Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000175766 Gene ID 253314 Accession 33179
Symbol EIF4E1B Alias NA Full Name eukaryotic translation initiation factor 4E family member 1B
Status Confidence Length 16027 bases Strand Plus strand
Position 5 : 176630618 - 176646644 RNA binding domain IF4E
Summary Predicted to enable RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Predicted to be involved in regulation of translation and translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 4F complex and mRNA cap binding activity complex. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000323714 IF4E PF01652 2.4e-52 1
ENSP00000427633 IF4E PF01652 2.4e-52 1
ENSP00000497422 IF4E PF01652 2.4e-52 1
ENSP00000422420 IF4E PF01652 1.8e-32 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
25463438 Distinct features of cap binding by eIF4E1b proteins. Dorota Kubacka 2015-01-30 Journal of molecular biology
36755190 Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition. Jing Guo 2023-04-01 Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Transcripts

Name Transcript ID bp Protein Translation ID
EIF4E1B-209 ENST00000647833 2137 242aa ENSP00000497422
EIF4E1B-201 ENST00000318682 1984 242aa ENSP00000323714
EIF4E1B-205 ENST00000510473 533 No protein -
EIF4E1B-206 ENST00000510660 581 90aa ENSP00000421009
EIF4E1B-208 ENST00000515458 2836 No protein -
EIF4E1B-203 ENST00000504597 1676 242aa ENSP00000427633
EIF4E1B-202 ENST00000503895 564 No protein -
EIF4E1B-204 ENST00000505497 514 171aa ENSP00000422420
EIF4E1B-207 ENST00000512734 561 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000175766homo_sapiensENSP0000039332440.62523.6607homo_sapiensENSP0000032371437.603321.9008
ENSG00000175766homo_sapiensENSP0000025841645.714328.9796homo_sapiensENSP0000032371446.28129.3388
ENSG00000175766homo_sapiensENSP0000038962478.34164.5161homo_sapiensENSP0000032371470.247957.8512

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000175766homo_sapiensENSP0000032371497.933996.6942nomascus_leucogenysENSNLEP0000001522198.340297.0954
ENSG00000175766homo_sapiensENSP0000032371497.107496.281pan_paniscusENSPPAP0000002689394.377593.5743
ENSG00000175766homo_sapiensENSP0000032371499.173697.5207pongo_abeliiENSPPYP0000001799299.173697.5207
ENSG00000175766homo_sapiensENSP0000032371498.760397.9339pan_troglodytesENSPTRP0000004782498.760397.9339
ENSG00000175766homo_sapiensENSP0000032371499.586898.3471gorilla_gorillaENSGGOP0000001707810098.7552
ENSG00000175766homo_sapiensENSP0000032371471.487663.2231sarcophilus_harrisiiENSSHAP0000000907880.092670.8333
ENSG00000175766homo_sapiensENSP0000032371458.264552.4793notamacropus_eugeniiENSMEUP0000000243976.216268.6487
ENSG00000175766homo_sapiensENSP0000032371481.40576.0331dasypus_novemcinctusENSDNOP0000003480874.339669.434
ENSG00000175766homo_sapiensENSP0000032371467.355457.438erinaceus_europaeusENSEEUP0000000537884.45672.0207
ENSG00000175766homo_sapiensENSP0000032371435.537232.6446echinops_telfairiENSETEP0000000400342.574339.1089
ENSG00000175766homo_sapiensENSP0000032371492.975288.4297callithrix_jacchusENSCJAP0000001358494.537889.916
