Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerCHIKVSARS-COV-OC43FlavivirusesHIVRVSARS-COV-2SINVDengueZika
Drug Drug
Main interacting RNAs rRNA
Moonlighting functions N.A.
Localizations Stress granucleNucleoli rim
BulkPerturb-seq DataSet_01_286 DataSet_01_366

Description

Ensembl ID ENSG00000181163 Gene ID 4869 Accession 7910
Symbol NPM1 Alias B23;NPM Full Name nucleophosmin 1
Status Confidence Length 24695 bases Strand Plus strand
Position 5 : 171387116 - 171411810 RNA binding domain Nucleoplasmin
Summary The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000503767 Nucleoplasmin PF03066 1.9e-40 1
ENSP00000503150 Nucleoplasmin PF03066 2.3e-40 1
ENSP00000503717 Nucleoplasmin PF03066 2.7e-40 1
ENSP00000377408 Nucleoplasmin PF03066 5.3e-40 1
ENSP00000503235 Nucleoplasmin PF03066 5.3e-40 1
ENSP00000341168 Nucleoplasmin PF03066 5.7e-40 1
ENSP00000296930 Nucleoplasmin PF03066 7.1e-40 1
ENSP00000428755 Nucleoplasmin PF03066 7.1e-40 1
ENSP00000504740 Nucleoplasmin PF03066 7.6e-40 1
ENSP00000503283 Nucleoplasmin PF03066 8.8e-40 1
ENSP00000504107 Nucleoplasmin PF03066 2.6e-22 1
ENSP00000504016 Nucleoplasmin PF03066 3e-21 1
ENSP00000503408 Nucleoplasmin PF03066 5.3e-21 1
ENSP00000504308 Nucleoplasmin PF03066 2.7e-19 1
ENSP00000429485 Nucleoplasmin PF03066 3.5e-19 1
ENSP00000503781 Nucleoplasmin PF03066 3.5e-19 1
ENSP00000428647 Nucleoplasmin PF03066 8.4e-10 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
29507312 Analysis of the oligomeric states of nucleophosmin using size exclusion chromatography. Gyosuke Sakashita 2018-03-05 Scientific reports
21152184 NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling. S Mikael Lindström 2011-01-01 Biochemistry research international
32937906 MicroRNAs as Biomarkers and Therapeutic Targets in Inflammation- and Ischemia-Reperfusion-Related Acute Renal Injury. Yueh-Lin Wu 2020-09-14 International journal of molecular sciences
20615901 Export of microRNAs and microRNA-protective protein by mammalian cells. Kai Wang 2010-11-01 Nucleic acids research
26950158 Circulating microRNAs as Potential Biomarkers in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma. B Marta Afonso 2016-03-03 Journal of clinical medicine
21425434 Expression patterns of placental microRNAs. Jean-Francois Mouillet 2011-08-01 Birth defects research. Part A, Clinical and molecular teratology
22362753 Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling. Mitsuru Okuwaki 2012-06-01 Nucleic acids research
21609964 Characterization of extracellular circulating microRNA. Andrey Turchinovich 2011-09-01 Nucleic acids research
32451752 MicroRNAs (miRNAs) and Long Non-Coding RNAs (lncRNAs) as New Tools for Cancer Therapy: First Steps from Bench to Bedside. Margherita Ratti 2020-06-01 Targeted oncology
29462963 Secreted and Tissue miRNAs as Diagnosis Biomarkers of Malignant Pleural Mesothelioma. Vanessa Martínez-Rivera 2018-02-17 International journal of molecular sciences
29312145 MicroRNA Exocytosis by Vesicle Fusion in Neuroendocrine Cells. Yongsoo Park 2017-01-01 Frontiers in endocrinology
31015836 Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase. Liset Westera 2019-01-01 Advances in virology
22817753 Extracellular small RNAs: what, where, why? M Anna Hoy 2012-08-01 Biochemical Society transactions
24273550 Cardiovascular extracellular microRNAs: emerging diagnostic markers and mechanisms of cell-to-cell RNA communication. Virginie Kinet 2013-01-01 Frontiers in genetics
27446198 Single Molecule Localization Microscopy of Mammalian Cell Nuclei on the Nanoscale. Aleksander Szczurek 2016-01-01 Frontiers in genetics
33502444 High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate. D Brian Freibaum 2021-03-01 The Journal of cell biology
22546315 Circulating microRNAs in cancer: origin, function and application. Ruimin Ma 2012-04-30 Journal of experimental & clinical cancer research : CR
