RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000184557	Gene ID	9021	Accession	19391
Symbol	SOCS3	Alias	CIS3;SSI3;ATOD4;Cish3;SSI-3;SOCS-3	Full Name	suppressor of cytokine signaling 3
Status	Confidence	Length	3300 bases	Strand	Minus strand
Position	17 : 78356778 - 78360077	RNA binding domain	N.A.
Summary	This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
23686487	SOCS3 regulates BAFF in human enterocytes under ribosomal stress.	Hun Kee Do	2013-06-15	Journal of immunology (Baltimore, Md. : 1950)
35600392	SOCS3 Acts as an Onco-immunological Biomarker With Value in Assessing the Tumor Microenvironment, Pathological Staging, Histological Subtypes, Therapeutic Effect, and Prognoses of Several Types of Cancer.	Lirui Dai	2022-01-01	Frontiers in oncology

Name	Transcript ID	bp	Protein	Translation ID
SOCS3-201	ENST00000330871	2734	225aa	ENSP00000330341
SOCS3-202	ENST00000587578	361	15aa	ENSP00000464727

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001784	enables phosphotyrosine residue binding	1	IEA	Homo_sapiens(9606)	Function
GO:0004860	enables protein kinase inhibitor activity	1	TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005829	is_active_in cytosol	2	TAS	Homo_sapiens(9606)	Component
GO:0005942	part_of phosphatidylinositol 3-kinase complex	1	IBA	Homo_sapiens(9606)	Component
GO:0009898	is_active_in cytoplasmic side of plasma membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0016567	involved_in protein ubiquitination	1	IEA	Homo_sapiens(9606)	Process
GO:0030292	enables protein tyrosine kinase inhibitor activity	1	IDA	Homo_sapiens(9606)	Function
GO:0035198	enables miRNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0035556	involved_in intracellular signal transduction	1	IEA	Homo_sapiens(9606)	Process
GO:0042532	involved_in negative regulation of tyrosine phosphorylation of STAT protein	1	IMP	Homo_sapiens(9606)	Process
GO:0043066	involved_in negative regulation of apoptotic process	1	TAS	Homo_sapiens(9606)	Process
GO:0045597	involved_in positive regulation of cell differentiation	1	IEA	Homo_sapiens(9606)	Process
GO:0046426	involved_in negative regulation of receptor signaling pathway via JAK-STAT	1	IMP	Homo_sapiens(9606)	Process
GO:0046627	involved_in negative regulation of insulin receptor signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0046854	involved_in phosphatidylinositol phosphate biosynthetic process	1	IBA	Homo_sapiens(9606)	Process
GO:0046935	enables 1-phosphatidylinositol-3-kinase regulator activity	1	IBA	Homo_sapiens(9606)	Function
GO:0050728	involved_in negative regulation of inflammatory response	1	IEA	Homo_sapiens(9606)	Process
GO:0060670	involved_in branching involved in labyrinthine layer morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0060674	involved_in placenta blood vessel development	1	IEA	Homo_sapiens(9606)	Process
GO:0072540	involved_in T-helper 17 cell lineage commitment	1	TAS	Homo_sapiens(9606)	Process
GO:0097398	involved_in cellular response to interleukin-17	1	IEA	Homo_sapiens(9606)	Process
GO:1990830	involved_in cellular response to leukemia inhibitory factor	1	IEA	Homo_sapiens(9606)	Process