RBP Type
Canonical_RBPs
Diseases
Drug
N.A.
Main interacting RNAs
N.A.
Moonlighting functions
N.A.
Localizations
N.A.
BulkPerturb-seq
Ensembl ID ENSG00000189283 Gene ID
2272 Accession
3701
Symbol
FHIT
Alias
FRA3B;AP3Aase
Full Name
fragile histidine triad diadenosine triphosphatase
Status
Confidence
Length
1504183 bases
Strand
Minus strand
Position
3 : 59747277 - 61251459
RNA binding domain
DcpS_C
Summary
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000417480
DcpS_C
PF11969 5.7e-06
1
ENSP00000417557
DcpS_C
PF11969 5.7e-06
1
ENSP00000418582
DcpS_C
PF11969 5.7e-06
1
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
29282095 Impact of FHIT loss on the translation of cancer-associated mRNAs.
L Daniel Kiss
2017-12-28
Molecular cancer
28093273 Identification of Fhit as a post-transcriptional effector of Thymidine Kinase 1 expression.
L Daniel Kiss
2017-03-01
Biochimica et biophysica acta. Gene regulatory mechanisms
35522782 Chemical Proteomics of the Tumor Suppressor Fhit Covalently Bound to the Cofactor Ap3 A Elucidates Its Inhibitory Action on Translation.
Doreen Herzog
2022-05-18
Journal of the American Chemical Society
Name
Transcript ID
bp
Protein
Translation ID
FHIT-207
ENST00000492590
3116
147aa
ENSP00000418582
FHIT-204
ENST00000476844
1033
147aa
ENSP00000417557
FHIT-202
ENST00000466788
3063
No protein
-
FHIT-203
ENST00000468189
1634
147aa
ENSP00000417480
FHIT-205
ENST00000488467
601
78aa
ENSP00000418596
FHIT-206
ENST00000490952
1720
No protein
-
FHIT-201
ENST00000465330
253
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
340 Respiratory Function Tests 1.63726832069856E-10 17903307 812 Sleep 1.86055357988859E-5 17903308 826 Sleep 5.49352541059896E-6 17903308 841 Sleep 1.11283815250505E-5 17903308 1174 Body Mass Index 2.53236272869172E-6 17903300 1245 Body Mass Index 3.74443613919476E-7 17903300 1265 Body Weight 8.70052763863913E-9 17903300 1343 Body Weight 7.2515516712443E-7 17903300 2122 Body Weights and Measures 6.64599416816817E-8 17903300 2439 Body Mass Index 2.20928492346421E-6 17903300 2545 Body Weight 6.67395575574214E-6 17903300 3639 Cholesterol, LDL 1.93077421409446E-9 17903299 3767 Cholesterol, LDL 2.28551705880493E-5 17903299 3784 Cholesterol, LDL 3.47305821472081E-5 17903299 3796 Cholesterol, LDL 3.45052861150386E-6 17903299 3809 Cholesterol, LDL 1.90735841276712E-6 17903299 5297 Cholesterol, LDL 6.63729425331994E-6 17903299 5310 Cholesterol, LDL 6.98976279678298E-6 17903299 6541 Fibrinogen 7.58738768995536E-8 17903294 7682 Glomerular Filtration Rate 1.15512639121322E-7 17903292 7884 Creatinine 1.33321366701441E-5 17903292 8647 Blood Pressure 8.34543393439189E-8 17903302 10348 Electrocardiography 8.18219302516354E-5 17903302 11570 Mental Competency 5.29972326537287E-5 17903295 12870 Schizophrenia 9.8E-5 - 13762 Myocardial Infarction 3.9439308E-004 - 14562 Prostatic Neoplasms 3.9520000E-005 18264096 15313 Heart Failure 7.3567272E-004 - 15476 Heart Failure 6.8380688E-004 - 15888 Stroke 6.7366618E-004 19369658 16684 Alcoholism 2.13E-05 - 16714 Alcoholism 3.67E-05 - 16776 Alcoholism 3.4E-05 - 20069 Creatinine 4.889e-005 - 21134 Altruism 4.496e-005 - 23750 Muscle, Skeletal 7.8870000E-005 - 23898 Obesity 5.7700000E-005 - 24970 Waist Circumference 3.9210000E-005 - 25461 Coronary Artery Disease 9.0450000E-005 - 26921 Blood Pressure 4.1710000E-005 - 27061 Blood Pressure 3.9260000E-005 - 27396 Hypertrophy, Left Ventricular 9.7590000E-005 - 29452 Cholesterol, LDL 6.6920000E-006 - 29548 Cholesterol 5.4900000E-005 - 29704 Lipoprotein(a) 6.3820000E-005 - 29984 Lipids 2.4980000E-005 - 30100 Cholesterol 5.6140000E-005 - 30202 Albumins 4.5080000E-005 - 31797 Erythrocyte Count 9.9610000E-005 - 31820 Erythrocyte Count 4.4260000E-005 - 32078 Fetal Hemoglobin 1.8700000E-006 20018918 35133 Platelet Function Tests 4.4700000E-006 - 40656 Platelet Function Tests 2.8590814E-006 - 41249 Platelet Function Tests 7.2828860E-006 - 