Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Nucleoli
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000172995 Gene ID 10777 Accession 16968
Symbol ARPP21 Alias RCS;TARPP;R3HDM3;ARPP-21 Full Name cAMP regulated phosphoprotein 21
Status Confidence Length 155552 bases Strand Plus strand
Position 3 : 35638945 - 35794496 RNA binding domain R3H , SUZ
Summary This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000399482 R3H PF01424 1.4e-12 1
ENSP00000396116 R3H PF01424 1.6e-12 1
ENSP00000408271 R3H PF01424 6.9e-12 1
ENSP00000405276 R3H PF01424 2e-11 1
ENSP00000412326 R3H PF01424 2.1e-11 1
ENSP00000187397 R3H PF01424 2.2e-11 1
ENSP00000187397 SUZ PF12752 1.6e-11 2
ENSP00000506922 R3H PF01424 2.3e-11 1
ENSP00000506922 SUZ PF12752 1.7e-11 2

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
36384944 Ascertaining cells' synaptic connections and RNA expression simultaneously with barcoded rabies virus libraries. Arpiar Saunders 2022-11-16 Nature communications
35283744 Inhibition of miR-128 Enhances Vocal Sequence Organization in Juvenile Songbirds. M Caitlin Aamodt 2022-01-01 Frontiers in behavioral neuroscience

Transcripts

Name Transcript ID bp Protein Translation ID
ARPP21-224 ENST00000450234 611 104aa ENSP00000411644
ARPP21-213 ENST00000428373 3150 89aa ENSP00000412411
ARPP21-209 ENST00000421492 544 32aa ENSP00000398598
ARPP21-221 ENST00000444190 3182 793aa ENSP00000405276
ARPP21-223 ENST00000449196 657 54aa ENSP00000409808
ARPP21-201 ENST00000187397 3433 812aa ENSP00000187397
ARPP21-225 ENST00000452563 620 96aa ENSP00000396324
ARPP21-219 ENST00000438577 590 94aa ENSP00000409331
ARPP21-206 ENST00000414496 715 98aa ENSP00000415134
ARPP21-208 ENST00000419330 543 43aa ENSP00000413005
ARPP21-211 ENST00000427542 568 89aa ENSP00000401602
ARPP21-231 ENST00000474696 572 89aa ENSP00000417838
ARPP21-204 ENST00000412048 2506 89aa ENSP00000390151
ARPP21-203 ENST00000396482 2416 89aa ENSP00000379742
ARPP21-215 ENST00000432682 1015 89aa ENSP00000389754
ARPP21-214 ENST00000432450 574 101aa ENSP00000412341
ARPP21-205 ENST00000413378 550 98aa ENSP00000390169
ARPP21-207 ENST00000417925 3086 813aa ENSP00000412326
ARPP21-202 ENST00000396481 1304 89aa ENSP00000379741
ARPP21-216 ENST00000434383 3124 No protein -
ARPP21-220 ENST00000441454 2880 89aa ENSP00000406964
ARPP21-217 ENST00000436702 561 89aa ENSP00000397720
ARPP21-218 ENST00000438071 1103 89aa ENSP00000410171
ARPP21-227 ENST00000461826 577 No protein -
ARPP21-222 ENST00000446068 700 145aa ENSP00000399482
ARPP21-210 ENST00000425289 781 261aa ENSP00000408271
ARPP21-212 ENST00000427590 787 124aa ENSP00000396116
ARPP21-233 ENST00000476327 305 No protein -
ARPP21-235 ENST00000494494 466 No protein -
ARPP21-234 ENST00000481854 837 No protein -
ARPP21-226 ENST00000457165 2014 241aa ENSP00000412233
ARPP21-228 ENST00000462173 647 No protein -
ARPP21-229 ENST00000463970 420 No protein -
ARPP21-230 ENST00000473138 407 No protein -
ARPP21-232 ENST00000476052 1104 No protein -
ARPP21-236 ENST00000684406 4158 847aa ENSP00000506922

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
9103Echocardiography5.5540043690146E-517903301
54800Fibrinogen3.1530000E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000172995homo_sapiensENSP0000050698051.322838.6243homo_sapiensENSP0000050692268.713151.7119
ENSG00000172995homo_sapiensENSP0000038583947.373735.6566homo_sapiensENSP0000050692255.371941.6765

