Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions Transmemebrane
Localizations Nucleoli
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000240344 Gene ID 53938 Accession 9262
Symbol PPIL3 Alias CYPJ Full Name peptidylprolyl isomerase like 3
Status Confidence Length 18397 bases Strand Minus strand
Position 2 : 200870907 - 200889303 RNA binding domain N.A.
Summary This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
PPIL3-202 ENST00000392283 1166 161aa ENSP00000376107
PPIL3-201 ENST00000286175 1370 165aa ENSP00000286175
PPIL3-209 ENST00000463866 1958 No protein -
PPIL3-210 ENST00000465823 1222 No protein -
PPIL3-216 ENST00000706557 1308 No protein -
PPIL3-217 ENST00000706558 1216 No protein -
PPIL3-218 ENST00000706559 1592 No protein -
PPIL3-219 ENST00000706560 988 No protein -
PPIL3-220 ENST00000706561 950 No protein -
PPIL3-221 ENST00000706562 1098 84aa ENSP00000516447
PPIL3-222 ENST00000706563 1146 94aa ENSP00000516448
PPIL3-223 ENST00000706564 1092 69aa ENSP00000516449
PPIL3-206 ENST00000415562 748 53aa ENSP00000400726
PPIL3-203 ENST00000409264 725 180aa ENSP00000386893
PPIL3-204 ENST00000409361 897 157aa ENSP00000386235
PPIL3-205 ENST00000409449 756 165aa ENSP00000387012
PPIL3-214 ENST00000497263 694 No protein -
PPIL3-207 ENST00000443398 313 73aa ENSP00000391082
PPIL3-208 ENST00000457063 596 80aa ENSP00000401196
PPIL3-213 ENST00000492074 592 No protein -
PPIL3-211 ENST00000470442 705 No protein -
PPIL3-215 ENST00000497501 272 No protein -
PPIL3-212 ENST00000487879 616 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
66138triptolide6E-726121980
66139Cell Survival6E-726121980
75101Breast Neoplasms1E-627117709

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000240344homo_sapiensENSP0000038181222.115415.3846homo_sapiensENSP0000037610771.428649.6894
ENSG00000240344homo_sapiensENSP0000036280358.433743.9759homo_sapiensENSP0000037610760.248445.3416
ENSG00000240344homo_sapiensENSP0000022517438.647330.9179homo_sapiensENSP0000037610749.689439.7516
ENSG00000240344homo_sapiensENSP0000042792927.652719.9357homo_sapiensENSP0000037610753.416138.5093
ENSG00000240344homo_sapiensENSP0000030375423.783818.6486homo_sapiensENSP0000037610754.658442.8571
ENSG00000240344homo_sapiensENSP0000031276927.574821.2625homo_sapiensENSP0000037610751.552839.7516
ENSG00000240344homo_sapiensENSP0000030305740.094333.4906homo_sapiensENSP0000037610752.79544.0994
ENSG00000240344homo_sapiensENSP0000025332918.495912.1951homo_sapiensENSP0000037610756.521737.2671
ENSG00000240344homo_sapiensENSP0000026130815.015512.0743homo_sapiensENSP0000037610760.248448.4472
ENSG00000240344homo_sapiensENSP0000030661447.457637.2881homo_sapiensENSP0000037610752.173940.9938
ENSG00000240344homo_sapiensENSP0000026097011.67119.15119homo_sapiensENSP0000037610754.658442.8571
ENSG00000240344homo_sapiensENSP0000037046019.279713.7712homo_sapiensENSP0000037610756.521740.3727
ENSG00000240344homo_sapiensENSP000002329786.019154.51436homo_sapiensENSP0000037610754.658440.9938
ENSG00000240344homo_sapiensENSP0000041942550.909140.6061homo_sapiensENSP0000037610752.173941.6149
ENSG00000240344homo_sapiensENSP0000039384547.56137.8049homo_sapiensENSP0000037610748.447238.5093
ENSG00000240344homo_sapiensENSP0000046461946.341535.9756homo_sapiensENSP0000037610747.20536.646
ENSG00000240344homo_sapiensENSP0000046305748.170737.8049homo_sapiensENSP0000037610749.068338.5093
ENSG00000240344homo_sapiensENSP0000046341947.56137.1951homo_sapiensENSP0000037610748.447237.8882
