RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000174672	Gene ID	9024	Accession	11405
Symbol	BRSK2	Alias	SAD1;SADA;SAD-A;STK29;PEN11B;C11orf7	Full Name	BR serine/threonine kinase 2
Status	Confidence	Length	72791 bases	Strand	Plus strand
Position	11 : 1389899 - 1462689	RNA binding domain	N.A.
Summary	Enables several functions, including ATP binding activity; ATPase binding activity; and protein kinase activity. Involved in several processes, including cellular protein metabolic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of insulin secretion involved in cellular response to glucose stimulus. Located in centrosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
BRSK2-201	ENST00000308219	4089	668aa	ENSP00000310697
BRSK2-209	ENST00000529433	3211	674aa	ENSP00000433684
BRSK2-208	ENST00000528841	4528	736aa	ENSP00000432000
BRSK2-212	ENST00000531197	3163	674aa	ENSP00000431152
BRSK2-204	ENST00000526678	2091	696aa	ENSP00000433370
BRSK2-206	ENST00000528596	581	86aa	ENSP00000434075
BRSK2-203	ENST00000524702	580	130aa	ENSP00000432672
BRSK2-207	ENST00000528710	3528	614aa	ENSP00000433235
BRSK2-202	ENST00000382179	3576	766aa	ENSP00000371614
BRSK2-210	ENST00000529951	1934	170aa	ENSP00000432252
BRSK2-211	ENST00000531078	600	No protein	-
BRSK2-214	ENST00000533606	2319	200aa	ENSP00000436474
BRSK2-205	ENST00000526768	1956	No protein	-
BRSK2-213	ENST00000531932	709	No protein	-
BRSK2-215	ENST00000544817	1842	170aa	ENSP00000445168

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
30360	Potassium	4.4380000E-005	-
79815	Heroin Dependence	4E-6	27936112

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000086	involved_in G2/M transition of mitotic cell cycle	1	IMP	Homo_sapiens(9606)	Process
GO:0000287	enables magnesium ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0004674	enables protein serine/threonine kinase activity	3	IBA,IDA,ISS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005783	located_in endoplasmic reticulum	1	IDA	Homo_sapiens(9606)	Component
GO:0005813	is_active_in centrosome	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0006468	involved_in protein phosphorylation	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0006887	involved_in exocytosis	1	IEA	Homo_sapiens(9606)	Process
GO:0007409	involved_in axonogenesis	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0010975	involved_in regulation of neuron projection development	1	ISS	Homo_sapiens(9606)	Process
GO:0018105	involved_in peptidyl-serine phosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0019901	enables protein kinase binding	1	IEA	Homo_sapiens(9606)	Function
GO:0030010	involved_in establishment of cell polarity	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0030036	involved_in actin cytoskeleton organization	1	IMP	Homo_sapiens(9606)	Process
GO:0030182	involved_in neuron differentiation	1	ISS	Homo_sapiens(9606)	Process
GO:0035556	involved_in intracellular signal transduction	1	IBA	Homo_sapiens(9606)	Process
GO:0036503	involved_in ERAD pathway	1	IMP	Homo_sapiens(9606)	Process
GO:0043462	involved_in regulation of ATP-dependent activity	1	NAS	Homo_sapiens(9606)	Process
GO:0048156	enables tau protein binding	1	NAS	Homo_sapiens(9606)	Function
GO:0048471	located_in perinuclear region of cytoplasm	1	IEA	Homo_sapiens(9606)	Component
GO:0050321	enables tau-protein kinase activity	4	IBA,IDA,ISS,NAS	Homo_sapiens(9606)	Function
GO:0050770	involved_in regulation of axonogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0051117	enables ATPase binding	1	IDA	Homo_sapiens(9606)	Function
GO:0051301	involved_in cell division	1	IEA	Homo_sapiens(9606)	Process
GO:0060590	enables ATPase regulator activity	1	NAS	Homo_sapiens(9606)	Function
GO:0061178	involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	2	IMP,ISS	Homo_sapiens(9606)	Process
GO:0070059	involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1	IMP	Homo_sapiens(9606)	Process
GO:0090176	involved_in microtubule cytoskeleton organization involved in establishment of planar polarity	1	ISS	Homo_sapiens(9606)	Process
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0150034	located_in distal axon	1	ISS	Homo_sapiens(9606)	Component
GO:1904152	involved_in regulation of retrograde protein transport, ER to cytosol	2	IC,NAS	Homo_sapiens(9606)	Process
GO:2000807	involved_in regulation of synaptic vesicle clustering	1	TAS	Homo_sapiens(9606)	Process