27092141 Is It worth Considering Circulating microRNAs in Multiple Sclerosis? Ferdinand Jagot 2016-01-01 Frontiers in immunology
23285058 Elucidation of motifs in ribosomal protein S9 that mediate its nucleolar localization and binding to NPM1/nucleophosmin. S Mikael Lindström 2012-01-01 PloS one
24795753 Expression of microRNAs in bovine and human pre-implantation embryo culture media. Jenna Kropp 2014-01-01 Frontiers in genetics
27669739 The human nucleophosmin 1 mutation A inhibits myeloid differentiation of leukemia cells by modulating miR-10b. Qin Zou 2016-11-01 Oncotarget
33795683 A KRAS-responsive long non-coding RNA controls microRNA processing. Lei Shi 2021-04-01 Nature communications
31447320 Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease. A Marcelo Mori 2019-10-01 Cell metabolism
30498217 Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms. C Mylene Ferrolino 2018-11-29 Nature communications
32093728 Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD. S Nadja Andrade 2020-02-24 Molecular neurodegeneration
22028337 Profiling of circulating microRNAs: from single biomarkers to re-wired networks. Anna Zampetaki 2012-03-15 Cardiovascular research
25655644 Base excision DNA repair and cancer. Gianluca Tell 2015-01-20 Oncotarget
31952319 Challenges in Using Circulating Micro-RNAs as Biomarkers for Cardiovascular Diseases. Kyriacos Felekkis 2020-01-15 International journal of molecular sciences
31067715 Extracellular Vesicle Encapsulated MicroRNAs in Patients with Type 2 Diabetes Are Affected by Metformin Treatment. Vikas Ghai 2019-05-07 Journal of clinical medicine
33233600 Extracellular MicroRNAs as Intercellular Mediators and Noninvasive Biomarkers of Cancer. Blanca Ortiz-Quintero 2020-11-20 Cancers
36142403 MicroRNAs, Stem Cells in Bipolar Disorder, and Lithium Therapeutic Approach. Donatella Coradduzza 2022-09-10 International journal of molecular sciences
27596437 Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles. Sriram Balusu 2016-10-01 EMBO molecular medicine
24733970 Emerging role of microRNAs in major depressive disorder: diagnosis and therapeutic implications. Yogesh Dwivedi 2014-03-01 Dialogues in clinical neuroscience
26836305 Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA. M Diana Mitrea 2016-02-02 eLife
29516617 Extracellular vesicle RNAs reflect placenta dysfunction and are a biomarker source for preterm labour. Shannon Fallen 2018-05-01 Journal of cellular and molecular medicine
20699270 Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions. Damiano Fantini 2010-12-01 Nucleic acids research
32957662 Circulating Cell-Free Nucleic Acids: Main Characteristics and Clinical Application. Melinda Szilágyi 2020-09-17 International journal of molecular sciences
29589547 Implication of B23/NPM1 in Viral Infections, Potential Uses of B23/NPM1 Inhibitors as Antiviral Therapy. Yadira Lobaina 2019-01-01 Infectious disorders drug targets

Transcripts

Name Transcript ID bp Protein Translation ID
NPM1-204 ENST00000517671 1338 294aa ENSP00000428755
NPM1-215 ENST00000676613 2676 156aa ENSP00000503767
NPM1-227 ENST00000678186 2674 No protein -
NPM1-228 ENST00000678267 2797 99aa ENSP00000504107
NPM1-217 ENST00000677297 883 123aa ENSP00000504016
NPM1-208 ENST00000521672 1263 230aa ENSP00000429485
NPM1-232 ENST00000679190 794 90aa ENSP00000503408
NPM1-229 ENST00000678280 1913 259aa ENSP00000503235
NPM1-220 ENST00000677467 2600 No protein -
NPM1-231 ENST00000679006 1116 No protein -
NPM1-216 ENST00000676625 3605 No protein -
NPM1-202 ENST00000351986 1237 265aa ENSP00000341168
NPM1-214 ENST00000676589 1338 323aa ENSP00000503283
NPM1-213 ENST00000676504 1936 No protein -
NPM1-233 ENST00000679233 1072 195aa ENSP00000503717
NPM1-219 ENST00000677357 1346 305aa ENSP00000504740
NPM1-201 ENST00000296930 1320 294aa ENSP00000296930
NPM1-203 ENST00000393820 1598 259aa ENSP00000377408
NPM1-210 ENST00000523339 268 No protein -
NPM1-209 ENST00000521710 1021 No protein -
