RBP Type	Canonical_RBPs
Diseases	Cancer Disease
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000189369	Gene ID	23708	Accession	4622
Symbol	GSPT2	Alias	GST2;ERF3B	Full Name	G1 to S phase transition 2
Status	Confidence	Length	2791 bases	Strand	Plus strand
Position	X : 51743442 - 51746232	RNA binding domain	GTP_EFTU , PAM2 , GTP_EFTU_D3
Summary	This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000341247	GTP_EFTU_D3	PF03143	6.6e-23	1
ENSP00000341247	PAM2	PF07145	1e-05	2
ENSP00000341247	GTP_EFTU	PF00009	1.8e-44	3

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
GSPT2-201	ENST00000340438	2791	628aa	ENSP00000341247

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000189369	homo_sapiens	ENSP00000307940	19.9301	10.4895	homo_sapiens	ENSP00000341247	27.2293	14.3312
ENSG00000189369	homo_sapiens	ENSP00000419038	21.9707	11.0519	homo_sapiens	ENSP00000341247	26.2739	13.2166
ENSG00000189369	homo_sapiens	ENSP00000322439	36.4835	22.8571	homo_sapiens	ENSP00000341247	26.4331	16.5605
ENSG00000189369	homo_sapiens	ENSP00000289371	21.2295	11.6393	homo_sapiens	ENSP00000341247	41.242	22.6115
ENSG00000189369	homo_sapiens	ENSP00000253039	36.0169	19.4915	homo_sapiens	ENSP00000341247	27.0701	14.6497
ENSG00000189369	homo_sapiens	ENSP00000445077	35.1695	19.2797	homo_sapiens	ENSP00000341247	26.4331	14.4904
ENSG00000189369	homo_sapiens	ENSP00000356811	49.1228	32.8947	homo_sapiens	ENSP00000341247	53.5032	35.828
ENSG00000189369	homo_sapiens	ENSP00000254730	30.3691	17.1141	homo_sapiens	ENSP00000341247	28.8217	16.242
ENSG00000189369	homo_sapiens	ENSP00000268206	17.3214	8.39286	homo_sapiens	ENSP00000341247	30.8917	14.9682
ENSG00000189369	homo_sapiens	ENSP00000281543	20.4783	11.2108	homo_sapiens	ENSP00000341247	21.8153	11.9427
ENSG00000189369	homo_sapiens	ENSP00000263629	25.9972	13.8927	homo_sapiens	ENSP00000341247	30.0955	16.0828
ENSG00000189369	homo_sapiens	ENSP00000398131	89.7959	86.6562	homo_sapiens	ENSP00000341247	91.0828	87.8981
ENSG00000189369	homo_sapiens	ENSP00000392094	19.0329	10.4938	homo_sapiens	ENSP00000341247	29.4586	16.242
ENSG00000189369	homo_sapiens	ENSP00000217182	55.7235	35.4212	homo_sapiens	ENSP00000341247	41.0828	26.1146
ENSG00000189369	homo_sapiens	ENSP00000339053	56.0606	36.3636	homo_sapiens	ENSP00000341247	41.242	26.7516
ENSG00000189369	homo_sapiens	ENSP00000303997	30.3987	17.7741	homo_sapiens	ENSP00000341247	29.1401	17.0382
ENSG00000189369	homo_sapiens	ENSP00000216044	27.8027	16.293	homo_sapiens	ENSP00000341247	29.6178	17.3567
ENSG00000189369	homo_sapiens	ENSP00000296805	24.3902	12.3235	homo_sapiens	ENSP00000341247	30.2548	15.2866

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000189369	homo_sapiens	ENSP00000341247	100	99.5223	pongo_abelii	ENSPPYP00000022791	100	99.5223
ENSG00000189369	homo_sapiens	ENSP00000341247	92.0382	88.6943	dasypus_novemcinctus	ENSDNOP00000009165	92.3323	88.9776
ENSG00000189369	homo_sapiens	ENSP00000341247	92.6752	89.8089	erinaceus_europaeus	ENSEEUP00000004853	94.0226	91.1147
ENSG00000189369	homo_sapiens	ENSP00000341247	97.9299	97.1338	callithrix_jacchus	ENSCJAP00000051844	98.2428	97.4441
ENSG00000189369	homo_sapiens	ENSP00000341247	99.2038	98.7261	macaca_fascicularis	ENSMFAP00000001832	99.8397	99.359