ENSG00000175766homo_sapiensENSP0000032371497.107493.8017cercocebus_atysENSCATP0000002624996.311593.0328
ENSG00000175766homo_sapiensENSP0000032371497.107493.8017macaca_fascicularisENSMFAP0000001715795.528592.2764
ENSG00000175766homo_sapiensENSP0000032371497.107493.8017macaca_nemestrinaENSMNEP0000001474495.528592.2764
ENSG00000175766homo_sapiensENSP0000032371497.107493.8017mandrillus_leucophaeusENSMLEP0000002613495.528592.2764
ENSG00000175766homo_sapiensENSP0000032371469.834766.1157tursiops_truncatusENSTTRP0000001330180.476276.1905
ENSG00000175766homo_sapiensENSP0000032371473.966969.0083vulpes_vulpesENSVVUP0000000185974.273969.2946
ENSG00000175766homo_sapiensENSP0000032371477.272765.2893mus_spretusMGP_SPRETEiJ_P003609474.863.2
ENSG00000175766homo_sapiensENSP0000032371486.776983.4711equus_asinusENSEASP0000501746578.651775.6554
ENSG00000175766homo_sapiensENSP0000032371470.247966.1157capra_hircusENSCHIP0000000274185.858680.8081
ENSG00000175766homo_sapiensENSP0000032371458.677753.719loxodonta_africanaENSLAFP0000002585478.45371.8232
ENSG00000175766homo_sapiensENSP0000032371484.710780.1653panthera_leoENSPLOP0000002176184.710780.1653
ENSG00000175766homo_sapiensENSP0000032371485.950479.3388ailuropoda_melanoleucaENSAMEP0000003192474.021468.3274
ENSG00000175766homo_sapiensENSP0000032371452.066150.4132bos_indicus_hybridENSBIXP0000502064295.454592.4242
ENSG00000175766homo_sapiensENSP0000032371475.619871.0744oryctolagus_cuniculusENSOCUP0000002900883.181878.1818
ENSG00000175766homo_sapiensENSP0000032371486.776982.2314equus_caballusENSECAP0000002515571.672467.9181
ENSG00000175766homo_sapiensENSP0000032371481.818275.6198canis_lupus_familiarisENSCAFP0084501691784.615478.2051
ENSG00000175766homo_sapiensENSP0000032371485.950481.405panthera_pardusENSPPRP0000001988284.210579.7571
ENSG00000175766homo_sapiensENSP0000032371482.644675.6198balaenoptera_musculusENSBMSP0001000834985.106477.8723
ENSG00000175766homo_sapiensENSP0000032371483.057974.7934cavia_porcellusENSCPOP0000000399781.707373.5772
ENSG00000175766homo_sapiensENSP0000032371477.68673.9669felis_catusENSFCAP0000000283188.262984.0376
ENSG00000175766homo_sapiensENSP0000032371478.099272.7273ursus_americanusENSUAMP000000286508478.2222
ENSG00000175766homo_sapiensENSP0000032371447.520742.562monodelphis_domesticaENSMODP0000002113268.047360.9467
ENSG00000175766homo_sapiensENSP0000032371444.628140.4959monodelphis_domesticaENSMODP0000005705666.257760.1227
ENSG00000175766homo_sapiensENSP0000032371471.487665.2893monodelphis_domesticaENSMODP0000000627379.723572.8111
ENSG00000175766homo_sapiensENSP0000032371479.338872.314bison_bison_bisonENSBBBP0000000135480.334773.2218
ENSG00000175766homo_sapiensENSP0000032371484.297578.0992monodon_monocerosENSMMNP0001500060886.07679.7468
ENSG00000175766homo_sapiensENSP0000032371486.776979.3388sus_scrofaENSSSCP0000001494285.020277.7328
ENSG00000175766homo_sapiensENSP0000032371475.206666.9421microcebus_murinusENSMICP0000004371873.684265.587
ENSG00000175766homo_sapiensENSP0000032371482.231473.5537octodon_degusENSODEP0000001268082.572673.8589
ENSG00000175766homo_sapiensENSP0000032371483.471175.6198jaculus_jaculusENSJJAP0000001537082.113874.3902