ENSG00000240344homo_sapiensENSP0000048563847.56137.1951homo_sapiensENSP0000037610748.447237.8882
ENSG00000240344homo_sapiensENSP0000043944446.951237.1951homo_sapiensENSP0000037610747.826137.8882
ENSG00000240344homo_sapiensENSP0000048520646.951236.5854homo_sapiensENSP0000037610747.826137.2671
ENSG00000240344homo_sapiensENSP0000030002640.740731.9444homo_sapiensENSP0000037610754.658442.8571

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000240344homo_sapiensENSP0000037610799.378998.1366nomascus_leucogenysENSNLEP0000002645688.888987.7778
ENSG00000240344homo_sapiensENSP0000037610799.378999.3789pan_paniscusENSPPAP0000003267888.888988.8889
ENSG00000240344homo_sapiensENSP0000037610799.378999.3789pan_troglodytesENSPTRP0000008985488.888988.8889
ENSG00000240344homo_sapiensENSP0000037610799.378999.3789gorilla_gorillaENSGGOP0000004390988.888988.8889
ENSG00000240344homo_sapiensENSP0000037610710098.7578dasypus_novemcinctusENSDNOP0000002144610098.7578
ENSG00000240344homo_sapiensENSP0000037610799.378998.7578callithrix_jacchusENSCJAP0000000795188.888988.3333
ENSG00000240344homo_sapiensENSP0000037610710098.7578cercocebus_atysENSCATP0000001433910098.7578
ENSG00000240344homo_sapiensENSP0000037610799.378998.1366macaca_fascicularisENSMFAP0000003883693.023391.8605
ENSG00000240344homo_sapiensENSP0000037610799.378998.1366macaca_nemestrinaENSMNEP0000001642990.395589.2655
ENSG00000240344homo_sapiensENSP0000037610799.378998.1366mandrillus_leucophaeusENSMLEP0000002982388.888987.7778
ENSG00000240344homo_sapiensENSP0000037610788.819988.8199vulpes_vulpesENSVVUP00000025946100100
ENSG00000240344homo_sapiensENSP0000037610799.378998.1366mus_spretusMGP_SPRETEiJ_P001878199.378998.1366
ENSG00000240344homo_sapiensENSP0000037610796.273395.6522capra_hircusENSCHIP0000002126810099.3548
ENSG00000240344homo_sapiensENSP00000376107100100panthera_leoENSPLOP00000021945100100
ENSG00000240344homo_sapiensENSP00000376107100100ailuropoda_melanoleucaENSAMEP00000006236100100
ENSG00000240344homo_sapiensENSP0000037610710099.3789bos_indicus_hybridENSBIXP0000504691910099.3789
ENSG00000240344homo_sapiensENSP00000376107100100oryctolagus_cuniculusENSOCUP00000009183100100
ENSG00000240344homo_sapiensENSP0000037610785.093280.7453equus_caballusENSECAP0000001748176.966373.0337
ENSG00000240344homo_sapiensENSP00000376107100100canis_lupus_familiarisENSCAFP00845041079100100
ENSG00000240344homo_sapiensENSP00000376107100100panthera_pardusENSPPRP00000020563100100
ENSG00000240344homo_sapiensENSP00000376107100100marmota_marmota_marmotaENSMMMP00000013536100100
ENSG00000240344homo_sapiensENSP0000037610710098.1366balaenoptera_musculusENSBMSP0001000528610098.1366
ENSG00000240344homo_sapiensENSP0000037610710096.8944cavia_porcellusENSCPOP0000000770010096.8944
ENSG00000240344homo_sapiensENSP00000376107100100felis_catusENSFCAP00000004981100100
ENSG00000240344homo_sapiensENSP0000037610799.378999.3789ursus_americanusENSUAMP0000001397298.159598.1595
ENSG00000240344homo_sapiensENSP0000037610710099.3789bison_bison_bisonENSBBBP0000001959010099.3789
ENSG00000240344homo_sapiensENSP0000037610710099.3789monodon_monocerosENSMMNP0001501183610099.3789
ENSG00000240344homo_sapiensENSP00000376107100100sus_scrofaENSSSCP00000017053100100
ENSG00000240344homo_sapiensENSP0000037610710099.3789microcebus_murinusENSMICP0000003803810099.3789
ENSG00000240344homo_sapiensENSP0000037610798.757894.4099octodon_degusENSODEP0000001015596.363692.1212
ENSG00000240344homo_sapiensENSP0000037610710099.3789ovis_aries_rambouilletENSOARP0002002104810099.3789