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000172995homo_sapiensENSP0000050692292.207892.0897nomascus_leucogenysENSNLEP0000000586599.744699.6169
ENSG00000172995homo_sapiensENSP0000050692295.985895.8678pan_paniscusENSPPAP0000001950010099.877
ENSG00000172995homo_sapiensENSP0000050692295.867895.6316pongo_abeliiENSPPYP0000001568910099.7537
ENSG00000172995homo_sapiensENSP0000050692299.881999.7639pan_troglodytesENSPTRP0000002541799.881999.7639
ENSG00000172995homo_sapiensENSP0000050692295.867895.7497gorilla_gorillaENSGGOP0000000913299.87799.754
ENSG00000172995homo_sapiensENSP000005069228.972857.91027ornithorhynchus_anatinusENSOANP0000004616784.444474.4444
ENSG00000172995homo_sapiensENSP0000050692284.651775.6789sarcophilus_harrisiiENSSHAP0000002955585.868376.7665
ENSG00000172995homo_sapiensENSP0000050692271.782863.046notamacropus_eugeniiENSMEUP0000000300174.784765.6827
ENSG00000172995homo_sapiensENSP0000050692291.499489.9646choloepus_hoffmanniENSCHOP0000000741895.67994.0741
ENSG00000172995homo_sapiensENSP0000050692295.749793.1523dasypus_novemcinctusENSDNOP0000001152195.862993.2624
ENSG00000172995homo_sapiensENSP0000050692267.296365.0531erinaceus_europaeusENSEEUP0000001434470.283667.9408
ENSG00000172995homo_sapiensENSP0000050692273.671870.4841echinops_telfairiENSETEP0000001259676.847373.5222
ENSG00000172995homo_sapiensENSP0000050692298.347197.6387callithrix_jacchusENSCJAP0000002260598.931198.2185
ENSG00000172995homo_sapiensENSP0000050692299.409799.0555cercocebus_atysENSCATP0000001632499.527299.1726
ENSG00000172995homo_sapiensENSP0000050692299.645899.2916macaca_fascicularisENSMFAP0000002903696.678196.3345
ENSG00000172995homo_sapiensENSP0000050692299.645899.4097macaca_mulattaENSMMUP0000002099499.645899.4097
ENSG00000172995homo_sapiensENSP0000050692299.645899.4097macaca_nemestrinaENSMNEP0000004260499.645899.4097
ENSG00000172995homo_sapiensENSP0000050692299.527799.1736papio_anubisENSPANP0000000844299.527799.1736
ENSG00000172995homo_sapiensENSP0000050692295.513695.2775mandrillus_leucophaeusENSMLEP0000001492299.50899.262
ENSG00000172995homo_sapiensENSP0000050692276.033173.6718tursiops_truncatusENSTTRP000000029008077.5155
ENSG00000172995homo_sapiensENSP0000050692295.985893.9788vulpes_vulpesENSVVUP0000003010096.21394.2012
ENSG00000172995homo_sapiensENSP0000050692287.367282.7627mus_spretusMGP_SPRETEiJ_P009413491.47186.6502
ENSG00000172995homo_sapiensENSP0000050692296.930395.1594equus_asinusENSEASP0000501032797.044995.2719
ENSG00000172995homo_sapiensENSP0000050692289.492386.3046capra_hircusENSCHIP0000001262393.811990.4703
ENSG00000172995homo_sapiensENSP0000050692290.909188.4297loxodonta_africanaENSLAFP0000001981494.594692.0147
ENSG00000172995homo_sapiensENSP0000050692290.79188.5478panthera_leoENSPLOP0000000971094.821292.4784
ENSG00000172995homo_sapiensENSP0000050692296.103994.3329ailuropoda_melanoleucaENSAMEP0000002286796.217594.4444
ENSG00000172995homo_sapiensENSP0000050692295.041391.7355bos_indicus_hybridENSBIXP0000501728196.06292.7208
ENSG00000172995homo_sapiensENSP0000050692296.103994.6871oryctolagus_cuniculusENSOCUP0000004977396.331494.9112
ENSG00000172995homo_sapiensENSP0000050692296.694294.9233equus_caballusENSECAP0000002061396.694294.9233
ENSG00000172995homo_sapiensENSP0000050692295.631693.6246canis_lupus_familiarisENSCAFP0084503508395.85893.8462
ENSG00000172995homo_sapiensENSP0000050692290.79188.6659panthera_pardusENSPPRP0000001327094.821292.6017
ENSG00000172995homo_sapiensENSP0000050692292.443991.0272marmota_marmota_marmotaENSMMMP0000001381796.3194.8339
ENSG00000172995homo_sapiensENSP0000050692291.735589.1381balaenoptera_musculusENSBMSP0001003123595.689792.9803
ENSG00000172995homo_sapiensENSP0000050692295.277591.6175cavia_porcellusENSCPOP0000003297695.50391.8343
ENSG00000172995homo_sapiensENSP0000050692290.79188.4297felis_catusENSFCAP0000001241994.821292.3551
