Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerSARS-COV-OC43FlavivirusesSARS-COV-2DengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations Stress granucleNucleoli
BulkPerturb-seq DataSet_01_316 DataSet_01_420 DataSet_02_20 DataSet_02_48

Description

Ensembl ID ENSG00000182944 Gene ID 2130 Accession 3508
Symbol EWSR1 Alias EWS;EWS-FLI1;bK984G1.4 Full Name EWS RNA binding protein 1
Status Confidence Length 32517 bases Strand Plus strand
Position 22 : 29268009 - 29300525 RNA binding domain zf-RanBP , RRM_1
Summary This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000353204 RRM_1 PF00076 7.6e-10 1
ENSP00000353204 zf-RanBP PF00641 5.3e-07 2
ENSP00000486709 RRM_1 PF00076 3.1e-09 1
ENSP00000486709 zf-RanBP PF00641 4.3e-12 2
ENSP00000331699 RRM_1 PF00076 3.3e-09 1
ENSP00000331699 zf-RanBP PF00641 4.5e-12 2
ENSP00000330896 RRM_1 PF00076 3.4e-09 1
ENSP00000330896 zf-RanBP PF00641 4.6e-12 2
ENSP00000330516 RRM_1 PF00076 3.5e-09 1
ENSP00000330516 zf-RanBP PF00641 4.6e-12 2
ENSP00000385726 RRM_1 PF00076 3.9e-09 1
ENSP00000385726 zf-RanBP PF00641 4.9e-12 2
ENSP00000381031 RRM_1 PF00076 3.9e-09 1
ENSP00000381031 zf-RanBP PF00641 4.9e-12 2
ENSP00000400142 RRM_1 PF00076 4e-09 1
ENSP00000400142 zf-RanBP PF00641 5e-12 2

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
29513652 EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma. Aparna Gorthi 2018-03-15 Nature
31571637 Primary parachordoma in the trachea: An unusual cause of dyspnoea. Qun-Cheng Zhang 2019-07-01 The Indian journal of medical research
35626258 Alveolar Soft Part Sarcoma of the Uterus: Clinicopathological and Molecular Characteristics. Yurimi Lee 2022-04-27 Diagnostics (Basel, Switzerland)
36083250 Metastatic sporadic paraganglioma with EWSR1::CREM gene fusion: A unique molecular profile that expands the phenotypic diversity of the molecular landscape of the EWSR1::CREM gene fusion positive tumors. Sehrish Javaid 2023-02-01 Genes, chromosomes & cancer
32362012 The clinical heterogeneity of round cell sarcomas with EWSR1/FUS gene fusions: Impact of gene fusion type on clinical features and outcome. Yusuke Tsuda 2020-09-01 Genes, chromosomes & cancer
36306280 A Proximity biotinylation assay with a host protein bait reveals multiple factors modulating enterovirus replication. Seyedehmahsa Moghimi 2022-10-01 PLoS pathogens
34612781 Overexpression of EWSR1 (Ewing sarcoma breakpoint region 1/EWS RNA binding protein 1) predicts poor survival in patients with hepatocellular carcinoma. Weijie Jiang 2021-12-01 Bioengineered
25751255 The cell cycle regulator CCDC6 is a key target of RNA-binding protein EWS. Sujitha Duggimpudi 2015-01-01 PloS one
35158743 Recent Advances on Immunohistochemistry and Molecular Biology for the Diagnosis of Adnexal Sweat Gland Tumors. Nicolas Macagno 2022-01-18 Cancers
26684580 Gene fusions in soft tissue tumors: Recurrent and overlapping pathogenetic themes. Fredrik Mertens 2016-04-01 Genes, chromosomes & cancer
31205866 Clear cell sarcoma in unusual sites mimicking metastatic melanoma. E Ifeyinwa Obiorah 2019-05-24 World journal of clinical oncology
24767700 An intraosseous sclerosing odontogenic tumor predominantly composed of epithelial cells: relation to (so-called) sclerosing odontogenic carcinoma and epithelial-rich central odontogenic fibroma. Hwa Sze Tan 2014-10-01 Oral surgery, oral medicine, oral pathology and oral radiology
30486883 The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response. Andrea Devecchi 2018-11-28 Cancer communications (London, England)
23329308 Molecular detection and targeting of EWSR1 fusion transcripts in soft tissue tumors. Monica Cantile 2013-03-01 Medical oncology (Northwood, London, England)
36338546 WEE1 inhibition augments CDC7 (DDK) inhibitor-induced cell death in Ewing sarcoma by forcing premature mitotic entry and mitotic catastrophe. C Jeffrey Martin 2022-06-01 Cancer research communications
