Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000179295 Gene ID 5781 Accession 9644
Symbol PTPN11 Alias CFC;NS1;JMML;SHP2;BPTP3;PTP2C;METCDS;PTP-1D;SH-PTP2;SH-PTP3 Full Name protein tyrosine phosphatase non-receptor type 11
Status Confidence Length 91012 bases Strand Plus strand
Position 12 : 112418907 - 112509918 RNA binding domain N.A.
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
PTPN11-204 ENST00000531326 573 No protein -
PTPN11-207 ENST00000639857 4455 578aa ENSP00000491593
PTPN11-214 ENST00000690210 6274 671aa ENSP00000509272
PTPN11-212 ENST00000688597 5738 468aa ENSP00000510628
PTPN11-216 ENST00000692624 6045 461aa ENSP00000508953
PTPN11-208 ENST00000685487 6926 536aa ENSP00000508503
PTPN11-202 ENST00000392597 1876 460aa ENSP00000376376
PTPN11-211 ENST00000687906 5995 555aa ENSP00000509536
PTPN11-201 ENST00000351677 6073 593aa ENSP00000340944
PTPN11-205 ENST00000635625 1794 597aa ENSP00000489597
PTPN11-203 ENST00000530818 486 108aa ENSP00000437013
PTPN11-206 ENST00000635652 588 196aa ENSP00000489541
PTPN11-215 ENST00000690472 5117 No protein -
PTPN11-213 ENST00000688701 5152 No protein -
PTPN11-210 ENST00000687624 2354 No protein -
PTPN11-209 ENST00000687120 7648 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
3987Triglycerides8.49630312948315E-717903299
4231Lipids2.10255017747455E-1017903299
5740Carotid Arteries6.9790165024175E-517903303
14129Attention Deficit Disorder with Hyperactivity9.9170000E-00518937294
47255Blood Pressure6.5919726E-011-
47256Blood Pressure6.3208597E-011-
59484Blood Pressure1.2057689E-013-
59591Blood Pressure3.4250095E-015-
59689Blood Pressure4.6170667E-011-
59793Blood Pressure8.4575461E-013-
59859Hypertension7.9023355E-006-
59947Hypertension2.3936323E-006-
60057Arterial Pressure7.7426308E-014-
60165Arterial Pressure7.5652497E-016-
80501Platelet Count8E-1219820697
82061Platelet Count1E-822139419
98113Cleft Lip2E-1028232668
98114Cleft Palate2E-1028232668

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000179295homo_sapiensENSP0000037704710.88557.34341homo_sapiensENSP0000034094442.495828.6678
ENSG00000179295homo_sapiensENSP0000036345933.809523.5714homo_sapiensENSP0000034094423.94616.6948
ENSG00000179295homo_sapiensENSP000004072498.893365.87525homo_sapiensENSP0000034094437.268124.6206
ENSG00000179295homo_sapiensENSP0000035592317.944410.8677homo_sapiensENSP0000034094435.919121.7538
ENSG00000179295homo_sapiensENSP0000035720918.055612.9167homo_sapiensENSP0000034094443.844931.3659
ENSG00000179295homo_sapiensENSP0000031185740.963925.5422homo_sapiensENSP0000034094428.667817.8752
ENSG00000179295homo_sapiensENSP0000048273231.534621.0793homo_sapiensENSP0000034094431.534621.0793
ENSG00000179295homo_sapiensENSP0000024859422.435914.8718homo_sapiensENSP0000034094429.51119.5616
ENSG00000179295homo_sapiensENSP0000035134230.265522.4779homo_sapiensENSP0000034094428.836421.4165
ENSG00000179295homo_sapiensENSP0000045241417.972710.9029homo_sapiensENSP0000034094435.581821.5852
ENSG00000179295homo_sapiensENSP0000026370823.002214.4708homo_sapiensENSP0000034094435.919122.597
ENSG00000179295homo_sapiensENSP0000046332518.15712.0819homo_sapiensENSP0000034094444.856729.8482
ENSG00000179295homo_sapiensENSP0000036068340.229924.5977homo_sapiensENSP0000034094429.51118.0438
ENSG00000179295homo_sapiensENSP0000028117117.927610.773homo_sapiensENSP0000034094436.762222.0911
ENSG00000179295homo_sapiensENSP0000041135517.534510.9495homo_sapiensENSP0000034094438.617224.1147
ENSG00000179295homo_sapiensENSP0000017575635.217423.2609homo_sapiensENSP0000034094427.318718.0438
ENSG00000179295homo_sapiensENSP0000025466730.142921.8571homo_sapiensENSP0000034094435.581825.801
ENSG00000179295homo_sapiensENSP0000036552818.744412.287homo_sapiensENSP0000034094435.244523.1029
ENSG00000179295homo_sapiensENSP0000033492810.83526.99774homo_sapiensENSP0000034094440.472226.1383
ENSG00000179295homo_sapiensENSP0000026556214.18098.37408homo_sapiensENSP0000034094439.123123.1029
ENSG00000179295homo_sapiensENSP0000036366721.796314.2388homo_sapiensENSP0000034094433.558221.9224
ENSG00000179295homo_sapiensENSP0000035283321.437413.6307homo_sapiensENSP0000034094429.173718.5497
ENSG00000179295homo_sapiensENSP0000050943644.722231.1111homo_sapiensENSP0000034094427.150118.887
