RBP Type	Canonical_RBPs
Diseases	CancerSARS-COV-2
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000179750	Gene ID	9582	Accession	17352
Symbol	APOBEC3B	Alias	A3B;ARP4;ARCD3;PHRBNL;APOBEC1L;bK150C2.2;DJ742C19.2	Full Name	apolipoprotein B mRNA editing enzyme catalytic subunit 3B
Status	Confidence	Length	10458 bases	Strand	Plus strand
Position	22 : 38982347 - 38992804	RNA binding domain	APOBEC_N , APOBEC_C
Summary	This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000327459	APOBEC_N	PF08210	4.2e-100	1
ENSP00000327459	APOBEC_N	PF08210	4.2e-100	2
ENSP00000327459	APOBEC_C	PF05240	2.4e-62	3
ENSP00000327459	APOBEC_C	PF05240	2.4e-62	4
ENSP00000385060	APOBEC_N	PF08210	1.2e-99	1
ENSP00000385060	APOBEC_N	PF08210	1.2e-99	2
ENSP00000385060	APOBEC_C	PF05240	5.7e-62	3
ENSP00000385060	APOBEC_C	PF05240	5.7e-62	4
ENSP00000385068	APOBEC_N	PF08210	3.5e-91	1
ENSP00000385068	APOBEC_N	PF08210	3.5e-91	2
ENSP00000385068	APOBEC_C	PF05240	1.9e-62	3
ENSP00000385068	APOBEC_C	PF05240	1.9e-62	4
ENSP00000338897	APOBEC_N	PF08210	2.3e-47	1
ENSP00000338897	APOBEC_C	PF05240	6e-32	2

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
36978112	Host-mediated RNA editing in viruses.	Tongtong Zhu	2023-03-28	Biology direct
33661412	Identification of anti-Epstein-Barr virus (EBV) antibody signature in EBV-associated gastric carcinoma.	Lusheng Song	2021-07-01	Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
30679582	A panel of eGFP reporters for single base editing by APOBEC-Cas9 editosome complexes.	St A Martin	2019-01-24	Scientific reports

Name	Transcript ID	bp	Protein	Translation ID
APOBEC3B-204	ENST00000407298	1282	357aa	ENSP00000385068
APOBEC3B-201	ENST00000333467	1590	382aa	ENSP00000327459
APOBEC3B-203	ENST00000402182	1844	490aa	ENSP00000385060
APOBEC3B-202	ENST00000335760	1359	251aa	ENSP00000338897

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000179750	homo_sapiens	ENSP00000229335	53.0303	39.3939	homo_sapiens	ENSP00000327459	27.4869	20.4188
ENSG00000179750	homo_sapiens	ENSP00000385057	69.0104	56.25	homo_sapiens	ENSP00000327459	69.3717	56.5445
ENSG00000179750	homo_sapiens	ENSP00000411754	54.6448	31.1475	homo_sapiens	ENSP00000327459	26.178	14.9215
ENSG00000179750	homo_sapiens	ENSP00000309749	69.7051	60.0536	homo_sapiens	ENSP00000327459	68.0628	58.6387
ENSG00000179750	homo_sapiens	ENSP00000216099	68.1347	59.5855	homo_sapiens	ENSP00000327459	68.8482	60.2094
ENSG00000179750	homo_sapiens	ENSP00000355340	54.7368	42.1053	homo_sapiens	ENSP00000327459	27.2251	20.9424
ENSG00000179750	homo_sapiens	ENSP00000229304	37.7119	22.8814	homo_sapiens	ENSP00000327459	23.2984	14.1361
ENSG00000179750	homo_sapiens	ENSP00000244669	47.7679	29.9107	homo_sapiens	ENSP00000327459	28.0105	17.5393
ENSG00000179750	homo_sapiens	ENSP00000249116	90.4523	86.9347	homo_sapiens	ENSP00000327459	47.1204	45.288

