Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000180957 Gene ID 23760 Accession 9002
Symbol PITPNB Alias VIB1B;PtdInsTP;PI-TP-beta Full Name phosphatidylinositol transfer protein beta
Status Confidence Length 68466 bases Strand Minus strand
Position 22 : 27851669 - 27920134 RNA binding domain N.A.
Summary This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
PITPNB-202 ENST00000335272 2914 271aa ENSP00000334738
PITPNB-201 ENST00000320996 2826 272aa ENSP00000321266
PITPNB-210 ENST00000634017 1017 273aa ENSP00000487693
PITPNB-208 ENST00000477861 786 No protein -
PITPNB-209 ENST00000493007 564 No protein -
PITPNB-203 ENST00000415296 884 120aa ENSP00000406542
PITPNB-204 ENST00000436663 590 167aa ENSP00000403675
PITPNB-206 ENST00000465179 629 No protein -
PITPNB-205 ENST00000460566 592 No protein -
PITPNB-207 ENST00000471825 766 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000139located_in Golgi membrane2ISS,TASHomo_sapiens(9606)Component
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005789located_in endoplasmic reticulum membrane2ISS,TASHomo_sapiens(9606)Component
GO:0005794located_in Golgi apparatus1ISSHomo_sapiens(9606)Component
GO:0006629involved_in lipid metabolic process1NASHomo_sapiens(9606)Process
GO:0006890involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum2IMP,TASHomo_sapiens(9606)Process
GO:0006997involved_in nucleus organization1TASHomo_sapiens(9606)Process
GO:0008525enables phosphatidylcholine transporter activity2IBA,IDAHomo_sapiens(9606)Function
GO:0008526enables phosphatidylinositol transfer activity3IBA,IDA,IMPHomo_sapiens(9606)Function
GO:0015914involved_in phospholipid transport1IDAHomo_sapiens(9606)Process
GO:0031210enables phosphatidylcholine binding2IBA,IDAHomo_sapiens(9606)Function
GO:0035091enables phosphatidylinositol binding2IBA,IDAHomo_sapiens(9606)Function
GO:0120009involved_in intermembrane lipid transfer1IEAHomo_sapiens(9606)Process
GO:0120019enables phosphatidylcholine transfer activity1IMPHomo_sapiens(9606)Function
GO:0140338enables sphingomyelin transfer activity1ISSHomo_sapiens(9606)Function

Expression