ENSG00000179295homo_sapiensENSP0000037406919.507412.7094homo_sapiensENSP0000034094433.389521.7538
ENSG00000179295homo_sapiensENSP0000029571819.918312.4617homo_sapiensENSP0000034094432.883620.5734
ENSG00000179295homo_sapiensENSP0000036228318.459412.1443homo_sapiensENSP0000034094444.856729.511
ENSG00000179295homo_sapiensENSP0000028322828.310519.0259homo_sapiensENSP0000034094431.365921.0793
ENSG00000179295homo_sapiensENSP0000036288417.618411.0028homo_sapiensENSP0000034094442.664426.6442
ENSG00000179295homo_sapiensENSP0000035303014.78769.7011homo_sapiensENSP0000034094447.554831.1973
ENSG00000179295homo_sapiensENSP0000040001016.604310.6208homo_sapiensENSP0000034094437.436823.946
ENSG00000179295homo_sapiensENSP0000026296314.579110.1129homo_sapiensENSP0000034094447.892133.2209
ENSG00000179295homo_sapiensENSP0000037059315.06289.98954homo_sapiensENSP0000034094448.566632.2091
ENSG00000179295homo_sapiensENSP0000041811217.923911.2803homo_sapiensENSP0000034094443.676227.4874
ENSG00000179295homo_sapiensENSP0000038278727.805518.8279homo_sapiensENSP0000034094437.605425.4637
ENSG00000179295homo_sapiensENSP0000032601071.260554.4538homo_sapiensENSP0000034094471.500854.6374

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000179295homo_sapiensENSP0000034094499.156899.1568nomascus_leucogenysENSNLEP0000000009999.66199.661
ENSG00000179295homo_sapiensENSP0000034094499.325599.1568pan_paniscusENSPPAP0000002505199.158298.9899
ENSG00000179295homo_sapiensENSP00000340944100100pongo_abeliiENSPPYP0000000567799.3399.33
ENSG00000179295homo_sapiensENSP0000034094496.458795.7841pan_troglodytesENSPTRP0000007322498.79198.1002
ENSG00000179295homo_sapiensENSP0000034094499.831499.8314pan_troglodytesENSPTRP0000006133699.831499.8314
ENSG00000179295homo_sapiensENSP00000340944100100gorilla_gorillaENSGGOP0000002830899.3399.33
ENSG00000179295homo_sapiensENSP0000034094491.736991.0624ornithorhynchus_anatinusENSOANP0000000959276.836276.2712
ENSG00000179295homo_sapiensENSP0000034094496.121495.4469sarcophilus_harrisiiENSSHAP0000002372695.158694.4908
ENSG00000179295homo_sapiensENSP0000034094489.88289.0388notamacropus_eugeniiENSMEUP0000000669391.738490.8778
ENSG00000179295homo_sapiensENSP0000034094457.841557.6729choloepus_hoffmanniENSCHOP0000001086962.250562.069
ENSG00000179295homo_sapiensENSP0000034094499.831499.4941dasypus_novemcinctusENSDNOP0000003176099.831499.4941
ENSG00000179295homo_sapiensENSP0000034094464.924163.9123erinaceus_europaeusENSEEUP0000000807466.265165.2324
ENSG00000179295homo_sapiensENSP0000034094481.956280.7757echinops_telfairiENSETEP0000000278682.372981.1864
ENSG00000179295homo_sapiensENSP0000034094492.917492.7487cercocebus_atysENSCATP0000001969299.818899.6377
ENSG00000179295homo_sapiensENSP0000034094493.591993.5919macaca_fascicularisENSMFAP00000040325100100
ENSG00000179295homo_sapiensENSP00000340944100100macaca_mulattaENSMMUP0000005021799.3399.33
ENSG00000179295homo_sapiensENSP00000340944100100macaca_nemestrinaENSMNEP0000000446999.3399.33
ENSG00000179295homo_sapiensENSP00000340944100100papio_anubisENSPANP0000000654999.3399.33
ENSG00000179295homo_sapiensENSP0000034094499.662799.4941mandrillus_leucophaeusENSMLEP0000000656490.091589.939
ENSG00000179295homo_sapiensENSP0000034094475.716775.3794tursiops_truncatusENSTTRP0000000855175.716775.3794
ENSG00000179295homo_sapiensENSP0000034094499.156898.9882vulpes_vulpesENSVVUP0000002315699.156898.9882
ENSG00000179295homo_sapiensENSP0000034094499.325599.1568vulpes_vulpesENSVVUP0000001420497.194797.0297
ENSG00000179295homo_sapiensENSP0000034094499.831499.4941mus_spretusMGP_SPRETEiJ_P007308599.162598.8275
ENSG00000179295homo_sapiensENSP0000034094499.325599.1568equus_asinusENSEASP0000501377897.840597.6744
ENSG00000179295homo_sapiensENSP0000034094499.325598.9882capra_hircusENSCHIP0000002082299.325598.9882
ENSG00000179295homo_sapiensENSP0000034094498.988298.6509loxodonta_africanaENSLAFP0000000184298.32597.99
ENSG00000179295homo_sapiensENSP0000034094499.494199.3255panthera_leoENSPLOP0000000738498.827598.66
ENSG00000179295homo_sapiensENSP0000034094499.494199.3255ailuropoda_melanoleucaENSAMEP0000000904698.827598.66
ENSG00000179295homo_sapiensENSP0000034094499.325598.9882bos_indicus_hybridENSBIXP0000502437199.325598.9882