ENSG00000189369	homo_sapiens	ENSP00000341247	93.949	93.6306	macaca_mulatta	ENSMMUP00000032771	99.8308	99.4924
ENSG00000189369	homo_sapiens	ENSP00000341247	94.4268	93.949	papio_anubis	ENSPANP00000058320	99.4966	98.9933
ENSG00000189369	homo_sapiens	ENSP00000341247	96.0191	93.3121	tursiops_truncatus	ENSTTRP00000010160	95.4114	92.7215
ENSG00000189369	homo_sapiens	ENSP00000341247	93.3121	91.4013	vulpes_vulpes	ENSVVUP00000007383	95.9083	93.9444
ENSG00000189369	homo_sapiens	ENSP00000341247	94.4268	90.1274	mus_spretus	MGP_SPRETEiJ_P0095907	93.8291	89.557
ENSG00000189369	homo_sapiens	ENSP00000341247	95.2229	93.1529	equus_asinus	ENSEASP00005045465	95.3748	93.3014
ENSG00000189369	homo_sapiens	ENSP00000341247	94.1083	90.2866	loxodonta_africana	ENSLAFP00000018205	91.9129	88.1804
ENSG00000189369	homo_sapiens	ENSP00000341247	96.0191	93.4713	panthera_leo	ENSPLOP00000009198	96.1722	93.6204
ENSG00000189369	homo_sapiens	ENSP00000341247	95.8599	93.7898	ailuropoda_melanoleuca	ENSAMEP00000020924	96.0128	93.9394
ENSG00000189369	homo_sapiens	ENSP00000341247	95.7006	92.8344	bos_indicus_hybrid	ENSBIXP00005031360	95.2456	92.393
ENSG00000189369	homo_sapiens	ENSP00000341247	95.8599	93.4713	oryctolagus_cuniculus	ENSOCUP00000028227	95.7075	93.3227
ENSG00000189369	homo_sapiens	ENSP00000341247	95.3822	93.3121	equus_caballus	ENSECAP00000053822	95.5343	93.4609
ENSG00000189369	homo_sapiens	ENSP00000341247	95.7006	93.949	canis_lupus_familiaris	ENSCAFP00845038271	95.8533	94.0989
ENSG00000189369	homo_sapiens	ENSP00000341247	95.8599	93.3121	panthera_pardus	ENSPPRP00000020555	96.0128	93.4609
ENSG00000189369	homo_sapiens	ENSP00000341247	88.8535	87.7389	marmota_marmota_marmota	ENSMMMP00000025521	95.7118	94.5111
ENSG00000189369	homo_sapiens	ENSP00000341247	96.1783	93.7898	balaenoptera_musculus	ENSBMSP00010023339	95.5696	93.1962
ENSG00000189369	homo_sapiens	ENSP00000341247	95.3822	93.3121	cavia_porcellus	ENSCPOP00000006388	95.3822	93.3121
ENSG00000189369	homo_sapiens	ENSP00000341247	95.8599	93.6306	ursus_americanus	ENSUAMP00000014392	95.8599	93.6306
ENSG00000189369	homo_sapiens	ENSP00000341247	95.8599	93.3121	monodon_monoceros	ENSMMNP00015020075	95.2532	92.7215
ENSG00000189369	homo_sapiens	ENSP00000341247	96.0191	93.4713	sus_scrofa	ENSSSCP00000013108	95.4114	92.8797
ENSG00000189369	homo_sapiens	ENSP00000341247	91.4013	88.535	jaculus_jaculus	ENSJJAP00000001110	92.8803	89.9676
ENSG00000189369	homo_sapiens	ENSP00000341247	96.1783	93.1529	ovis_aries_rambouillet	ENSOARP00020015404	95.5696	92.5633
ENSG00000189369	homo_sapiens	ENSP00000341247	78.3439	77.0701	ursus_maritimus	ENSUMAP00000018167	98.7952	97.1888
ENSG00000189369	homo_sapiens	ENSP00000341247	95.5414	92.9936	delphinapterus_leucas	ENSDLEP00000011329	93.0233	90.5426
ENSG00000189369	homo_sapiens	ENSP00000341247	95.8599	93.4713	physeter_catodon	ENSPCTP00005031185	95.1027	92.733
ENSG00000189369	homo_sapiens	ENSP00000341247	94.586	90.1274	mus_caroli	MGP_CAROLIEiJ_P0092141	93.9873	89.557
ENSG00000189369	homo_sapiens	ENSP00000341247	94.4268	90.1274	mus_musculus	ENSMUSP00000109523	93.8291	89.557
