RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	SARS-COV-2
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq

Description

Ensembl ID	ENSG00000198467	Gene ID	7169	Accession	12011
Symbol	TPM2	Alias	DA1;DA2B;NEM4;TMSB;AMCD1;DA2B4;CMYP23;HEL-S-273	Full Name	tropomyosin 2
Status	Confidence	Length	8065 bases	Strand	Minus strand
Position	9 : 35681992 - 35690056	RNA binding domain	Tropomyosin
Summary	This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000496494	Tropomyosin	PF00261	9.9e-97	1
ENSP00000367541	Tropomyosin	PF00261	2.5e-94	1
ENSP00000495440	Tropomyosin	PF00261	7e-92	1
ENSP00000367542	Tropomyosin	PF00261	1.7e-89	1
ENSP00000475952	Tropomyosin	PF00261	6.9e-43	1
ENSP00000495075	Tropomyosin	PF00261	2.4e-27	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
TPM2-208	ENST00000644325	1117	133aa	ENSP00000495075
TPM2-202	ENST00000378292	1182	284aa	ENSP00000367542
TPM2-201	ENST00000329305	1018	284aa	ENSP00000367541
TPM2-207	ENST00000643485	1580	No protein	-
TPM2-209	ENST00000645482	1190	284aa	ENSP00000496494
TPM2-210	ENST00000647435	1185	284aa	ENSP00000495440
TPM2-206	ENST00000607559	518	111aa	ENSP00000475952
TPM2-203	ENST00000471212	1363	No protein	-
TPM2-204	ENST00000486018	699	No protein	-
TPM2-205	ENST00000604975	573	No protein	-

Gene Model

Click here to download ENSG00000198467's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
10128	Exercise Test	9.30633063380704E-5	17903301

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000198467's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003779	enables actin binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0005862	part_of muscle thin filament tropomyosin	1	TAS	Homo_sapiens(9606)	Component
GO:0005884	is_active_in actin filament	1	IBA	Homo_sapiens(9606)	Component
GO:0006936	involved_in muscle contraction	1	IBA	Homo_sapiens(9606)	Process
GO:0007015	involved_in actin filament organization	1	IBA	Homo_sapiens(9606)	Process
GO:0008307	enables structural constituent of muscle	1	TAS	Homo_sapiens(9606)	Function
GO:0015629	located_in actin cytoskeleton	1	ISS	Homo_sapiens(9606)	Component
GO:0042802	enables identical protein binding	1	ISS	Homo_sapiens(9606)	Function
GO:0042803	enables protein homodimerization activity	1	ISS	Homo_sapiens(9606)	Function
GO:0043462	involved_in regulation of ATP-dependent activity	1	IDA	Homo_sapiens(9606)	Process
GO:0046982	enables protein heterodimerization activity	1	ISS	Homo_sapiens(9606)	Function
GO:0051015	enables actin filament binding	2	IBA,ISS	Homo_sapiens(9606)	Function

Expression