Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000186868 Gene ID 4137 Accession 6893
Symbol MAPT Alias TAU;MSTD;PPND;DDPAC;MAPTL;MTBT1;MTBT2;tau-40;FTDP-17;PPP1R103;Tau-PHF6 Full Name microtubule associated protein tau
Status Confidence Length 133808 bases Strand Plus strand
Position 17 : 45894527 - 46028334 RNA binding domain N.A.
Summary This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
34858989 Human Induced Pluripotent Stem Cell Models of Frontotemporal Dementia With Tau Pathology. Rebekka Kühn 2021-01-01 Frontiers in cell and developmental biology
27109057 Microarray-based technologies for the discovery of selective, RNA-binding molecules. A Fardokht Abulwerdi 2016-07-01 Methods (San Diego, Calif.)
33066368 Microglia in Alzheimer's Disease in the Context of Tau Pathology. Ramón Juan Perea 2020-10-14 Biomolecules
33900085 Proteomic Profiling of the Substantia Nigra to Identify Determinants of Lewy Body Pathology and Dopaminergic Neuronal Loss. A Vladislav Petyuk 2021-05-07 Journal of proteome research
27222125 Tau mis-splicing in the pathogenesis of neurodegenerative disorders. Ah Sun Park 2016-08-01 BMB reports
36909621 Long non-coding RNA SNHG8 drives stress granule formation in tauopathies. Reshma Bhagat 2023-03-01 medRxiv : the preprint server for health sciences
25115866 Bottom-up design of small molecules that stimulate exon 10 skipping in mutant MAPT pre-mRNA. Yiling Luo 2014-09-22 Chembiochem : a European journal of chemical biology
24462217 Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy. Andrea Cortese 2014-06-01 Neurobiology of aging
34314701 ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. R Kathryn Bowles 2021-08-19 Cell
34732566 RNALigands: a database and web server for RNA-ligand interactions. Saisai Sun 2022-02-01 RNA (New York, N.Y.)
25359609 Hypoxia alters expression of zebrafish microtubule-associated protein tau (mapta, maptb) gene transcripts. Hani Seyyed SH Moussavi 2014-10-31 BMC research notes
30385607 Drugging the RNA World. D Matthew Disney 2018-11-01 Cold Spring Harbor perspectives in biology
26139368 RNA Structures as Mediators of Neurological Diseases and as Drug Targets. Viachaslau Bernat 2015-07-01 Neuron

Transcripts

Name Transcript ID bp Protein Translation ID
MAPT-218 ENST00000680674 1936 424aa ENSP00000505478
MAPT-219 ENST00000703922 2058 412aa ENSP00000515557
MAPT-220 ENST00000703923 2884 383aa ENSP00000515558
MAPT-221 ENST00000703924 2971 412aa ENSP00000515559
MAPT-222 ENST00000703974 735 No protein -
MAPT-209 ENST00000535772 1353 381aa ENSP00000443028
MAPT-201 ENST00000262410 6815 833aa ENSP00000262410
MAPT-204 ENST00000351559 5639 441aa ENSP00000303214
MAPT-203 ENST00000344290 2609 736aa ENSP00000340820
MAPT-206 ENST00000420682 1871 412aa ENSP00000413056
MAPT-211 ENST00000571311 544 59aa ENSP00000460048
MAPT-223 ENST00000703975 2863 No protein -
MAPT-210 ENST00000570299 889 No protein -
MAPT-224 ENST00000703976 2912 No protein -
MAPT-225 ENST00000703977 614 No protein -
MAPT-217 ENST00000680542 2988 412aa ENSP00000505258
MAPT-226 ENST00000703978 2919 441aa ENSP00000515600
MAPT-202 ENST00000334239 1107 352aa ENSP00000334886
MAPT-208 ENST00000446361 5345 383aa ENSP00000408975
MAPT-227 ENST00000703979 853 No protein -
MAPT-205 ENST00000415613 2331 776aa ENSP00000410838
MAPT-207 ENST00000431008 1233 410aa ENSP00000389250
MAPT-212 ENST00000571987 2277 758aa ENSP00000458742
MAPT-214 ENST00000574436 1326 441aa ENSP00000460965
MAPT-215 ENST00000576518 6778 No protein -
MAPT-213 ENST00000572440 5015 No protein -
MAPT-216 ENST00000577017 142 No protein -
MAPT-228 ENST00000703980 1080 No protein -
MAPT-229 ENST00000703981 994 No protein -
MAPT-230 ENST00000703982 1228 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
11189Hip2.70473933381407E-517903296
13329Parkinson Disease2.02E-719915575
13367Parkinson Disease3.36E-719915575
13393Parkinson Disease3.44E-719915575
34836Platelet Function Tests1.3800000E-009-
34837Platelet Function Tests1.2200000E-009-
34838Platelet Function Tests7.4600000E-010-
34841Platelet Function Tests7.7700000E-010-
34856Platelet Function Tests1.5100000E-009-
34857Platelet Function Tests1.5100000E-009-
34858Platelet Function Tests1.5100000E-009-
34859Platelet Function Tests7.7700000E-010-
34860Platelet Function Tests1.5100000E-009-
56997Lung Diseases, Interstitial2.5157780E-008-