35031058 EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3. Ziwen Pan 2022-01-14 Molecular cancer
29455671 Oncogenic fusion proteins adopt the insulin-like growth factor signaling pathway. Haim Werner 2018-02-19 Molecular cancer
26256788 The yin and yang of hepatitis C: synthesis and decay of hepatitis C virus RNA. You Li 2015-09-01 Nature reviews. Microbiology
28472972 Primary Ewing's sarcoma/primitive neuroectodermal tumor of the ileum: case report of a 16-year-old Chinese female and literature review. Teng Li 2017-05-04 Diagnostic pathology
31078563 EWSR1/FUS-NFATc2 rearranged round cell sarcoma: clinicopathological series of 4 cases and literature review. A Julio Diaz-Perez 2019-08-01 Human pathology

Transcripts

Name Transcript ID bp Protein Translation ID
EWSR1-212 ENST00000444626 560 77aa ENSP00000416171
EWSR1-203 ENST00000332050 2552 620aa ENSP00000330896
EWSR1-222 ENST00000629659 2446 584aa ENSP00000486709
EWSR1-210 ENST00000436425 553 156aa ENSP00000406824
EWSR1-213 ENST00000447973 582 166aa ENSP00000405947
EWSR1-204 ENST00000333395 1315 354aa ENSP00000327456
EWSR1-206 ENST00000397938 2400 656aa ENSP00000381031
EWSR1-219 ENST00000485037 479 No protein -
EWSR1-207 ENST00000406548 2207 655aa ENSP00000385726
EWSR1-211 ENST00000437155 933 292aa ENSP00000412670
EWSR1-209 ENST00000415761 587 180aa ENSP00000395200
EWSR1-201 ENST00000331029 2267 618aa ENSP00000330516
EWSR1-217 ENST00000483415 3231 No protein -
EWSR1-208 ENST00000414183 2189 661aa ENSP00000400142
EWSR1-214 ENST00000455726 710 233aa ENSP00000393637
EWSR1-202 ENST00000332035 1989 600aa ENSP00000331699
EWSR1-220 ENST00000493426 581 No protein -
EWSR1-216 ENST00000479135 7285 No protein -
EWSR1-215 ENST00000469669 2630 No protein -
EWSR1-218 ENST00000483629 1818 No protein -
EWSR1-205 ENST00000360091 1289 308aa ENSP00000353204
EWSR1-221 ENST00000610553 2300 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000182944homo_sapiensENSP0000025410867.490556.0836homo_sapiensENSP0000038103154.115944.9695
ENSG00000182944homo_sapiensENSP000004740965039.6959homo_sapiensENSP0000038103145.12235.8232

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000182944homo_sapiensENSP0000038103195.731795.4268nomascus_leucogenysENSNLEP0000000345099.367199.0506
ENSG00000182944homo_sapiensENSP0000038103199.847699.6951pan_paniscusENSPPAP0000001976499.092398.941
ENSG00000182944homo_sapiensENSP0000038103199.847699.6951pongo_abeliiENSPPYP0000004039799.092398.941
ENSG00000182944homo_sapiensENSP0000038103199.847699.6951pan_troglodytesENSPTRP0000008849699.092398.941
ENSG00000182944homo_sapiensENSP0000038103199.847699.6951gorilla_gorillaENSGGOP0000001729499.092398.941
ENSG00000182944homo_sapiensENSP0000038103197.256194.3598ornithorhynchus_anatinusENSOANP0000000209498.153895.2308
ENSG00000182944homo_sapiensENSP0000038103197.713495.8841sarcophilus_harrisiiENSSHAP0000004032588.170686.5199
ENSG00000182944homo_sapiensENSP0000038103153.963450.1524notamacropus_eugeniiENSMEUP0000000249283.886377.9621
ENSG00000182944homo_sapiensENSP0000038103170.426869.5122erinaceus_europaeusENSEEUP0000001174970.967770.0461
ENSG00000182944homo_sapiensENSP0000038103194.512292.9878echinops_telfairiENSETEP0000000316695.384693.8462
ENSG00000182944homo_sapiensENSP0000038103199.847699.5427callithrix_jacchusENSCJAP0000003726698.942698.6405
ENSG00000182944homo_sapiensENSP0000038103199.847699.5427cercocebus_atysENSCATP0000002914499.092398.7897
ENSG00000182944homo_sapiensENSP0000038103199.847699.5427macaca_fascicularisENSMFAP0000003992998.942698.6405
ENSG00000182944homo_sapiensENSP0000038103199.847699.5427macaca_mulattaENSMMUP0000002815697.615597.3174
ENSG00000182944homo_sapiensENSP0000038103199.847699.5427macaca_nemestrinaENSMNEP0000002634899.092398.7897
ENSG00000182944homo_sapiensENSP0000038103199.847699.5427papio_anubisENSPANP0000003452699.092398.7897
ENSG00000182944homo_sapiensENSP0000038103199.847699.5427mandrillus_leucophaeusENSMLEP0000000385799.092398.7897
