Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000239732 Gene ID 54106 Accession 15633
Symbol TLR9 Alias CD289 Full Name toll like receptor 9
Status Confidence Length 4566 bases Strand Minus strand
Position 3 : 52221080 - 52225645 RNA binding domain N.A.
Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Aug 2017]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
24037211 Toll-like receptor variants are associated with infant HIV-1 acquisition and peak plasma HIV-1 RNA level. M Kristin Beima-Sofie 2013-09-24 AIDS (London, England)
19524994 Human cytomegalovirus suppresses type I interferon secretion by plasmacytoid dendritic cells through its interleukin 10 homolog. William L W Chang 2009-08-01 Virology
28652702 Spotlight on ixekizumab for the treatment of moderate-to-severe plaque psoriasis: design, development, and use in therapy. Alessandro Giunta 2017-01-01 Drug design, development and therapy
25416804 Inhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells. Ying Tan 2015-01-01 Journal of immunology (Baltimore, Md. : 1950)
33634129 Overcoming Chemoresistance: Altering pH of Cellular Compartments by Chloroquine and Hydroxychloroquine. W Peter Halcrow 2021-01-01 Frontiers in cell and developmental biology

Transcripts

Name Transcript ID bp Protein Translation ID
TLR9-201 ENST00000360658 3352 1032aa ENSP00000353874

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000139located_in Golgi membrane1TASHomo_sapiens(9606)Component
GO:0001774involved_in microglial cell activation1IEAHomo_sapiens(9606)Process
GO:0001932involved_in regulation of protein phosphorylation1IEAHomo_sapiens(9606)Process
GO:0002224involved_in toll-like receptor signaling pathway2IBA,IDAHomo_sapiens(9606)Process
GO:0002639involved_in positive regulation of immunoglobulin production1IDAHomo_sapiens(9606)Process
GO:0002730involved_in regulation of dendritic cell cytokine production1IEAHomo_sapiens(9606)Process
GO:0002755involved_in MyD88-dependent toll-like receptor signaling pathway1IEAHomo_sapiens(9606)Process
GO:0005149enables interleukin-1 receptor binding1IPIHomo_sapiens(9606)Function
GO:0005576located_in extracellular region1NASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005764located_in lysosome1ISSHomo_sapiens(9606)Component
GO:0005768located_in endosome1ISSHomo_sapiens(9606)Component
GO:0005783is_active_in endoplasmic reticulum2IDA,ISSHomo_sapiens(9606)Component
GO:0005789located_in endoplasmic reticulum membrane1TASHomo_sapiens(9606)Component
GO:0005886is_active_in plasma membrane2IBA,IDAHomo_sapiens(9606)Component
GO:0007249involved_in I-kappaB kinase/NF-kappaB signaling1IBAHomo_sapiens(9606)Process
GO:0008584involved_in male gonad development1IEAHomo_sapiens(9606)Process
GO:0010008located_in endosome membrane1TASHomo_sapiens(9606)Component
GO:0010508involved_in positive regulation of autophagy1IEAHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression1IDAHomo_sapiens(9606)Process
GO:0016323located_in basolateral plasma membrane1IDAHomo_sapiens(9606)Component
GO:0016324located_in apical plasma membrane1IDAHomo_sapiens(9606)Component
GO:0030277involved_in maintenance of gastrointestinal epithelium1ISSHomo_sapiens(9606)Process
GO:0030890involved_in positive regulation of B cell proliferation1IDAHomo_sapiens(9606)Process
GO:0032009located_in early phagosome1ISSHomo_sapiens(9606)Component
GO:0032490involved_in detection of molecule of bacterial origin1IDAHomo_sapiens(9606)Process
GO:0032722involved_in positive regulation of chemokine production1IDAHomo_sapiens(9606)Process
GO:0032725involved_in positive regulation of granulocyte macrophage colony-stimulating factor production1IDAHomo_sapiens(9606)Process
GO:0032727involved_in positive regulation of interferon-alpha production1IDAHomo_sapiens(9606)Process
GO:0032728involved_in positive regulation of interferon-beta production2IDA,ISSHomo_sapiens(9606)Process
GO:0032729involved_in positive regulation of type II interferon production1IDAHomo_sapiens(9606)Process
GO:0032733involved_in positive regulation of interleukin-10 production1ISSHomo_sapiens(9606)Process
GO:0032735involved_in positive regulation of interleukin-12 production1ISSHomo_sapiens(9606)Process
GO:0032741involved_in positive regulation of interleukin-18 production1ISSHomo_sapiens(9606)Process
GO:0032755involved_in positive regulation of interleukin-6 production2IBA,IDAHomo_sapiens(9606)Process
GO:0032757acts_upstream_of positive regulation of interleukin-8 production2IDAHomo_sapiens(9606)Process
GO:0032760involved_in positive regulation of tumor necrosis factor production1ISSHomo_sapiens(9606)Process
GO:0034162involved_in toll-like receptor 9 signaling pathway1IDAHomo_sapiens(9606)Process
GO:0034163involved_in regulation of toll-like receptor 9 signaling pathway1IDAHomo_sapiens(9606)Process
GO:0034165involved_in positive regulation of toll-like receptor 9 signaling pathway1IEAHomo_sapiens(9606)Process
GO:0035197enables siRNA binding1IMPHomo_sapiens(9606)Function
GO:0036019located_in endolysosome1ISSHomo_sapiens(9606)Component
GO:0036020located_in endolysosome membrane1TASHomo_sapiens(9606)Component
GO:0038187enables pattern recognition receptor activity2IBA,IDAHomo_sapiens(9606)Function
GO:0042742involved_in defense response to bacterium1NASHomo_sapiens(9606)Process
GO:0042803enables protein homodimerization activity1ISSHomo_sapiens(9606)Function
GO:0043123involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling1IDAHomo_sapiens(9606)Process
GO:0043410involved_in positive regulation of MAPK cascade1IDAHomo_sapiens(9606)Process
GO:0045087involved_in innate immune response1TASHomo_sapiens(9606)Process
GO:0045322enables unmethylated CpG binding1ISSHomo_sapiens(9606)Function
GO:0045577involved_in regulation of B cell differentiation1IDAHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0046330involved_in positive regulation of JNK cascade1IDAHomo_sapiens(9606)Process
GO:0050729involved_in positive regulation of inflammatory response1ICHomo_sapiens(9606)Process
GO:0050829involved_in defense response to Gram-negative bacterium1IMPHomo_sapiens(9606)Process
GO:0050871involved_in positive regulation of B cell activation1IDAHomo_sapiens(9606)Process
GO:0051092involved_in positive regulation of NF-kappaB transcription factor activity1IBAHomo_sapiens(9606)Process
GO:0051607involved_in defense response to virus1IBAHomo_sapiens(9606)Process
GO:0070373involved_in negative regulation of ERK1 and ERK2 cascade1IEAHomo_sapiens(9606)Process
GO:0071222involved_in cellular response to lipopolysaccharide1IEAHomo_sapiens(9606)Process
GO:0071248involved_in cellular response to metal ion1IEAHomo_sapiens(9606)Process
GO:1901224involved_in positive regulation of NIK/NF-kappaB signaling1IDAHomo_sapiens(9606)Process
GO:1901895involved_in negative regulation of ATPase-coupled calcium transmembrane transporter activity1IDAHomo_sapiens(9606)Process
GO:1902350involved_in cellular response to chloroquine1IEAHomo_sapiens(9606)Process
GO:1905300involved_in positive regulation of intestinal epithelial cell development1ISSHomo_sapiens(9606)Process

Expression