ENSG00000179295homo_sapiensENSP0000034094499.494198.9882oryctolagus_cuniculusENSOCUP0000000391198.827598.325
ENSG00000179295homo_sapiensENSP0000034094499.156898.9882equus_caballusENSECAP0000008953595.609895.4472
ENSG00000179295homo_sapiensENSP0000034094499.662799.4941canis_lupus_familiarisENSCAFP0084502951598.99598.8275
ENSG00000179295homo_sapiensENSP0000034094499.494199.3255panthera_pardusENSPPRP0000000952398.827598.66
ENSG00000179295homo_sapiensENSP0000034094499.494199.1568marmota_marmota_marmotaENSMMMP0000001665199.494199.1568
ENSG00000179295homo_sapiensENSP0000034094498.988298.8196marmota_marmota_marmotaENSMMMP0000002457899.155498.9865
ENSG00000179295homo_sapiensENSP0000034094499.494199.1568balaenoptera_musculusENSBMSP0001002615195.31594.9919
ENSG00000179295homo_sapiensENSP0000034094498.482398.145cavia_porcellusENSCPOP0000001217999.319798.9796
ENSG00000179295homo_sapiensENSP0000034094499.494199.3255felis_catusENSFCAP0000002980898.827598.66
ENSG00000179295homo_sapiensENSP0000034094492.411592.0742ursus_americanusENSUAMP0000001028999.275498.913
ENSG00000179295homo_sapiensENSP0000034094496.290195.2782monodelphis_domesticaENSMODP0000000380495.325594.3239
ENSG00000179295homo_sapiensENSP0000034094498.482398.145bison_bison_bisonENSBBBP0000002002598.482398.145
ENSG00000179295homo_sapiensENSP0000034094499.325598.9882monodon_monocerosENSMMNP0001501662498.6698.325
ENSG00000179295homo_sapiensENSP0000034094499.325598.9882sus_scrofaENSSSCP0000006434599.325598.9882
ENSG00000179295homo_sapiensENSP0000034094499.831499.4941microcebus_murinusENSMICP0000002103099.162598.8275
ENSG00000179295homo_sapiensENSP0000034094498.650997.6391microcebus_murinusENSMICP0000004342498.817697.8041
ENSG00000179295homo_sapiensENSP0000034094498.988298.6509octodon_degusENSODEP0000001704198.489998.1544
ENSG00000179295homo_sapiensENSP0000034094493.423388.7015jaculus_jaculusENSJJAP0000002017394.217789.4558
ENSG00000179295homo_sapiensENSP0000034094499.156898.8196jaculus_jaculusENSJJAP0000001552299.324398.9865
ENSG00000179295homo_sapiensENSP0000034094499.325598.9882ovis_aries_rambouilletENSOARP0002002452798.6698.325
ENSG00000179295homo_sapiensENSP0000034094499.325599.1568ursus_maritimusENSUMAP0000001340098.166798
ENSG00000179295homo_sapiensENSP0000034094498.14597.6391ochotona_princepsENSOPRP0000001079198.310897.8041
ENSG00000179295homo_sapiensENSP0000034094495.615595.2782delphinapterus_leucasENSDLEP0000002766599.299598.9492
ENSG00000179295homo_sapiensENSP0000034094499.494199.3255physeter_catodonENSPCTP0000501746998.827598.66
ENSG00000179295homo_sapiensENSP0000034094499.831499.4941mus_caroliMGP_CAROLIEiJ_P007040199.162598.8275
ENSG00000179295homo_sapiensENSP0000034094499.831499.4941mus_musculusENSMUSP0000005875799.162598.8275
ENSG00000179295homo_sapiensENSP0000034094497.639197.3019dipodomys_ordiiENSDORP0000000776099.313998.9708
ENSG00000179295homo_sapiensENSP0000034094499.662799.4941mustela_putorius_furoENSMPUP0000000250499.662799.4941
ENSG00000179295homo_sapiensENSP0000034094475.548175.3794vicugna_pacosENSVPAP0000000851475.548175.3794
ENSG00000179295homo_sapiensENSP00000340944100100chlorocebus_sabaeusENSCSAP0000001557199.496699.4966
ENSG00000179295homo_sapiensENSP0000034094486.677986.3406tupaia_belangeriENSTBEP0000000124487.863387.5214
ENSG00000179295homo_sapiensENSP0000034094499.662799.3255mesocricetus_auratusENSMAUP0000001374799.161198.8255
ENSG00000179295homo_sapiensENSP0000034094499.325598.9882phocoena_sinusENSPSNP0000001121298.6698.325
ENSG00000179295homo_sapiensENSP0000034094493.08692.9174camelus_dromedariusENSCDRP0000502866799.459599.2793
ENSG00000179295homo_sapiensENSP0000034094488.870288.8702carlito_syrichtaENSTSYP0000000253999.060299.0602
ENSG00000179295homo_sapiensENSP0000034094498.988298.6509panthera_tigris_altaicaENSPTIP0000000750798.988298.6509
ENSG00000179295homo_sapiensENSP0000034094499.325598.4823rattus_norvegicusENSRNOP0000009019995.307494.4984
ENSG00000179295homo_sapiensENSP0000034094499.494199.1568prolemur_simusENSPSMP0000000050499.662299.3243
ENSG00000179295homo_sapiensENSP0000034094498.14596.9646microtus_ochrogasterENSMOCP0000001969797.324496.1538
ENSG00000179295homo_sapiensENSP0000034094449.915749.747sorex_araneusENSSARP0000000807155.534755.3471
