Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug Drug
Main interacting RNAs snRNA
Moonlighting functions Transmemebrane
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000205571 Gene ID 6607 Accession 11118
Symbol SMN2 Alias SMNC;BCD541;GEMIN1;TDRD16B;C-BCD541 Full Name survival of motor neuron 2, centromeric
Status Confidence Length 28885 bases Strand Plus strand
Position 5 : 70049638 - 70078522 RNA binding domain SMN
Summary This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. This gene may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Sep 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000370117 SMN PF06003 2.4e-103 1
ENSP00000370119 SMN PF06003 2.4e-103 1
ENSP00000486152 SMN PF06003 2.5e-99 1
ENSP00000424799 SMN PF06003 2.7e-99 1
ENSP00000486268 SMN PF06003 2.7e-99 1
ENSP00000492675 SMN PF06003 3.9e-99 1
ENSP00000370118 SMN PF06003 1.9e-90 1
ENSP00000370118 SMN PF06003 1.9e-90 2
ENSP00000479279 SMN PF06003 1.9e-90 1
ENSP00000479279 SMN PF06003 1.9e-90 2
ENSP00000424282 SMN PF06003 8.1e-56 1
ENSP00000424282 SMN PF06003 8.1e-56 2
ENSP00000475331 SMN PF06003 3.9e-17 1
ENSP00000475824 SMN PF06003 1.5e-06 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
32067433 Carrier Frequency of Spinal Muscular Atrophy in a Large-scale Korean Population. Eun Jong Park 2020-07-01 Annals of laboratory medicine
35941229 Targeting RNA structures with small molecules. L Jessica Childs-Disney 2022-10-01 Nature reviews. Drug discovery
37182892 RNA Transcript Diversity in Neuromuscular Research. Fang Wooi Lim 2023-01-01 Journal of neuromuscular diseases
33000450 Heterogeneous Nuclear Ribonucleoproteins: Implications in Neurological Diseases. Yi-Hua Low 2021-02-01 Molecular neurobiology
36689327 How does precursor RNA structure influence RNA processing and gene expression? Austin Herbert 2023-03-31 Bioscience reports
28977438 Spinal muscular atrophy: antisense oligonucleotide therapy opens the door to an integrated therapeutic landscape. A J Matthew Wood 2017-10-01 Human molecular genetics
32929000 RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges. Ai-Ming Yu 2020-10-01 Pharmacological reviews
31671515 Neurofilament Heavy Chain and Tau Protein Are Not Elevated in Cerebrospinal Fluid of Adult Patients with Spinal Muscular Atrophy during Loading with Nusinersen. Andreas Totzeck 2019-10-30 International journal of molecular sciences
33501671 Safety and efficacy of nusinersen in spinal muscular atrophy: The EMBRACE study. Gyula Acsadi 2021-05-01 Muscle & nerve
36881759 Chemistry, structure and function of approved oligonucleotide therapeutics. Martin Egli 2023-04-11 Nucleic acids research
34301951 Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia. Masahiko Ajiro 2021-07-23 Nature communications
28034912 Pharmacology of Modulators of Alternative Splicing. O David Bates 2017-01-01 Pharmacological reviews
20186123 The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. Simona Pedrotti 2010-04-07 The EMBO journal
24692659 Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation. Ahmed Moursy 2014-06-01 Nucleic acids research
35456491 High Concentration or Combined Treatment of Antisense Oligonucleotides for Spinal Muscular Atrophy Perturbed SMN2 Splicing in Patient Fibroblasts. Silvana Onky Yogik Wijaya 2022-04-13 Genes
22325991 Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation. Rui Xiao 2012-03-09 Molecular cell
33912591 A Comprehensive Analysis of the Role of hnRNP A1 Function and Dysfunction in the Pathogenesis of Neurodegenerative Disease. P Joseph Clarke 2021-01-01 Frontiers in molecular biosciences
32536347 Hypoxia-induced alternative splicing: the 11th Hallmark of Cancer. Rosella Antonietta Farina 2020-06-15 Journal of experimental & clinical cancer research : CR
29977051 Principles for targeting RNA with drug-like small molecules. Deigan Katherine Warner 2018-08-01 Nature reviews. Drug discovery