ENSG00000182944homo_sapiensENSP0000038103198.018397.4085tursiops_truncatusENSTTRP0000001126997.129996.5257
ENSG00000182944homo_sapiensENSP0000038103115.243914.7866vulpes_vulpesENSVVUP0000001985784.745882.2034
ENSG00000182944homo_sapiensENSP0000038103115.091514.0244vulpes_vulpesENSVVUP0000001922986.08780
ENSG00000182944homo_sapiensENSP0000038103199.237898.1707mus_spretusMGP_SPRETEiJ_P002682598.487197.4281
ENSG00000182944homo_sapiensENSP0000038103199.542799.2378equus_asinusENSEASP0000501446898.789798.4871
ENSG00000182944homo_sapiensENSP0000038103194.817194.0549capra_hircusENSCHIP0000000318197.645296.8603
ENSG00000182944homo_sapiensENSP0000038103199.237898.4756loxodonta_africanaENSLAFP0000001321798.1997.4359
ENSG00000182944homo_sapiensENSP0000038103199.390298.9329panthera_leoENSPLOP0000001703198.638498.1846
ENSG00000182944homo_sapiensENSP0000038103199.085498.7805ailuropoda_melanoleucaENSAMEP0000000881998.335998.0333
ENSG00000182944homo_sapiensENSP0000038103199.085498.6281bos_indicus_hybridENSBIXP0000500104498.187397.7341
ENSG00000182944homo_sapiensENSP0000038103194.969593.9024oryctolagus_cuniculusENSOCUP0000002000298.57697.4684
ENSG00000182944homo_sapiensENSP0000038103189.481788.2622oryctolagus_cuniculusENSOCUP0000002570198.489997.1477
ENSG00000182944homo_sapiensENSP0000038103198.932997.7134oryctolagus_cuniculusENSOCUP0000002900798.333397.1212
ENSG00000182944homo_sapiensENSP0000038103199.695199.2378equus_caballusENSECAP0000001993198.791598.3384
ENSG00000182944homo_sapiensENSP0000038103184.908583.8415canis_lupus_familiarisENSCAFP0084501081998.758997.5177
ENSG00000182944homo_sapiensENSP0000038103184.756183.689canis_lupus_familiarisENSCAFP0084502126492.666791.5
ENSG00000182944homo_sapiensENSP0000038103199.390299.0854canis_lupus_familiarisENSCAFP0084504253198.638498.3359
ENSG00000182944homo_sapiensENSP0000038103199.390298.7805panthera_pardusENSPPRP0000001778598.638498.0333
ENSG00000182944homo_sapiensENSP0000038103189.93989.4817panthera_pardusENSPPRP0000000924399.494198.9882
ENSG00000182944homo_sapiensENSP0000038103195.426894.8171marmota_marmota_marmotaENSMMMP0000001987498.582797.9528
ENSG00000182944homo_sapiensENSP0000038103199.085498.3232balaenoptera_musculusENSBMSP0001001827398.335997.5794
ENSG00000182944homo_sapiensENSP0000038103198.170797.2561cavia_porcellusENSCPOP0000002442498.621797.7029
ENSG00000182944homo_sapiensENSP0000038103199.390298.9329felis_catusENSFCAP0000005094798.638498.1846
ENSG00000182944homo_sapiensENSP0000038103194.817194.5122ursus_americanusENSUAMP0000001572098.730298.4127
ENSG00000182944homo_sapiensENSP0000038103158.079355.4878monodelphis_domesticaENSMODP0000005993870.817867.658
ENSG00000182944homo_sapiensENSP0000038103198.628198.1707bison_bison_bisonENSBBBP0000000119797.88297.4281
ENSG00000182944homo_sapiensENSP0000038103199.085498.3232monodon_monocerosENSMMNP0001501097598.335997.5794
ENSG00000182944homo_sapiensENSP0000038103199.542799.0854sus_scrofaENSSSCP0000007396898.789798.3359
ENSG00000182944homo_sapiensENSP0000038103175.457374.2378microcebus_murinusENSMICP0000002712896.303594.7471
ENSG00000182944homo_sapiensENSP0000038103196.951296.189microcebus_murinusENSMICP0000002213498.911498.1338
ENSG00000182944homo_sapiensENSP0000038103193.292791.6159octodon_degusENSODEP0000000588495.178893.4681
ENSG00000182944homo_sapiensENSP0000038103175.457373.9329octodon_degusENSODEP0000000008889.028887.2302
ENSG00000182944homo_sapiensENSP0000038103174.542771.7988octodon_degusENSODEP0000000441290.221486.9004
ENSG00000182944homo_sapiensENSP0000038103199.237898.6281jaculus_jaculusENSJJAP0000000208798.487197.882
ENSG00000182944homo_sapiensENSP0000038103145.426844.5122ovis_aries_rambouilletENSOARP0002002002695.819993.8907
ENSG00000182944homo_sapiensENSP0000038103199.237898.9329ursus_maritimusENSUMAP0000002190599.237898.9329
ENSG00000182944homo_sapiensENSP0000038103139.481734.7561ochotona_princepsENSOPRP0000001589276.854667.6558
ENSG00000182944homo_sapiensENSP0000038103130.640230.0305ochotona_princepsENSOPRP0000001387458.771957.6023
