Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs tRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000213638 Gene ID 113179 Accession 25151
Symbol ADAT3 Alias TAD3;MRT36;FWP005;MST121;NEDBGF;S863-5;MSTP121 Full Name adenosine deaminase tRNA specific 3
Status Confidence Length 8049 bases Strand Plus strand
Position 19 : 1905399 - 1913447 RNA binding domain N.A.
Summary This gene encodes a subunit of a tRNA-specific adenosine deaminase. This heterodimeric enzyme converts adenosine to inosine in the tRNA anticodon. A mutation in this gene causes a syndrome characterized by intellectual disability and strabismus. This gene shares its 5' exon with the overlapping gene, secretory carrier membrane protein 4 (Gene ID: 113178). [provided by RefSeq, Jul 2016]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
36347890 Structural basis for sequence-independent substrate selection by eukaryotic wobble base tRNA deaminase ADAT2/3. G Luciano Dolce 2022-11-08 Nature communications
27869537 RNA binding to APOBEC deaminases; Not simply a substrate for C to U editing. C Harold Smith 2017-09-02 RNA biology
34057470 The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination. Elizabeth Ramos-Morales 2021-06-21 Nucleic acids research
33921764 Inosine in Biology and Disease. Sundaramoorthy Srinivasan 2021-04-19 Genes
30737359 tRNA deamination by ADAT requires substrate-specific recognition mechanisms and can be inhibited by tRFs. Helena H Roura 2019-05-01 RNA (New York, N.Y.)

Transcripts

Name Transcript ID bp Protein Translation ID
ADAT3-201 ENST00000329478 1599 367aa ENSP00000332448
ADAT3-202 ENST00000454697 983 69aa ENSP00000404502

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000213638homo_sapiensENSP0000023728336.649224.0838homo_sapiensENSP0000033244819.073612.5341

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000213638homo_sapiensENSP0000033244898.365197.2752nomascus_leucogenysENSNLEP0000000239098.365197.2752
ENSG00000213638homo_sapiensENSP0000033244889.645889.3733pan_paniscusENSPPAP0000003809799.69799.3939
ENSG00000213638homo_sapiensENSP0000033244878.746672.752dasypus_novemcinctusENSDNOP0000000593679.834373.7569
ENSG00000213638homo_sapiensENSP0000033244876.566870.8447echinops_telfairiENSETEP0000000813281.68675.5814
ENSG00000213638homo_sapiensENSP0000033244899.182698.0926macaca_mulattaENSMMUP0000008090199.182698.0926
ENSG00000213638homo_sapiensENSP0000033244898.910197.8202macaca_nemestrinaENSMNEP0000000319098.910197.8202
ENSG00000213638homo_sapiensENSP0000033244898.637697.0027papio_anubisENSPANP0000000415598.637697.0027
ENSG00000213638homo_sapiensENSP0000033244885.831180.3815vulpes_vulpesENSVVUP0000000287281.606276.4249
ENSG00000213638homo_sapiensENSP0000033244883.923777.3842mus_spretusMGP_SPRETEiJ_P002514988.252281.3754
ENSG00000213638homo_sapiensENSP0000033244883.378779.0191equus_asinusENSEASP0000503870485.474981.0056
ENSG00000213638homo_sapiensENSP0000033244880.381574.3869loxodonta_africanaENSLAFP0000001779184.045677.7778
ENSG00000213638homo_sapiensENSP0000033244886.648582.0163panthera_leoENSPLOP0000000666289.325884.5506
ENSG00000213638homo_sapiensENSP0000033244887.738481.4714ailuropoda_melanoleucaENSAMEP0000001975468.803463.8889
ENSG00000213638homo_sapiensENSP0000033244882.288875.7493bos_indicus_hybridENSBIXP0000500344488.046681.0496