NPM1-205 ENST00000518587 1382 No protein -
NPM1-230 ENST00000678774 1289 175aa ENSP00000503150
NPM1-207 ENST00000521260 1571 No protein -
NPM1-221 ENST00000677600 2506 No protein -
NPM1-224 ENST00000677741 2459 No protein -
NPM1-211 ENST00000523622 247 59aa ENSP00000428647
NPM1-218 ENST00000677325 2258 230aa ENSP00000503781
NPM1-222 ENST00000677672 2627 No protein -
NPM1-226 ENST00000677907 1335 201aa ENSP00000504308
NPM1-225 ENST00000677904 1469 No protein -
NPM1-223 ENST00000677682 2534 No protein -
NPM1-206 ENST00000519955 571 No protein -
NPM1-212 ENST00000524204 640 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
31172Erythrocyte Indices8.3100000E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000181163homo_sapiensENSP0000035912851.685434.8315homo_sapiensENSP0000029693031.292521.0884
ENSG00000181163homo_sapiensENSP0000042774150.934630.8411homo_sapiensENSP0000029693037.074822.449

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000181163homo_sapiensENSP0000029693010099.6599nomascus_leucogenysENSNLEP0000000040010099.6599
ENSG00000181163homo_sapiensENSP0000029693099.659999.6599pan_paniscusENSPPAP0000003834599.659999.6599
ENSG00000181163homo_sapiensENSP0000029693090.136189.7959pongo_abeliiENSPPYP0000001794999.624199.2481
ENSG00000181163homo_sapiensENSP00000296930100100pan_troglodytesENSPTRP00000068344100100
ENSG00000181163homo_sapiensENSP00000296930100100gorilla_gorillaENSGGOP00000037355100100
ENSG00000181163homo_sapiensENSP0000029693086.054472.449ornithorhynchus_anatinusENSOANP0000001241384.615471.2375
ENSG00000181163homo_sapiensENSP0000029693096.598688.0952sarcophilus_harrisiiENSSHAP0000002734296.928388.3959
ENSG00000181163homo_sapiensENSP0000029693099.319798.2993callithrix_jacchusENSCJAP0000003592098.648797.6351
ENSG00000181163homo_sapiensENSP0000029693095.578294.5578callithrix_jacchusENSCJAP0000005492097.909496.8641
ENSG00000181163homo_sapiensENSP0000029693010099.6599cercocebus_atysENSCATP0000000339610099.6599
ENSG00000181163homo_sapiensENSP0000029693090.136189.7959macaca_fascicularisENSMFAP0000002393610099.6226
ENSG00000181163homo_sapiensENSP0000029693010099.6599macaca_mulattaENSMMUP0000002073710099.6599
ENSG00000181163homo_sapiensENSP0000029693010099.3197macaca_nemestrinaENSMNEP0000003133610099.3197
ENSG00000181163homo_sapiensENSP0000029693090.136189.7959papio_anubisENSPANP0000002216110099.6226
ENSG00000181163homo_sapiensENSP0000029693010099.6599mandrillus_leucophaeusENSMLEP0000001353610099.6599
ENSG00000181163homo_sapiensENSP0000029693073.469469.3878mus_spretusMGP_SPRETEiJ_P009035194.736889.4737
ENSG00000181163homo_sapiensENSP0000029693097.278994.898mus_spretusMGP_SPRETEiJ_P002746297.945295.5479
ENSG00000181163homo_sapiensENSP0000029693098.299395.2381loxodonta_africanaENSLAFP0000000644998.299395.2381
ENSG00000181163homo_sapiensENSP0000029693075.850373.8095loxodonta_africanaENSLAFP0000002547494.491591.9492
ENSG00000181163homo_sapiensENSP0000029693059.523854.0816loxodonta_africanaENSLAFP0000002818883.732176.0766
ENSG00000181163homo_sapiensENSP00000296930100100ailuropoda_melanoleucaENSAMEP00000023639100100
ENSG00000181163homo_sapiensENSP0000029693099.319797.619oryctolagus_cuniculusENSOCUP0000000956999.319797.619
ENSG00000181163homo_sapiensENSP0000029693076.190572.7891oryctolagus_cuniculusENSOCUP0000002075392.946188.7967
ENSG00000181163homo_sapiensENSP0000029693099.659997.619oryctolagus_cuniculusENSOCUP0000002178393.610291.6933
ENSG00000181163homo_sapiensENSP0000029693096.938894.898oryctolagus_cuniculusENSOCUP0000002319297.602795.5479
ENSG00000181163homo_sapiensENSP0000029693091.496680.9524monodelphis_domesticaENSMODP0000001780192.439981.7869
ENSG00000181163homo_sapiensENSP0000029693091.496681.6327monodelphis_domesticaENSMODP0000000807197.111986.6426
ENSG00000181163homo_sapiensENSP0000029693071.428670.068microcebus_murinusENSMICP0000002669096.774294.9309
ENSG00000181163homo_sapiensENSP0000029693088.435486.0544microcebus_murinusENSMICP0000005115498.113295.4717