ENSG00000179295homo_sapiensENSP0000034094499.831499.4941peromyscus_maniculatus_bairdiiENSPEMP0000000517799.162598.8275
ENSG00000179295homo_sapiensENSP0000034094499.325598.9882bos_mutusENSBMUP0000001157099.325598.9882
ENSG00000179295homo_sapiensENSP0000034094499.831499.4941mus_spicilegusENSMSIP0000001197399.162598.8275
ENSG00000179295homo_sapiensENSP0000034094499.831499.4941cricetulus_griseus_chok1gshdENSCGRP0000101729199.831499.4941
ENSG00000179295homo_sapiensENSP0000034094498.650998.145pteropus_vampyrusENSPVAP0000001170098.650998.145
ENSG00000179295homo_sapiensENSP0000034094463.406462.9005myotis_lucifugusENSMLUP0000000623899.208498.4169
ENSG00000179295homo_sapiensENSP0000034094499.156898.4823vombatus_ursinusENSVURP0001000487698.492597.8224
ENSG00000179295homo_sapiensENSP0000034094499.662798.9882rhinolophus_ferrumequinumENSRFEP0001001498598.99598.325
ENSG00000179295homo_sapiensENSP0000034094490.556589.2074neovison_visonENSNVIP0000002029695.551694.1281
ENSG00000179295homo_sapiensENSP0000034094499.325598.9882bos_taurusENSBTAP0000000265399.325598.9882
ENSG00000179295homo_sapiensENSP0000034094499.831499.6627heterocephalus_glaber_femaleENSHGLP0000002231099.162598.995
ENSG00000179295homo_sapiensENSP0000034094499.156898.8196canis_lupus_dingoENSCAFP0002002222397.674497.3422
ENSG00000179295homo_sapiensENSP0000034094499.831499.6627sciurus_vulgarisENSSVLP0000500666399.162598.995
ENSG00000179295homo_sapiensENSP0000034094477.740376.5599sciurus_vulgarisENSSVLP0000503008097.669596.1864
ENSG00000179295homo_sapiensENSP0000034094498.650997.9764phascolarctos_cinereusENSPCIP0000002508098.650997.9764
ENSG00000179295homo_sapiensENSP0000034094486.003485.6661procavia_capensisENSPCAP0000001332486.003485.6661
ENSG00000179295homo_sapiensENSP00000340944100100nannospalax_galiliENSNGAP0000000567799.3399.33
ENSG00000179295homo_sapiensENSP0000034094499.325598.9882bos_grunniensENSBGRP0000003152898.6698.325
ENSG00000179295homo_sapiensENSP0000034094499.494199.4941chinchilla_lanigeraENSCLAP0000002104199.494199.4941
ENSG00000179295homo_sapiensENSP0000034094499.494199.1568cervus_hanglu_yarkandensisENSCHYP0000000642498.827598.4925
ENSG00000179295homo_sapiensENSP0000034094499.325599.1568catagonus_wagneriENSCWAP0000002226898.6698.4925
ENSG00000179295homo_sapiensENSP0000034094494.603793.9292ictidomys_tridecemlineatusENSSTOP0000001996294.444493.771
ENSG00000179295homo_sapiensENSP0000034094410099.8314otolemur_garnettiiENSOGAP0000000031198.998398.8314
ENSG00000179295homo_sapiensENSP0000034094499.831499.6627urocitellus_parryiiENSUPAP0001001087099.831499.6627
ENSG00000179295homo_sapiensENSP0000034094499.325598.9882moschus_moschiferusENSMMSP0000002289398.6698.325
ENSG00000179295homo_sapiensENSP00000340944100100rhinopithecus_roxellanaENSRROP00000015111100100
ENSG00000179295homo_sapiensENSP0000034094499.831499.4941mus_pahariMGP_PahariEiJ_P005861399.162598.8275
ENSG00000179295homo_sapiensENSP0000034094410099.8314propithecus_coquereliENSPCOP0000002943799.3399.1625
ENSG00000179295homo_sapiensENSP0000034094417.706615.8516petromyzon_marinusENSPMAP0000000826493.7583.9286
ENSG00000179295homo_sapiensENSP0000034094484.148473.1872eptatretus_burgeriENSEBUP0000002773180.225169.7749
ENSG00000179295homo_sapiensENSP0000034094492.748789.0388callorhinchus_miliiENSCMIP0000003850186.887883.4123
ENSG00000179295homo_sapiensENSP0000034094495.446992.7487latimeria_chalumnaeENSLACP0000000716096.58793.8567
ENSG00000179295homo_sapiensENSP0000034094495.952892.4115lepisosteus_oculatusENSLOCP0000000930195.791292.2559
ENSG00000179295homo_sapiensENSP0000034094495.278291.0624clupea_harengusENSCHAP0000005129894.323990.1503
ENSG00000179295homo_sapiensENSP0000034094494.94191.7369danio_rerioENSDARP0000007604094.781191.5825
ENSG00000179295homo_sapiensENSP0000034094495.109692.2428carassius_auratusENSCARP0000005883790.2487.52
ENSG00000179295homo_sapiensENSP0000034094494.94191.7369carassius_auratusENSCARP0000001631093.833390.6667
ENSG00000179295homo_sapiensENSP0000034094495.109691.9056carassius_auratusENSCARP0000007242094.156990.985
ENSG00000179295homo_sapiensENSP0000034094495.109692.2428carassius_auratusENSCARP0000006602194.949592.0875
ENSG00000179295homo_sapiensENSP0000034094495.952892.7487astyanax_mexicanusENSAMXP0000004968095.791292.5926