ENSG00000240344homo_sapiensENSP00000376107100100ursus_maritimusENSUMAP00000029659100100
ENSG00000240344homo_sapiensENSP0000037610710099.3789delphinapterus_leucasENSDLEP0000002430410099.3789
ENSG00000240344homo_sapiensENSP0000037610710099.3789physeter_catodonENSPCTP0000500239510099.3789
ENSG00000240344homo_sapiensENSP0000037610798.757898.1366mus_caroliMGP_CAROLIEiJ_P001777397.54696.9325
ENSG00000240344homo_sapiensENSP0000037610799.378998.1366mus_musculusENSMUSP0000011294799.378998.1366
ENSG00000240344homo_sapiensENSP0000037610799.378998.7578dipodomys_ordiiENSDORP0000000693010099.375
ENSG00000240344homo_sapiensENSP0000037610710098.7578chlorocebus_sabaeusENSCSAP0000000707210098.7578
ENSG00000240344homo_sapiensENSP0000037610760.248459.6273mesocricetus_auratusENSMAUP0000002330210098.9691
ENSG00000240344homo_sapiensENSP0000037610710099.3789phocoena_sinusENSPSNP0000002480510099.3789
ENSG00000240344homo_sapiensENSP0000037610710099.3789camelus_dromedariusENSCDRP0000501015010099.3789
ENSG00000240344homo_sapiensENSP0000037610710098.7578carlito_syrichtaENSTSYP0000001469910098.7578
ENSG00000240344homo_sapiensENSP00000376107100100panthera_tigris_altaicaENSPTIP00000014645100100
ENSG00000240344homo_sapiensENSP0000037610799.378998.1366prolemur_simusENSPSMP0000000456391.95490.8046
ENSG00000240344homo_sapiensENSP0000037610710099.3789prolemur_simusENSPSMP0000002657910099.3789
ENSG00000240344homo_sapiensENSP0000037610799.378997.5155microtus_ochrogasterENSMOCP0000001323598.159596.319
ENSG00000240344homo_sapiensENSP0000037610791.925586.9565microtus_ochrogasterENSMOCP0000000966591.35886.4198
ENSG00000240344homo_sapiensENSP0000037610798.136696.8944peromyscus_maniculatus_bairdiiENSPEMP0000001067698.136696.8944
ENSG00000240344homo_sapiensENSP0000037610710099.3789bos_mutusENSBMUP0000003579010099.3789
ENSG00000240344homo_sapiensENSP0000037610710097.5155mus_spicilegusENSMSIP0000002804610097.5155
ENSG00000240344homo_sapiensENSP0000037610710098.7578cricetulus_griseus_chok1gshdENSCGRP0000102316410098.7578
ENSG00000240344homo_sapiensENSP0000037610798.757897.5155myotis_lucifugusENSMLUP0000001199999.37598.125
ENSG00000240344homo_sapiensENSP00000376107100100rhinolophus_ferrumequinumENSRFEP00010026893100100
ENSG00000240344homo_sapiensENSP0000037610710096.8944heterocephalus_glaber_femaleENSHGLP0000005679280.578
ENSG00000240344homo_sapiensENSP0000037610799.378998.1366canis_lupus_dingoENSCAFP0002000535298.159596.9325
ENSG00000240344homo_sapiensENSP0000037610798.757898.7578sciurus_vulgarisENSSVLP0000500506498.757898.7578
ENSG00000240344homo_sapiensENSP0000037610798.757894.4099phascolarctos_cinereusENSPCIP0000002589599.37595
ENSG00000240344homo_sapiensENSP0000037610710099.3789nannospalax_galiliENSNGAP0000001343410099.3789
ENSG00000240344homo_sapiensENSP0000037610710096.2733chinchilla_lanigeraENSCLAP0000002050610096.2733
ENSG00000240344homo_sapiensENSP00000376107100100cervus_hanglu_yarkandensisENSCHYP00000007801100100
ENSG00000240344homo_sapiensENSP00000376107100100catagonus_wagneriENSCWAP00000013422100100
ENSG00000240344homo_sapiensENSP00000376107100100ictidomys_tridecemlineatusENSSTOP00000017362100100
ENSG00000240344homo_sapiensENSP0000037610774.534273.2919otolemur_garnettiiENSOGAP0000000634786.330984.8921
ENSG00000240344homo_sapiensENSP0000037610799.378998.7578cebus_imitatorENSCCAP0000000414688.888988.3333
ENSG00000240344homo_sapiensENSP00000376107100100urocitellus_parryiiENSUPAP00010019160100100
ENSG00000240344homo_sapiensENSP0000037610710099.3789moschus_moschiferusENSMMSP0000003297510099.3789