ENSG00000181163homo_sapiensENSP0000029693099.319797.9592microcebus_murinusENSMICP0000004833198.98397.6271
ENSG00000181163homo_sapiensENSP0000029693065.646362.585octodon_degusENSODEP0000000246696.592
ENSG00000181163homo_sapiensENSP0000029693078.231377.551ovis_aries_rambouilletENSOARP0002003394497.457696.6102
ENSG00000181163homo_sapiensENSP0000029693081.972879.2517ochotona_princepsENSOPRP0000000676487.956285.0365
ENSG00000181163homo_sapiensENSP0000029693097.61994.2177mus_caroliMGP_CAROLIEiJ_P002611298.287794.863
ENSG00000181163homo_sapiensENSP0000029693097.61994.2177mus_musculusENSMUSP0000007506798.287794.863
ENSG00000181163homo_sapiensENSP0000029693086.734782.6531dipodomys_ordiiENSDORP0000002726896.590992.0455
ENSG00000181163homo_sapiensENSP0000029693092.176988.4354dipodomys_ordiiENSDORP0000002216199.267495.2381
ENSG00000181163homo_sapiensENSP0000029693067.346962.585dipodomys_ordiiENSDORP0000002229994.736888.0383
ENSG00000181163homo_sapiensENSP0000029693010099.6599chlorocebus_sabaeusENSCSAP0000000592710099.6599
ENSG00000181163homo_sapiensENSP0000029693097.61994.2177rattus_norvegicusENSRNOP0000000659181.766478.9174
ENSG00000181163homo_sapiensENSP0000029693078.231374.4898rattus_norvegicusENSRNOP0000005820292.741988.3064
ENSG00000181163homo_sapiensENSP0000029693082.312979.2517rattus_norvegicusENSRNOP0000009510795.275691.7323
ENSG00000181163homo_sapiensENSP0000029693048.979644.5578rattus_norvegicusENSRNOP0000007442687.272779.3939
ENSG00000181163homo_sapiensENSP0000029693083.673577.551rattus_norvegicusENSRNOP0000008821589.78183.2117
ENSG00000181163homo_sapiensENSP0000029693094.89891.4966rattus_norvegicusENSRNOP0000002557596.539893.0796
ENSG00000181163homo_sapiensENSP0000029693093.877588.7755microtus_ochrogasterENSMOCP0000000583994.19889.0785
ENSG00000181163homo_sapiensENSP0000029693098.299395.2381microtus_ochrogasterENSMOCP0000000191798.972695.8904
ENSG00000181163homo_sapiensENSP0000029693075.170171.4286microtus_ochrogasterENSMOCP0000000208396.08791.3043
ENSG00000181163homo_sapiensENSP0000029693076.530670.7483microtus_ochrogasterENSMOCP0000002239496.153888.8889
ENSG00000181163homo_sapiensENSP0000029693081.632775.8503microtus_ochrogasterENSMOCP0000002664691.603185.1145
ENSG00000181163homo_sapiensENSP0000029693052.38148.6395peromyscus_maniculatus_bairdiiENSPEMP0000000598070.642265.5963
ENSG00000181163homo_sapiensENSP0000029693081.972878.5714peromyscus_maniculatus_bairdiiENSPEMP0000002248296.015992.0319
ENSG00000181163homo_sapiensENSP0000029693085.03481.6327peromyscus_maniculatus_bairdiiENSPEMP0000003328799.206495.2381
ENSG00000181163homo_sapiensENSP0000029693098.299395.2381peromyscus_maniculatus_bairdiiENSPEMP0000000836598.972695.8904
ENSG00000181163homo_sapiensENSP0000029693080.952476.5306mus_spicilegusENSMSIP0000001778696.356391.0931
ENSG00000181163homo_sapiensENSP0000029693095.578292.517mus_spicilegusENSMSIP0000001400897.909494.7735
ENSG00000181163homo_sapiensENSP0000029693083.333380.2721mus_spicilegusENSMSIP0000003179296.456792.9134
ENSG00000181163homo_sapiensENSP0000029693080.952477.2109mus_spicilegusENSMSIP0000000114990.494386.3118
ENSG00000181163homo_sapiensENSP0000029693097.61994.2177mus_spicilegusENSMSIP0000002793398.287794.863
ENSG00000181163homo_sapiensENSP0000029693066.326563.6054cricetulus_griseus_chok1gshdENSCGRP0000100626394.202990.3382
ENSG00000181163homo_sapiensENSP0000029693076.530669.7279cricetulus_griseus_chok1gshdENSCGRP0000101167288.932881.0277
ENSG00000181163homo_sapiensENSP0000029693086.054480.9524cricetulus_griseus_chok1gshdENSCGRP0000100978696.197790.4943
ENSG00000181163homo_sapiensENSP0000029693097.959294.5578cricetulus_griseus_chok1gshdENSCGRP0000100199098.630195.2055
ENSG00000181163homo_sapiensENSP0000029693079.93274.8299cricetulus_griseus_chok1gshdENSCGRP0000100679891.439785.6031
ENSG00000181163homo_sapiensENSP0000029693073.469456.1224vombatus_ursinusENSVURP0001000419280.297461.3383