ENSG00000179295homo_sapiensENSP0000034094493.760589.882ictalurus_punctatusENSIPUP0000002196692.976689.1304
ENSG00000179295homo_sapiensENSP0000034094496.290191.9056esox_luciusENSELUP0000000105594.536490.2318
ENSG00000179295homo_sapiensENSP0000034094495.784191.3997electrophorus_electricusENSEEEP0000002183895.622991.2458
ENSG00000179295homo_sapiensENSP0000034094495.615590.7251oncorhynchus_kisutchENSOKIP0000500456992.647187.9085
ENSG00000179295homo_sapiensENSP0000034094496.290191.5683oncorhynchus_kisutchENSOKIP0000505004193.914589.3092
ENSG00000179295homo_sapiensENSP0000034094494.097888.3643oncorhynchus_mykissENSOMYP0000011489392.537386.8988
ENSG00000179295homo_sapiensENSP0000034094489.544784.6543oncorhynchus_mykissENSOMYP0000013056584.824380.1917
ENSG00000179295homo_sapiensENSP0000034094495.615590.5565salmo_salarENSSSAP0000001069494.029989.0547
ENSG00000179295homo_sapiensENSP0000034094496.458791.7369salmo_salarENSSSAP0000013708295.016690.3654
ENSG00000179295homo_sapiensENSP0000034094496.458791.7369salmo_truttaENSSTUP0000003730295.016690.3654
ENSG00000179295homo_sapiensENSP0000034094496.79692.2428salmo_truttaENSSTUP0000005697195.033190.5629
ENSG00000179295homo_sapiensENSP0000034094495.446991.5683gadus_morhuaENSGMOP0000001906894.333390.5
ENSG00000179295homo_sapiensENSP0000034094477.571771.8381fundulus_heteroclitusENSFHEP0000000112991.089184.3564
ENSG00000179295homo_sapiensENSP0000034094496.290190.8938poecilia_reticulataENSPREP0000002456095.805490.4362
ENSG00000179295homo_sapiensENSP0000034094496.121490.5565xiphophorus_maculatusENSXMAP0000003037995.637690.1007
ENSG00000179295homo_sapiensENSP0000034094496.121491.5683oryzias_latipesENSORLP0000003921095.637691.1074
ENSG00000179295homo_sapiensENSP0000034094495.952891.5683cyclopterus_lumpusENSCLMP0000503378694.518390.1993
ENSG00000179295homo_sapiensENSP0000034094495.784191.231oreochromis_niloticusENSONIP0000007111392.207887.8247
ENSG00000179295homo_sapiensENSP0000034094495.952891.7369haplochromis_burtoniENSHBUP0000002791094.361590.2156
ENSG00000179295homo_sapiensENSP0000034094495.952891.7369astatotilapia_callipteraENSACLP0000003637494.361590.2156
ENSG00000179295homo_sapiensENSP0000034094495.952891.9056sparus_aurataENSSAUP0001001526194.518390.5316
ENSG00000179295homo_sapiensENSP0000034094494.266490.2192lates_calcariferENSLCAP0001002349594.107790.0673
ENSG00000179295homo_sapiensENSP0000034094496.627394.2664xenopus_tropicalisENSXETP0000006552494.088791.7898
ENSG00000179295homo_sapiensENSP0000034094499.494198.8196chrysemys_picta_belliiENSCPBP0000000849095.779295.1299
ENSG00000179295homo_sapiensENSP0000034094493.929292.5801sphenodon_punctatusENSSPUP0000001257794.727993.3673
ENSG00000179295homo_sapiensENSP0000034094499.325598.6509crocodylus_porosusENSCPRP0000502229699.325598.6509
ENSG00000179295homo_sapiensENSP0000034094498.650996.9646laticauda_laticaudataENSLLTP0000000106498.484896.8013
ENSG00000179295homo_sapiensENSP0000034094498.650996.796notechis_scutatusENSNSUP0000001575198.484896.633
ENSG00000179295homo_sapiensENSP0000034094498.650996.796pseudonaja_textilisENSPTXP0000002551798.484896.633
ENSG00000179295homo_sapiensENSP0000034094498.988297.9764anas_platyrhynchos_platyrhynchosENSAPLP0000001522798.988297.9764
ENSG00000179295homo_sapiensENSP0000034094498.650997.8078gallus_gallusENSGALP0001002955798.650997.8078
ENSG00000179295homo_sapiensENSP0000034094499.156898.3137meleagris_gallopavoENSMGAP0000000566699.156898.3137
ENSG00000179295homo_sapiensENSP0000034094498.819697.8078serinus_canariaENSSCAP0000000976498.819697.8078
ENSG00000179295homo_sapiensENSP0000034094498.650997.6391parus_majorENSPMJP0000000954498.817697.8041
ENSG00000179295homo_sapiensENSP0000034094498.819697.4705anolis_carolinensisENSACAP0000000293796.699795.3795
ENSG00000179295homo_sapiensENSP0000034094495.784191.231neolamprologus_brichardiENSNBRP0000002446893.114888.6885
ENSG00000179295homo_sapiensENSP0000034094497.301995.2782naja_najaENSNNAP0000002697996.649994.6399
ENSG00000179295homo_sapiensENSP0000034094493.08691.7369podarcis_muralisENSPMRP0000001684997.699196.2832
ENSG00000179295homo_sapiensENSP0000034094498.819697.8078geospiza_fortisENSGFOP0000001271298.819697.8078
ENSG00000179295homo_sapiensENSP0000034094496.290195.4469taeniopygia_guttataENSTGUP0000000702298.1197.2509