ENSG00000182944homo_sapiensENSP0000038103197.713496.9512delphinapterus_leucasENSDLEP0000002534095.958195.2096
ENSG00000182944homo_sapiensENSP0000038103199.085498.0183mus_caroliMGP_CAROLIEiJ_P002549398.335997.2769
ENSG00000182944homo_sapiensENSP0000038103199.085497.7134mus_musculusENSMUSP0000009999498.335996.9743
ENSG00000182944homo_sapiensENSP0000038103148.323247.561dipodomys_ordiiENSDORP0000000836810098.4227
ENSG00000182944homo_sapiensENSP0000038103199.390298.9329mustela_putorius_furoENSMPUP0000001333299.23998.7823
ENSG00000182944homo_sapiensENSP0000038103199.695199.3902aotus_nancymaaeENSANAP0000002947999.090998.7879
ENSG00000182944homo_sapiensENSP0000038103199.847699.5427saimiri_boliviensis_boliviensisENSSBOP0000002720599.092398.7897
ENSG00000182944homo_sapiensENSP0000038103114.176813.4146mesocricetus_auratusENSMAUP0000000615681.578977.193
ENSG00000182944homo_sapiensENSP0000038103199.085498.4756phocoena_sinusENSPSNP0000001231698.335997.7307
ENSG00000182944homo_sapiensENSP000003810315047.8659camelus_dromedariusENSCDRP0000501220088.409784.6361
ENSG00000182944homo_sapiensENSP0000038103199.695199.2378carlito_syrichtaENSTSYP0000003001198.94198.4871
ENSG00000182944homo_sapiensENSP0000038103199.390298.9329panthera_tigris_altaicaENSPTIP0000000669798.638498.1846
ENSG00000182944homo_sapiensENSP0000038103199.542798.4756rattus_norvegicusENSRNOP0000005419398.789797.7307
ENSG00000182944homo_sapiensENSP0000038103199.695199.2378prolemur_simusENSPSMP0000002151698.94198.4871
ENSG00000182944homo_sapiensENSP0000038103198.170797.2561microtus_ochrogasterENSMOCP0000001408398.320697.4046
ENSG00000182944homo_sapiensENSP0000038103199.542798.7805peromyscus_maniculatus_bairdiiENSPEMP0000002093798.789798.0333
ENSG00000182944homo_sapiensENSP0000038103115.548814.939bos_mutusENSBMUP0000000061091.891988.2883
ENSG00000182944homo_sapiensENSP0000038103113.719512.9573bos_mutusENSBMUP0000003371657.692354.4872
ENSG00000182944homo_sapiensENSP0000038103192.073290.3963mus_spicilegusENSMSIP0000001369296.950295.1846
ENSG00000182944homo_sapiensENSP0000038103199.390298.1707mus_spicilegusENSMSIP0000002177498.638497.4281
ENSG00000182944homo_sapiensENSP0000038103199.542798.7805cricetulus_griseus_chok1gshdENSCGRP0000100620298.789798.0333
ENSG00000182944homo_sapiensENSP0000038103199.542799.0854pteropus_vampyrusENSPVAP0000000925298.640598.1873
ENSG00000182944homo_sapiensENSP0000038103198.628196.7988vombatus_ursinusENSVURP0001001339198.179196.3581
ENSG00000182944homo_sapiensENSP0000038103199.390298.7805rhinolophus_ferrumequinumENSRFEP0001003326298.638498.0333
ENSG00000182944homo_sapiensENSP0000038103194.512293.75neovison_visonENSNVIP0000001604398.101397.3101
ENSG00000182944homo_sapiensENSP0000038103198.323297.7134bos_taurusENSBTAP0000007187484.645784.1207
ENSG00000182944homo_sapiensENSP0000038103199.847699.0854heterocephalus_glaber_femaleENSHGLP0000002515698.942698.1873
ENSG00000182944homo_sapiensENSP0000038103193.140292.8354rhinopithecus_bietiENSRBIP0000001802599.027598.7034
ENSG00000182944homo_sapiensENSP0000038103190.548888.8719canis_lupus_dingoENSCAFP0002000041990.273688.6018
ENSG00000182944homo_sapiensENSP0000038103191.615990.5488canis_lupus_dingoENSCAFP0002003561197.249296.1165
ENSG00000182944homo_sapiensENSP0000038103198.932998.1707canis_lupus_dingoENSCAFP0002000342798.932998.1707
ENSG00000182944homo_sapiensENSP0000038103184.451282.6219canis_lupus_dingoENSCAFP0002000962593.423391.3997
ENSG00000182944homo_sapiensENSP0000038103191.31190.8537sciurus_vulgarisENSSVLP0000500799998.844998.3498
ENSG00000182944homo_sapiensENSP0000038103199.390298.9329sciurus_vulgarisENSSVLP0000502096098.638498.1846
ENSG00000182944homo_sapiensENSP0000038103198.780596.9512phascolarctos_cinereusENSPCIP0000000730598.330896.5099
ENSG00000182944homo_sapiensENSP0000038103197.256196.4939procavia_capensisENSPCAP0000001028296.520495.764
ENSG00000182944homo_sapiensENSP0000038103199.237898.7805nannospalax_galiliENSNGAP0000000964198.487198.0333
