 PF01165 6.2e-16 1
ENSP00000480129 Ribosomal_S21 PF01165 6.2e-16 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
MRPS21-202 ENST00000614145 1085 87aa ENSP00000480129
MRPS21-201 ENST00000581066 1462 87aa ENSP00000461930

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
74855Dermatitis, Atopic5E-926482879
93855Substance-Related Disorders5E-623942779
98690Dermatitis, Atopic1E-726482879

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000266472

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000266472homo_sapiensENSP0000048012997.701197.7011nomascus_leucogenysENSNLEP0000002938997.701197.7011
ENSG00000266472homo_sapiensENSP0000048012998.850698.8506pan_paniscusENSPPAP0000003760898.850698.8506
ENSG00000266472homo_sapiensENSP0000048012998.850698.8506pongo_abeliiENSPPYP0000003457898.850698.8506
ENSG00000266472homo_sapiensENSP0000048012998.850698.8506pan_troglodytesENSPTRP0000000212398.850698.8506
ENSG00000266472homo_sapiensENSP0000048012998.850698.8506gorilla_gorillaENSGGOP0000002455298.850698.8506
ENSG00000266472homo_sapiensENSP0000048012991.95483.908ornithorhynchus_anatinusENSOANP0000004343991.95483.908
ENSG00000266472homo_sapiensENSP0000048012991.95489.6552sarcophilus_harrisiiENSSHAP0000003985091.95489.6552
ENSG00000266472homo_sapiensENSP0000048012993.103490.8046notamacropus_eugeniiENSMEUP0000000623593.103490.8046
ENSG00000266472homo_sapiensENSP0000048012982.758680.4598choloepus_hoffmanniENSCHOP0000000796883.720981.3953
ENSG00000266472homo_sapiensENSP0000048012956.321855.1724choloepus_hoffmanniENSCHOP0000000001979.032377.4194
ENSG00000266472homo_sapiensENSP0000048012995.402393.1034dasypus_novemcinctusENSDNOP0000001749795.402393.1034
ENSG00000266472homo_sapiensENSP0000048012997.701196.5517callithrix_jacchusENSCJAP0000006628197.701196.5517
ENSG00000266472homo_sapiensENSP0000048012995.402394.2529macaca_fascicularisENSMFAP0000003038295.402394.2529
ENSG00000266472homo_sapiensENSP0000048012995.402394.2529macaca_mulattaENSMMUP0000002818095.402394.2529
ENSG00000266472homo_sapiensENSP0000048012995.402394.2529macaca_nemestrinaENSMNEP0000001411895.402394.2529
ENSG00000266472homo_sapiensENSP0000048012995.402394.2529macaca_nemestrinaENSMNEP0000000242495.402394.2529
ENSG00000266472homo_sapiensENSP0000048012996.551796.5517papio_anubisENSPANP0000003180096.551796.5517
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023tursiops_truncatusENSTTRP0000001653595.402395.4023
ENSG00000266472homo_sapiensENSP0000048012994.252993.1034vulpes_vulpesENSVVUP0000001065194.252993.1034
ENSG00000266472homo_sapiensENSP0000048012991.95486.2069vulpes_vulpesENSVVUP0000003210891.95486.2069
ENSG00000266472homo_sapiensENSP0000048012989.655289.6552mus_spretusMGP_SPRETEiJ_P006162389.655289.6552
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023equus_asinusENSEASP0000500197695.402395.4023
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023capra_hircusENSCHIP0000002424995.402395.4023
ENSG00000266472homo_sapiensENSP0000048012991.95489.6552loxodonta_africanaENSLAFP0000002646091.95489.6552
ENSG00000266472homo_sapiensENSP0000048012993.103493.1034panthera_leoENSPLOP0000002396293.103493.1034
ENSG00000266472homo_sapiensENSP0000048012966.666750.5747panthera_leoENSPLOP0000000431165.909150