ENSG00000213638homo_sapiensENSP0000033244885.013680.9264equus_caballusENSECAP0000008957387.887383.662
ENSG00000213638homo_sapiensENSP0000033244884.196278.7466marmota_marmota_marmotaENSMMMP0000001828088.034282.3362
ENSG00000213638homo_sapiensENSP0000033244850.136246.049cavia_porcellusENSCPOP0000001689079.653773.1602
ENSG00000213638homo_sapiensENSP0000033244877.111771.1172bison_bison_bisonENSBBBP0000001078377.322471.3115
ENSG00000213638homo_sapiensENSP0000033244884.468778.2016sus_scrofaENSSSCP0000003318488.319181.7664
ENSG00000213638homo_sapiensENSP0000033244880.926474.1144octodon_degusENSODEP0000001783485.344878.1609
ENSG00000213638homo_sapiensENSP0000033244882.833876.0218ovis_aries_rambouilletENSOARP0002002653486.363679.2614
ENSG00000213638homo_sapiensENSP0000033244885.286179.564physeter_catodonENSPCTP0000502726789.428683.4286
ENSG00000213638homo_sapiensENSP0000033244883.651277.3842mus_caroliMGP_CAROLIEiJ_P002398387.965681.3754
ENSG00000213638homo_sapiensENSP0000033244884.468777.6567mus_musculusENSMUSP0000013625988.825281.6619
ENSG00000213638homo_sapiensENSP0000033244884.468777.6567mus_musculusENSMUSP0000004055188.825281.6619
ENSG00000213638homo_sapiensENSP0000033244885.286177.9292dipodomys_ordiiENSDORP0000001974288.418180.791
ENSG00000213638homo_sapiensENSP0000033244886.103581.1989mustela_putorius_furoENSMPUP0000001985289.265584.1808
ENSG00000213638homo_sapiensENSP0000033244884.741182.8338saimiri_boliviensis_boliviensisENSSBOP0000001147693.393491.2913
ENSG00000213638homo_sapiensENSP0000033244884.468778.2016mesocricetus_auratusENSMAUP0000000321088.825282.235
ENSG00000213638homo_sapiensENSP0000033244884.741179.0191phocoena_sinusENSPSNP0000002441888.857182.8571
ENSG00000213638homo_sapiensENSP0000033244885.831179.2915camelus_dromedariusENSCDRP0000501661889.743682.906
ENSG00000213638homo_sapiensENSP0000033244883.651277.1117rattus_norvegicusENSRNOP0000008959087.965681.0888
ENSG00000213638homo_sapiensENSP0000033244887.465982.5613prolemur_simusENSPSMP0000001270791.45386.3248
ENSG00000213638homo_sapiensENSP0000033244885.286177.9292microtus_ochrogasterENSMOCP0000001937289.173881.4815
ENSG00000213638homo_sapiensENSP0000033244877.111770.8447peromyscus_maniculatus_bairdiiENSPEMP0000001193888.993781.761
ENSG00000213638homo_sapiensENSP0000033244884.196277.3842mus_spicilegusENSMSIP0000002601888.538781.3754
ENSG00000213638homo_sapiensENSP0000033244884.468777.9292cricetulus_griseus_chok1gshdENSCGRP0000100735588.319181.4815
ENSG00000213638homo_sapiensENSP0000033244885.286179.0191pteropus_vampyrusENSPVAP0000000896689.173882.6211
ENSG00000213638homo_sapiensENSP0000033244883.923777.1117myotis_lucifugusENSMLUP0000001646587.005779.9435
ENSG00000213638homo_sapiensENSP0000033244880.926472.4796nannospalax_galiliENSNGAP0000002381384.13675.3541
ENSG00000213638homo_sapiensENSP0000033244885.558679.0191otolemur_garnettiiENSOGAP0000001183889.971383.0946
ENSG00000213638homo_sapiensENSP0000033244883.923778.4741urocitellus_parryiiENSUPAP0001001621887.749382.0513
ENSG00000213638homo_sapiensENSP0000033244883.923778.2016mus_pahariMGP_PahariEiJ_P008713588.505782.4713
ENSG00000213638homo_sapiensENSP0000033244836.784723.1608caenorhabditis_elegansY47D3A.14.147.038329.6167