ENSG00000175766homo_sapiensENSP0000032371479.752173.1405ovis_aries_rambouilletENSOARP0002001326383.91376.9565
ENSG00000175766homo_sapiensENSP0000032371456.611654.1322ochotona_princepsENSOPRP0000000812591.333387.3333
ENSG00000175766homo_sapiensENSP0000032371483.471176.4463delphinapterus_leucasENSDLEP0000001662179.841973.1225
ENSG00000175766homo_sapiensENSP0000032371483.057976.4463physeter_catodonENSPCTP0000500452480.079773.7052
ENSG00000175766homo_sapiensENSP0000032371476.033163.2231mus_caroliMGP_CAROLIEiJ_P003444475.720262.963
ENSG00000175766homo_sapiensENSP0000032371476.859564.876mus_musculusENSMUSP0000011869774.462.8
ENSG00000175766homo_sapiensENSP0000032371477.68670.2479dipodomys_ordiiENSDORP0000001509181.385373.5931
ENSG00000175766homo_sapiensENSP0000032371483.884378.5124mustela_putorius_furoENSMPUP0000001241377.186372.2433
ENSG00000175766homo_sapiensENSP0000032371493.801788.843aotus_nancymaaeENSANAP0000001361595.378290.3361
ENSG00000175766homo_sapiensENSP0000032371493.388488.0165saimiri_boliviensis_boliviensisENSSBOP0000002868094.95889.4958
ENSG00000175766homo_sapiensENSP0000032371496.694292.562chlorocebus_sabaeusENSCSAP0000000545194.736890.6883
ENSG00000175766homo_sapiensENSP0000032371457.024852.8926tupaia_belangeriENSTBEP0000000140977.966172.3164
ENSG00000175766homo_sapiensENSP0000032371440.082637.6033mesocricetus_auratusENSMAUP0000000105093.269287.5
ENSG00000175766homo_sapiensENSP0000032371484.297577.686phocoena_sinusENSPSNP0000002305586.07679.3249
ENSG00000175766homo_sapiensENSP0000032371483.884377.2727camelus_dromedariusENSCDRP0000501718084.232477.5934
ENSG00000175766homo_sapiensENSP0000032371475.619867.7686carlito_syrichtaENSTSYP0000001865580.263271.9298
ENSG00000175766homo_sapiensENSP0000032371485.12479.7521panthera_tigris_altaicaENSPTIP0000001211484.426279.0984
ENSG00000175766homo_sapiensENSP0000032371480.578570.6612rattus_norvegicusENSRNOP000000862337868.4
ENSG00000175766homo_sapiensENSP0000032371450.413247.5207prolemur_simusENSPSMP0000000443192.424287.1212
ENSG00000175766homo_sapiensENSP0000032371439.256237.1901microtus_ochrogasterENSMOCP0000002426691.346286.5385
ENSG00000175766homo_sapiensENSP0000032371439.256233.8843sorex_araneusENSSARP0000000942380.508569.4915
ENSG00000175766homo_sapiensENSP0000032371480.165372.314peromyscus_maniculatus_bairdiiENSPEMP0000000416279.183771.4286
ENSG00000175766homo_sapiensENSP0000032371472.727366.5289bos_mutusENSBMUP0000002571776.855970.3057
ENSG00000175766homo_sapiensENSP0000032371447.520741.3223mus_spicilegusENSMSIP0000002775983.941672.9927
ENSG00000175766homo_sapiensENSP0000032371476.446364.4628mus_spicilegusENSMSIP000000095397462.4
ENSG00000175766homo_sapiensENSP0000032371477.68668.1818cricetulus_griseus_chok1gshdENSCGRP0000100324371.482962.7376
ENSG00000175766homo_sapiensENSP0000032371473.140569.8347pteropus_vampyrusENSPVAP0000001607282.325678.6047
ENSG00000175766homo_sapiensENSP0000032371486.776980.1653myotis_lucifugusENSMLUP0000000131885.020278.5425
ENSG00000175766homo_sapiensENSP0000032371471.074464.4628vombatus_ursinusENSVURP0001000206563.235357.3529