ENSG00000266472homo_sapiensENSP0000048012994.252993.1034panthera_leoENSPLOP0000000424294.252993.1034
ENSG00000266472homo_sapiensENSP0000048012980.459877.0115panthera_leoENSPLOP0000000754859.829157.265
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023panthera_leoENSPLOP0000002573395.402395.4023
ENSG00000266472homo_sapiensENSP0000048012994.252993.1034ailuropoda_melanoleucaENSAMEP0000000177594.252993.1034
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023bos_indicus_hybridENSBIXP0000502356795.402395.4023
ENSG00000266472homo_sapiensENSP0000048012994.252993.1034oryctolagus_cuniculusENSOCUP0000002170494.252993.1034
ENSG00000266472homo_sapiensENSP0000048012990.804688.5057oryctolagus_cuniculusENSOCUP0000000178290.804688.5057
ENSG00000266472homo_sapiensENSP0000048012994.252993.1034canis_lupus_familiarisENSCAFP0084502351394.252993.1034
ENSG00000266472homo_sapiensENSP0000048012994.252993.1034panthera_pardusENSPPRP0000002620594.252993.1034
ENSG00000266472homo_sapiensENSP0000048012980.459877.0115panthera_pardusENSPPRP0000002912259.829157.265
ENSG00000266472homo_sapiensENSP0000048012959.770150.5747panthera_pardusENSPPRP0000002238573.239461.9718
ENSG00000266472homo_sapiensENSP0000048012993.103493.1034panthera_pardusENSPPRP0000002804193.103493.1034
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023panthera_pardusENSPPRP0000000499695.402395.4023
ENSG00000266472homo_sapiensENSP0000048012994.252989.6552marmota_marmota_marmotaENSMMMP0000001169694.252989.6552
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023balaenoptera_musculusENSBMSP0001001979095.402395.4023
ENSG00000266472homo_sapiensENSP0000048012994.252991.954cavia_porcellusENSCPOP0000001845894.252991.954
ENSG00000266472homo_sapiensENSP0000048012968.965567.8161felis_catusENSFCAP0000003586468.181867.0455
ENSG00000266472homo_sapiensENSP0000048012964.367849.4253felis_catusENSFCAP0000002842663.636448.8636
ENSG00000266472homo_sapiensENSP0000048012979.310374.7126felis_catusENSFCAP0000004752050.735347.7941
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023felis_catusENSFCAP0000003474795.402395.4023
ENSG00000266472homo_sapiensENSP0000048012994.252994.2529ursus_americanusENSUAMP0000001144294.252994.2529
ENSG00000266472homo_sapiensENSP0000048012993.103491.954monodelphis_domesticaENSMODP0000002342493.103491.954
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023bison_bison_bisonENSBBBP0000002736195.402395.4023
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023monodon_monocerosENSMMNP0001500632695.402395.4023
ENSG00000266472homo_sapiensENSP0000048012994.252994.2529sus_scrofaENSSSCP0000007516594.252994.2529
ENSG00000266472homo_sapiensENSP0000048012994.252988.5057sus_scrofaENSSSCP0000008047294.252988.5057
ENSG00000266472homo_sapiensENSP0000048012993.103493.1034microcebus_murinusENSMICP0000001672393.103493.1034
ENSG00000266472homo_sapiensENSP0000048012993.103493.1034microcebus_murinusENSMICP0000003548493.103493.1034
ENSG00000266472homo_sapiensENSP0000048012993.103493.1034microcebus_murinusENSMICP0000004542193.103493.1034
ENSG00000266472homo_sapiensENSP0000048012980.459877.0115microcebus_murinusENSMICP0000002840587.583.75
ENSG00000266472homo_sapiensENSP0000048012991.95490.8046octodon_degusENSODEP0000002595891.95490.8046
ENSG00000266472homo_sapiensENSP0000048012994.252993.1034octodon_degusENSODEP0000002598494.252993.1034