35847983 Structural Context of a Critical Exon of Spinal Muscular Atrophy Gene. N Natalia Singh 2022-01-01 Frontiers in molecular biosciences
17761657 SMN transcript stability: could modulation of messenger RNA degradation provide a novel therapy for spinal muscular atrophy? R Christopher Heier 2007-08-01 Journal of child neurology
29133793 Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers. Manaswini Sivaramakrishnan 2017-11-14 Nature communications
26438828 SAM68 is a physiological regulator of SMN2 splicing in spinal muscular atrophy. Vittoria Pagliarini 2015-10-12 The Journal of cell biology
29625167 Idiosyncrasies of hnRNP A1-RNA recognition: Can binding mode influence function. D Jeffrey Levengood 2019-02-01 Seminars in cell & developmental biology
31239059 A click chemistry assay to identify natural product ligands for pre-microRNAs. L Amanda Garner 2019-01-01 Methods in enzymology
32212706 How We Think about Targeting RNA with Small Molecules. G Matthew Costales 2020-09-10 Journal of medicinal chemistry
30251629 Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs. Pradeep Sai Velagapudi 2018-09-20 Cell chemical biology

Transcripts

Name Transcript ID bp Protein Translation ID
SMN2-210 ENST00000511812 867 227aa ENSP00000424282
SMN2-214 ENST00000626847 1440 282aa ENSP00000486152
SMN2-206 ENST00000506734 1550 294aa ENSP00000424799
SMN2-202 ENST00000380742 1388 262aa ENSP00000370118
SMN2-203 ENST00000380743 1482 294aa ENSP00000370119
SMN2-215 ENST00000628696 885 294aa ENSP00000486268
SMN2-201 ENST00000380741 900 294aa ENSP00000370117
SMN2-213 ENST00000614240 804 262aa ENSP00000479279
SMN2-204 ENST00000503678 761 No protein -
SMN2-211 ENST00000511873 431 79aa ENSP00000475824
SMN2-209 ENST00000509805 499 No protein -
SMN2-205 ENST00000505346 707 No protein -
SMN2-212 ENST00000514914 662 No protein -
SMN2-208 ENST00000508258 211 No protein -
SMN2-207 ENST00000507458 1045 46aa ENSP00000475331

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000205571homo_sapiensENSP00000370083100100homo_sapiensENSP00000370119100100
ENSG00000205571homo_sapiensENSP0000035861634.453824.3697homo_sapiensENSP0000037011927.891219.7279
ENSG00000205571homo_sapiensENSP00000487421100100homo_sapiensENSP00000370119100100
ENSG00000205571homo_sapiensENSP00000483515100100homo_sapiensENSP00000370119100100

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000205571homo_sapiensENSP0000037011999.319798.9796nomascus_leucogenysENSNLEP0000004139899.319798.9796
ENSG00000205571homo_sapiensENSP0000037011910099.6599pan_paniscusENSPPAP0000002717610099.6599
ENSG00000205571homo_sapiensENSP0000037011999.319798.9796pongo_abeliiENSPPYP0000001736099.319798.9796
ENSG00000205571homo_sapiensENSP00000370119100100pan_troglodytesENSPTRP0000009013998.989998.9899
ENSG00000205571homo_sapiensENSP0000037011986.054485.3742gorilla_gorillaENSGGOP0000002447296.564995.8015
ENSG00000205571homo_sapiensENSP0000037011976.530676.5306gorilla_gorillaENSGGOP00000027565100100
ENSG00000205571homo_sapiensENSP0000037011970.408260.5442ornithorhynchus_anatinusENSOANP0000000259774.460464.0288
ENSG00000205571homo_sapiensENSP0000037011972.789163.9456sarcophilus_harrisiiENSSHAP0000000168257.219250.2674
ENSG00000205571homo_sapiensENSP0000037011956.122448.6395notamacropus_eugeniiENSMEUP0000001039574.660664.7059
ENSG00000205571homo_sapiensENSP0000037011967.006863.6054choloepus_hoffmanniENSCHOP0000000650578.486174.502
ENSG00000205571homo_sapiensENSP0000037011959.863954.7619dasypus_novemcinctusENSDNOP0000002430780.365373.516
ENSG00000205571homo_sapiensENSP0000037011972.108868.7075dasypus_novemcinctusENSDNOP0000000564188.333384.1667
ENSG00000205571homo_sapiensENSP0000037011973.809569.0476erinaceus_europaeusENSEEUP0000001440687.581.8548
ENSG00000205571homo_sapiensENSP0000037011956.122449.6599echinops_telfairiENSETEP0000000113180.882471.5686
ENSG00000205571homo_sapiensENSP0000037011992.857189.7959callithrix_jacchusENSCJAP0000009284966.585464.3902