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000179750	homo_sapiens	ENSP00000327459	90.0524	84.2932	nomascus_leucogenys	ENSNLEP00000018464	70.7819	66.2551
ENSG00000179750	homo_sapiens	ENSP00000327459	96.3351	92.4084	pan_paniscus	ENSPPAP00000002122	75.102	72.0408
ENSG00000179750	homo_sapiens	ENSP00000327459	90.0524	84.8168	pongo_abelii	ENSPPYP00000044599	70.2041	66.1225
ENSG00000179750	homo_sapiens	ENSP00000327459	85.3403	81.6754	pan_troglodytes	ENSPTRP00000024776	66.5306	63.6735
ENSG00000179750	homo_sapiens	ENSP00000327459	97.1204	92.6702	gorilla_gorilla	ENSGGOP00000006577	97.1204	92.6702
ENSG00000179750	homo_sapiens	ENSP00000327459	20.9424	13.089	sarcophilus_harrisii	ENSSHAP00000043123	27.7778	17.3611
ENSG00000179750	homo_sapiens	ENSP00000327459	74.3456	65.1832	callithrix_jacchus	ENSCJAP00000088528	73.9583	64.8438
ENSG00000179750	homo_sapiens	ENSP00000327459	88.2199	82.199	cercocebus_atys	ENSCATP00000003628	68.7755	64.0816
ENSG00000179750	homo_sapiens	ENSP00000327459	44.5026	40.8377	macaca_mulatta	ENSMMUP00000014095	49.7076	45.614
ENSG00000179750	homo_sapiens	ENSP00000327459	89.5288	84.2932	macaca_mulatta	ENSMMUP00000014096	89.5288	84.2932
ENSG00000179750	homo_sapiens	ENSP00000327459	76.4398	71.2042	macaca_nemestrina	ENSMNEP00000040658	83.908	78.1609
ENSG00000179750	homo_sapiens	ENSP00000327459	88.7435	83.5079	mandrillus_leucophaeus	ENSMLEP00000001202	88.7435	83.5079
ENSG00000179750	homo_sapiens	ENSP00000327459	21.466	13.6126	monodelphis_domestica	ENSMODP00000040505	31.5385	20
ENSG00000179750	homo_sapiens	ENSP00000327459	36.1257	32.7225	chlorocebus_sabaeus	ENSCSAP00000014407	66.0287	59.8086
ENSG00000179750	homo_sapiens	ENSP00000327459	89.0052	83.2461	chlorocebus_sabaeus	ENSCSAP00000002728	69.3878	64.898
ENSG00000179750	homo_sapiens	ENSP00000327459	21.2042	13.6126	vombatus_ursinus	ENSVURP00010031524	27.1812	17.4497
ENSG00000179750	homo_sapiens	ENSP00000327459	90.0524	84.555	rhinopithecus_bieti	ENSRBIP00000038646	90.0524	84.555
ENSG00000179750	homo_sapiens	ENSP00000327459	21.466	14.9215	phascolarctos_cinereus	ENSPCIP00000049844	31.5385	21.9231
ENSG00000179750	homo_sapiens	ENSP00000327459	73.2984	62.0419	cebus_imitator	ENSCCAP00000019211	72.9167	61.7188
ENSG00000179750	homo_sapiens	ENSP00000327459	90.0524	84.555	rhinopithecus_roxellana	ENSRROP00000008655	90.0524	84.555
ENSG00000179750	homo_sapiens	ENSP00000327459	20.4188	10.733	callorhinchus_milii	ENSCMIP00000004961	37.1429	19.5238
ENSG00000179750	homo_sapiens	ENSP00000327459	20.6806	12.5654	latimeria_chalumnae	ENSLACP00000018020	22.9651	13.9535
ENSG00000179750	homo_sapiens	ENSP00000327459	22.2513	12.5654	lepisosteus_oculatus	ENSLOCP00000004258	31.1355	17.5824
ENSG00000179750	homo_sapiens	ENSP00000327459	23.5602	13.3508	xenopus_tropicalis	ENSXETP00000073758	40.5405	22.973
ENSG00000179750	homo_sapiens	ENSP00000327459	21.9895	12.5654	anolis_carolinensis	ENSACAP00000018261	31.2268	17.8439
ENSG00000179750	homo_sapiens	ENSP00000327459	19.6335	9.94764	podarcis_muralis	ENSPMRP00000035742	35.7143	18.0952
ENSG00000179750	homo_sapiens	ENSP00000327459	21.466	12.5654	erpetoichthys_calabaricus	ENSECRP00000021015	31.4176	18.3908
ENSG00000179750	homo_sapiens	ENSP00000327459	20.9424	12.5654	paramormyrops_kingsleyae	ENSPKIP00000029857	38.6473	23.1884
ENSG00000179750	homo_sapiens	ENSP00000327459	20.4188	12.0419	scleropages_formosus	ENSSFOP00015009596	39.3939	23.2323

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000932	is_active_in P-body	1	IBA	Homo_sapiens(9606)	Component
GO:0003723	enables RNA binding	2	HDA,IBA	Homo_sapiens(9606)	Function
GO:0004126	enables cytidine deaminase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0008270	enables zinc ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0009972	involved_in cytidine deamination	1	IEA	Homo_sapiens(9606)	Process
GO:0010526	involved_in retrotransposon silencing	1	IDA	Homo_sapiens(9606)	Process
GO:0016554	involved_in cytidine to uridine editing	1	IBA	Homo_sapiens(9606)	Process
GO:0044355	involved_in clearance of foreign intracellular DNA	1	IDA	Homo_sapiens(9606)	Process
GO:0045087	involved_in innate immune response	1	IEA	Homo_sapiens(9606)	Process
GO:0045869	involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	1	IBA	Homo_sapiens(9606)	Process
GO:0047844	enables deoxycytidine deaminase activity	2	IBA,IMP	Homo_sapiens(9606)	Function
GO:0051607	involved_in defense response to virus	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0070383	involved_in DNA cytosine deamination	1	IBA	Homo_sapiens(9606)	Process
GO:0080111	involved_in DNA demethylation	1	IBA	Homo_sapiens(9606)	Process