ENSG00000266472homo_sapiensENSP0000048012970.114966.6667octodon_degusENSODEP0000000389787.142982.8571
ENSG00000266472homo_sapiensENSP0000048012993.103490.8046octodon_degusENSODEP0000002566993.103490.8046
ENSG00000266472homo_sapiensENSP0000048012994.252993.1034octodon_degusENSODEP0000001583694.252993.1034
ENSG00000266472homo_sapiensENSP0000048012991.95490.8046octodon_degusENSODEP0000002567293.023391.8605
ENSG00000266472homo_sapiensENSP0000048012990.804688.5057jaculus_jaculusENSJJAP0000000886891.860589.5349
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023ovis_aries_rambouilletENSOARP0002001001495.402395.4023
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023ursus_maritimusENSUMAP0000000463195.402395.4023
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023delphinapterus_leucasENSDLEP0000001335495.402395.4023
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023physeter_catodonENSPCTP0000501373095.402395.4023
ENSG00000266472homo_sapiensENSP0000048012990.804690.8046mus_caroliMGP_CAROLIEiJ_P005924790.804690.8046
ENSG00000266472homo_sapiensENSP0000048012989.655289.6552mus_musculusENSMUSP0000006699089.655289.6552
ENSG00000266472homo_sapiensENSP0000048012995.402394.2529dipodomys_ordiiENSDORP0000001975795.402394.2529
ENSG00000266472homo_sapiensENSP0000048012994.252993.1034mustela_putorius_furoENSMPUP0000000518494.252993.1034
ENSG00000266472homo_sapiensENSP0000048012990.804683.908aotus_nancymaaeENSANAP0000001743897.530990.1235
ENSG00000266472homo_sapiensENSP0000048012996.551793.1034aotus_nancymaaeENSANAP0000001651796.551793.1034
ENSG00000266472homo_sapiensENSP0000048012996.551794.2529saimiri_boliviensis_boliviensisENSSBOP0000000018196.551794.2529
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023vicugna_pacosENSVPAP0000001173095.402395.4023
ENSG00000266472homo_sapiensENSP0000048012996.551796.5517chlorocebus_sabaeusENSCSAP0000001410396.551796.5517
ENSG00000266472homo_sapiensENSP0000048012978.160974.7126mesocricetus_auratusENSMAUP0000000711889.473785.5263
ENSG00000266472homo_sapiensENSP0000048012990.804689.6552mesocricetus_auratusENSMAUP0000001490390.804689.6552
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023phocoena_sinusENSPSNP0000000235195.402395.4023
ENSG00000266472homo_sapiensENSP0000048012966.666757.4713camelus_dromedariusENSCDRP0000503194168.235358.8235
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023camelus_dromedariusENSCDRP0000502415795.402395.4023
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023carlito_syrichtaENSTSYP0000001365595.402395.4023
ENSG00000266472homo_sapiensENSP0000048012993.103490.8046panthera_tigris_altaicaENSPTIP0000000112693.103490.8046
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023panthera_tigris_altaicaENSPTIP0000000149695.402395.4023
ENSG00000266472homo_sapiensENSP0000048012991.95490.8046rattus_norvegicusENSRNOP0000003859491.95490.8046
ENSG00000266472homo_sapiensENSP0000048012989.655287.3563microtus_ochrogasterENSMOCP0000000282389.655287.3563
ENSG00000266472homo_sapiensENSP0000048012988.505783.908microtus_ochrogasterENSMOCP0000000213288.505783.908
ENSG00000266472homo_sapiensENSP0000048012980.459877.0115microtus_ochrogasterENSMOCP0000002174874.468171.2766
