Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000198795 Gene ID 25925 Accession 24605
Symbol ZNF521 Alias EHZF;Evi3 Full Name zinc finger protein 521
Status Confidence Length 290243 bases Strand Minus strand
Position 18 : 25061924 - 25352166 RNA binding domain zf-met
Summary Enables protein domain specific binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within neuron fate commitment. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000382352 zf-met PF12874 2.6e-05 1
ENSP00000382352 zf-met PF12874 2.6e-05 2
ENSP00000382352 zf-met PF12874 2.6e-05 3

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
25502183 UMG Lenti: novel lentiviral vectors for efficient transgene- and reporter gene expression in human early hematopoietic progenitors. Emanuela Chiarella 2014-01-01 PloS one

Transcripts

Name Transcript ID bp Protein Translation ID
ZNF521-201 ENST00000361524 4887 1311aa ENSP00000354794
ZNF521-214 ENST00000584787 4327 1091aa ENSP00000463000
ZNF521-202 ENST00000399425 4345 1244aa ENSP00000382352
ZNF521-203 ENST00000538137 4253 1311aa ENSP00000440768
ZNF521-206 ENST00000577775 552 184aa ENSP00000463748
ZNF521-205 ENST00000577720 555 No protein -
ZNF521-207 ENST00000577801 694 224aa ENSP00000462724
ZNF521-210 ENST00000581869 531 No protein -
ZNF521-209 ENST00000580488 547 144aa ENSP00000464415
ZNF521-212 ENST00000583005 541 No protein -
ZNF521-208 ENST00000579111 594 No protein -
ZNF521-213 ENST00000583398 406 No protein -
ZNF521-211 ENST00000582584 590 No protein -
ZNF521-204 ENST00000577461 338 30aa ENSP00000462746

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
10966Hip1.18922840174945E-1117903296
11053Hip9.642024058532E-717903296
21024Personality Inventory4.226e-005-
21813Personality6.213e-005-
21818Personality6.213e-005-
23865Waist-Hip Ratio6.7520000E-005-
25312Waist-Hip Ratio6.8680000E-005-
33255Leukoaraiosis4.2911674E-005-
33295Leukoaraiosis5.9559630E-005-
35911Platelet Function Tests4.5500000E-006-
36004Platelet Function Tests8.5100000E-007-
36109Platelet Function Tests4.5500000E-006-
39067Platelet Function Tests3.3800000E-006-
52230Child Development Disorders, Pervasive1.8000000E-005-
53003Receptors, Interleukin-63.5470000E-006-
54054Cholesterol, LDL7.9510000E-005-
60904Periodontitis5E-624024966
69997DNA, Mitochondrial3E-625240745
72973Polychlorinated Biphenyls9E-725839716
78870Urinary Incontinence2E-725524241
79992Selenium8E-625343990
85340Motor Activity3E-623251661
85436Motor Activity5E-623251661
85872Motor Activity2E-623251661
91969Anticonvulsants6E-622379998
94076Arthritis, Juvenile2E-627927641
98411Schizophrenia4E-626198764
101475Electrocardiography2E-827958378
101476Sulfonylurea Compounds2E-827958378
102271Body Weight3E-719851299

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding1IBAHomo_sapiens(9606)Function
GO:0001228enables DNA-binding transcription activator activity, RNA polymerase II-specific1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0006357involved_in regulation of transcription by RNA polymerase II1IBAHomo_sapiens(9606)Process
GO:0019904enables protein domain specific binding1IPIHomo_sapiens(9606)Function
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0048663involved_in neuron fate commitment1IEAHomo_sapiens(9606)Process

Expression