ENSG00000182944homo_sapiensENSP0000038103198.628197.8659bos_grunniensENSBGRP0000003284090.616289.916
ENSG00000182944homo_sapiensENSP0000038103199.542798.7805chinchilla_lanigeraENSCLAP0000000930198.789798.0333
ENSG00000182944homo_sapiensENSP0000038103181.097679.7256cervus_hanglu_yarkandensisENSCHYP0000000372193.333391.7544
ENSG00000182944homo_sapiensENSP0000038103199.542799.0854catagonus_wagneriENSCWAP0000002020098.789798.3359
ENSG00000182944homo_sapiensENSP0000038103174.085472.1037ictidomys_tridecemlineatusENSSTOP0000002275583.505281.2715
ENSG00000182944homo_sapiensENSP0000038103199.695199.0854otolemur_garnettiiENSOGAP0000001118298.94198.3359
ENSG00000182944homo_sapiensENSP0000038103199.847699.5427cebus_imitatorENSCCAP0000003525199.092398.7897
ENSG00000182944homo_sapiensENSP0000038103198.932998.4756moschus_moschiferusENSMMSP0000000779898.184697.7307
ENSG00000182944homo_sapiensENSP0000038103199.847699.5427rhinopithecus_roxellanaENSRROP0000003348899.092398.7897
ENSG00000182944homo_sapiensENSP0000038103195.579394.0549mus_pahariMGP_PahariEiJ_P003045498.122196.5571
ENSG00000182944homo_sapiensENSP0000038103186.128184.7561propithecus_coquereliENSPCOP0000002677997.920396.3605
ENSG00000182944homo_sapiensENSP0000038103128.048823.1707caenorhabditis_elegansC27H5.3a.141.071433.9286
ENSG00000182944homo_sapiensENSP0000038103129.725623.9329drosophila_melanogasterFBpp007399648.872239.3484
ENSG00000182944homo_sapiensENSP0000038103118.140213.2622ciona_intestinalisENSCINP0000003578168.786150.289
ENSG00000182944homo_sapiensENSP0000038103171.341561.8902callorhinchus_miliiENSCMIP0000001541070.694961.3293
ENSG00000182944homo_sapiensENSP0000038103182.012272.4085latimeria_chalumnaeENSLACP0000000946780.780871.3213
ENSG00000182944homo_sapiensENSP0000038103176.981767.6829lepisosteus_oculatusENSLOCP0000000986175.712166.5667
ENSG00000182944homo_sapiensENSP0000038103160.213453.0488clupea_harengusENSCHAP0000001532667.986259.8967
ENSG00000182944homo_sapiensENSP0000038103169.054959.1463danio_rerioENSDARP0000002410272.364261.9808
ENSG00000182944homo_sapiensENSP0000038103161.280551.6768danio_rerioENSDARP0000000226969.430158.5492
ENSG00000182944homo_sapiensENSP0000038103141.920736.5854danio_rerioENSDARP0000005724763.073455.0459
ENSG00000182944homo_sapiensENSP0000038103170.579360.5183carassius_auratusENSCARP0000001692673.492163.0159
ENSG00000182944homo_sapiensENSP0000038103160.975652.439carassius_auratusENSCARP0000006645669.324159.6187
ENSG00000182944homo_sapiensENSP0000038103161.890253.0488carassius_auratusENSCARP0000012493369.165259.2845
ENSG00000182944homo_sapiensENSP0000038103130.792725.1524astyanax_mexicanusENSAMXP0000001921764.331252.5478
ENSG00000182944homo_sapiensENSP0000038103159.146350.4573astyanax_mexicanusENSAMXP0000004813564.774655.2588
ENSG00000182944homo_sapiensENSP0000038103166.615957.622ictalurus_punctatusENSIPUP0000003606561.89853.5411
ENSG00000182944homo_sapiensENSP0000038103158.079349.2378ictalurus_punctatusENSIPUP0000002427058.615449.6923
ENSG00000182944homo_sapiensENSP0000038103166.463458.689esox_luciusENSELUP0000003951368.661460.6299
ENSG00000182944homo_sapiensENSP0000038103163.414654.4207esox_luciusENSELUP0000001345267.42357.8606
ENSG00000182944homo_sapiensENSP0000038103160.213450.4573electrophorus_electricusENSEEEP0000002621867.521456.5812
ENSG00000182944homo_sapiensENSP0000038103167.378158.689electrophorus_electricusENSEEEP0000005166369.496960.5346
ENSG00000182944homo_sapiensENSP0000038103162.957353.0488oncorhynchus_kisutchENSOKIP0000511724065.974455.5911
ENSG00000182944homo_sapiensENSP0000038103160.975651.9817oncorhynchus_kisutchENSOKIP0000504010666.33556.5506
ENSG00000182944homo_sapiensENSP0000038103165.701256.7073oncorhynchus_kisutchENSOKIP0000511497168.196258.8608
ENSG00000182944homo_sapiensENSP0000038103165.396356.25oncorhynchus_mykissENSOMYP0000010441167.772558.2938
ENSG00000182944homo_sapiensENSP0000038103160.975651.9817oncorhynchus_mykissENSOMYP0000002121466.33556.5506