ENSG00000205571homo_sapiensENSP0000037011997.959296.5986cercocebus_atysENSCATP0000002723597.959296.5986
ENSG00000205571homo_sapiensENSP0000037011993.877591.8367macaca_fascicularisENSMFAP0000001063694.19892.1502
ENSG00000205571homo_sapiensENSP0000037011998.979697.619macaca_fascicularisENSMFAP0000001700698.979697.619
ENSG00000205571homo_sapiensENSP0000037011994.89893.1973macaca_mulattaENSMMUP0000006062893.939492.2559
ENSG00000205571homo_sapiensENSP0000037011984.353782.3129macaca_mulattaENSMMUP0000006827190.181888
ENSG00000205571homo_sapiensENSP0000037011971.768767.3469macaca_nemestrinaENSMNEP0000002590884.479.2
ENSG00000205571homo_sapiensENSP0000037011998.639597.2789macaca_nemestrinaENSMNEP0000002306898.639597.2789
ENSG00000205571homo_sapiensENSP0000037011998.979697.619papio_anubisENSPANP0000005262798.979697.619
ENSG00000205571homo_sapiensENSP0000037011985.03482.3129papio_anubisENSPANP0000001128590.909188
ENSG00000205571homo_sapiensENSP0000037011998.639596.9388mandrillus_leucophaeusENSMLEP0000003557498.976197.2696
ENSG00000205571homo_sapiensENSP0000037011988.095283.6735tursiops_truncatusENSTTRP0000000477589.003484.5361
ENSG00000205571homo_sapiensENSP0000037011989.115684.6939vulpes_vulpesENSVVUP0000000929382.389978.3019
ENSG00000205571homo_sapiensENSP0000037011986.734781.6327mus_spretusMGP_SPRETEiJ_P003695288.541783.3333
ENSG00000205571homo_sapiensENSP0000037011990.136185.7143equus_asinusENSEASP0000506267473.204469.6133
ENSG00000205571homo_sapiensENSP0000037011989.115684.0136capra_hircusENSCHIP0000001455488.813683.7288
ENSG00000205571homo_sapiensENSP0000037011989.115684.0136loxodonta_africanaENSLAFP0000000285086.184281.25
ENSG00000205571homo_sapiensENSP0000037011991.496688.0952panthera_leoENSPLOP0000000550492.758689.3103
ENSG00000205571homo_sapiensENSP0000037011989.455884.0136ailuropoda_melanoleucaENSAMEP0000000351487.959982.6087
ENSG00000205571homo_sapiensENSP0000037011987.755182.6531bos_indicus_hybridENSBIXP0000501291189.273484.083
ENSG00000205571homo_sapiensENSP0000037011982.312978.5714oryctolagus_cuniculusENSOCUP0000002021289.298985.2399
ENSG00000205571homo_sapiensENSP0000037011990.136185.3742oryctolagus_cuniculusENSOCUP0000002309090.443785.6655
ENSG00000205571homo_sapiensENSP0000037011990.136186.0544oryctolagus_cuniculusENSOCUP0000001469389.830585.7627
ENSG00000205571homo_sapiensENSP0000037011988.435482.9932equus_caballusENSECAP0000007810880.495475.5418
ENSG00000205571homo_sapiensENSP0000037011989.455884.6939canis_lupus_familiarisENSCAFP0084501839881.424177.0898
ENSG00000205571homo_sapiensENSP0000037011991.496688.0952panthera_pardusENSPPRP0000001170992.758689.3103
ENSG00000205571homo_sapiensENSP0000037011978.231375.1701marmota_marmota_marmotaENSMMMP0000000336284.558881.25
ENSG00000205571homo_sapiensENSP0000037011989.115684.6939balaenoptera_musculusENSBMSP0001001141875.287471.5517
ENSG00000205571homo_sapiensENSP0000037011987.41580.9524cavia_porcellusENSCPOP0000002603488.620782.069
ENSG00000205571homo_sapiensENSP0000037011985.03477.8912cavia_porcellusENSCPOP0000003067782.781575.8278
ENSG00000205571homo_sapiensENSP0000037011988.095285.034felis_catusENSFCAP0000001913888.095285.034
ENSG00000205571homo_sapiensENSP0000037011965.646362.2449ursus_americanusENSUAMP0000003269170.69667.033
ENSG00000205571homo_sapiensENSP0000037011972.108862.585monodelphis_domesticaENSMODP0000005807873.611163.8889
ENSG00000205571homo_sapiensENSP0000037011987.41581.9728bison_bison_bisonENSBBBP0000000486088.927383.391
ENSG00000205571homo_sapiensENSP0000037011989.115684.3537monodon_monocerosENSMMNP0001500811790.344885.5172
ENSG00000205571homo_sapiensENSP0000037011988.775585.7143sus_scrofaENSSSCP000000179798784
ENSG00000205571homo_sapiensENSP0000037011947.959246.2585sus_scrofaENSSSCP0000003242579.213576.4045
ENSG00000205571homo_sapiensENSP0000037011977.210973.8095microcebus_murinusENSMICP0000004404187.644883.7838