ENSG00000175766homo_sapiensENSP0000032371486.776979.3388rhinolophus_ferrumequinumENSRFEP0001001655070.945964.8649
ENSG00000175766homo_sapiensENSP0000032371483.471176.0331neovison_visonENSNVIP0000002768173.722667.1533
ENSG00000175766homo_sapiensENSP0000032371476.859570.2479bos_taurusENSBTAP0000000403782.666775.5556
ENSG00000175766homo_sapiensENSP0000032371483.884377.686heterocephalus_glaber_femaleENSHGLP0000002365982.186276.1134
ENSG00000175766homo_sapiensENSP0000032371497.107494.2149rhinopithecus_bietiENSRBIP0000003079295.918493.0612
ENSG00000175766homo_sapiensENSP0000032371476.033170.2479canis_lupus_dingoENSCAFP0002001429676.033170.2479
ENSG00000175766homo_sapiensENSP0000032371467.768662.3967phascolarctos_cinereusENSPCIP000000244628275.5
ENSG00000175766homo_sapiensENSP0000032371445.867843.3884procavia_capensisENSPCAP0000000335592.587.5
ENSG00000175766homo_sapiensENSP0000032371440.495938.843nannospalax_galiliENSNGAP0000001037994.230890.3846
ENSG00000175766homo_sapiensENSP0000032371478.512472.314bos_grunniensENSBGRP0000002432678.512472.314
ENSG00000175766homo_sapiensENSP0000032371484.297576.0331chinchilla_lanigeraENSCLAP0000001950282.926874.7967
ENSG00000175766homo_sapiensENSP0000032371469.834765.7025cervus_hanglu_yarkandensisENSCHYP0000000246283.251278.3251
ENSG00000175766homo_sapiensENSP0000032371483.057975.6198catagonus_wagneriENSCWAP0000000279582.377175
ENSG00000175766homo_sapiensENSP0000032371485.537276.8595ictidomys_tridecemlineatusENSSTOP0000000178385.892177.1784
ENSG00000175766homo_sapiensENSP0000032371476.446372.314otolemur_garnettiiENSOGAP0000000523088.516783.7321
ENSG00000175766homo_sapiensENSP0000032371494.628189.2562cebus_imitatorENSCCAP0000000131296.218590.7563
ENSG00000175766homo_sapiensENSP0000032371476.033167.7686urocitellus_parryiiENSUPAP0001001666777.966169.4915
ENSG00000175766homo_sapiensENSP0000032371481.40573.9669moschus_moschiferusENSMMSP0000002176486.026278.1659
ENSG00000175766homo_sapiensENSP0000032371497.107494.2149rhinopithecus_roxellanaENSRROP0000003731795.918493.0612
ENSG00000175766homo_sapiensENSP0000032371477.68665.7025mus_pahariMGP_PahariEiJ_P004105677.049265.1639
ENSG00000175766homo_sapiensENSP0000032371479.752172.314propithecus_coquereliENSPCOP0000001628381.779774.1525
ENSG00000175766homo_sapiensENSP0000032371449.173632.6446caenorhabditis_elegansF53A2.6a.151.515234.1991
ENSG00000175766homo_sapiensENSP0000032371445.041333.0578caenorhabditis_elegansY57A10A.30.154.228939.801
ENSG00000175766homo_sapiensENSP0000032371440.082623.5537caenorhabditis_elegansC05D9.5.145.754726.8868
ENSG00000175766homo_sapiensENSP0000032371436.363624.3802drosophila_melanogasterFBpp028970235.483923.7903
ENSG00000175766homo_sapiensENSP0000032371452.892636.3636drosophila_melanogasterFBpp007024229.836820.5128
ENSG00000175766homo_sapiensENSP0000032371453.71937.6033drosophila_melanogasterFBpp007667256.768639.738
ENSG00000175766homo_sapiensENSP0000032371439.256230.5785drosophila_melanogasterFBpp029167754.913342.7746
ENSG00000175766homo_sapiensENSP0000032371448.347132.2314drosophila_melanogasterFBpp007642447.950831.9672
ENSG00000175766homo_sapiensENSP0000032371454.545538.0165drosophila_melanogasterFBpp030601750.965335.5212