ENSG00000179295homo_sapiensENSP0000034094493.591988.7015erpetoichthys_calabaricusENSECRP0000003091093.277388.4034
ENSG00000179295homo_sapiensENSP0000034094494.94189.0388kryptolebias_marmoratusENSKMAP0000002060194.463188.5906
ENSG00000179295homo_sapiensENSP0000034094498.650996.796salvator_merianaeENSSMRP0000001183798.484896.633
ENSG00000179295homo_sapiensENSP0000034094496.627391.5683oryzias_javanicusENSOJAP0000001017996.140991.1074
ENSG00000179295homo_sapiensENSP0000034094495.784190.8938amphilophus_citrinellusENSACIP0000000961495.30290.4362
ENSG00000179295homo_sapiensENSP0000034094496.290192.0742dicentrarchus_labraxENSDLAP0000506404489.638985.7143
ENSG00000179295homo_sapiensENSP0000034094496.458792.2428amphiprion_perculaENSAPEP0000001537695.016690.8638
ENSG00000179295homo_sapiensENSP0000034094496.121491.5683oryzias_sinensisENSOSIP0000003938695.637691.1074
ENSG00000179295homo_sapiensENSP0000034094450.590250.253pelodiscus_sinensisENSPSIP0000001343996.774296.129
ENSG00000179295homo_sapiensENSP0000034094496.458795.6155pelodiscus_sinensisENSPSIP0000000370896.785195.9391
ENSG00000179295homo_sapiensENSP0000034094436.930935.4132pelodiscus_sinensisENSPSIP0000000562296.475892.511
ENSG00000179295homo_sapiensENSP0000034094499.494198.6509gopherus_evgoodeiENSGEVP0000502836499.159798.3193
ENSG00000179295homo_sapiensENSP0000034094499.325598.4823chelonoidis_abingdoniiENSCABP0000002265099.158298.3165
ENSG00000179295homo_sapiensENSP0000034094496.121491.9056seriola_dumeriliENSSDUP0000003280294.684490.5316
ENSG00000179295homo_sapiensENSP0000034094495.615591.0624cottoperca_gobioENSCGOP0000005577693.256688.8158
ENSG00000179295homo_sapiensENSP0000034094498.988297.9764struthio_camelus_australisENSSCUP0000000204498.32597.3199
ENSG00000179295homo_sapiensENSP0000034094499.156898.145anser_brachyrhynchusENSABRP0000002521498.492597.4874
ENSG00000179295homo_sapiensENSP0000034094495.952891.9056gasterosteus_aculeatusENSGACP0000002055295.469891.443
ENSG00000179295homo_sapiensENSP0000034094496.290191.3997cynoglossus_semilaevisENSCSEP0000001904494.850590.0332
ENSG00000179295homo_sapiensENSP0000034094496.290190.8938poecilia_formosaENSPFOP0000001003195.805490.4362
ENSG00000179295homo_sapiensENSP0000034094495.446990.7251myripristis_murdjanENSMMDP0000502586995.286290.5724
ENSG00000179295homo_sapiensENSP0000034094494.603789.7133sander_luciopercaENSSLUP0000004028892.118287.3563
ENSG00000179295homo_sapiensENSP0000034094495.109694.2664strigops_habroptilaENSSHBP0000500936498.947498.0702
ENSG00000179295homo_sapiensENSP0000034094496.458792.2428amphiprion_ocellarisENSAOCP0000000816095.016690.8638
ENSG00000179295homo_sapiensENSP0000034094499.494198.8196terrapene_carolina_triunguisENSTMTP0000003055099.326698.6532
ENSG00000179295homo_sapiensENSP0000034094496.458791.9056hucho_huchoENSHHUP0000001732891.082886.7834
ENSG00000179295homo_sapiensENSP0000034094495.952891.231hucho_huchoENSHHUP0000007951694.518389.8671
ENSG00000179295homo_sapiensENSP0000034094496.290192.5801betta_splendensENSBSLP0000002444193.606690
ENSG00000179295homo_sapiensENSP0000034094496.290192.5801pygocentrus_nattereriENSPNAP0000000695696.127992.4242
ENSG00000179295homo_sapiensENSP0000034094495.615591.5683anabas_testudineusENSATEP0000004691593.564489.604
ENSG00000179295homo_sapiensENSP0000034094493.08688.8702seriola_lalandi_dorsalisENSSLDP0000001407795.501791.1765
ENSG00000179295homo_sapiensENSP0000034094495.952892.0742labrus_bergyltaENSLBEP0000001895494.518390.6977
ENSG00000179295homo_sapiensENSP0000034094495.952891.7369pundamilia_nyerereiENSPNYP0000000463294.361590.2156
ENSG00000179295homo_sapiensENSP0000034094495.446990.7251mastacembelus_armatusENSMAMP0000005859294.019989.3688
ENSG00000179295homo_sapiensENSP0000034094496.458792.4115stegastes_partitusENSSPAP0000001576495.016691.0299
ENSG00000179295homo_sapiensENSP0000034094494.097889.2074oncorhynchus_tshawytschaENSOTSP0000509087389.855185.1852
ENSG00000179295homo_sapiensENSP0000034094496.79692.2428oncorhynchus_tshawytschaENSOTSP0000504674491.111186.8254
ENSG00000179295homo_sapiensENSP0000034094496.458792.5801acanthochromis_polyacanthusENSAPOP0000001069795.016691.196
ENSG00000179295homo_sapiensENSP0000034094499.156898.3137aquila_chrysaetos_chrysaetosENSACCP0002000546599.156898.3137