ENSG00000205571homo_sapiensENSP0000037011984.353777.8912octodon_degusENSODEP0000002172584.931578.4247
ENSG00000205571homo_sapiensENSP0000037011946.258542.517jaculus_jaculusENSJJAP0000001154591.275283.8926
ENSG00000205571homo_sapiensENSP0000037011951.020447.9592ovis_aries_rambouilletENSOARP0002003172387.719382.4561
ENSG00000205571homo_sapiensENSP0000037011988.775583.3333ovis_aries_rambouilletENSOARP0002003061988.775583.3333
ENSG00000205571homo_sapiensENSP0000037011987.41583.6735ursus_maritimusENSUMAP0000001043065.561262.7551
ENSG00000205571homo_sapiensENSP0000037011977.55171.4286ochotona_princepsENSOPRP0000000185090.118683.004
ENSG00000205571homo_sapiensENSP0000037011989.115684.3537delphinapterus_leucasENSDLEP0000001577190.344885.5172
ENSG00000205571homo_sapiensENSP0000037011988.775583.3333physeter_catodonENSPCTP0000500129471.311566.9399
ENSG00000205571homo_sapiensENSP0000037011987.41582.3129mus_caroliMGP_CAROLIEiJ_P003527489.236184.0278
ENSG00000205571homo_sapiensENSP0000037011987.41582.3129mus_musculusENSMUSP0000002214789.236184.0278
ENSG00000205571homo_sapiensENSP0000037011982.312977.551dipodomys_ordiiENSDORP0000001980390.298585.0746
ENSG00000205571homo_sapiensENSP0000037011987.755184.3537mustela_putorius_furoENSMPUP0000001436091.489487.9433
ENSG00000205571homo_sapiensENSP0000037011994.557892.1769aotus_nancymaaeENSANAP0000002863893.918991.5541
ENSG00000205571homo_sapiensENSP0000037011979.591874.8299saimiri_boliviensis_boliviensisENSSBOP0000000630981.533176.6551
ENSG00000205571homo_sapiensENSP0000037011994.89892.517saimiri_boliviensis_boliviensisENSSBOP0000000233295.876393.4708
ENSG00000205571homo_sapiensENSP0000037011972.789170.7483vicugna_pacosENSVPAP0000000920177.256375.0903
ENSG00000205571homo_sapiensENSP0000037011998.979696.9388chlorocebus_sabaeusENSCSAP0000001174498.979696.9388
ENSG00000205571homo_sapiensENSP0000037011963.605461.2245tupaia_belangeriENSTBEP0000000206190.338286.9565
ENSG00000205571homo_sapiensENSP0000037011985.374279.5918mesocricetus_auratusENSMAUP0000000898485.958980.137
ENSG00000205571homo_sapiensENSP0000037011989.115684.3537phocoena_sinusENSPSNP0000001046375.504371.4697
ENSG00000205571homo_sapiensENSP0000037011990.476288.0952camelus_dromedariusENSCDRP0000500512389.562387.2054
ENSG00000205571homo_sapiensENSP0000037011991.496688.0952carlito_syrichtaENSTSYP0000002347193.728290.2439
ENSG00000205571homo_sapiensENSP0000037011991.836788.4354panthera_tigris_altaicaENSPTIP0000000566892.783589.3471
ENSG00000205571homo_sapiensENSP0000037011983.673575.5102rattus_norvegicusENSRNOP0000002445675.460168.0982
ENSG00000205571homo_sapiensENSP0000037011982.993278.2313microtus_ochrogasterENSMOCP0000002004184.429179.5848
ENSG00000205571homo_sapiensENSP0000037011984.693979.932bos_mutusENSBMUP0000003169978.548974.1325
ENSG00000205571homo_sapiensENSP0000037011987.074881.9728mus_spicilegusENSMSIP0000003460588.888983.6806
ENSG00000205571homo_sapiensENSP0000037011969.047663.9456cricetulus_griseus_chok1gshdENSCGRP0000101675285.294178.9916
ENSG00000205571homo_sapiensENSP0000037011987.755183.3333cricetulus_griseus_chok1gshdENSCGRP0000101811789.895585.3659
ENSG00000205571homo_sapiensENSP0000037011991.496688.4354pteropus_vampyrusENSPVAP0000000564792.123389.0411
ENSG00000205571homo_sapiensENSP0000037011991.156588.0952myotis_lucifugusENSMLUP0000000966086.173683.2797
ENSG00000205571homo_sapiensENSP0000037011969.387860.2041vombatus_ursinusENSVURP0001002414070.588261.2457
ENSG00000205571homo_sapiensENSP0000037011993.197390.4762rhinolophus_ferrumequinumENSRFEP0001003142493.197390.4762
ENSG00000205571homo_sapiensENSP0000037011991.496688.4354neovison_visonENSNVIP0000001900192.758689.6552
ENSG00000205571homo_sapiensENSP0000037011985.03480.2721bos_taurusENSBTAP0000007144278.864474.448
ENSG00000205571homo_sapiensENSP0000037011986.054480.9524heterocephalus_glaber_femaleENSHGLP0000000130685.47380.4054
ENSG00000205571homo_sapiensENSP0000037011998.639597.2789rhinopithecus_bietiENSRBIP0000002639398.639597.2789