ENSG00000266472homo_sapiensENSP0000048012989.655287.3563microtus_ochrogasterENSMOCP0000000522589.655287.3563
ENSG00000266472homo_sapiensENSP0000048012990.804690.8046peromyscus_maniculatus_bairdiiENSPEMP0000001407490.804690.8046
ENSG00000266472homo_sapiensENSP0000048012979.310374.7126peromyscus_maniculatus_bairdiiENSPEMP0000002556575.824271.4286
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023bos_mutusENSBMUP0000003142695.402395.4023
ENSG00000266472homo_sapiensENSP0000048012989.655289.6552mus_spicilegusENSMSIP0000000835389.655289.6552
ENSG00000266472homo_sapiensENSP0000048012989.655289.6552mus_spicilegusENSMSIP0000001344889.655289.6552
ENSG00000266472homo_sapiensENSP0000048012979.310375.8621cricetulus_griseus_chok1gshdENSCGRP0000100577675.824272.5275
ENSG00000266472homo_sapiensENSP0000048012982.758679.3103cricetulus_griseus_chok1gshdENSCGRP0000100305182.758679.3103
ENSG00000266472homo_sapiensENSP0000048012987.356386.2069cricetulus_griseus_chok1gshdENSCGRP0000101435787.356386.2069
ENSG00000266472homo_sapiensENSP0000048012995.402393.1034pteropus_vampyrusENSPVAP0000001699795.402393.1034
ENSG00000266472homo_sapiensENSP0000048012994.252993.1034myotis_lucifugusENSMLUP0000001718894.252993.1034
ENSG00000266472homo_sapiensENSP0000048012993.103490.8046vombatus_ursinusENSVURP0001002036193.103490.8046
ENSG00000266472homo_sapiensENSP0000048012993.103490.8046vombatus_ursinusENSVURP0001000073493.103490.8046
ENSG00000266472homo_sapiensENSP0000048012981.609278.1609rhinolophus_ferrumequinumENSRFEP0001000788278.02274.7253
ENSG00000266472homo_sapiensENSP0000048012994.252991.954rhinolophus_ferrumequinumENSRFEP0001000572193.181890.9091
ENSG00000266472homo_sapiensENSP0000048012994.252993.1034rhinolophus_ferrumequinumENSRFEP0001003081194.252993.1034
ENSG00000266472homo_sapiensENSP0000048012994.252993.1034neovison_visonENSNVIP0000002168694.252993.1034
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023bos_taurusENSBTAP0000003368295.402395.4023
ENSG00000266472homo_sapiensENSP0000048012995.402394.2529heterocephalus_glaber_femaleENSHGLP0000002292095.402394.2529
ENSG00000266472homo_sapiensENSP0000048012994.252993.1034canis_lupus_dingoENSCAFP0002002502794.252993.1034
ENSG00000266472homo_sapiensENSP0000048012995.402394.2529sciurus_vulgarisENSSVLP0000500119395.402394.2529
ENSG00000266472homo_sapiensENSP0000048012990.804686.2069phascolarctos_cinereusENSPCIP0000000945790.804686.2069
ENSG00000266472homo_sapiensENSP0000048012993.103489.6552phascolarctos_cinereusENSPCIP0000001084793.103489.6552
ENSG00000266472homo_sapiensENSP0000048012993.103490.8046nannospalax_galiliENSNGAP0000000224193.103490.8046
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023bos_grunniensENSBGRP0000000043795.402395.4023
ENSG00000266472homo_sapiensENSP0000048012995.402390.8046chinchilla_lanigeraENSCLAP0000001950195.402390.8046
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023cervus_hanglu_yarkandensisENSCHYP0000001872095.402395.4023
ENSG00000266472homo_sapiensENSP0000048012991.95487.3563cervus_hanglu_yarkandensisENSCHYP0000000450791.95487.3563
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023catagonus_wagneriENSCWAP0000001158195.402395.4023
ENSG00000266472homo_sapiensENSP0000048012994.252991.954ictidomys_tridecemlineatusENSSTOP0000002159594.252991.954