ENSG00000175766homo_sapiensENSP0000032371454.132235.124drosophila_melanogasterFBpp007646456.465536.6379
ENSG00000175766homo_sapiensENSP0000032371462.809947.1074ciona_intestinalisENSCINP0000000867267.555650.6667
ENSG00000175766homo_sapiensENSP0000032371458.264544.2149eptatretus_burgeriENSEBUP0000002398271.573654.3147
ENSG00000175766homo_sapiensENSP0000032371466.115752.8926lepisosteus_oculatusENSLOCP0000001455372.072157.6577
ENSG00000175766homo_sapiensENSP0000032371461.983551.6529clupea_harengusENSCHAP0000000517369.124457.6037
ENSG00000175766homo_sapiensENSP0000032371464.462854.1322danio_rerioENSDARP0000002290672.897261.215
ENSG00000175766homo_sapiensENSP0000032371463.636453.3058carassius_auratusENSCARP0000008402767.841456.8282
ENSG00000175766homo_sapiensENSP0000032371454.958745.8678astyanax_mexicanusENSAMXP0000005432768.556757.2165
ENSG00000175766homo_sapiensENSP0000032371466.115757.0248ictalurus_punctatusENSIPUP0000003057174.074163.8889
ENSG00000175766homo_sapiensENSP0000032371464.462854.5455esox_luciusENSELUP0000004102766.38356.1702
ENSG00000175766homo_sapiensENSP0000032371465.289354.9587electrophorus_electricusENSEEEP0000003266373.488461.8605
ENSG00000175766homo_sapiensENSP0000032371465.702556.1983oncorhynchus_kisutchENSOKIP0000511367573.271962.6728
ENSG00000175766homo_sapiensENSP0000032371465.289355.3719oncorhynchus_mykissENSOMYP0000010585572.146161.1872
ENSG00000175766homo_sapiensENSP0000032371465.702555.7851salmo_salarENSSSAP0000001288472.602761.6438
ENSG00000175766homo_sapiensENSP0000032371465.702555.7851salmo_truttaENSSTUP0000010815072.602761.6438
ENSG00000175766homo_sapiensENSP0000032371449.586844.2149chrysemys_picta_belliiENSCPBP0000003226890.909181.0606
ENSG00000175766homo_sapiensENSP0000032371469.834760.7438sphenodon_punctatusENSSPUP0000000829477.522967.4312
ENSG00000175766homo_sapiensENSP0000032371466.942159.0909crocodylus_porosusENSCPRP0000501950042.187537.2396
ENSG00000175766homo_sapiensENSP0000032371448.347140.9091laticauda_laticaudataENSLLTP0000001125188.636475
ENSG00000175766homo_sapiensENSP0000032371448.347140.9091notechis_scutatusENSNSUP0000001029288.636475
ENSG00000175766homo_sapiensENSP0000032371448.347140.9091pseudonaja_textilisENSPTXP0000002023188.636475
ENSG00000175766homo_sapiensENSP0000032371442.975239.6694anas_platyrhynchos_platyrhynchosENSAPLP0000000176088.888982.0513
ENSG00000175766homo_sapiensENSP0000032371468.181860.7438meleagris_gallopavoENSMGAP0000002542078.199169.6682
ENSG00000175766homo_sapiensENSP0000032371467.355459.5041serinus_canariaENSSCAP0000001840778.365469.2308
ENSG00000175766homo_sapiensENSP0000032371471.900862.3967parus_majorENSPMJP0000000944966.666757.8544
ENSG00000175766homo_sapiensENSP0000032371469.834761.157anolis_carolinensisENSACAP0000000690480.094870.1422
ENSG00000175766homo_sapiensENSP0000032371447.520741.7355naja_najaENSNNAP0000001438772.32763.522
ENSG00000175766homo_sapiensENSP0000032371448.347141.3223naja_najaENSNNAP0000002624888.636475.7576
ENSG00000175766homo_sapiensENSP000003237145042.9752podarcis_muralisENSPMRP0000001194091.666778.7879
ENSG00000175766homo_sapiensENSP0000032371467.355460.3306geospiza_fortisENSGFOP0000000251678.365470.1923