ENSG00000240344homo_sapiensENSP0000037610710098.7578mus_pahariMGP_PahariEiJ_P007309210098.7578
ENSG00000240344homo_sapiensENSP0000037610710099.3789propithecus_coquereliENSPCOP0000003095610099.3789
ENSG00000240344homo_sapiensENSP0000037610781.366569.5652caenorhabditis_elegansB0252.4b.181.366569.5652
ENSG00000240344homo_sapiensENSP0000037610786.956575.1553ciona_intestinalisENSCINP0000001559386.956575.1553
ENSG00000240344homo_sapiensENSP0000037610778.88270.1863eptatretus_burgeriENSEBUP0000001206593.382483.0882
ENSG00000240344homo_sapiensENSP0000037610793.167781.3665callorhinchus_miliiENSCMIP0000003317293.167781.3665
ENSG00000240344homo_sapiensENSP0000037610795.031186.3354lepisosteus_oculatusENSLOCP0000000371891.071482.7381
ENSG00000240344homo_sapiensENSP0000037610795.652285.0932electrophorus_electricusENSEEEP0000000025695.652285.0932
ENSG00000240344homo_sapiensENSP0000037610792.546682.6087oncorhynchus_kisutchENSOKIP0000503283892.546682.6087
ENSG00000240344homo_sapiensENSP0000037610792.546683.2298oncorhynchus_mykissENSOMYP0000002461692.546683.2298
ENSG00000240344homo_sapiensENSP0000037610791.925582.6087salmo_salarENSSSAP0000016236775.126967.5127
ENSG00000240344homo_sapiensENSP0000037610791.925582.6087salmo_truttaENSSTUP0000006188280.434872.2826
ENSG00000240344homo_sapiensENSP0000037610793.788883.8509oryzias_latipesENSORLP0000000097993.788883.8509
ENSG00000240344homo_sapiensENSP0000037610792.546682.6087cyclopterus_lumpusENSCLMP0000504219692.546682.6087
ENSG00000240344homo_sapiensENSP0000037610793.788884.472haplochromis_burtoniENSHBUP0000000983088.823580
ENSG00000240344homo_sapiensENSP0000037610793.788885.0932sparus_aurataENSSAUP0001005244482.96775.2747
ENSG00000240344homo_sapiensENSP0000037610793.788885.7143xenopus_tropicalisENSXETP0000003941393.788885.7143
ENSG00000240344homo_sapiensENSP0000037610798.136693.1677chrysemys_picta_belliiENSCPBP0000001591998.136693.1677
ENSG00000240344homo_sapiensENSP0000037610788.198882.6087sphenodon_punctatusENSSPUP0000000404098.611192.3611
ENSG00000240344homo_sapiensENSP0000037610786.956582.6087crocodylus_porosusENSCPRP0000501206897.902193.007
ENSG00000240344homo_sapiensENSP0000037610786.956583.8509anas_platyrhynchos_platyrhynchosENSAPLP0000001585197.902194.4056
ENSG00000240344homo_sapiensENSP0000037610798.136694.4099gallus_gallusENSGALP0001003731888.76485.3933
ENSG00000240344homo_sapiensENSP0000037610796.894493.1677meleagris_gallopavoENSMGAP0000000778097.593.75
ENSG00000240344homo_sapiensENSP0000037610798.136694.4099serinus_canariaENSSCAP0000000322398.136694.4099
ENSG00000240344homo_sapiensENSP0000037610798.757892.5466anolis_carolinensisENSACAP0000001675598.757892.5466
ENSG00000240344homo_sapiensENSP0000037610787.577682.6087podarcis_muralisENSPMRP0000000423098.601493.007
ENSG00000240344homo_sapiensENSP0000037610798.136695.0311geospiza_fortisENSGFOP0000000018498.136695.0311
ENSG00000240344homo_sapiensENSP0000037610798.136694.4099taeniopygia_guttataENSTGUP0000001071998.136694.4099
ENSG00000240344homo_sapiensENSP0000037610788.819980.1242erpetoichthys_calabaricusENSECRP0000001830281.714373.7143
ENSG00000240344homo_sapiensENSP0000037610787.577683.8509salvator_merianaeENSSMRP0000002594598.601494.4056
ENSG00000240344homo_sapiensENSP0000037610793.788885.0932amphilophus_citrinellusENSACIP0000002944192.073283.5366
ENSG00000240344homo_sapiensENSP0000037610786.335478.882dicentrarchus_labraxENSDLAP0000502422193.918985.8108
ENSG00000240344homo_sapiensENSP0000037610788.819979.5031oryzias_sinensisENSOSIP0000004407488.271679.0123