ENSG00000205571homo_sapiensENSP0000037011983.673580.6122rhinopithecus_bietiENSRBIP0000002579289.78186.4964
ENSG00000205571homo_sapiensENSP0000037011991.836787.0748canis_lupus_dingoENSCAFP0002002442482.317178.0488
ENSG00000205571homo_sapiensENSP0000037011985.03481.2925sciurus_vulgarisENSSVLP0000500968093.98589.8496
ENSG00000205571homo_sapiensENSP0000037011991.156587.7551sciurus_vulgarisENSSVLP0000500598991.780888.3562
ENSG00000205571homo_sapiensENSP0000037011980.952476.8708sciurus_vulgarisENSSVLP0000502121386.861382.4818
ENSG00000205571homo_sapiensENSP0000037011973.129264.2857phascolarctos_cinereusENSPCIP0000004751672.635163.8514
ENSG00000205571homo_sapiensENSP0000037011980.952475.1701procavia_capensisENSPCAP0000000390288.80682.4627
ENSG00000205571homo_sapiensENSP0000037011987.41581.9728nannospalax_galiliENSNGAP0000002028588.927383.391
ENSG00000205571homo_sapiensENSP0000037011987.755180.2721chinchilla_lanigeraENSCLAP0000000033187.457680
ENSG00000205571homo_sapiensENSP0000037011988.775583.3333cervus_hanglu_yarkandensisENSCHYP0000002542188.775583.3333
ENSG00000205571homo_sapiensENSP0000037011985.03478.9116cervus_hanglu_yarkandensisENSCHYP0000003765371.022765.9091
ENSG00000205571homo_sapiensENSP0000037011990.476287.7551catagonus_wagneriENSCWAP0000000211990.78588.0546
ENSG00000205571homo_sapiensENSP0000037011985.714382.3129ictidomys_tridecemlineatusENSSTOP0000001101391.970888.3212
ENSG00000205571homo_sapiensENSP0000037011980.952477.2109otolemur_garnettiiENSOGAP0000001850982.638978.8194
ENSG00000205571homo_sapiensENSP0000037011995.238193.5374cebus_imitatorENSCCAP0000000342495.563193.8567
ENSG00000205571homo_sapiensENSP0000037011990.816387.7551urocitellus_parryiiENSUPAP0001001834491.752688.6598
ENSG00000205571homo_sapiensENSP0000037011988.775583.3333moschus_moschiferusENSMMSP0000003115388.775583.3333
ENSG00000205571homo_sapiensENSP0000037011983.333381.6327rhinopithecus_roxellanaENSRROP0000001373690.740788.8889
ENSG00000205571homo_sapiensENSP0000037011998.639597.2789rhinopithecus_roxellanaENSRROP0000003143698.639597.2789
ENSG00000205571homo_sapiensENSP0000037011984.693978.5714mus_pahariMGP_PahariEiJ_P002693687.062980.7692
ENSG00000205571homo_sapiensENSP0000037011968.707565.6463propithecus_coquereliENSPCOP0000002065891.818287.7273
ENSG00000205571homo_sapiensENSP0000037011934.693924.1497caenorhabditis_elegansC41G7.1b.149.275434.2995
ENSG00000205571homo_sapiensENSP0000037011937.074823.8095drosophila_melanogasterFBpp030295448.230130.9735
ENSG00000205571homo_sapiensENSP0000037011931.972822.449ciona_intestinalisENSCINP0000002614237.903226.6129
ENSG00000205571homo_sapiensENSP0000037011951.360540.1361petromyzon_marinusENSPMAP0000000549752.613241.115
ENSG00000205571homo_sapiensENSP0000037011925.510220.4082petromyzon_marinusENSPMAP000000003096048
ENSG00000205571homo_sapiensENSP0000037011950.340138.7755eptatretus_burgeriENSEBUP0000001913551.388939.5833
ENSG00000205571homo_sapiensENSP0000037011959.863947.2789callorhinchus_miliiENSCMIP0000001796058.471846.1794
ENSG00000205571homo_sapiensENSP0000037011954.421838.0952latimeria_chalumnaeENSLACP0000001114652.631636.8421
ENSG00000205571homo_sapiensENSP0000037011961.224550.3401lepisosteus_oculatusENSLOCP0000001393364.516153.0466
ENSG00000205571homo_sapiensENSP0000037011953.741542.1769clupea_harengusENSCHAP0000002712361.240348.062
ENSG00000205571homo_sapiensENSP0000037011959.183748.9796danio_rerioENSDARP0000001763661.921751.2456
ENSG00000205571homo_sapiensENSP0000037011957.823146.2585carassius_auratusENSCARP0000001997359.649147.7193
ENSG00000205571homo_sapiensENSP0000037011956.122445.5782astyanax_mexicanusENSAMXP0000003099454.455444.2244
ENSG00000205571homo_sapiensENSP0000037011959.523848.6395ictalurus_punctatusENSIPUP0000001855355.555645.3968
ENSG00000205571homo_sapiensENSP0000037011955.442246.2585esox_luciusENSELUP0000003823956.99347.5524
ENSG00000205571homo_sapiensENSP0000037011959.863948.2993electrophorus_electricusENSEEEP0000003301362.857150.7143