ENSG00000266472homo_sapiensENSP0000048012988.505783.908ictidomys_tridecemlineatusENSSTOP0000001843489.534984.8837
ENSG00000266472homo_sapiensENSP0000048012994.252991.954urocitellus_parryiiENSUPAP0001000217594.252991.954
ENSG00000266472homo_sapiensENSP0000048012991.95487.3563urocitellus_parryiiENSUPAP0001001154891.95487.3563
ENSG00000266472homo_sapiensENSP0000048012995.402395.4023moschus_moschiferusENSMMSP0000002706295.402395.4023
ENSG00000266472homo_sapiensENSP0000048012996.551796.5517rhinopithecus_roxellanaENSRROP0000002267196.551796.5517
ENSG00000266472homo_sapiensENSP0000048012990.804690.8046mus_pahariMGP_PahariEiJ_P007021590.804690.8046
ENSG00000266472homo_sapiensENSP0000048012994.252994.2529propithecus_coquereliENSPCOP0000002277294.252994.2529
ENSG00000266472homo_sapiensENSP0000048012985.057585.0575propithecus_coquereliENSPCOP0000000236590.243990.2439
ENSG00000266472homo_sapiensENSP0000048012989.655278.1609latimeria_chalumnaeENSLACP0000001264189.655278.1609
ENSG00000266472homo_sapiensENSP0000048012985.057570.1149xenopus_tropicalisENSXETP0000008998363.247952.1368
ENSG00000266472homo_sapiensENSP0000048012988.505781.6092chrysemys_picta_belliiENSCPBP0000001071588.505781.6092
ENSG00000266472homo_sapiensENSP0000048012985.057579.3103sphenodon_punctatusENSSPUP0000000101685.057579.3103
ENSG00000266472homo_sapiensENSP0000048012982.758668.9655laticauda_laticaudataENSLLTP0000000746954.961845.8015
ENSG00000266472homo_sapiensENSP0000048012982.758668.9655notechis_scutatusENSNSUP0000001100782.758668.9655
ENSG00000266472homo_sapiensENSP0000048012982.758668.9655pseudonaja_textilisENSPTXP0000001383382.758668.9655
ENSG00000266472homo_sapiensENSP0000048012986.206975.8621anolis_carolinensisENSACAP0000004009286.206975.8621
ENSG00000266472homo_sapiensENSP0000048012983.90868.9655naja_najaENSNNAP0000002480383.90868.9655
ENSG00000266472homo_sapiensENSP0000048012987.356377.0115podarcis_muralisENSPMRP0000001081987.356377.0115
ENSG00000266472homo_sapiensENSP0000048012987.356378.1609podarcis_muralisENSPMRP0000002760987.356378.1609
ENSG00000266472homo_sapiensENSP0000048012987.356379.3103erpetoichthys_calabaricusENSECRP0000002590387.356379.3103
ENSG00000266472homo_sapiensENSP0000048012986.206971.2644salvator_merianaeENSSMRP0000001009486.206971.2644
ENSG00000266472homo_sapiensENSP0000048012986.206979.3103pelodiscus_sinensisENSPSIP0000001633786.206979.3103
ENSG00000266472homo_sapiensENSP0000048012988.505780.4598gopherus_evgoodeiENSGEVP0000502034288.505780.4598
ENSG00000266472homo_sapiensENSP0000048012987.356377.0115chelonoidis_abingdoniiENSCABP0000001453487.356377.0115
ENSG00000266472homo_sapiensENSP0000048012988.505781.6092terrapene_carolina_triunguisENSTMTP0000000488688.505781.6092
ENSG00000266472homo_sapiensENSP0000048012987.356370.1149leptobrachium_leishanenseENSLLEP0000003991087.356370.1149

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0003735enables structural constituent of ribosome2ISS,NASHomo_sapiens(9606)Function
GO:0005743located_in mitochondrial inner membrane2NAS,TASHomo_sapiens(9606)Component
GO:0005763part_of mitochondrial small ribosomal subunit2IDA,NASHomo_sapiens(9606)Component
GO:0006412involved_in translation1NASHomo_sapiens(9606)Process
GO:0032543involved_in mitochondrial translation2ISS,NASHomo_sapiens(9606)Process

Expression