RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000181481	Gene ID	84282	Accession	21158
Symbol	RNF135	Alias	L13;MMFD;REUL;Riplet	Full Name	ring finger protein 135
Status	Confidence	Length	28928 bases	Strand	Plus strand
Position	17 : 30970984 - 30999911	RNA binding domain	SPRY
Summary	The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000328340	SPRY	PF00622	3.6e-09	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
RNF135-204	ENST00000443677	1261	162aa	ENSP00000411965
RNF135-201	ENST00000324689	1905	210aa	ENSP00000323693
RNF135-202	ENST00000328381	2054	432aa	ENSP00000328340
RNF135-205	ENST00000535306	2098	286aa	ENSP00000440470
RNF135-206	ENST00000580444	475	158aa	ENSP00000464549
RNF135-203	ENST00000434242	257	86aa	ENSP00000467799

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
94007	Paliperidone Palmitate	4E-6	27846195
94008	Schizophrenia	4E-6	27846195

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000209	involved_in protein polyubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:0004842	enables ubiquitin-protein transferase activity	3	EXP,IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0010494	located_in cytoplasmic stress granule	1	IDA	Homo_sapiens(9606)	Component
GO:0010994	involved_in free ubiquitin chain polymerization	1	IDA	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:0032728	involved_in positive regulation of interferon-beta production	1	IMP	Homo_sapiens(9606)	Process
GO:0039529	involved_in RIG-I signaling pathway	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0039552	enables RIG-I binding	1	IPI	Homo_sapiens(9606)	Function
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0043021	enables ribonucleoprotein complex binding	3	IBA,IDA,IPI	Homo_sapiens(9606)	Function
GO:0045087	involved_in innate immune response	1	TAS	Homo_sapiens(9606)	Process
GO:0045088	involved_in regulation of innate immune response	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0051260	involved_in protein homooligomerization	1	IDA	Homo_sapiens(9606)	Process
GO:0061630	enables ubiquitin protein ligase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0070534	involved_in protein K63-linked ubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:0140374	involved_in antiviral innate immune response	1	IMP	Homo_sapiens(9606)	Process
GO:1990904	part_of ribonucleoprotein complex	1	IDA	Homo_sapiens(9606)	Component