ENSG00000205571homo_sapiensENSP0000037011957.823146.2585oncorhynchus_kisutchENSOKIP0000507735260.714348.5714
ENSG00000205571homo_sapiensENSP0000037011959.523846.5986oncorhynchus_kisutchENSOKIP0000502513862.277648.7544
ENSG00000205571homo_sapiensENSP0000037011956.802744.5578oncorhynchus_mykissENSOMYP0000001152059.219946.4539
ENSG00000205571homo_sapiensENSP0000037011957.823146.2585oncorhynchus_mykissENSOMYP0000001151460.498248.3986
ENSG00000205571homo_sapiensENSP000003701195038.7755salmo_salarENSSSAP000001674195038.7755
ENSG00000205571homo_sapiensENSP0000037011960.544250salmo_salarENSSSAP0000001602763.571452.5
ENSG00000205571homo_sapiensENSP0000037011961.224550.3401salmo_truttaENSSTUP0000004039064.285752.8571
ENSG00000205571homo_sapiensENSP0000037011959.863947.619salmo_truttaENSSTUP0000009870862.633549.8221
ENSG00000205571homo_sapiensENSP0000037011955.782344.2177gadus_morhuaENSGMOP0000001857458.36346.2633
ENSG00000205571homo_sapiensENSP0000037011957.48347.2789fundulus_heteroclitusENSFHEP0000003217161.231950.3623
ENSG00000205571homo_sapiensENSP0000037011955.782347.2789poecilia_reticulataENSPREP0000000855753.246845.1299
ENSG00000205571homo_sapiensENSP0000037011959.523849.6599xiphophorus_maculatusENSXMAP0000003718361.837551.5901
ENSG00000205571homo_sapiensENSP0000037011959.863948.9796oryzias_latipesENSORLP0000001323062.190850.8834
ENSG00000205571homo_sapiensENSP0000037011958.843548.9796cyclopterus_lumpusENSCLMP0000504632361.565851.2456
ENSG00000205571homo_sapiensENSP0000037011959.863950.3401oreochromis_niloticusENSONIP0000004098162.411352.4823
ENSG00000205571homo_sapiensENSP0000037011959.183748.2993haplochromis_burtoniENSHBUP000000122826048.9655
ENSG00000205571homo_sapiensENSP0000037011958.503447.619astatotilapia_callipteraENSACLP0000001069557.333346.6667
ENSG00000205571homo_sapiensENSP0000037011959.523848.9796sparus_aurataENSSAUP0001005667061.837550.8834
ENSG00000205571homo_sapiensENSP0000037011959.863950lates_calcariferENSLCAP0001005976561.971851.7606
ENSG00000205571homo_sapiensENSP0000037011966.326554.0816xenopus_tropicalisENSXETP0000003944969.148956.383
ENSG00000205571homo_sapiensENSP0000037011971.428659.8639chrysemys_picta_belliiENSCPBP0000001476866.455755.6962
ENSG00000205571homo_sapiensENSP0000037011970.06859.1837sphenodon_punctatusENSSPUP0000000038674.637763.0435
ENSG00000205571homo_sapiensENSP0000037011963.265353.7415crocodylus_porosusENSCPRP0000500164367.391357.2464
ENSG00000205571homo_sapiensENSP0000037011967.687157.483laticauda_laticaudataENSLLTP0000002308471.582760.7914
ENSG00000205571homo_sapiensENSP0000037011955.782348.6395notechis_scutatusENSNSUP0000001504771.615762.4454
ENSG00000205571homo_sapiensENSP0000037011968.367358.8435pseudonaja_textilisENSPTXP0000000005572.302262.2302
ENSG00000205571homo_sapiensENSP0000037011964.96653.7415anas_platyrhynchos_platyrhynchosENSAPLP0000002531873.180160.5364
ENSG00000205571homo_sapiensENSP0000037011958.163346.2585gallus_gallusENSGALP0001001298362.181849.4545
ENSG00000205571homo_sapiensENSP0000037011947.61938.4354meleagris_gallopavoENSMGAP0000000913272.538958.5492
ENSG00000205571homo_sapiensENSP0000037011968.027257.483serinus_canariaENSSCAP0000001782872.463861.2319
ENSG00000205571homo_sapiensENSP0000037011968.027257.483parus_majorENSPMJP0000000482558.139549.1279
ENSG00000205571homo_sapiensENSP0000037011968.367357.483anolis_carolinensisENSACAP0000000987572.04360.5735
ENSG00000205571homo_sapiensENSP0000037011960.544250.6803neolamprologus_brichardiENSNBRP0000003022763.120652.8369
ENSG00000205571homo_sapiensENSP0000037011962.925254.0816naja_najaENSNNAP0000000437058.176150
ENSG00000205571homo_sapiensENSP0000037011970.748360.2041podarcis_muralisENSPMRP0000001662375.636464.3636
ENSG00000205571homo_sapiensENSP0000037011963.945653.7415geospiza_fortisENSGFOP0000001281772.030760.5364
ENSG00000205571homo_sapiensENSP0000037011962.925253.4014taeniopygia_guttataENSTGUP0000003850158.359649.5268