57025Lung Diseases, Interstitial3.8658810E-008-
57034Lung Diseases, Interstitial3.3884340E-008-
68247tau Proteins1E-1228100725
77896Lung Diseases, Interstitial9E-1423583980
81817Parkinson Disease7E-1221044948
86698Supranuclear Palsy, Progressive9E-1821685912
102023Electrocardiography2E-1427659466
103924Parkinson Disease2E-4825064009
103989Supranuclear Palsy, Progressive2E-11821685912
104794Bone Density5E-1122504420

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000226involved_in microtubule cytoskeleton organization3IBA,IDA,NASHomo_sapiens(9606)Process
GO:0001774involved_in microglial cell activation1TASHomo_sapiens(9606)Process
GO:0003677enables DNA binding2ISS,TASHomo_sapiens(9606)Function
GO:0003680enables minor groove of adenine-thymine-rich DNA binding1TASHomo_sapiens(9606)Function
GO:0003690enables double-stranded DNA binding1TASHomo_sapiens(9606)Function
GO:0003697enables single-stranded DNA binding1TASHomo_sapiens(9606)Function
GO:0003723enables RNA binding1TASHomo_sapiens(9606)Function
GO:0003779enables actin binding1TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005576located_in extracellular region1NASHomo_sapiens(9606)Component
GO:0005634located_in nucleus2ISS,TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm3IDA,IMP,ISSHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol3IDA,ISS,TASHomo_sapiens(9606)Component
GO:0005874colocalizes_with microtubule1ISSHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane2IDA,TASHomo_sapiens(9606)Component
GO:0006475involved_in internal protein amino acid acetylation1TASHomo_sapiens(9606)Process
GO:0006919involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process1TASHomo_sapiens(9606)Process
GO:0006974involved_in DNA damage response1IMPHomo_sapiens(9606)Process
GO:0007267involved_in cell-cell signaling1NASHomo_sapiens(9606)Process
GO:0007613involved_in memory1IMPHomo_sapiens(9606)Process
GO:0008017enables microtubule binding5IBA,IDA,IMP,NAS,TASHomo_sapiens(9606)Function
GO:0010288involved_in response to lead ion1ISSHomo_sapiens(9606)Process
GO:0010506acts_upstream_of_or_within regulation of autophagy1IGIHomo_sapiens(9606)Process
GO:0010629involved_in negative regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0010917involved_in negative regulation of mitochondrial membrane potential1IMPHomo_sapiens(9606)Process
GO:0015630located_in microtubule cytoskeleton2IDA,NASHomo_sapiens(9606)Component
GO:0016020colocalizes_with membrane1IMPHomo_sapiens(9606)Component
GO:0016072involved_in rRNA metabolic process1TASHomo_sapiens(9606)Process
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0017124enables SH3 domain binding1IPIHomo_sapiens(9606)Function
GO:0019896involved_in axonal transport of mitochondrion1TASHomo_sapiens(9606)Process
GO:0019899enables enzyme binding2IPI,ISSHomo_sapiens(9606)Function
GO:0019901enables protein kinase binding2IPI,ISSHomo_sapiens(9606)Function
GO:0021954involved_in central nervous system neuron development1TASHomo_sapiens(9606)Process
GO:0030424located_in axon3IDA,NAS,TASHomo_sapiens(9606)Component
GO:0030425located_in dendrite1IDAHomo_sapiens(9606)Component
GO:0030426located_in growth cone1IDAHomo_sapiens(9606)Component
GO:0030673located_in axolemma1IDAHomo_sapiens(9606)Component
GO:0030674enables protein-macromolecule adaptor activity1TASHomo_sapiens(9606)Function
GO:0031110involved_in regulation of microtubule polymerization or depolymerization1IMPHomo_sapiens(9606)Process
GO:0031113involved_in regulation of microtubule polymerization2NAS,TASHomo_sapiens(9606)Process
GO:0031116involved_in positive regulation of microtubule polymerization1IDAHomo_sapiens(9606)Process
GO:0031122involved_in cytoplasmic microtubule organization1TASHomo_sapiens(9606)Process
GO:0031175involved_in neuron projection development2IBA,TASHomo_sapiens(9606)Process
GO:0032930involved_in positive regulation of superoxide anion generation1IMPHomo_sapiens(9606)Process
GO:0033044involved_in regulation of chromosome organization1TASHomo_sapiens(9606)Process
GO:0033673involved_in negative regulation of kinase activity1IMPHomo_sapiens(9606)Process
GO:0034063involved_in stress granule assembly1TASHomo_sapiens(9606)Process
GO:0034185enables apolipoprotein binding1IPIHomo_sapiens(9606)Function
GO:0034399located_in nuclear periphery1IDAHomo_sapiens(9606)Component
GO:0034452enables dynactin binding1TASHomo_sapiens(9606)Function