ENSG00000181163homo_sapiensENSP0000029693096.598687.7551vombatus_ursinusENSVURP0001000173396.928388.0546
ENSG00000181163homo_sapiensENSP0000029693010099.6599rhinopithecus_bietiENSRBIP0000003801210099.6599
ENSG00000181163homo_sapiensENSP0000029693096.598687.7551phascolarctos_cinereusENSPCIP0000001785096.928388.0546
ENSG00000181163homo_sapiensENSP0000029693077.55168.0272phascolarctos_cinereusENSPCIP0000003958990.118679.0514
ENSG00000181163homo_sapiensENSP0000029693049.319745.9184phascolarctos_cinereusENSPCIP0000001694296.026589.404
ENSG00000181163homo_sapiensENSP0000029693086.734783.6735procavia_capensisENSPCAP0000000611787.328884.2466
ENSG00000181163homo_sapiensENSP0000029693099.319798.2993catagonus_wagneriENSCWAP0000000129599.319798.2993
ENSG00000181163homo_sapiensENSP0000029693098.299396.5986urocitellus_parryiiENSUPAP0001002806698.972697.2603
ENSG00000181163homo_sapiensENSP0000029693010099.6599rhinopithecus_roxellanaENSRROP0000004435810099.6599
ENSG00000181163homo_sapiensENSP0000029693088.435484.0136mus_pahariMGP_PahariEiJ_P003288494.890590.146
ENSG00000181163homo_sapiensENSP0000029693085.374280.9524propithecus_coquereliENSPCOP0000002296790.613785.9206
ENSG00000181163homo_sapiensENSP0000029693029.251718.7075drosophila_melanogasterFBpp008491856.578936.1842
ENSG00000181163homo_sapiensENSP0000029693027.891217.0068drosophila_melanogasterFBpp008497152.564132.0513
ENSG00000181163homo_sapiensENSP0000029693057.48336.3946ciona_intestinalisENSCINP0000003301951.057432.3263
ENSG00000181163homo_sapiensENSP0000029693053.061235.7143eptatretus_burgeriENSEBUP0000002060240.310127.1318
ENSG00000181163homo_sapiensENSP0000029693056.462641.1565lepisosteus_oculatusENSLOCP0000001182962.641545.6604
ENSG00000181163homo_sapiensENSP0000029693065.646348.2993danio_rerioENSDARP0000011796569.175650.8961
ENSG00000181163homo_sapiensENSP0000029693064.285748.2993carassius_auratusENSCARP0000008457261.563546.2541
ENSG00000181163homo_sapiensENSP0000029693063.605444.2177carassius_auratusENSCARP0000011852965.845145.7746
ENSG00000181163homo_sapiensENSP0000029693065.986445.9184carassius_auratusENSCARP0000003021366.666746.3918
ENSG00000181163homo_sapiensENSP0000029693060.884444.5578astyanax_mexicanusENSAMXP0000001047969.11250.5792
ENSG00000181163homo_sapiensENSP0000029693066.326547.619ictalurus_punctatusENSIPUP0000002875766.780847.9452
ENSG00000181163homo_sapiensENSP0000029693065.646345.5782esox_luciusENSELUP0000001362665.870345.7338
ENSG00000181163homo_sapiensENSP0000029693067.687149.6599electrophorus_electricusENSEEEP0000000228765.676648.1848
ENSG00000181163homo_sapiensENSP0000029693052.721138.4354oncorhynchus_kisutchENSOKIP0000511548858.052442.3221
ENSG00000181163homo_sapiensENSP0000029693060.884443.5374oncorhynchus_kisutchENSOKIP0000507699460.47343.2432
ENSG00000181163homo_sapiensENSP0000029693060.544244.5578oncorhynchus_mykissENSOMYP0000010555663.345246.6192
ENSG00000181163homo_sapiensENSP0000029693060.544243.1973oncorhynchus_mykissENSOMYP0000012256558.940442.053
ENSG00000181163homo_sapiensENSP0000029693063.265344.898salmo_salarENSSSAP0000018071256.53540.1216
ENSG00000181163homo_sapiensENSP0000029693057.48342.517salmo_salarENSSSAP0000006575162.132445.9559
ENSG00000181163homo_sapiensENSP0000029693064.625845.9184salmo_truttaENSSTUP0000004668063.758445.302
ENSG00000181163homo_sapiensENSP0000029693060.544244.2177salmo_truttaENSSTUP0000002044763.799346.595
ENSG00000181163homo_sapiensENSP0000029693062.244944.2177gadus_morhuaENSGMOP0000005773363.321844.9827
ENSG00000181163homo_sapiensENSP0000029693064.285745.9184fundulus_heteroclitusENSFHEP000000111136345
ENSG00000181163homo_sapiensENSP0000029693065.986448.6395poecilia_reticulataENSPREP0000000222064.882947.8261
ENSG00000181163homo_sapiensENSP0000029693063.945646.5986xiphophorus_maculatusENSXMAP0000000039562.046245.2145
ENSG00000181163homo_sapiensENSP0000029693064.625845.9184oryzias_latipesENSORLP0000001276365.068546.2329