ENSG00000182944homo_sapiensENSP0000038103163.567153.811oncorhynchus_mykissENSOMYP0000005729569.039758.4437
ENSG00000182944homo_sapiensENSP0000038103165.853756.8598salmo_salarENSSSAP0000005040167.605658.3725
ENSG00000182944homo_sapiensENSP0000038103163.414653.6585salmo_salarENSSSAP0000005781768.085157.6105
ENSG00000182944homo_sapiensENSP0000038103161.280552.1341salmo_salarENSSSAP0000003895662.132952.8594
ENSG00000182944homo_sapiensENSP0000038103166.006157.0122salmo_truttaENSSTUP0000001788867.762158.5289
ENSG00000182944homo_sapiensENSP0000038103161.280552.1341salmo_truttaENSSTUP0000009681566.556356.6225
ENSG00000182944homo_sapiensENSP0000038103161.12851.8293salmo_truttaENSSTUP0000006591266.833356.6667
ENSG00000182944homo_sapiensENSP0000038103163.719553.811gadus_morhuaENSGMOP0000004983569.205358.4437
ENSG00000182944homo_sapiensENSP0000038103163.87255.1829fundulus_heteroclitusENSFHEP0000001470369.949960.4341
ENSG00000182944homo_sapiensENSP0000038103164.176854.7256poecilia_reticulataENSPREP0000003223465.781256.0938
ENSG00000182944homo_sapiensENSP0000038103163.87254.4207xiphophorus_maculatusENSXMAP0000001797869.717159.401
ENSG00000182944homo_sapiensENSP0000038103163.567154.7256oryzias_latipesENSORLP0000000842969.61659.9332
ENSG00000182944homo_sapiensENSP0000038103164.176855.6402cyclopterus_lumpusENSCLMP0000504235869.586860.3306
ENSG00000182944homo_sapiensENSP0000038103153.353745.8841oreochromis_niloticusENSONIP0000001681767.567658.1081
ENSG00000182944homo_sapiensENSP0000038103164.176854.7256haplochromis_burtoniENSHBUP0000000436069.357559.1433
ENSG00000182944homo_sapiensENSP0000038103164.329355.0305astatotilapia_callipteraENSACLP0000003766065.123555.7099
ENSG00000182944homo_sapiensENSP0000038103164.329354.7256sparus_aurataENSSAUP0001002077670.216359.7338
ENSG00000182944homo_sapiensENSP0000038103164.176854.5732lates_calcariferENSLCAP0001006075469.817659.3698
ENSG00000182944homo_sapiensENSP0000038103183.68974.5427xenopus_tropicalisENSXETP0000005335481.45472.5519
ENSG00000182944homo_sapiensENSP0000038103183.993980.3354chrysemys_picta_belliiENSCPBP0000002582294.673590.5498
ENSG00000182944homo_sapiensENSP0000038103111.432910.6707sphenodon_punctatusENSSPUP0000001748991.463485.3659
ENSG00000182944homo_sapiensENSP0000038103195.274491.1585crocodylus_porosusENSCPRP0000500980092.592688.5926
ENSG00000182944homo_sapiensENSP0000038103194.207388.1098laticauda_laticaudataENSLLTP0000001951291.150485.2507
ENSG00000182944homo_sapiensENSP0000038103193.445187.3476notechis_scutatusENSNSUP0000001482390.546584.6381
ENSG00000182944homo_sapiensENSP0000038103145.579342.6829pseudonaja_textilisENSPTXP0000002349594.025288.0503
ENSG00000182944homo_sapiensENSP0000038103146.493943.1402pseudonaja_textilisENSPTXP0000002474293.846287.0769
ENSG00000182944homo_sapiensENSP0000038103145.579342.6829pseudonaja_textilisENSPTXP0000002349794.025288.0503
ENSG00000182944homo_sapiensENSP0000038103136.12834.7561anas_platyrhynchos_platyrhynchosENSAPLP0000003226790.114186.692
ENSG00000182944homo_sapiensENSP0000038103141.920739.4817anas_platyrhynchos_platyrhynchosENSAPLP0000000558778.796674.212
ENSG00000182944homo_sapiensENSP0000038103194.664690.5488gallus_gallusENSGALP0001000037090.261686.3372
ENSG00000182944homo_sapiensENSP0000038103193.902489.4817meleagris_gallopavoENSMGAP0000000523291.803387.4814
ENSG00000182944homo_sapiensENSP0000038103172.408566.311serinus_canariaENSSCAP0000000299182.465375.5208
ENSG00000182944homo_sapiensENSP0000038103190.853785.061parus_majorENSPMJP0000002582693.270787.3239
ENSG00000182944homo_sapiensENSP0000038103192.530587.5anolis_carolinensisENSACAP0000003978587.087582.3529
ENSG00000182944homo_sapiensENSP0000038103156.2547.4085neolamprologus_brichardiENSNBRP0000001203665.194354.947
ENSG00000182944homo_sapiensENSP0000038103193.902487.8049naja_najaENSNNAP0000002607990.989785.0812
ENSG00000182944homo_sapiensENSP0000038103194.664690.3963podarcis_muralisENSPMRP0000003681587.588283.6389