ENSG00000240344homo_sapiensENSP0000037610797.515593.7888pelodiscus_sinensisENSPSIP0000000421297.515593.7888
ENSG00000240344homo_sapiensENSP0000037610798.136693.1677gopherus_evgoodeiENSGEVP0000501934498.136693.1677
ENSG00000240344homo_sapiensENSP0000037610798.757894.4099chelonoidis_abingdoniiENSCABP0000001669498.757894.4099
ENSG00000240344homo_sapiensENSP0000037610793.167783.8509cottoperca_gobioENSCGOP0000000772893.167783.8509
ENSG00000240344homo_sapiensENSP0000037610797.515593.1677struthio_camelus_australisENSSCUP0000002245397.515593.1677
ENSG00000240344homo_sapiensENSP0000037610796.894493.7888anser_brachyrhynchusENSABRP0000001560197.594.375
ENSG00000240344homo_sapiensENSP0000037610792.546683.2298gasterosteus_aculeatusENSGACP0000001855392.546683.2298
ENSG00000240344homo_sapiensENSP0000037610793.167785.7143poecilia_formosaENSPFOP0000000118187.719380.7018
ENSG00000240344homo_sapiensENSP0000037610798.136694.4099strigops_habroptilaENSSHBP0000502528198.136694.4099
ENSG00000240344homo_sapiensENSP0000037610798.136693.1677terrapene_carolina_triunguisENSTMTP0000001340398.136693.1677
ENSG00000240344homo_sapiensENSP0000037610793.167781.9876anabas_testudineusENSATEP0000006502292.024580.9816
ENSG00000240344homo_sapiensENSP0000037610749.068337.2671saccharomyces_cerevisiaeYDR155C48.765437.037
ENSG00000240344homo_sapiensENSP0000037610749.689437.8882saccharomyces_cerevisiaeYML078W43.95633.5165
ENSG00000240344homo_sapiensENSP0000037610793.167784.472labrus_bergyltaENSLBEP0000001241093.167784.472
ENSG00000240344homo_sapiensENSP0000037610785.093278.2609mastacembelus_armatusENSMAMP0000000761088.387181.2903
ENSG00000240344homo_sapiensENSP0000037610793.167784.472nothobranchius_furzeriENSNFUP0001504539392.592683.9506
ENSG00000240344homo_sapiensENSP0000037610793.788885.0932cyprinodon_variegatusENSCVAP0000000858693.788885.0932
ENSG00000240344homo_sapiensENSP0000037610783.229876.3975takifugu_rubripesENSTRUP0000004219593.055685.4167
ENSG00000240344homo_sapiensENSP0000037610793.788888.1988ficedula_albicollisENSFALP0000001860790.963985.5422
ENSG00000240344homo_sapiensENSP0000037610786.956584.472coturnix_japonicaENSCJPP0000501874497.222294.4444
ENSG00000240344homo_sapiensENSP0000037610793.167785.7143poecilia_latipinnaENSPLAP0000002199387.719380.7018
ENSG00000240344homo_sapiensENSP0000037610794.409983.8509tetraodon_nigroviridisENSTNIP0000001867194.409983.8509
ENSG00000240344homo_sapiensENSP0000037610794.409985.7143paramormyrops_kingsleyaeENSPKIP0000000031494.409985.7143
ENSG00000240344homo_sapiensENSP0000037610795.652284.472scleropages_formosusENSSFOP0001502016695.652284.472
ENSG00000240344homo_sapiensENSP0000037610790.683281.9876leptobrachium_leishanenseENSLLEP0000003444092.993684.0764
ENSG00000240344homo_sapiensENSP0000037610792.546681.9876scophthalmus_maximusENSSMAP0000001845691.41180.9816
ENSG00000240344homo_sapiensENSP0000037610744.720536.646oryzias_melastigmaENSOMEP0000002471272.727359.596
ENSG00000240344homo_sapiensENSP0000037610793.167782.6087oryzias_melastigmaENSOMEP0000001000093.167782.6087

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000398involved_in mRNA splicing, via spliceosome1ICHomo_sapiens(9606)Process
GO:0000413involved_in protein peptidyl-prolyl isomerization1IBAHomo_sapiens(9606)Process
GO:0003755enables peptidyl-prolyl cis-trans isomerase activity1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0006457involved_in protein folding1IEAHomo_sapiens(9606)Process
GO:0071013part_of catalytic step 2 spliceosome2IBA,IDAHomo_sapiens(9606)Component

Expression