ENSG00000213638homo_sapiensENSP0000033244844.414228.3379drosophila_melanogasterFBpp008588445.277828.8889
ENSG00000213638homo_sapiensENSP0000033244846.59431.0627ciona_intestinalisENSCINP0000003351947.368431.5789
ENSG00000213638homo_sapiensENSP0000033244858.855647.139petromyzon_marinusENSPMAP0000001125659.833847.9224
ENSG00000213638homo_sapiensENSP0000033244856.130842.7793eptatretus_burgeriENSEBUP0000001122849.878938.0145
ENSG00000213638homo_sapiensENSP0000033244865.667651.4986latimeria_chalumnaeENSLACP0000001635167.318452.7933
ENSG00000213638homo_sapiensENSP0000033244863.760250.1362lepisosteus_oculatusENSLOCP0000002193668.023353.4884
ENSG00000213638homo_sapiensENSP0000033244863.760248.2289clupea_harengusENSCHAP0000005498466.666750.4273
ENSG00000213638homo_sapiensENSP0000033244862.397847.4114danio_rerioENSDARP0000001877068.154851.7857
ENSG00000213638homo_sapiensENSP0000033244864.850150.4087carassius_auratusENSCARP0000005068570.414254.7337
ENSG00000213638homo_sapiensENSP0000033244863.215348.7738astyanax_mexicanusENSAMXP0000002581665.352150.4225
ENSG00000213638homo_sapiensENSP0000033244862.670347.6839ictalurus_punctatusENSIPUP0000001241565.155849.5751
ENSG00000213638homo_sapiensENSP0000033244864.850150.9537esox_luciusENSELUP0000003499365.92851.8006
ENSG00000213638homo_sapiensENSP0000033244861.307945.7766electrophorus_electricusENSEEEP0000004939764.285748
ENSG00000213638homo_sapiensENSP0000033244865.122649.5913oncorhynchus_kisutchENSOKIP0000502979165.659350
ENSG00000213638homo_sapiensENSP0000033244866.212549.5913oncorhynchus_mykissENSOMYP0000006917766.758250
ENSG00000213638homo_sapiensENSP0000033244853.95138.1471salmo_salarENSSSAP0000004991360.365942.6829
ENSG00000213638homo_sapiensENSP0000033244865.940150.1362salmo_salarENSSSAP0000017726766.666750.6887
ENSG00000213638homo_sapiensENSP0000033244865.667649.8638salmo_truttaENSSTUP0000007597666.208850.2747
ENSG00000213638homo_sapiensENSP0000033244862.670350.1362gadus_morhuaENSGMOP0000004460464.066851.2535
ENSG00000213638homo_sapiensENSP0000033244857.765746.8665fundulus_heteroclitusENSFHEP0000000944361.627950
ENSG00000213638homo_sapiensENSP0000033244862.125350.9537poecilia_reticulataENSPREP0000000151966.279154.3605
ENSG00000213638homo_sapiensENSP0000033244862.942851.2262xiphophorus_maculatusENSXMAP0000002744858.778647.8372
ENSG00000213638homo_sapiensENSP0000033244863.760251.2262cyclopterus_lumpusENSCLMP0000502890965.915552.9577
ENSG00000213638homo_sapiensENSP0000033244861.580449.3188oreochromis_niloticusENSONIP0000002645766.470653.2353
ENSG00000213638homo_sapiensENSP0000033244862.125349.5913haplochromis_burtoniENSHBUP0000002124664.589251.5581
ENSG00000213638homo_sapiensENSP0000033244861.035448.7738astatotilapia_callipteraENSACLP0000000266065.882452.6471
ENSG00000213638homo_sapiensENSP0000033244864.032750.4087sparus_aurataENSSAUP0001000992660.56747.6804
ENSG00000213638homo_sapiensENSP0000033244862.942850.6812lates_calcariferENSLCAP0001000052666.76353.7572
ENSG00000213638homo_sapiensENSP0000033244852.86138.6921xenopus_tropicalisENSXETP0000010410845.862933.5697
ENSG00000213638homo_sapiensENSP0000033244863.760253.951chrysemys_picta_belliiENSCPBP0000001405268.823558.2353
ENSG00000213638homo_sapiensENSP0000033244866.757554.2234laticauda_laticaudataENSLLTP0000002291170.809257.5145