ENSG00000182944homo_sapiensENSP0000038103184.908578.811taeniopygia_guttataENSTGUP0000002886875.474370.0542
ENSG00000182944homo_sapiensENSP0000038103164.93953.2012erpetoichthys_calabaricusENSECRP0000000162061.031550
ENSG00000182944homo_sapiensENSP0000038103163.719553.5061kryptolebias_marmoratusENSKMAP0000002375369.090958.0165
ENSG00000182944homo_sapiensENSP0000038103195.274490.2439salvator_merianaeENSSMRP0000002330391.107986.2974
ENSG00000182944homo_sapiensENSP0000038103163.87255.0305oryzias_javanicusENSOJAP0000004225969.949960.2671
ENSG00000182944homo_sapiensENSP0000038103160.670751.9817amphilophus_citrinellusENSACIP0000001394570.692760.5684
ENSG00000182944homo_sapiensENSP0000038103164.786655.4878dicentrarchus_labraxENSDLAP0000505470070.480960.3648
ENSG00000182944homo_sapiensENSP0000038103164.329355.3354amphiprion_perculaENSAPEP0000003398770.099760.299
ENSG00000182944homo_sapiensENSP0000038103163.719554.7256oryzias_sinensisENSOSIP0000005049267.094757.6244
ENSG00000182944homo_sapiensENSP0000038103196.18991.9207pelodiscus_sinensisENSPSIP0000000462694.602790.4048
ENSG00000182944homo_sapiensENSP0000038103196.036692.8354gopherus_evgoodeiENSGEVP0000502439996.330393.1193
ENSG00000182944homo_sapiensENSP0000038103186.890283.689chelonoidis_abingdoniiENSCABP0000001926075.898873.1025
ENSG00000182944homo_sapiensENSP0000038103161.432952.5915seriola_dumeriliENSSDUP0000001541970.701860.5263
ENSG00000182944homo_sapiensENSP0000038103164.786655.1829cottoperca_gobioENSCGOP0000001853170.364259.9338
ENSG00000182944homo_sapiensENSP0000038103193.445189.6341struthio_camelus_australisENSSCUP0000002025192.458588.6878
ENSG00000182944homo_sapiensENSP0000038103195.121991.1585anser_brachyrhynchusENSABRP0000002252168.271365.4267
ENSG00000182944homo_sapiensENSP0000038103165.853756.25gasterosteus_aculeatusENSGACP0000001138168.571458.5714
ENSG00000182944homo_sapiensENSP0000038103162.042752.8963cynoglossus_semilaevisENSCSEP0000001918068.518558.4175
ENSG00000182944homo_sapiensENSP0000038103156.859847.8659cynoglossus_semilaevisENSCSEP0000002501167.328556.6787
ENSG00000182944homo_sapiensENSP0000038103163.87254.5732poecilia_formosaENSPFOP0000000762569.601359.4684
ENSG00000182944homo_sapiensENSP0000038103164.329355.4878myripristis_murdjanENSMMDP0000500203070.450860.7679
ENSG00000182944homo_sapiensENSP0000038103164.481755.0305sander_luciopercaENSSLUP0000000304070.149359.8673
ENSG00000182944homo_sapiensENSP0000038103193.292788.1098strigops_habroptilaENSSHBP0000501991992.307787.1795
ENSG00000182944homo_sapiensENSP0000038103164.329355.3354amphiprion_ocellarisENSAOCP0000000753570.099760.299
ENSG00000182944homo_sapiensENSP0000038103196.18992.8354terrapene_carolina_triunguisENSTMTP0000001843896.483293.1193
ENSG00000182944homo_sapiensENSP0000038103165.853755.7927hucho_huchoENSHHUP0000005724863.905354.142
ENSG00000182944homo_sapiensENSP0000038103160.823251.6768hucho_huchoENSHHUP0000004681663.43453.8951
ENSG00000182944homo_sapiensENSP0000038103161.12851.8293hucho_huchoENSHHUP0000004676966.944956.7613
ENSG00000182944homo_sapiensENSP0000038103164.481755.6402betta_splendensENSBSLP0000001262370.149360.5307
ENSG00000182944homo_sapiensENSP0000038103169.512259.6037pygocentrus_nattereriENSPNAP0000000267270.917660.8087
ENSG00000182944homo_sapiensENSP0000038103152.896344.3598pygocentrus_nattereriENSPNAP0000000791268.172957.1709
ENSG00000182944homo_sapiensENSP0000038103164.176855.0305anabas_testudineusENSATEP0000001533269.933659.9668
ENSG00000182944homo_sapiensENSP0000038103145.884137.5seriola_lalandi_dorsalisENSSLDP0000003233555.128245.0549
ENSG00000182944homo_sapiensENSP0000038103164.176854.5732labrus_bergyltaENSLBEP0000000207369.933659.4684
ENSG00000182944homo_sapiensENSP0000038103164.481754.878pundamilia_nyerereiENSPNYP0000002015669.68759.3081
ENSG00000182944homo_sapiensENSP0000038103165.243955.7927mastacembelus_armatusENSMAMP0000002455070.860960.596
ENSG00000182944homo_sapiensENSP0000038103164.329355.0305stegastes_partitusENSSPAP0000001275870.099759.9668