41434 Platelet Function Tests 8.0528946E-006 - 41808 Platelet Function Tests 8.5686678E-006 - 42899 Platelet Function Tests 1.6533146E-006 - 43990 Platelet Function Tests 9.2349175E-006 - 44021 Platelet Function Tests 1.7673226E-006 - 45513 Platelet Function Tests 1.6156600E-005 - 45531 Platelet Function Tests 8.8780901E-006 - 45896 Platelet Function Tests 3.5598600E-005 - 46551 Coronary Artery Disease 8.5110000E-005 - 46552 Coronary Artery Disease 8.5110000E-005 - 47845 Child Development Disorders, Pervasive 7.6034000E-006 - 47918 Child Development Disorders, Pervasive 1.2020000E-005 - 48620 Child Development Disorders, Pervasive 7.3102000E-006 - 50810 Child Development Disorders, Pervasive 3.7676000E-006 - 50818 Child Development Disorders, Pervasive 2.5886000E-006 - 51545 Child Development Disorders, Pervasive 1.7947000E-005 - 52206 Child Development Disorders, Pervasive 4.3000000E-005 - 52775 Interleukin-10 5.7630000E-005 - 53177 Hydrocortisone 4.4730000E-007 - 53211 Dehydroepiandrosterone 7.5250000E-007 - 53700 Testosterone 1.9640000E-005 - 53702 Testosterone 4.4030000E-005 - 55776 Folic Acid 5.9440000E-005 - 55830 Lutein 1.4360000E-005 - 55838 Lutein 2.4420000E-005 - 63470 Lip 1E-7 27560520 64059 Orofacial Cleft 1 7E-6 22419666 65862 Schizophrenia 5E-8 26198764 67351 Attention Deficit Disorder with Hyperactivity 8E-6 18821565 68659 Autosomal dominant compelling helio ophthalmic outburst syndrome 2E-36 27182965 72269 Asperger Syndrome 4E-6 21182207 73161 Body Mass Index 3E-6 25673413 74591 Pancreatitis 8E-6 27114598 74592 Precursor Cell Lymphoblastic Leukemia-Lymphoma 8E-6 27114598 75839 Bronchopulmonary Dysplasia 3E-6 23897914 76824 Drug Resistance 2E-6 22952603 78842 Myopia, Degenerative 3E-6 23049088 79791 Antidepressive Agents 2E-6 22760553 82290 Dental Caries 5E-6 23470693 82900 Body Mass Index 3E-7 25673413 88215 Body Mass Index 1E-10 25673413 90473 Aorta 8E-6 21223598 90841 Blood Pressure 8E-7 24954895 92154 Breast 2E-6 22747683 92155 Breast Neoplasms 2E-6 22747683 93561 Cognition 6E-6 25644384 94719 Body Mass Index 2E-10 25673413 96809 Anticonvulsants 7E-7 22379998 99988 Methadone 6E-6 28115739 99989 Opioid-Related Disorders 6E-6 28115739 104312 Depressive Disorder 4E-6 20125088 106505 Depressive Disorder 7E-10 28049566
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000166 enables nucleotide binding 1 IEA Homo_sapiens(9606) Function GO:0001650 located_in fibrillar center 1 IDA Homo_sapiens(9606) Component GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005634 is_active_in nucleus 1 IBA Homo_sapiens(9606) Component GO:0005737 is_active_in cytoplasm 2 IBA,IDA Homo_sapiens(9606) Component GO:0005739 located_in mitochondrion 1 IEA Homo_sapiens(9606) Component GO:0005829 located_in cytosol 1 IDA Homo_sapiens(9606) Component GO:0005886 is_active_in plasma membrane 2 IBA,IDA Homo_sapiens(9606) Component GO:0006163 involved_in purine nucleotide metabolic process 2 IBA,IDA Homo_sapiens(9606) Process GO:0015964 involved_in diadenosine triphosphate catabolic process 2 IBA,IDA Homo_sapiens(9606) Process GO:0031625 enables ubiquitin protein ligase binding 2 IBA,IPI Homo_sapiens(9606) Function GO:0032435 involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process 2 IBA,IMP Homo_sapiens(9606) Process GO:0042802 enables identical protein binding 1 IPI Homo_sapiens(9606) Function GO:0043530 enables adenosine 5-monophosphoramidase activity 1 IDA Homo_sapiens(9606) Function GO:0047352 enables adenylylsulfate-ammonia adenylyltransferase activity 1 IDA Homo_sapiens(9606) Function GO:0047627 enables adenylylsulfatase activity 1 IDA Homo_sapiens(9606) Function GO:0047710 enables bis(5-adenosyl)-triphosphatase activity 2 IBA,IDA Homo_sapiens(9606) Function GO:0072332 involved_in intrinsic apoptotic signaling pathway by p53 class mediator 2 IBA,IMP Homo_sapiens(9606) Process
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