ENSG00000189369	homo_sapiens	ENSP00000341247	95.3822	92.8344	dipodomys_ordii	ENSDORP00000011962	93.8871	91.3793
ENSG00000189369	homo_sapiens	ENSP00000341247	95.7006	93.3121	mustela_putorius_furo	ENSMPUP00000018663	95.8533	93.4609
ENSG00000189369	homo_sapiens	ENSP00000341247	97.7707	96.6561	aotus_nancymaae	ENSANAP00000026691	98.0831	96.9649
ENSG00000189369	homo_sapiens	ENSP00000341247	98.2484	96.9745	saimiri_boliviensis_boliviensis	ENSSBOP00000040695	98.5623	97.2843
ENSG00000189369	homo_sapiens	ENSP00000341247	95.7006	93.4713	vicugna_pacos	ENSVPAP00000002964	95.7006	93.4713
ENSG00000189369	homo_sapiens	ENSP00000341247	99.8408	99.3631	chlorocebus_sabaeus	ENSCSAP00000017865	99.8408	99.3631
ENSG00000189369	homo_sapiens	ENSP00000341247	95.8599	93.1529	phocoena_sinus	ENSPSNP00000019917	95.2532	92.5633
ENSG00000189369	homo_sapiens	ENSP00000341247	95.7006	93.3121	camelus_dromedarius	ENSCDRP00005029336	94.795	92.429
ENSG00000189369	homo_sapiens	ENSP00000341247	95.2229	92.8344	panthera_tigris_altaica	ENSPTIP00000006074	95.5272	93.131
ENSG00000189369	homo_sapiens	ENSP00000341247	93.7898	90.6051	rattus_norvegicus	ENSRNOP00000068098	93.1962	90.0316
ENSG00000189369	homo_sapiens	ENSP00000341247	97.6115	95.8599	prolemur_simus	ENSPSMP00000006090	97.6115	95.8599
ENSG00000189369	homo_sapiens	ENSP00000341247	92.6752	87.8981	microtus_ochrogaster	ENSMOCP00000001643	93.12	88.32
ENSG00000189369	homo_sapiens	ENSP00000341247	82.4841	77.707	sorex_araneus	ENSSARP00000010689	93.3333	87.9279
ENSG00000189369	homo_sapiens	ENSP00000341247	95.0637	90.6051	peromyscus_maniculatus_bairdii	ENSPEMP00000031270	94.462	90.0316
ENSG00000189369	homo_sapiens	ENSP00000341247	91.5605	88.6943	bos_mutus	ENSBMUP00000030895	93.6482	90.7166
ENSG00000189369	homo_sapiens	ENSP00000341247	78.1847	76.5924	bos_mutus	ENSBMUP00000016339	98.7928	96.7807
ENSG00000189369	homo_sapiens	ENSP00000341247	94.2675	89.8089	mus_spicilegus	ENSMSIP00000015431	93.6709	89.2405
ENSG00000189369	homo_sapiens	ENSP00000341247	94.586	91.0828	cricetulus_griseus_chok1gshd	ENSCGRP00001002519	94.1363	90.6498
ENSG00000189369	homo_sapiens	ENSP00000341247	95.8599	92.3567	myotis_lucifugus	ENSMLUP00000019472	95.8599	92.3567
ENSG00000189369	homo_sapiens	ENSP00000341247	94.4268	91.242	rhinolophus_ferrumequinum	ENSRFEP00010003852	94.5774	91.3876
ENSG00000189369	homo_sapiens	ENSP00000341247	93.3121	90.7643	neovison_vison	ENSNVIP00000006899	96.3816	93.75
ENSG00000189369	homo_sapiens	ENSP00000341247	95.7006	92.8344	bos_taurus	ENSBTAP00000073557	95.2456	92.393
ENSG00000189369	homo_sapiens	ENSP00000341247	90.6051	89.3312	heterocephalus_glaber_female	ENSHGLP00000002062	95.7912	94.4444
ENSG00000189369	homo_sapiens	ENSP00000341247	97.1338	96.8153	rhinopithecus_bieti	ENSRBIP00000020929	99.026	98.7013
ENSG00000189369	homo_sapiens	ENSP00000341247	95.7006	93.949	canis_lupus_dingo	ENSCAFP00020025442	95.8533	94.0989
ENSG00000189369	homo_sapiens	ENSP00000341247	96.8153	95.0637	sciurus_vulgaris	ENSSVLP00005020153	96.8153	95.0637
ENSG00000189369	homo_sapiens	ENSP00000341247	80.5732	77.5478	procavia_capensis	ENSPCAP00000013020	96.381	92.7619
ENSG00000189369	homo_sapiens	ENSP00000341247	93.7898	89.6497	nannospalax_galili	ENSNGAP00000011007	94.0895	89.9361