ENSG00000182944homo_sapiensENSP0000038103165.548856.4024oncorhynchus_tshawytschaENSOTSP0000507914268.03858.5443
ENSG00000182944homo_sapiensENSP0000038103163.262253.3537oncorhynchus_tshawytschaENSOTSP0000506537066.613256.1798
ENSG00000182944homo_sapiensENSP0000038103150.914642.0732oncorhynchus_tshawytschaENSOTSP0000504248061.510150.8287
ENSG00000182944homo_sapiensENSP0000038103164.481755.1829acanthochromis_polyacanthusENSAPOP0000000490570.265860.1329
ENSG00000182944homo_sapiensENSP0000038103196.18992.3781aquila_chrysaetos_chrysaetosENSACCP0002000236790.791487.1942
ENSG00000182944homo_sapiensENSP0000038103139.329331.0976nothobranchius_furzeriENSNFUP0001504392766.494852.5773
ENSG00000182944homo_sapiensENSP0000038103163.719554.2683cyprinodon_variegatusENSCVAP0000001154769.435259.1362
ENSG00000182944homo_sapiensENSP0000038103148.323239.4817denticeps_clupeoidesENSDCDP0000000877561.793450.4873
ENSG00000182944homo_sapiensENSP0000038103155.792747.2561denticeps_clupeoidesENSDCDP0000001631064.778854.8673
ENSG00000182944homo_sapiensENSP0000038103164.176854.7256larimichthys_croceaENSLCRP0000505061670.049959.7338
ENSG00000182944homo_sapiensENSP0000038103164.024453.6585takifugu_rubripesENSTRUP0000005513970.116958.7646
ENSG00000182944homo_sapiensENSP0000038103163.414656.0976ficedula_albicollisENSFALP0000003092853.955947.7302
ENSG00000182944homo_sapiensENSP0000038103160.975651.9817hippocampus_comesENSHCOP0000002267162.015552.8682
ENSG00000182944homo_sapiensENSP0000038103161.585452.5915cyprinus_carpio_carpioENSCCRP0000002270768.707558.6735
ENSG00000182944homo_sapiensENSP0000038103166.158557.0122cyprinus_carpio_carpioENSCCRP0000009466973.809563.6054
ENSG00000182944homo_sapiensENSP0000038103162.347653.3537cyprinus_carpio_carpioENSCCRP0000002270269.32259.322
ENSG00000182944homo_sapiensENSP0000038103186.128181.7073coturnix_japonicaENSCJPP0000501927887.461382.9721
ENSG00000182944homo_sapiensENSP0000038103163.567154.2683poecilia_latipinnaENSPLAP0000000197369.269159.1362
ENSG00000182944homo_sapiensENSP0000038103161.585452.7439sinocyclocheilus_grahamiENSSGRP0000008275069.535359.5525
ENSG00000182944homo_sapiensENSP0000038103157.317149.3902sinocyclocheilus_grahamiENSSGRP0000004699568.738659.2322
ENSG00000182944homo_sapiensENSP0000038103170.579360.8232sinocyclocheilus_grahamiENSSGRP0000007769673.726163.535
ENSG00000182944homo_sapiensENSP0000038103164.329354.878maylandia_zebraENSMZEP0000502326669.63759.4059
ENSG00000182944homo_sapiensENSP0000038103161.737851.372tetraodon_nigroviridisENSTNIP0000001893964.285753.4921
ENSG00000182944homo_sapiensENSP0000038103168.445157.9268paramormyrops_kingsleyaeENSPKIP0000003056570.156259.375
ENSG00000182944homo_sapiensENSP0000038103172.103762.1951paramormyrops_kingsleyaeENSPKIP0000000682969.970460.355
ENSG00000182944homo_sapiensENSP0000038103175.762266.0061scleropages_formosusENSSFOP0001500317272.980963.583
ENSG00000182944homo_sapiensENSP0000038103182.469573.7805leptobrachium_leishanenseENSLLEP0000000458577.841769.6403
ENSG00000182944homo_sapiensENSP0000038103158.68949.5427scophthalmus_maximusENSSMAP0000002524269.369458.5586
ENSG00000182944homo_sapiensENSP0000038103162.804953.6585oryzias_melastigmaENSOMEP0000002244468.666758.6667

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003712enables transcription coregulator activity1IBAHomo_sapiens(9606)Function
GO:0003723enables RNA binding2HDA,IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005516enables calmodulin binding1IEAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IEAHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IEAHomo_sapiens(9606)Component
GO:0006351involved_in DNA-templated transcription1IEAHomo_sapiens(9606)Process
GO:0006355involved_in regulation of DNA-templated transcription1IEAHomo_sapiens(9606)Process
GO:0015030located_in Cajal body1IEAHomo_sapiens(9606)Component
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function

Expression