ENSG00000175766homo_sapiensENSP0000032371470.661261.9835taeniopygia_guttataENSTGUP0000003236566.53758.3658
ENSG00000175766homo_sapiensENSP0000032371445.041334.2975erpetoichthys_calabaricusENSECRP0000003094864.117648.8235
ENSG00000175766homo_sapiensENSP0000032371456.611647.9339salvator_merianaeENSSMRP0000000847189.542575.817
ENSG00000175766homo_sapiensENSP0000032371454.132248.7603gopherus_evgoodeiENSGEVP0000501052188.513579.7297
ENSG00000175766homo_sapiensENSP0000032371449.586843.8017chelonoidis_abingdoniiENSCABP0000002488990.909180.303
ENSG00000175766homo_sapiensENSP0000032371447.933942.1488struthio_camelus_australisENSSCUP0000000757781.118971.3287
ENSG00000175766homo_sapiensENSP0000032371469.421562.3967anser_brachyrhynchusENSABRP0000001946777.419469.5853
ENSG00000175766homo_sapiensENSP0000032371469.008360.3306strigops_habroptilaENSSHBP0000501124966.533958.1673
ENSG00000175766homo_sapiensENSP0000032371465.702559.0909terrapene_carolina_triunguisENSTMTP0000001024876.811669.0821
ENSG00000175766homo_sapiensENSP0000032371465.289355.3719hucho_huchoENSHHUP0000007559772.146161.1872
ENSG00000175766homo_sapiensENSP0000032371465.289354.5455pygocentrus_nattereriENSPNAP0000000033073.488461.3953
ENSG00000175766homo_sapiensENSP0000032371445.041326.4463saccharomyces_cerevisiaeYOL139C51.173730.0469
ENSG00000175766homo_sapiensENSP0000032371465.702556.1983oncorhynchus_tshawytschaENSOTSP0000507975172.935862.3853
ENSG00000175766homo_sapiensENSP0000032371449.173643.3884aquila_chrysaetos_chrysaetosENSACCP0002002328790.151579.5455
ENSG00000175766homo_sapiensENSP0000032371465.289355.3719denticeps_clupeoidesENSDCDP0000003523774.528363.2075
ENSG00000175766homo_sapiensENSP0000032371471.900862.3967ficedula_albicollisENSFALP0000000898161.484153.3569
ENSG00000175766homo_sapiensENSP0000032371461.15751.2397cyprinus_carpio_carpioENSCCRP0000009502175.897463.5897
ENSG00000175766homo_sapiensENSP0000032371468.181855.7851cyprinus_carpio_carpioENSCCRP0000009128764.705952.9412
ENSG00000175766homo_sapiensENSP0000032371469.008360.7438coturnix_japonicaENSCJPP0000501325669.008360.7438
ENSG00000175766homo_sapiensENSP0000032371447.520738.0165sinocyclocheilus_grahamiENSSGRP0000006640653.990643.1925
ENSG00000175766homo_sapiensENSP0000032371453.71942.9752sinocyclocheilus_grahamiENSSGRP0000002628564.356451.4851
ENSG00000175766homo_sapiensENSP0000032371465.289355.3719paramormyrops_kingsleyaeENSPKIP0000001029574.528363.2075
ENSG00000175766homo_sapiensENSP0000032371464.462854.9587scleropages_formosusENSSFOP0001500839571.232960.7306

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000340enables RNA 7-methylguanosine cap binding1IBAHomo_sapiens(9606)Function
GO:0003743enables translation initiation factor activity1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005845part_of mRNA cap binding complex1ISSHomo_sapiens(9606)Component
GO:0006413involved_in translational initiation1IEAHomo_sapiens(9606)Process
GO:0006417involved_in regulation of translation1IEAHomo_sapiens(9606)Process
GO:0016281part_of eukaryotic translation initiation factor 4F complex1IBAHomo_sapiens(9606)Component

Expression