GO:0034605involved_in cellular response to heat1TASHomo_sapiens(9606)Process
GO:0034614involved_in cellular response to reactive oxygen species1TASHomo_sapiens(9606)Process
GO:0035091enables phosphatidylinositol binding1TASHomo_sapiens(9606)Function
GO:0036464located_in cytoplasmic ribonucleoprotein granule1IDAHomo_sapiens(9606)Component
GO:0036477located_in somatodendritic compartment2IMP,TASHomo_sapiens(9606)Component
GO:0042802enables identical protein binding3IDA,IMP,IPIHomo_sapiens(9606)Function
GO:0043005is_active_in neuron projection1IBAHomo_sapiens(9606)Component
GO:0043025located_in neuronal cell body1IMPHomo_sapiens(9606)Component
GO:0043197located_in dendritic spine1TASHomo_sapiens(9606)Component
GO:0043565enables sequence-specific DNA binding1TASHomo_sapiens(9606)Function
GO:0044297located_in cell body2IDA,ISSHomo_sapiens(9606)Component
GO:0044304located_in main axon1ISSHomo_sapiens(9606)Component
GO:0045121located_in membrane raft1ISSHomo_sapiens(9606)Component
GO:0045298part_of tubulin complex1IDAHomo_sapiens(9606)Component
GO:0045773involved_in positive regulation of axon extension1IDAHomo_sapiens(9606)Process
GO:0046785involved_in microtubule polymerization1TASHomo_sapiens(9606)Process
GO:0048143involved_in astrocyte activation1TASHomo_sapiens(9606)Process
GO:0048167involved_in regulation of synaptic plasticity1TASHomo_sapiens(9606)Process
GO:0048312involved_in intracellular distribution of mitochondria1IMPHomo_sapiens(9606)Process
GO:0048699involved_in generation of neurons1NASHomo_sapiens(9606)Process
GO:0050808involved_in synapse organization1IMPHomo_sapiens(9606)Process
GO:0050848involved_in regulation of calcium-mediated signaling1IDAHomo_sapiens(9606)Process
GO:0051087enables protein-folding chaperone binding1IPIHomo_sapiens(9606)Function
GO:0051258involved_in protein polymerization1IMPHomo_sapiens(9606)Process
GO:0051721enables protein phosphatase 2A binding1TASHomo_sapiens(9606)Function
GO:0051879enables Hsp90 protein binding1IPIHomo_sapiens(9606)Function
GO:0061564involved_in axon development1TASHomo_sapiens(9606)Process
GO:0070507involved_in regulation of microtubule cytoskeleton organization2IMP,TASHomo_sapiens(9606)Process
GO:0071813enables lipoprotein particle binding1IPIHomo_sapiens(9606)Function
GO:0072386involved_in plus-end-directed organelle transport along microtubule1TASHomo_sapiens(9606)Process
GO:0090140involved_in regulation of mitochondrial fission1ICHomo_sapiens(9606)Process
GO:0090258involved_in negative regulation of mitochondrial fission1IMPHomo_sapiens(9606)Process
GO:0097386located_in glial cell projection1ISSHomo_sapiens(9606)Component
GO:0097418located_in neurofibrillary tangle2IDA,NASHomo_sapiens(9606)Component
GO:0097435involved_in supramolecular fiber organization2IDA,IMPHomo_sapiens(9606)Process
GO:0098930involved_in axonal transport2NAS,TASHomo_sapiens(9606)Process
GO:0099077enables histone-dependent DNA binding1TASHomo_sapiens(9606)Function
GO:0099609enables microtubule lateral binding1IMPHomo_sapiens(9606)Function
GO:1900034involved_in regulation of cellular response to heat1IMPHomo_sapiens(9606)Process
GO:1900452involved_in regulation of long-term synaptic depression1TASHomo_sapiens(9606)Process
GO:1901216involved_in positive regulation of neuron death1IMPHomo_sapiens(9606)Process
GO:1902474involved_in positive regulation of protein localization to synapse1IMPHomo_sapiens(9606)Process
GO:1902936enables phosphatidylinositol bisphosphate binding1TASHomo_sapiens(9606)Function
GO:1902988involved_in neurofibrillary tangle assembly1NASHomo_sapiens(9606)Process
GO:1903748involved_in negative regulation of establishment of protein localization to mitochondrion1IMPHomo_sapiens(9606)Process
GO:1903829involved_in positive regulation of protein localization1IMPHomo_sapiens(9606)Process
GO:1904115located_in axon cytoplasm1IEAHomo_sapiens(9606)Component
GO:1904428involved_in negative regulation of tubulin deacetylation2IGI,TASHomo_sapiens(9606)Process
GO:1905689involved_in positive regulation of diacylglycerol kinase activity1ISSHomo_sapiens(9606)Process
GO:1990000involved_in amyloid fibril formation1IMPHomo_sapiens(9606)Process
GO:1990090involved_in cellular response to nerve growth factor stimulus1TASHomo_sapiens(9606)Process
GO:1990416involved_in cellular response to brain-derived neurotrophic factor stimulus1TASHomo_sapiens(9606)Process

Expression