ENSG00000181163homo_sapiensENSP0000029693032.312925.1701cyclopterus_lumpusENSCLMP0000504440453.977342.0455
ENSG00000181163homo_sapiensENSP0000029693055.10239.7959oreochromis_niloticusENSONIP0000007100656.842141.0526
ENSG00000181163homo_sapiensENSP0000029693067.687148.2993haplochromis_burtoniENSHBUP0000002017763.174645.0794
ENSG00000181163homo_sapiensENSP0000029693054.421840.8163astatotilapia_callipteraENSACLP0000001227959.259344.4444
ENSG00000181163homo_sapiensENSP0000029693068.367350.3401sparus_aurataENSSAUP0001000508667.224149.4983
ENSG00000181163homo_sapiensENSP0000029693055.10238.0952lates_calcariferENSLCAP0001004529257.651239.8577
ENSG00000181163homo_sapiensENSP0000029693063.605444.5578neolamprologus_brichardiENSNBRP0000001706260.912142.671
ENSG00000181163homo_sapiensENSP0000029693063.605443.8776kryptolebias_marmoratusENSKMAP0000001428064.261244.3299
ENSG00000181163homo_sapiensENSP0000029693061.904844.2177oryzias_javanicusENSOJAP0000003949157.961841.4013
ENSG00000181163homo_sapiensENSP0000029693059.863943.8776amphilophus_citrinellusENSACIP0000001821264.705947.4265
ENSG00000181163homo_sapiensENSP0000029693067.346948.9796dicentrarchus_labraxENSDLAP0000505349166.220748.1605
ENSG00000181163homo_sapiensENSP0000029693066.326548.2993amphiprion_perculaENSAPEP0000001203765.436247.651
ENSG00000181163homo_sapiensENSP0000029693051.360535.7143oryzias_sinensisENSOSIP0000002810764.806945.0644
ENSG00000181163homo_sapiensENSP0000029693067.346945.5782seriola_dumeriliENSSDUP0000002144166.44344.9664
ENSG00000181163homo_sapiensENSP0000029693062.58544.898cottoperca_gobioENSCGOP0000005640963.888945.8333
ENSG00000181163homo_sapiensENSP0000029693062.244943.5374gasterosteus_aculeatusENSGACP0000002684759.803941.8301
ENSG00000181163homo_sapiensENSP0000029693053.741537.415cynoglossus_semilaevisENSCSEP0000001741565.020645.2675
ENSG00000181163homo_sapiensENSP0000029693048.979634.3537cynoglossus_semilaevisENSCSEP0000003179338.095226.7196
ENSG00000181163homo_sapiensENSP0000029693065.986447.9592poecilia_formosaENSPFOP0000001928864.882947.1572
ENSG00000181163homo_sapiensENSP0000029693047.278930.6122myripristis_murdjanENSMMDP0000505471448.432131.3589
ENSG00000181163homo_sapiensENSP0000029693063.945646.9388sander_luciopercaENSSLUP0000001241265.051947.7509
ENSG00000181163homo_sapiensENSP0000029693052.38139.7959amphiprion_ocellarisENSAOCP0000000188266.666750.6493
ENSG00000181163homo_sapiensENSP0000029693060.544244.5578hucho_huchoENSHHUP0000004333563.571446.7857
ENSG00000181163homo_sapiensENSP0000029693064.96646.5986hucho_huchoENSHHUP0000007365263.455245.5149
ENSG00000181163homo_sapiensENSP0000029693057.142942.1769betta_splendensENSBSLP0000005555759.154943.662
ENSG00000181163homo_sapiensENSP0000029693064.285745.2381pygocentrus_nattereriENSPNAP0000003622163.636444.7811
ENSG00000181163homo_sapiensENSP0000029693035.374126.1905anabas_testudineusENSATEP0000006825656.830642.0765
ENSG00000181163homo_sapiensENSP0000029693059.183736.7347ciona_savignyiENSCSAVP0000001906651.327431.8584
ENSG00000181163homo_sapiensENSP0000029693067.346946.5986seriola_lalandi_dorsalisENSSLDP0000002286466.666746.1279
ENSG00000181163homo_sapiensENSP0000029693065.646346.9388labrus_bergyltaENSLBEP0000001140564.765146.3087
ENSG00000181163homo_sapiensENSP0000029693067.006848.2993pundamilia_nyerereiENSPNYP0000002561963.548445.8064
ENSG00000181163homo_sapiensENSP0000029693067.006850.3401mastacembelus_armatusENSMAMP0000001377555.182141.4566
ENSG00000181163homo_sapiensENSP0000029693055.442241.8367stegastes_partitusENSSPAP0000002878465.725849.5968
ENSG00000181163homo_sapiensENSP0000029693059.183743.8776oncorhynchus_tshawytschaENSOTSP0000500529462.589946.4029
ENSG00000181163homo_sapiensENSP0000029693062.925244.898oncorhynchus_tshawytschaENSOTSP0000501021262.925244.898
ENSG00000181163homo_sapiensENSP0000029693067.006849.3197acanthochromis_polyacanthusENSAPOP0000000151265.886348.495
ENSG00000181163homo_sapiensENSP0000029693062.58546.2585nothobranchius_furzeriENSNFUP0001505403964.111547.3868
