RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzymeE3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000177565	Gene ID	79718	Accession	29529
Symbol	TBL1XR1	Alias	C21;DC42;IRA1;MRD41;TBLR1	Full Name	TBL1X/Y related 1
Status	Confidence	Length	208657 bases	Strand	Minus strand
Position	3 : 177019344 - 177228000	RNA binding domain	eIF2A
Summary	This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000490514	eIF2A	PF08662	4.8e-06	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
TBL1XR1-227	ENST00000636864	6888	No protein	-
TBL1XR1-214	ENST00000457928	8182	514aa	ENSP00000413251
TBL1XR1-208	ENST00000430069	7948	514aa	ENSP00000405574
TBL1XR1-237	ENST00000704383	8082	514aa	ENSP00000515885
TBL1XR1-232	ENST00000637659	3105	271aa	ENSP00000490514
TBL1XR1-215	ENST00000474363	6229	No protein	-
TBL1XR1-236	ENST00000673974	6502	514aa	ENSP00000501274
TBL1XR1-221	ENST00000631253	4186	474aa	ENSP00000486324
TBL1XR1-209	ENST00000431421	3814	427aa	ENSP00000402402
TBL1XR1-201	ENST00000352800	2454	514aa	ENSP00000263964
TBL1XR1-203	ENST00000422066	2619	514aa	ENSP00000398477
TBL1XR1-204	ENST00000422442	2535	514aa	ENSP00000387849
TBL1XR1-238	ENST00000704384	1991	514aa	ENSP00000515886
TBL1XR1-217	ENST00000626758	355	67aa	ENSP00000486622
TBL1XR1-239	ENST00000704385	1902	514aa	ENSP00000515887
TBL1XR1-235	ENST00000638074	100	No protein	-
TBL1XR1-225	ENST00000636348	100	No protein	-
TBL1XR1-222	ENST00000635757	100	No protein	-
TBL1XR1-233	ENST00000637681	100	No protein	-
TBL1XR1-207	ENST00000428970	575	75aa	ENSP00000391559
TBL1XR1-205	ENST00000424913	592	73aa	ENSP00000404863
TBL1XR1-211	ENST00000437738	565	145aa	ENSP00000392180
TBL1XR1-223	ENST00000635794	768	131aa	ENSP00000490246
TBL1XR1-219	ENST00000630796	656	122aa	ENSP00000486235
TBL1XR1-213	ENST00000450267	588	120aa	ENSP00000406297
TBL1XR1-220	ENST00000630833	567	105aa	ENSP00000486082
TBL1XR1-210	ENST00000431674	559	96aa	ENSP00000397450
TBL1XR1-212	ENST00000443315	580	81aa	ENSP00000396120
TBL1XR1-218	ENST00000627825	312	No protein	-
TBL1XR1-206	ENST00000427349	554	61aa	ENSP00000401044
TBL1XR1-202	ENST00000413084	592	33aa	ENSP00000415506
TBL1XR1-230	ENST00000637137	107	No protein	-
TBL1XR1-216	ENST00000491623	582	No protein	-
TBL1XR1-231	ENST00000637544	214	No protein	-
TBL1XR1-226	ENST00000636478	100	No protein	-
TBL1XR1-234	ENST00000637755	98	No protein	-
TBL1XR1-224	ENST00000636187	171	No protein	-
TBL1XR1-228	ENST00000636912	100	No protein	-
TBL1XR1-229	ENST00000637123	138	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000118	part_of histone deacetylase complex	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0000976	enables transcription cis-regulatory region binding	2	IDA,ISS	Homo_sapiens(9606)	Function
GO:0001835	involved_in blastocyst hatching	1	IEA	Homo_sapiens(9606)	Process
GO:0002021	involved_in response to dietary excess	1	IEA	Homo_sapiens(9606)	Process
GO:0003714	enables transcription corepressor activity	3	IBA,IDA,IGI	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0006325	involved_in chromatin organization	1	IEA	Homo_sapiens(9606)	Process
GO:0006357	involved_in regulation of transcription by RNA polymerase II	1	IBA	Homo_sapiens(9606)	Process
GO:0008013	enables beta-catenin binding	1	IPI	Homo_sapiens(9606)	Function
GO:0016042	involved_in lipid catabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0017053	part_of transcription repressor complex	1	IDA	Homo_sapiens(9606)	Component
GO:0035264	involved_in multicellular organism growth	1	IEA	Homo_sapiens(9606)	Process
GO:0042393	enables histone binding	1	IDA	Homo_sapiens(9606)	Function
GO:0043161	involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	1	ISS	Homo_sapiens(9606)	Process
GO:0045893	involved_in positive regulation of DNA-templated transcription	1	IDA	Homo_sapiens(9606)	Process
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0050872	involved_in white fat cell differentiation	1	IEA	Homo_sapiens(9606)	Process
GO:0060613	involved_in fat pad development	1	IEA	Homo_sapiens(9606)	Process
GO:0072686	located_in mitotic spindle	1	IDA	Homo_sapiens(9606)	Component
GO:0090207	involved_in regulation of triglyceride metabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0090263	involved_in positive regulation of canonical Wnt signaling pathway	1	IMP	Homo_sapiens(9606)	Process