ENSG00000213638homo_sapiensENSP0000033244866.757554.4959notechis_scutatusENSNSUP0000002547470.809257.8035
ENSG00000213638homo_sapiensENSP0000033244866.757554.4959pseudonaja_textilisENSPTXP0000001697570.809257.8035
ENSG00000213638homo_sapiensENSP0000033244843.051833.2425gallus_gallusENSGALP0001000284746.064135.5685
ENSG00000213638homo_sapiensENSP0000033244847.683936.2398anolis_carolinensisENSACAP0000002165251.319639.0029
ENSG00000213638homo_sapiensENSP0000033244861.580449.0463neolamprologus_brichardiENSNBRP0000002375466.470652.9412
ENSG00000213638homo_sapiensENSP0000033244866.48554.7684naja_najaENSNNAP0000001672867.403355.5249
ENSG00000213638homo_sapiensENSP0000033244866.212554.4959podarcis_muralisENSPMRP0000002004265.498653.9084
ENSG00000213638homo_sapiensENSP0000033244844.686632.4251taeniopygia_guttataENSTGUP000000235949.808617.11722
ENSG00000213638homo_sapiensENSP0000033244862.670349.8638erpetoichthys_calabaricusENSECRP0000000897066.666753.0435
ENSG00000213638homo_sapiensENSP0000033244863.215351.2262kryptolebias_marmoratusENSKMAP0000000523870.30356.9697
ENSG00000213638homo_sapiensENSP0000033244864.305254.7684salvator_merianaeENSSMRP0000000771967.045557.1023
ENSG00000213638homo_sapiensENSP0000033244862.670349.5913oryzias_javanicusENSOJAP0000004580864.066850.6964
ENSG00000213638homo_sapiensENSP0000033244861.580450.6812amphilophus_citrinellusENSACIP0000000808267.261955.3571
ENSG00000213638homo_sapiensENSP0000033244864.850151.2262dicentrarchus_labraxENSDLAP0000505181160.10147.4747
ENSG00000213638homo_sapiensENSP0000033244863.760249.5913amphiprion_perculaENSAPEP0000000553667.241452.2989
ENSG00000213638homo_sapiensENSP0000033244862.942849.8638oryzias_sinensisENSOSIP0000002434263.461550.2747
ENSG00000213638homo_sapiensENSP0000033244866.212553.951pelodiscus_sinensisENSPSIP0000000118771.470658.2353
ENSG00000213638homo_sapiensENSP0000033244864.577754.7684gopherus_evgoodeiENSGEVP0000502289171.171260.3604
ENSG00000213638homo_sapiensENSP0000033244863.215350.9537seriola_dumeriliENSSDUP0000001010967.638554.519
ENSG00000213638homo_sapiensENSP0000033244861.580448.5014cottoperca_gobioENSCGOP0000004911063.841850.2825
ENSG00000213638homo_sapiensENSP0000033244863.760251.4986gasterosteus_aculeatusENSGACP0000000346169.850756.4179
ENSG00000213638homo_sapiensENSP0000033244862.125350.6812cynoglossus_semilaevisENSCSEP0000002569966.279154.0698
ENSG00000213638homo_sapiensENSP0000033244861.852950.4087poecilia_formosaENSPFOP0000002005968.168255.5556
ENSG00000213638homo_sapiensENSP0000033244862.942850.4087myripristis_murdjanENSMMDP0000504644664.345451.532
ENSG00000213638homo_sapiensENSP0000033244864.577750.6812sander_luciopercaENSSLUP0000004186365.833351.6667
ENSG00000213638homo_sapiensENSP0000033244863.760249.3188amphiprion_ocellarisENSAOCP0000001870569.026653.3923
ENSG00000213638homo_sapiensENSP0000033244847.683937.6022hucho_huchoENSHHUP0000005521362.549.2857
ENSG00000213638homo_sapiensENSP0000033244865.122649.5913hucho_huchoENSHHUP0000008800865.840250.1377
ENSG00000213638homo_sapiensENSP0000033244865.395149.5913betta_splendensENSBSLP0000002123143.715833.1512
ENSG00000213638homo_sapiensENSP0000033244864.305249.3188pygocentrus_nattereriENSPNAP0000001463466.666751.1299
ENSG00000213638homo_sapiensENSP0000033244864.032750.4087anabas_testudineusENSATEP0000001274769.117654.4118