ENSG00000179295homo_sapiensENSP0000034094494.435189.7133nothobranchius_furzeriENSNFUP0001501310592.56287.9339
ENSG00000179295homo_sapiensENSP0000034094496.121491.231cyprinodon_variegatusENSCVAP000000051719590.1667
ENSG00000179295homo_sapiensENSP0000034094495.784192.4115denticeps_clupeoidesENSDCDP0000000615494.666791.3333
ENSG00000179295homo_sapiensENSP0000034094494.94190.5565larimichthys_croceaENSLCRP0000506122092.751288.4679
ENSG00000179295homo_sapiensENSP0000034094498.988297.9764ficedula_albicollisENSFALP0000000933598.988297.9764
ENSG00000179295homo_sapiensENSP0000034094495.784191.5683hippocampus_comesENSHCOP0000001943594.352290.1993
ENSG00000179295homo_sapiensENSP0000034094494.603791.7369cyprinus_carpio_carpioENSCCRP0000001519793.590.6667
ENSG00000179295homo_sapiensENSP0000034094495.278292.0742cyprinus_carpio_carpioENSCCRP0000003615994.323991.1519
ENSG00000179295homo_sapiensENSP0000034094499.156898.145coturnix_japonicaENSCJPP0000500815099.156898.145
ENSG00000179295homo_sapiensENSP0000034094496.290190.8938poecilia_latipinnaENSPLAP0000003025795.805490.4362
ENSG00000179295homo_sapiensENSP0000034094483.305280.1012sinocyclocheilus_grahamiENSSGRP0000010303992.509488.9513
ENSG00000179295homo_sapiensENSP0000034094484.822981.7875sinocyclocheilus_grahamiENSSGRP0000011149789.982186.7621
ENSG00000179295homo_sapiensENSP0000034094495.952891.7369maylandia_zebraENSMZEP0000501076986.870283.0534
ENSG00000179295homo_sapiensENSP0000034094439.62936.425maylandia_zebraENSMZEP0000503483885.454578.5455
ENSG00000179295homo_sapiensENSP0000034094494.097889.2074paramormyrops_kingsleyaeENSPKIP0000000789493.939489.0572
ENSG00000179295homo_sapiensENSP0000034094491.736986.6779paramormyrops_kingsleyaeENSPKIP0000000790594.117688.9273
ENSG00000179295homo_sapiensENSP0000034094494.435189.882scleropages_formosusENSSFOP0001506957392.409287.9538
ENSG00000179295homo_sapiensENSP0000034094495.784192.0742scleropages_formosusENSSFOP0001505662094.195790.5473
ENSG00000179295homo_sapiensENSP0000034094496.79693.4233leptobrachium_leishanenseENSLLEP0000000025396.308792.953
ENSG00000179295homo_sapiensENSP0000034094495.952891.3997scophthalmus_maximusENSSMAP0000006166189.606385.3543
ENSG00000179295homo_sapiensENSP0000034094496.458791.3997oryzias_melastigmaENSOMEP0000003592695.973290.9396

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000077involved_in DNA damage checkpoint signaling1IEAHomo_sapiens(9606)Process
GO:0001784enables phosphotyrosine residue binding2IMP,IPIHomo_sapiens(9606)Function
GO:0004721enables phosphoprotein phosphatase activity1IDAHomo_sapiens(9606)Function
GO:0004725enables protein tyrosine phosphatase activity4EXP,IDA,IMP,TASHomo_sapiens(9606)Function
GO:0004726enables non-membrane spanning protein tyrosine phosphatase activity4IBA,IDA,IMP,TASHomo_sapiens(9606)Function
GO:0005158enables insulin receptor binding1IPIHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm3IBA,IC,IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006470involved_in protein dephosphorylation2IBA,IMPHomo_sapiens(9606)Process
GO:0006641involved_in triglyceride metabolic process1IEAHomo_sapiens(9606)Process
GO:0007173involved_in epidermal growth factor receptor signaling pathway1TASHomo_sapiens(9606)Process
GO:0007229involved_in integrin-mediated signaling pathway1IEAHomo_sapiens(9606)Process
GO:0007409involved_in axonogenesis1IEAHomo_sapiens(9606)Process
GO:0007420involved_in brain development1IMPHomo_sapiens(9606)Process
GO:0007507involved_in heart development1IMPHomo_sapiens(9606)Process
GO:0008543involved_in fibroblast growth factor receptor signaling pathway1IMPHomo_sapiens(9606)Process
GO:0009755involved_in hormone-mediated signaling pathway1IEAHomo_sapiens(9606)Process
GO:0019221involved_in cytokine-mediated signaling pathway1TASHomo_sapiens(9606)Process
GO:0019901enables protein kinase binding1ISSHomo_sapiens(9606)Function
GO:0021697involved_in cerebellar cortex formation1IEAHomo_sapiens(9606)Process
GO:0030159enables signaling receptor complex adaptor activity1IPIHomo_sapiens(9606)Function
GO:0030220involved_in platelet formation1IEAHomo_sapiens(9606)Process
GO:0030971enables receptor tyrosine kinase binding1IBAHomo_sapiens(9606)Function
