Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000196433 Gene ID 438 Accession 750
Symbol ASMT Alias ASMTY;HIOMT;HIOMTY Full Name acetylserotonin O-methyltransferase
Status Confidence Length 28023 bases Strand Plus strand
Position X : 1615059 - 1643081 RNA binding domain Methyltransf_31
Summary This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000370627 Methyltransf_31 PF13847 2e-06 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
ASMT-203 ENST00000381241 1330 373aa ENSP00000370639
ASMT-201 ENST00000381229 1087 345aa ENSP00000370627
ASMT-202 ENST00000381233 989 298aa ENSP00000370631
ASMT-205 ENST00000509780 510 No protein -
ASMT-204 ENST00000432523 442 124aa ENSP00000392053

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006412involved_in translation1TASHomo_sapiens(9606)Process
GO:0006629involved_in lipid metabolic process1IEAHomo_sapiens(9606)Process
GO:0008171enables O-methyltransferase activity1TASHomo_sapiens(9606)Function
GO:0008172enables S-methyltransferase activity1TASHomo_sapiens(9606)Function
GO:0017096enables acetylserotonin O-methyltransferase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0030187involved_in melatonin biosynthetic process3IBA,IDA,IEAHomo_sapiens(9606)Process
GO:0032259involved_in methylation1IBAHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0042803enables protein homodimerization activity1IPIHomo_sapiens(9606)Function
GO:0046219involved_in indolalkylamine biosynthetic process1TASHomo_sapiens(9606)Process

Expression