ENSG00000189369	homo_sapiens	ENSP00000341247	92.0382	89.0127	bos_grunniens	ENSBGRP00000040878	91.8919	88.8712
ENSG00000189369	homo_sapiens	ENSP00000341247	96.0191	92.9936	cervus_hanglu_yarkandensis	ENSCHYP00000024793	95.4114	92.4051
ENSG00000189369	homo_sapiens	ENSP00000341247	95.7006	93.3121	catagonus_wagneri	ENSCWAP00000007580	95.2456	92.8685
ENSG00000189369	homo_sapiens	ENSP00000341247	96.8153	95.2229	ictidomys_tridecemlineatus	ENSSTOP00000023642	96.8153	95.2229
ENSG00000189369	homo_sapiens	ENSP00000341247	96.6561	94.9045	otolemur_garnettii	ENSOGAP00000004710	96.6561	94.9045
ENSG00000189369	homo_sapiens	ENSP00000341247	98.2484	97.293	cebus_imitator	ENSCCAP00000028467	98.5623	97.6038
ENSG00000189369	homo_sapiens	ENSP00000341247	96.4968	95.0637	urocitellus_parryii	ENSUPAP00010029599	96.4968	95.0637
ENSG00000189369	homo_sapiens	ENSP00000341247	95.7006	92.5159	moschus_moschiferus	ENSMMSP00000006988	95.3968	92.2222
ENSG00000189369	homo_sapiens	ENSP00000341247	94.2675	89.6497	mus_pahari	MGP_PahariEiJ_P0089765	93.6709	89.0823
ENSG00000189369	homo_sapiens	ENSP00000341247	23.2484	14.0127	caenorhabditis_elegans	C43E11.4.1	33.2574	20.0456
ENSG00000189369	homo_sapiens	ENSP00000341247	25.3185	14.6497	caenorhabditis_elegans	Y39G10AR.8.1	33.9019	19.6162
ENSG00000189369	homo_sapiens	ENSP00000341247	23.8854	14.6497	drosophila_melanogaster	FBpp0088054	32.8947	20.1754
ENSG00000189369	homo_sapiens	ENSP00000341247	25	14.172	drosophila_melanogaster	FBpp0307983	33.0526	18.7368
ENSG00000189369	homo_sapiens	ENSP00000341247	49.6815	39.6497	eptatretus_burgeri	ENSEBUP00000006575	73.5849	58.7264
ENSG00000189369	homo_sapiens	ENSP00000341247	25.4777	14.4904	danio_rerio	ENSDARP00000113373	18.7573	10.6682
ENSG00000189369	homo_sapiens	ENSP00000341247	25.7962	14.8089	danio_rerio	ENSDARP00000118068	18.9696	10.8899
ENSG00000189369	homo_sapiens	ENSP00000341247	14.9682	7.48408	hucho_hucho	ENSHHUP00000015942	33.452	16.726
ENSG00000189369	homo_sapiens	ENSP00000341247	25	14.0127	saccharomyces_cerevisiae	YER025W	29.7913	16.6983
ENSG00000189369	homo_sapiens	ENSP00000341247	3.98089	1.75159	seriola_lalandi_dorsalis	ENSSLDP00000001964	12.5	5.5
ENSG00000189369	homo_sapiens	ENSP00000341247	21.0191	10.6688	oncorhynchus_tshawytscha	ENSOTSP00005039722	21.5334	10.9299
ENSG00000189369	homo_sapiens	ENSP00000341247	53.9809	48.7261	sinocyclocheilus_grahami	ENSSGRP00000001271	80.9069	73.031

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000184	involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	1	IEA	Homo_sapiens(9606)	Process
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0003747	enables translation release factor activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0003924	enables GTPase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005525	enables GTP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006412	involved_in translation	1	IBA	Homo_sapiens(9606)	Process
GO:0006415	involved_in translational termination	1	IDA	Homo_sapiens(9606)	Process
GO:0007049	involved_in cell cycle	1	IEA	Homo_sapiens(9606)	Process
GO:0018444	part_of translation release factor complex	1	IBA	Homo_sapiens(9606)	Component