GO:0031295involved_in T cell costimulation1TASHomo_sapiens(9606)Process
GO:0032331involved_in negative regulation of chondrocyte differentiation1ISSHomo_sapiens(9606)Process
GO:0032480involved_in negative regulation of type I interferon production1IDAHomo_sapiens(9606)Process
GO:0032528involved_in microvillus organization1IEAHomo_sapiens(9606)Process
GO:0032728involved_in positive regulation of interferon-beta production1ISSHomo_sapiens(9606)Process
GO:0032755involved_in positive regulation of interleukin-6 production1ISSHomo_sapiens(9606)Process
GO:0032760involved_in positive regulation of tumor necrosis factor production1ISSHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex1IMPHomo_sapiens(9606)Component
GO:0033628involved_in regulation of cell adhesion mediated by integrin1IMPHomo_sapiens(9606)Process
GO:0033629involved_in negative regulation of cell adhesion mediated by integrin1IEAHomo_sapiens(9606)Process
GO:0035264involved_in multicellular organism growth1IEAHomo_sapiens(9606)Process
GO:0035265involved_in organ growth1IEAHomo_sapiens(9606)Process
GO:0035335involved_in peptidyl-tyrosine dephosphorylation2IDA,IMPHomo_sapiens(9606)Process
GO:0035855involved_in megakaryocyte development1IEAHomo_sapiens(9606)Process
GO:0036302involved_in atrioventricular canal development1IMPHomo_sapiens(9606)Process
GO:0038127involved_in ERBB signaling pathway1IDAHomo_sapiens(9606)Process
GO:0042445involved_in hormone metabolic process1IEAHomo_sapiens(9606)Process
GO:0042593involved_in glucose homeostasis1IEAHomo_sapiens(9606)Process
GO:0043254involved_in regulation of protein-containing complex assembly1IDAHomo_sapiens(9606)Process
GO:0045296enables cadherin binding1IPIHomo_sapiens(9606)Function
GO:0045778involved_in positive regulation of ossification1ISSHomo_sapiens(9606)Process
GO:0045931involved_in positive regulation of mitotic cell cycle1IEAHomo_sapiens(9606)Process
GO:0046326involved_in positive regulation of glucose import1IDAHomo_sapiens(9606)Process
GO:0046628involved_in positive regulation of insulin receptor signaling pathway1IDAHomo_sapiens(9606)Process
GO:0046676involved_in negative regulation of insulin secretion1IEAHomo_sapiens(9606)Process
GO:0046825involved_in regulation of protein export from nucleus1IEAHomo_sapiens(9606)Process
GO:0046887involved_in positive regulation of hormone secretion1IEAHomo_sapiens(9606)Process
GO:0048008involved_in platelet-derived growth factor receptor signaling pathway1IEAHomo_sapiens(9606)Process
GO:0048011involved_in neurotrophin TRK receptor signaling pathway1IEAHomo_sapiens(9606)Process
GO:0048013involved_in ephrin receptor signaling pathway1IDAHomo_sapiens(9606)Process
GO:0048609involved_in multicellular organismal reproductive process1IEAHomo_sapiens(9606)Process
GO:0048806involved_in genitalia development1IMPHomo_sapiens(9606)Process
GO:0048839involved_in inner ear development1IMPHomo_sapiens(9606)Process
GO:0048873involved_in homeostasis of number of cells within a tissue1IEAHomo_sapiens(9606)Process
GO:0050731involved_in positive regulation of peptidyl-tyrosine phosphorylation1IMPHomo_sapiens(9606)Process
GO:0050839enables cell adhesion molecule binding2IBA,IPIHomo_sapiens(9606)Function
GO:0051428enables peptide hormone receptor binding1IEAHomo_sapiens(9606)Function
GO:0051463involved_in negative regulation of cortisol secretion1IEAHomo_sapiens(9606)Process
GO:0060020involved_in Bergmann glial cell differentiation1IEAHomo_sapiens(9606)Process
GO:0060090enables molecular adaptor activity1IDAHomo_sapiens(9606)Function
GO:0060125involved_in negative regulation of growth hormone secretion1IEAHomo_sapiens(9606)Process
GO:0060325involved_in face morphogenesis1IMPHomo_sapiens(9606)Process
GO:0060338involved_in regulation of type I interferon-mediated signaling pathway1TASHomo_sapiens(9606)Process
GO:0061582involved_in intestinal epithelial cell migration1IEAHomo_sapiens(9606)Process
GO:0070374involved_in positive regulation of ERK1 and ERK2 cascade2IBA,IMPHomo_sapiens(9606)Process
GO:0071364involved_in cellular response to epidermal growth factor stimulus1IMPHomo_sapiens(9606)Process
GO:1990782enables protein tyrosine kinase binding1IPIHomo_sapiens(9606)Function

Expression