ENSG00000205571homo_sapiensENSP0000037011959.523850erpetoichthys_calabaricusENSECRP0000002151961.837551.9435
ENSG00000205571homo_sapiensENSP0000037011961.224550.3401kryptolebias_marmoratusENSKMAP0000000965463.829852.4823
ENSG00000205571homo_sapiensENSP0000037011969.387857.8231salvator_merianaeENSSMRP0000000799873.91361.5942
ENSG00000205571homo_sapiensENSP0000037011959.523848.6395oryzias_javanicusENSOJAP0000000303461.619750.3521
ENSG00000205571homo_sapiensENSP0000037011954.421843.8776amphilophus_citrinellusENSACIP0000002552160.836549.0494
ENSG00000205571homo_sapiensENSP0000037011937.41531.6327amphilophus_citrinellusENSACIP0000000969163.583853.7572
ENSG00000205571homo_sapiensENSP0000037011956.802746.2585dicentrarchus_labraxENSDLAP0000501459358.802847.8873
ENSG00000205571homo_sapiensENSP0000037011961.224550amphiprion_perculaENSAPEP0000002322363.604251.9435
ENSG00000205571homo_sapiensENSP0000037011935.714330.2721oryzias_sinensisENSOSIP0000002231371.917860.9589
ENSG00000205571homo_sapiensENSP0000037011935.714330.2721oryzias_sinensisENSOSIP0000002235071.917860.9589
ENSG00000205571homo_sapiensENSP0000037011959.863949.3197oryzias_sinensisENSOSIP0000004768362.190851.2367
ENSG00000205571homo_sapiensENSP0000037011968.027257.1429pelodiscus_sinensisENSPSIP0000001658766.225255.6291
ENSG00000205571homo_sapiensENSP0000037011971.088458.8435gopherus_evgoodeiENSGEVP0000500188275.451362.4549
ENSG00000205571homo_sapiensENSP0000037011971.088459.8639chelonoidis_abingdoniiENSCABP0000002020274.910463.0824
ENSG00000205571homo_sapiensENSP0000037011954.081645.5782seriola_dumeriliENSSDUP0000002555953.535445.1178
ENSG00000205571homo_sapiensENSP0000037011958.163347.619cottoperca_gobioENSCGOP000000115406049.1228
ENSG00000205571homo_sapiensENSP0000037011953.061244.5578struthio_camelus_australisENSSCUP0000002584767.826156.9565
ENSG00000205571homo_sapiensENSP0000037011965.646355.4422anser_brachyrhynchusENSABRP0000001236673.106161.7424
ENSG00000205571homo_sapiensENSP0000037011956.802746.2585gasterosteus_aculeatusENSGACP0000001400359.642948.5714
ENSG00000205571homo_sapiensENSP0000037011951.020439.4558cynoglossus_semilaevisENSCSEP0000002387751.194539.5904
ENSG00000205571homo_sapiensENSP0000037011958.843549.3197poecilia_formosaENSPFOP0000000779561.130751.2367
ENSG00000205571homo_sapiensENSP0000037011960.544250myripristis_murdjanENSMMDP0000502312363.345252.3132
ENSG00000205571homo_sapiensENSP0000037011960.204149.3197sander_luciopercaENSSLUP0000002117462.544251.2367
ENSG00000205571homo_sapiensENSP0000037011965.306153.7415strigops_habroptilaENSSHBP0000502309972.727359.8485
ENSG00000205571homo_sapiensENSP0000037011961.224549.6599amphiprion_ocellarisENSAOCP0000003223063.604251.5901
ENSG00000205571homo_sapiensENSP0000037011971.428660.2041terrapene_carolina_triunguisENSTMTP0000001595675.812363.8989
ENSG00000205571homo_sapiensENSP0000037011949.659938.7755hucho_huchoENSHHUP0000005964649.324338.5135
ENSG00000205571homo_sapiensENSP0000037011960.544249.6599hucho_huchoENSHHUP0000007358163.571452.1429
ENSG00000205571homo_sapiensENSP0000037011959.183749.6599betta_splendensENSBSLP0000002742962.589952.518
ENSG00000205571homo_sapiensENSP0000037011959.183748.2993pygocentrus_nattereriENSPNAP0000000827054.71744.6541
ENSG00000205571homo_sapiensENSP0000037011960.544250.3401anabas_testudineusENSATEP0000007041762.676152.1127
ENSG00000205571homo_sapiensENSP0000037011934.353723.4694ciona_savignyiENSCSAVP0000001433038.40326.2357
ENSG00000205571homo_sapiensENSP0000037011958.843549.6599seriola_lalandi_dorsalisENSSLDP0000002721060.915551.4085
ENSG00000205571homo_sapiensENSP0000037011960.544249.3197labrus_bergyltaENSLBEP0000002988162.676151.0563
ENSG00000205571homo_sapiensENSP0000037011960.544250.6803pundamilia_nyerereiENSPNYP0000001873063.120652.8369
ENSG00000205571homo_sapiensENSP0000037011958.843548.2993mastacembelus_armatusENSMAMP0000001629060.915550
