RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000175093	Gene ID	92369	Accession	30630
Symbol	SPSB4	Alias	SSB4;SSB-4	Full Name	splA/ryanodine receptor domain and SOCS box containing 4
Status	Confidence	Length	97265 bases	Strand	Plus strand
Position	3 : 141051347 - 141148611	RNA binding domain	SPRY
Summary	Enables ubiquitin ligase-substrate adaptor activity. Involved in cellular protein metabolic process; positive regulation of protein polyubiquitination; and regulation of circadian rhythm. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000311609	SPRY	PF00622	3.3e-18	1
ENSP00000422034	SPRY	PF00622	1.2e-09	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
SPSB4-201	ENST00000310546	2963	273aa	ENSP00000311609
SPSB4-203	ENST00000508126	1752	90aa	ENSP00000422034
SPSB4-204	ENST00000508828	537	No protein	-
SPSB4-202	ENST00000507895	576	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
8467	Atrial Fibrillation	5.42076881911287E-7	17903304
8481	Atrial Fibrillation	1.3375363234802E-6	17903304
27970	Diabetes Mellitus	4.5830000E-005	-
34914	Platelet Function Tests	6.9500000E-006	-
35824	Platelet Function Tests	1.5343000E-005	-
35928	Platelet Function Tests	1.1960400E-005	-
35930	Platelet Function Tests	1.2910000E-005	-
35947	Platelet Function Tests	4.1400000E-006	-
36016	Platelet Function Tests	7.2800000E-006	-
36018	Platelet Function Tests	7.8900000E-006	-
36038	Platelet Function Tests	2.1000000E-006	-
36126	Platelet Function Tests	1.1960400E-005	-
36128	Platelet Function Tests	1.2910000E-005	-
36145	Platelet Function Tests	4.1400000E-006	-
36709	Platelet Function Tests	9.4500000E-006	-
72805	Stroke	6E-7	23041239
78286	Depressive Disorder	3E-7	27622933
78287	Citalopram	3E-7	27622933
78288	Mood Disorders	3E-7	27622933
95143	Stroke	7E-7	24262325

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006511	involved_in ubiquitin-dependent protein catabolic process	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	2	IDA,IEA	Homo_sapiens(9606)	Process
GO:0019005	part_of SCF ubiquitin ligase complex	1	IBA	Homo_sapiens(9606)	Component
GO:0035556	involved_in intracellular signal transduction	1	IEA	Homo_sapiens(9606)	Process
GO:0042752	involved_in regulation of circadian rhythm	1	IMP	Homo_sapiens(9606)	Process
GO:0043161	involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0048511	involved_in rhythmic process	1	IEA	Homo_sapiens(9606)	Process
GO:1902916	involved_in positive regulation of protein polyubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:1990756	enables ubiquitin ligase-substrate adaptor activity	1	IPI	Homo_sapiens(9606)	Function