Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000204389 Gene ID 3303 Accession 5232
Symbol HSPA1A Alias HSP70;HSP72;HSPA1;HSP70I;HSP70-1;HSP70-2;HSP70.1;HSP70.2;HSP70-1A;HEL-S-103 Full Name heat shock protein family A (Hsp70) member 1A
Status Confidence Length 2404 bases Strand Plus strand
Position 6 : 31815543 - 31817946 RNA binding domain N.A.
Summary This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
37251843 RNAseq analysis of the drug jian-yan-ling (JYL) using both in vivo and in vitro models. Xiaobo Zhang 2023-05-01 Heliyon
36685529 Comprehensive bulk and single-cell transcriptome profiling give useful insights into the characteristics of osteoarthritis associated synovial macrophages. Shengyou Liao 2022-01-01 Frontiers in immunology
32216017 LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma. Yuanyuan Ban 2020-06-01 Molecular oncology

Transcripts

Name Transcript ID bp Protein Translation ID

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0001618enables virus receptor activity1IEAHomo_sapiens(9606)Function
GO:0001664enables G protein-coupled receptor binding1IDAHomo_sapiens(9606)Function
GO:0003714enables transcription corepressor activity1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005102enables signaling receptor binding1IPIHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IDAHomo_sapiens(9606)Function
GO:0005576located_in extracellular region1TASHomo_sapiens(9606)Component
GO:0005615is_active_in extracellular space1IDAHomo_sapiens(9606)Component
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1TASHomo_sapiens(9606)Component
GO:0005783located_in endoplasmic reticulum1TASHomo_sapiens(9606)Component
GO:0005813located_in centrosome1IDAHomo_sapiens(9606)Component
GO:0005814located_in centriole1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion1HDAHomo_sapiens(9606)Component
GO:0006402involved_in mRNA catabolic process1IDAHomo_sapiens(9606)Process
GO:0006986involved_in response to unfolded protein1IDAHomo_sapiens(9606)Process
GO:0007041involved_in lysosomal transport1ISSHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction1IEAHomo_sapiens(9606)Process
GO:0008285involved_in negative regulation of cell population proliferation1IMPHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0016234located_in inclusion body1IDAHomo_sapiens(9606)Component
GO:0016235located_in aggresome1IDAHomo_sapiens(9606)Component
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0016887enables ATP hydrolysis activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0019899enables enzyme binding1IPIHomo_sapiens(9606)Function
GO:0030308involved_in negative regulation of cell growth1IMPHomo_sapiens(9606)Process
GO:0030512involved_in negative regulation of transforming growth factor beta receptor signaling pathway1IMPHomo_sapiens(9606)Process
GO:0031072enables heat shock protein binding2IBA,IPIHomo_sapiens(9606)Function
GO:0031249enables denatured protein binding1IPIHomo_sapiens(9606)Function
GO:0031396involved_in regulation of protein ubiquitination1IDAHomo_sapiens(9606)Process
GO:0031397involved_in negative regulation of protein ubiquitination1IDAHomo_sapiens(9606)Process
GO:0031625enables ubiquitin protein ligase binding2IBA,IPIHomo_sapiens(9606)Function
GO:0031982located_in vesicle1HDAHomo_sapiens(9606)Component
GO:0032436involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process2IBA,IDAHomo_sapiens(9606)Process
GO:0032757involved_in positive regulation of interleukin-8 production1IMPHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0033120involved_in positive regulation of RNA splicing1IDAHomo_sapiens(9606)Process
GO:0034599involved_in cellular response to oxidative stress1TASHomo_sapiens(9606)Process
GO:0034605involved_in cellular response to heat1IDAHomo_sapiens(9606)Process
GO:0034620involved_in cellular response to unfolded protein1IMPHomo_sapiens(9606)Process
GO:0038177enables death receptor agonist activity1IDAHomo_sapiens(9606)Function
GO:0042026involved_in protein refolding3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0042826enables histone deacetylase binding1IPIHomo_sapiens(9606)Function
GO:0043066involved_in negative regulation of apoptotic process2IMP,TASHomo_sapiens(9606)Process
GO:0044183enables protein folding chaperone2IBA,IDAHomo_sapiens(9606)Function
GO:0045296enables cadherin binding1HDAHomo_sapiens(9606)Function
GO:0045648involved_in positive regulation of erythrocyte differentiation1IMPHomo_sapiens(9606)Process
GO:0046034involved_in ATP metabolic process1IDAHomo_sapiens(9606)Process
GO:0046718involved_in viral entry into host cell1IEAHomo_sapiens(9606)Process
GO:0048018enables receptor ligand activity1IDAHomo_sapiens(9606)Function
GO:0048471located_in perinuclear region of cytoplasm1IDAHomo_sapiens(9606)Component
GO:0050821involved_in protein stabilization3IDA,IMP,TASHomo_sapiens(9606)Process
GO:0051082enables unfolded protein binding3IDA,NAS,TASHomo_sapiens(9606)Function
GO:0051085involved_in chaperone cofactor-dependent protein refolding1IBAHomo_sapiens(9606)Process
GO:0051092involved_in positive regulation of NF-kappaB transcription factor activity1IMPHomo_sapiens(9606)Process
GO:0051131involved_in chaperone-mediated protein complex assembly1IDAHomo_sapiens(9606)Process
GO:0051787enables misfolded protein binding1IDAHomo_sapiens(9606)Function
GO:0055131enables C3HC4-type RING finger domain binding1IPIHomo_sapiens(9606)Function
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070370involved_in cellular heat acclimation1IMPHomo_sapiens(9606)Process
GO:0070434involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway1IMPHomo_sapiens(9606)Process
GO:0071383involved_in cellular response to steroid hormone stimulus1TASHomo_sapiens(9606)Process
GO:0072562located_in blood microparticle1HDAHomo_sapiens(9606)Component
GO:0090063involved_in positive regulation of microtubule nucleation1IMPHomo_sapiens(9606)Process
GO:0090084involved_in negative regulation of inclusion body assembly1IDAHomo_sapiens(9606)Process
GO:0097718enables disordered domain specific binding1IPIHomo_sapiens(9606)Function
GO:0140416enables transcription regulator inhibitor activity1IDAHomo_sapiens(9606)Function
GO:0140545enables ATP-dependent protein disaggregase activity1IDAHomo_sapiens(9606)Function
GO:0140662enables ATP-dependent protein folding chaperone1IEAHomo_sapiens(9606)Function
GO:1901029involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway1IDAHomo_sapiens(9606)Process
GO:1901673involved_in regulation of mitotic spindle assembly2IBA,IMPHomo_sapiens(9606)Process
GO:1902236involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway1IDAHomo_sapiens(9606)Process
GO:1902380involved_in positive regulation of endoribonuclease activity1IDAHomo_sapiens(9606)Process
GO:1903265involved_in positive regulation of tumor necrosis factor-mediated signaling pathway1IMPHomo_sapiens(9606)Process
GO:1904813located_in ficolin-1-rich granule lumen1TASHomo_sapiens(9606)Component
GO:1990904part_of ribonucleoprotein complex1IDAHomo_sapiens(9606)Component
GO:2001240involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand1IMPHomo_sapiens(9606)Process

Expression