ENSG00000205571homo_sapiensENSP0000037011961.224549.3197stegastes_partitusENSSPAP0000000561663.604251.2367
ENSG00000205571homo_sapiensENSP0000037011957.823146.2585oncorhynchus_tshawytschaENSOTSP0000507894860.714348.5714
ENSG00000205571homo_sapiensENSP0000037011957.48344.898oncorhynchus_tshawytschaENSOTSP0000502095959.929146.8085
ENSG00000205571homo_sapiensENSP0000037011960.544249.6599acanthochromis_polyacanthusENSAPOP0000000907462.897551.5901
ENSG00000205571homo_sapiensENSP0000037011966.666755.102aquila_chrysaetos_chrysaetosENSACCP0002001954874.524761.597
ENSG00000205571homo_sapiensENSP0000037011957.142947.2789nothobranchius_furzeriENSNFUP0001504005252.012443.0341
ENSG00000205571homo_sapiensENSP0000037011958.843547.9592cyprinodon_variegatusENSCVAP0000000601460.915549.6479
ENSG00000205571homo_sapiensENSP0000037011958.503445.9184denticeps_clupeoidesENSDCDP0000002097963.703750
ENSG00000205571homo_sapiensENSP0000037011959.863947.2789larimichthys_croceaENSLCRP0000505516061.111148.2639
ENSG00000205571homo_sapiensENSP0000037011957.142946.2585takifugu_rubripesENSTRUP0000000176860.431748.9209
ENSG00000205571homo_sapiensENSP0000037011964.96654.7619ficedula_albicollisENSFALP0000001286972.348560.9848
ENSG00000205571homo_sapiensENSP0000037011956.122446.5986hippocampus_comesENSHCOP0000001389755.932246.4407
ENSG00000205571homo_sapiensENSP0000037011961.224547.2789cyprinus_carpio_carpioENSCCRP0000007746664.285749.6429
ENSG00000205571homo_sapiensENSP0000037011960.884448.2993cyprinus_carpio_carpioENSCCRP0000002760963.928650.7143
ENSG00000205571homo_sapiensENSP0000037011966.326554.4218coturnix_japonicaENSCJPP0000500640674.427561.0687
ENSG00000205571homo_sapiensENSP0000037011958.843549.6599poecilia_latipinnaENSPLAP0000002521961.130751.5901
ENSG00000205571homo_sapiensENSP0000037011960.544248.2993sinocyclocheilus_grahamiENSSGRP0000009053263.571450.7143
ENSG00000205571homo_sapiensENSP0000037011956.802745.5782sinocyclocheilus_grahamiENSSGRP0000010605362.546850.1873
ENSG00000205571homo_sapiensENSP0000037011960.544250.3401maylandia_zebraENSMZEP0000501814463.799353.0466
ENSG00000205571homo_sapiensENSP0000037011957.823145.9184tetraodon_nigroviridisENSTNIP0000001278359.649147.3684
ENSG00000205571homo_sapiensENSP0000037011958.503446.9388paramormyrops_kingsleyaeENSPKIP0000003023461.870549.6403
ENSG00000205571homo_sapiensENSP0000037011959.863948.6395scleropages_formosusENSSFOP000150243706452
ENSG00000205571homo_sapiensENSP0000037011963.265351.0204leptobrachium_leishanenseENSLLEP0000000010468.131954.9451
ENSG00000205571homo_sapiensENSP0000037011950.340139.1156scophthalmus_maximusENSSMAP0000006108051.748340.2098
ENSG00000205571homo_sapiensENSP0000037011959.863949.3197oryzias_melastigmaENSOMEP0000000676462.190851.2367

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000245involved_in spliceosomal complex assembly2IMP,NASHomo_sapiens(9606)Process
GO:0000387involved_in spliceosomal snRNP assembly3EXP,IBA,IDAHomo_sapiens(9606)Process
GO:0003723enables RNA binding1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0006353involved_in DNA-templated transcription termination1IMPHomo_sapiens(9606)Process
GO:0007399involved_in nervous system development1IEAHomo_sapiens(9606)Process
GO:0015030is_active_in Cajal body2IBA,IDAHomo_sapiens(9606)Component
GO:0016604located_in nuclear body1IDAHomo_sapiens(9606)Component
GO:0030018located_in Z disc1IEAHomo_sapiens(9606)Component
GO:0030424located_in axon1IEAHomo_sapiens(9606)Component
GO:0032797part_of SMN complex3IBA,IDA,IPIHomo_sapiens(9606)Component
GO:0034719part_of SMN-Sm protein complex1IDAHomo_sapiens(9606)Component
GO:0036464located_in cytoplasmic ribonucleoprotein granule1IDAHomo_sapiens(9606)Component
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043005located_in neuron projection1IDAHomo_sapiens(9606)Component
GO:0043204located_in perikaryon1IDAHomo_sapiens(9606)Component
GO:0097504is_active_in Gemini of coiled bodies2IBA,IDAHomo_sapiens(9606)Component

Expression