RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000185338	Gene ID	8651	Accession	19383
Symbol	SOCS1	Alias	JAB;CIS1;SSI1;TIP3;CISH1;SSI-1;TIP-3;AISIMD;SOCS-1	Full Name	suppressor of cytokine signaling 1
Status	Confidence	Length	1788 bases	Strand	Minus strand
Position	16 : 11254417 - 11256204	RNA binding domain	N.A.
Summary	This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
SOCS1-201	ENST00000332029	1238	211aa	ENSP00000329418
SOCS1-202	ENST00000644787	1784	211aa	ENSP00000496577

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
95701	Crohn Disease	1E-13	22482804
95702	Psoriasis	1E-13	22482804

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001817	involved_in regulation of cytokine production	1	IEA	Homo_sapiens(9606)	Process
GO:0001932	involved_in regulation of protein phosphorylation	1	ISS	Homo_sapiens(9606)	Process
GO:0004860	enables protein kinase inhibitor activity	1	TAS	Homo_sapiens(9606)	Function
GO:0005159	enables insulin-like growth factor receptor binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0005942	part_of phosphatidylinositol 3-kinase complex	1	IBA	Homo_sapiens(9606)	Component
GO:0007259	involved_in receptor signaling pathway via JAK-STAT	1	IEA	Homo_sapiens(9606)	Process
GO:0010533	involved_in regulation of activation of Janus kinase activity	1	IEA	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	1	IEA	Homo_sapiens(9606)	Process
GO:0019210	enables kinase inhibitor activity	1	ISS	Homo_sapiens(9606)	Function
GO:0019221	involved_in cytokine-mediated signaling pathway	1	ISS	Homo_sapiens(9606)	Process
GO:0019901	enables protein kinase binding	1	IPI	Homo_sapiens(9606)	Function
GO:0030225	involved_in macrophage differentiation	1	IMP	Homo_sapiens(9606)	Process
GO:0031410	located_in cytoplasmic vesicle	1	IEA	Homo_sapiens(9606)	Component
GO:0035556	involved_in intracellular signal transduction	1	IEA	Homo_sapiens(9606)	Process
GO:0036464	located_in cytoplasmic ribonucleoprotein granule	1	IDA	Homo_sapiens(9606)	Component
GO:0042532	involved_in negative regulation of tyrosine phosphorylation of STAT protein	2	IMP,ISS	Homo_sapiens(9606)	Process
GO:0043372	involved_in positive regulation of CD4-positive, alpha-beta T cell differentiation	1	ISS	Homo_sapiens(9606)	Process
GO:0043377	involved_in negative regulation of CD8-positive, alpha-beta T cell differentiation	1	ISS	Homo_sapiens(9606)	Process
GO:0045444	involved_in fat cell differentiation	1	IEA	Homo_sapiens(9606)	Process
GO:0045591	involved_in positive regulation of regulatory T cell differentiation	1	IMP	Homo_sapiens(9606)	Process
GO:0046426	involved_in negative regulation of receptor signaling pathway via JAK-STAT	3	IMP,ISS,NAS	Homo_sapiens(9606)	Process
GO:0046627	involved_in negative regulation of insulin receptor signaling pathway	1	ISS	Homo_sapiens(9606)	Process
GO:0046854	involved_in phosphatidylinositol phosphate biosynthetic process	1	IBA	Homo_sapiens(9606)	Process
GO:0046935	enables 1-phosphatidylinositol-3-kinase regulator activity	1	IBA	Homo_sapiens(9606)	Function
GO:0071230	involved_in cellular response to amino acid stimulus	1	IEA	Homo_sapiens(9606)	Process