RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	Nucleoli
BulkPerturb-seq

Ensembl ID	ENSG00000182670	Gene ID	7267	Accession	12393
Symbol	TTC3	Alias	DCRR1;RNF105;TPRDIII	Full Name	tetratricopeptide repeat domain 3
Status	Confidence	Length	129887 bases	Strand	Plus strand
Position	21 : 37073226 - 37203112	RNA binding domain	TTC3_DZIP3_dom
Summary	Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000512891	TTC3_DZIP3_dom	PF19179	3.6e-51	1
ENSP00000442875	TTC3_DZIP3_dom	PF19179	4.5e-51	1
ENSP00000512892	TTC3_DZIP3_dom	PF19179	7.3e-51	1
ENSP00000391891	TTC3_DZIP3_dom	PF19179	1.2e-50	1
ENSP00000512889	TTC3_DZIP3_dom	PF19179	4.8e-50	1
ENSP00000512893	TTC3_DZIP3_dom	PF19179	4.8e-50	1
ENSP00000346791	TTC3_DZIP3_dom	PF19179	5.9e-50	1
ENSP00000381981	TTC3_DZIP3_dom	PF19179	5.9e-50	1
ENSP00000403943	TTC3_DZIP3_dom	PF19179	5.9e-50	1
ENSP00000408456	TTC3_DZIP3_dom	PF19179	5.9e-50	1
ENSP00000387880	TTC3_DZIP3_dom	PF19179	6e-50	1
ENSP00000512890	TTC3_DZIP3_dom	PF19179	6e-50	1
ENSP00000414658	TTC3_DZIP3_dom	PF19179	1.2e-25	1
ENSP00000414658	TTC3_DZIP3_dom	PF19179	1.2e-25	2

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
TTC3-222	ENST00000492275	6577	1715aa	ENSP00000512889
TTC3-206	ENST00000418766	7842	2025aa	ENSP00000403943
TTC3-218	ENST00000485402	3626	72aa	ENSP00000512883
TTC3-208	ENST00000438055	3606	1165aa	ENSP00000391891
TTC3-209	ENST00000450533	7695	2025aa	ENSP00000408456
TTC3-225	ENST00000696811	7021	2043aa	ENSP00000512890
TTC3-226	ENST00000696812	6757	463aa	ENSP00000512891
TTC3-216	ENST00000481605	2691	766aa	ENSP00000512892
TTC3-211	ENST00000463216	6926	1715aa	ENSP00000512893
TTC3-223	ENST00000494243	861	No protein	-
TTC3-224	ENST00000540756	2025	612aa	ENSP00000442875
TTC3-202	ENST00000399010	2115	300aa	ENSP00000381974
TTC3-204	ENST00000411496	7775	2043aa	ENSP00000387880
TTC3-203	ENST00000399017	10363	2025aa	ENSP00000381981
TTC3-217	ENST00000484047	1945	No protein	-
TTC3-201	ENST00000354749	9084	2025aa	ENSP00000346791
TTC3-215	ENST00000479930	8998	200aa	ENSP00000512894
TTC3-210	ENST00000460328	573	No protein	-
TTC3-221	ENST00000491952	247	No protein	-
TTC3-214	ENST00000476784	7425	No protein	-
TTC3-205	ENST00000414818	831	277aa	ENSP00000414658
TTC3-219	ENST00000487711	925	No protein	-
TTC3-213	ENST00000472398	2305	No protein	-
TTC3-212	ENST00000469939	739	No protein	-
TTC3-207	ENST00000428693	999	317aa	ENSP00000393681
TTC3-220	ENST00000488522	853	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
1751	Body Weight Changes	8.11426262096428E-5	17903300
100775	Eye Color	2E-10	20463881

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004842	enables ubiquitin-protein transferase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005730	located_in nucleolus	1	IDA	Homo_sapiens(9606)	Component
GO:0005794	located_in Golgi apparatus	1	IEA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0006511	involved_in ubiquitin-dependent protein catabolic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0070936	involved_in protein K48-linked ubiquitination	1	IDA	Homo_sapiens(9606)	Process