ENSG00000181163homo_sapiensENSP0000029693063.945645.5782cyprinodon_variegatusENSCVAP0000002470563.513545.2703
ENSG00000181163homo_sapiensENSP0000029693049.319732.3129denticeps_clupeoidesENSDCDP0000000371758.943138.6179
ENSG00000181163homo_sapiensENSP0000029693035.03424.4898denticeps_clupeoidesENSDCDP0000000376556.593439.5604
ENSG00000181163homo_sapiensENSP0000029693067.346946.2585denticeps_clupeoidesENSDCDP0000000365468.512147.0588
ENSG00000181163homo_sapiensENSP0000029693041.156526.5306denticeps_clupeoidesENSDCDP0000000376964.361741.4894
ENSG00000181163homo_sapiensENSP0000029693031.972825.5102larimichthys_croceaENSLCRP0000505591561.03948.7013
ENSG00000181163homo_sapiensENSP0000029693065.986445.5782takifugu_rubripesENSTRUP0000005534361.783442.6752
ENSG00000181163homo_sapiensENSP0000029693058.843542.517hippocampus_comesENSHCOP0000000027765.28347.1698
ENSG00000181163homo_sapiensENSP0000029693067.006849.3197cyprinus_carpio_carpioENSCCRP0000010689463.548446.7742
ENSG00000181163homo_sapiensENSP0000029693058.163339.7959cyprinus_carpio_carpioENSCCRP0000017297663.333343.3333
ENSG00000181163homo_sapiensENSP0000029693064.96648.2993poecilia_latipinnaENSPLAP0000000028664.09447.651
ENSG00000181163homo_sapiensENSP0000029693066.666747.619sinocyclocheilus_grahamiENSSGRP0000009536167.820148.4429
ENSG00000181163homo_sapiensENSP0000029693067.006846.9388sinocyclocheilus_grahamiENSSGRP0000011263059.878441.9453
ENSG00000181163homo_sapiensENSP0000029693066.666747.2789maylandia_zebraENSMZEP0000501827362.619844.4089
ENSG00000181163homo_sapiensENSP0000029693062.58543.5374tetraodon_nigroviridisENSTNIP0000001369763.230243.9863
ENSG00000181163homo_sapiensENSP0000029693064.625848.2993paramormyrops_kingsleyaeENSPKIP0000000846263.122947.1761
ENSG00000181163homo_sapiensENSP0000029693063.605449.3197scleropages_formosusENSSFOP0001501090865.845151.0563
ENSG00000181163homo_sapiensENSP0000029693059.183745.9184scophthalmus_maximusENSSMAP0000003117756.677543.9739
ENSG00000181163homo_sapiensENSP0000029693064.285745.2381oryzias_melastigmaENSOMEP0000000604364.505145.3925

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000055involved_in ribosomal large subunit export from nucleus1IBAHomo_sapiens(9606)Process
GO:0000056involved_in ribosomal small subunit export from nucleus1IBAHomo_sapiens(9606)Process
GO:0001046enables core promoter sequence-specific DNA binding1IDAHomo_sapiens(9606)Function
GO:0001558involved_in regulation of cell growth1IEAHomo_sapiens(9606)Process
GO:0001652located_in granular component1TASHomo_sapiens(9606)Component
GO:0003682enables chromatin binding1IBAHomo_sapiens(9606)Function
GO:0003713enables transcription coactivator activity1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding4HDA,IBA,IDA,IPIHomo_sapiens(9606)Function
GO:0004860enables protein kinase inhibitor activity1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus2HDA,IDAHomo_sapiens(9606)Component
GO:0005654is_active_in nucleoplasm3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0005730is_active_in nucleolus2IBA,IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005813is_active_in centrosome2IBA,IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion1HDAHomo_sapiens(9606)Component
GO:0006281involved_in DNA repair1IDAHomo_sapiens(9606)Process
GO:0006334involved_in nucleosome assembly1IDAHomo_sapiens(9606)Process
GO:0006338involved_in chromatin remodeling1IBAHomo_sapiens(9606)Process
GO:0006407involved_in rRNA export from nucleus1IBAHomo_sapiens(9606)Process
GO:0006884involved_in cell volume homeostasis1IEAHomo_sapiens(9606)Process
GO:0006886involved_in intracellular protein transport1TASHomo_sapiens(9606)Process
GO:0006913involved_in nucleocytoplasmic transport2IDA,TASHomo_sapiens(9606)Process
GO:0007098involved_in centrosome cycle1IMPHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction1NASHomo_sapiens(9606)Process