ENSG00000213638homo_sapiensENSP0000033244843.596730.2452ciona_savignyiENSCSAVP0000000472649.079834.0491
ENSG00000213638homo_sapiensENSP0000033244834.059919.6185saccharomyces_cerevisiaeYLR316C38.819922.3602
ENSG00000213638homo_sapiensENSP0000033244862.942850.6812seriola_lalandi_dorsalisENSSLDP0000001945167.346954.2274
ENSG00000213638homo_sapiensENSP0000033244862.942848.5014labrus_bergyltaENSLBEP0000003773666.570651.2968
ENSG00000213638homo_sapiensENSP0000033244861.580449.0463pundamilia_nyerereiENSPNYP0000001515166.470652.9412
ENSG00000213638homo_sapiensENSP0000033244863.215349.3188mastacembelus_armatusENSMAMP0000001576968.639153.5503
ENSG00000213638homo_sapiensENSP0000033244864.305251.4986stegastes_partitusENSSPAP0000000076768.208154.6243
ENSG00000213638homo_sapiensENSP0000033244865.667649.5913oncorhynchus_tshawytschaENSOTSP0000502474466.208850
ENSG00000213638homo_sapiensENSP0000033244863.487749.0463acanthochromis_polyacanthusENSAPOP0000001281365.266150.4202
ENSG00000213638homo_sapiensENSP0000033244862.397850.1362nothobranchius_furzeriENSNFUP0001502938568.562955.0898
ENSG00000213638homo_sapiensENSP0000033244863.487753.1335cyprinodon_variegatusENSCVAP0000000347170.606159.0909
ENSG00000213638homo_sapiensENSP0000033244863.215350.1362denticeps_clupeoidesENSDCDP0000004667564.62451.2535
ENSG00000213638homo_sapiensENSP0000033244863.760249.8638larimichthys_croceaENSLCRP0000504480165.915551.5493
ENSG00000213638homo_sapiensENSP0000033244863.487749.8638takifugu_rubripesENSTRUP0000003234968.934954.142
ENSG00000213638homo_sapiensENSP0000033244857.765745.7766hippocampus_comesENSHCOP0000000779967.515953.5032
ENSG00000213638homo_sapiensENSP0000033244857.765743.3242cyprinus_carpio_carpioENSCCRP0000011077865.432149.0741
ENSG00000213638homo_sapiensENSP0000033244864.577750.6812cyprinus_carpio_carpioENSCCRP0000011505370.118355.0296
ENSG00000213638homo_sapiensENSP0000033244827.792921.2534coturnix_japonicaENSCJPP000050026032519.1176
ENSG00000213638homo_sapiensENSP0000033244861.852950.6812poecilia_latipinnaENSPLAP0000001962966.764754.7059
ENSG00000213638homo_sapiensENSP0000033244863.760249.8638sinocyclocheilus_grahamiENSSGRP0000007976369.230854.142
ENSG00000213638homo_sapiensENSP0000033244860.490546.049sinocyclocheilus_grahamiENSSGRP0000009207368.944152.4845
ENSG00000213638homo_sapiensENSP0000033244861.035448.7738maylandia_zebraENSMZEP0000501890965.882452.6471
ENSG00000213638homo_sapiensENSP0000033244862.125350.6812tetraodon_nigroviridisENSTNIP0000001879269.724856.8807
ENSG00000213638homo_sapiensENSP0000033244865.940149.5913paramormyrops_kingsleyaeENSPKIP0000002731568.7551.7045
ENSG00000213638homo_sapiensENSP0000033244862.942848.7738scleropages_formosusENSSFOP0001501195564.345449.8607
ENSG00000213638homo_sapiensENSP0000033244853.95137.0572leptobrachium_leishanenseENSLLEP0000004903149.253733.8308
ENSG00000213638homo_sapiensENSP0000033244863.215348.7738scophthalmus_maximusENSSMAP0000002667366.096950.9972
ENSG00000213638homo_sapiensENSP0000033244862.125349.8638oryzias_melastigmaENSOMEP0000002019765.89652.8902

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0008033involved_in tRNA processing1IEAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0052717contributes_to tRNA-specific adenosine-34 deaminase activity1IBAHomo_sapiens(9606)Function

Expression