GO:0008104involved_in protein localization1IDAHomo_sapiens(9606)Process
GO:0008284involved_in positive regulation of cell population proliferation1IDAHomo_sapiens(9606)Process
GO:0008285involved_in negative regulation of cell population proliferation1IMPHomo_sapiens(9606)Process
GO:0010824involved_in regulation of centrosome duplication1IBAHomo_sapiens(9606)Process
GO:0010825involved_in positive regulation of centrosome duplication1IEAHomo_sapiens(9606)Process
GO:0010826involved_in negative regulation of centrosome duplication1IMPHomo_sapiens(9606)Process
GO:0015934part_of large ribosomal subunit1IEAHomo_sapiens(9606)Component
GO:0015935part_of small ribosomal subunit1IEAHomo_sapiens(9606)Component
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0016607located_in nuclear speck1IEAHomo_sapiens(9606)Component
GO:0019843enables rRNA binding1EXPHomo_sapiens(9606)Function
GO:0019901enables protein kinase binding1IPIHomo_sapiens(9606)Function
GO:0030957enables Tat protein binding1IDAHomo_sapiens(9606)Function
GO:0031398involved_in positive regulation of protein ubiquitination1IEAHomo_sapiens(9606)Process
GO:0031616located_in spindle pole centrosome1IDAHomo_sapiens(9606)Component
GO:0032071involved_in regulation of endodeoxyribonuclease activity1IDAHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0032993part_of protein-DNA complex1IDAHomo_sapiens(9606)Component
GO:0034644involved_in cellular response to UV1IDAHomo_sapiens(9606)Process
GO:0042255involved_in ribosome assembly1TASHomo_sapiens(9606)Process
GO:0042273involved_in ribosomal large subunit biogenesis1IBAHomo_sapiens(9606)Process
GO:0042274involved_in ribosomal small subunit biogenesis1IBAHomo_sapiens(9606)Process
GO:0042393enables histone binding2IBA,IDAHomo_sapiens(9606)Function
GO:0042803enables protein homodimerization activity1IDAHomo_sapiens(9606)Function
GO:0043023enables ribosomal large subunit binding1IDAHomo_sapiens(9606)Function
GO:0043024enables ribosomal small subunit binding1IDAHomo_sapiens(9606)Function
GO:0043066involved_in negative regulation of apoptotic process2IDA,NASHomo_sapiens(9606)Process
GO:0043516involved_in regulation of DNA damage response, signal transduction by p53 class mediator1IEAHomo_sapiens(9606)Process
GO:0044387involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation1IDAHomo_sapiens(9606)Process
GO:0045727involved_in positive regulation of translation1IDAHomo_sapiens(9606)Process
GO:0045860involved_in positive regulation of protein kinase activity1IEAHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0046599involved_in regulation of centriole replication1IMPHomo_sapiens(9606)Process
GO:0048025involved_in negative regulation of mRNA splicing, via spliceosome1IEAHomo_sapiens(9606)Process
GO:0050821involved_in protein stabilization1IEAHomo_sapiens(9606)Process
GO:0051059enables NF-kappaB binding1IDAHomo_sapiens(9606)Function
GO:0051082enables unfolded protein binding1IDAHomo_sapiens(9606)Function
GO:0051092involved_in positive regulation of NF-kappaB transcription factor activity1IMPHomo_sapiens(9606)Process
GO:0060699involved_in regulation of endoribonuclease activity1IDAHomo_sapiens(9606)Process
GO:0060735involved_in regulation of eIF2 alpha phosphorylation by dsRNA1IDAHomo_sapiens(9606)Process
GO:0090398involved_in cellular senescence1IMPHomo_sapiens(9606)Process
GO:0140297enables DNA-binding transcription factor binding1IPIHomo_sapiens(9606)Function
GO:0140693enables molecular condensate scaffold activity2EXP,IDAHomo_sapiens(9606)Function
GO:1902629involved_in regulation of mRNA stability involved in cellular response to UV1IMPHomo_sapiens(9606)Process
GO:1902751involved_in positive regulation of cell cycle G2/M phase transition1IDAHomo_sapiens(9606)Process
GO:1904751involved_in positive regulation of protein localization to nucleolus1IEAHomo_sapiens(9606)Process
GO:1990904part_of ribonucleoprotein complex2IBA,IDAHomo_sapiens(9606)Component

Expression