ENSG00000172995homo_sapiensENSP000005069229.799299.56316ursus_americanusENSUAMP0000002367793.258491.0112
ENSG00000172995homo_sapiensENSP0000050692245.690743.4475ursus_americanusENSUAMP0000002367688.558384.2105
ENSG00000172995homo_sapiensENSP0000050692280.755671.5466monodelphis_domesticaENSMODP0000000281582.310572.9242
ENSG00000172995homo_sapiensENSP0000050692291.263387.9575bison_bison_bisonENSBBBP0000001129995.905792.4318
ENSG00000172995homo_sapiensENSP0000050692291.617588.7839monodon_monocerosENSMMNP0001502230695.566592.6108
ENSG00000172995homo_sapiensENSP0000050692290.67387.7214sus_scrofaENSSSCP0000001198696.240693.1078
ENSG00000172995homo_sapiensENSP0000050692298.22997.2845microcebus_murinusENSMICP0000005148698.345297.3995
ENSG00000172995homo_sapiensENSP0000050692291.735589.1381octodon_degusENSODEP0000000560495.689792.9803
ENSG00000172995homo_sapiensENSP0000050692288.075683.5891jaculus_jaculusENSJJAP0000001727992.212687.5154
ENSG00000172995homo_sapiensENSP0000050692290.909187.8394ovis_aries_rambouilletENSOARP0002003337795.533592.3077
ENSG00000172995homo_sapiensENSP0000050692294.332992.562ursus_maritimusENSUMAP0000000862195.803494.0048
ENSG00000172995homo_sapiensENSP0000050692271.310568.595ochotona_princepsENSOPRP0000000944377.535374.5828
ENSG00000172995homo_sapiensENSP0000050692295.749792.7981delphinapterus_leucasENSDLEP0000001493995.862992.9078
ENSG00000172995homo_sapiensENSP0000050692291.971789.2562physeter_catodonENSPCTP0000500900495.93693.1034
ENSG00000172995homo_sapiensENSP0000050692287.721483.1169mus_caroliMGP_CAROLIEiJ_P009040391.841887.021
ENSG00000172995homo_sapiensENSP0000050692287.721482.7627mus_musculusENSMUSP0000010750391.841886.6502
ENSG00000172995homo_sapiensENSP0000050692290.436887.4852dipodomys_ordiiENSDORP0000001628194.567991.4815
ENSG00000172995homo_sapiensENSP0000050692294.923392.562mustela_putorius_furoENSMPUP0000000294295.147992.7811
ENSG00000172995homo_sapiensENSP0000050692295.277594.451aotus_nancymaaeENSANAP0000003533699.506898.6436
ENSG00000172995homo_sapiensENSP0000050692298.819498.229saimiri_boliviensis_boliviensisENSSBOP0000002603199.170698.5782
ENSG00000172995homo_sapiensENSP0000050692279.456977.0956vicugna_pacosENSVPAP0000001168583.706581.2189
ENSG00000172995homo_sapiensENSP0000050692299.291698.8194chlorocebus_sabaeusENSCSAP0000000557599.40998.9362
ENSG00000172995homo_sapiensENSP0000050692259.740358.9138tupaia_belangeriENSTBEP0000000317562.392161.529
ENSG00000172995homo_sapiensENSP0000050692285.005979.575mesocricetus_auratusENSMAUP0000002503888.6783.0049
ENSG00000172995homo_sapiensENSP0000050692291.735588.902phocoena_sinusENSPSNP0000002929295.689792.734
ENSG00000172995homo_sapiensENSP0000050692294.805291.3813camelus_dromedariusENSCDRP0000502008896.167792.6946
ENSG00000172995homo_sapiensENSP0000050692277.80477.3318carlito_syrichtaENSTSYP0000002050097.197696.6077
ENSG00000172995homo_sapiensENSP0000050692290.67388.4297panthera_tigris_altaicaENSPTIP0000000290194.697992.3551
ENSG00000172995homo_sapiensENSP0000050692291.971787.2491rattus_norvegicusENSRNOP0000006966192.408187.6631
ENSG00000172995homo_sapiensENSP0000050692294.332993.2704prolemur_simusENSPSMP0000001499598.39997.2906
ENSG00000172995homo_sapiensENSP000005069229.208978.73672microtus_ochrogasterENSMOCP0000000506589.655285.0575
ENSG00000172995homo_sapiensENSP0000050692280.755677.686sorex_araneusENSSARP0000000726884.863581.6377
ENSG00000172995homo_sapiensENSP0000050692288.547884.7698peromyscus_maniculatus_bairdiiENSPEMP0000000793092.70788.7515
ENSG00000172995homo_sapiensENSP0000050692295.041391.6175bos_mutusENSBMUP0000002642896.06292.6014
ENSG00000172995homo_sapiensENSP0000050692287.603382.9988mus_spicilegusENSMSIP0000003395691.718286.8974
ENSG00000172995homo_sapiensENSP0000050692288.547883.8253cricetulus_griseus_chok1gshdENSCGRP0000101028692.821887.8713
ENSG00000172995homo_sapiensENSP0000050692288.90286.8949pteropus_vampyrusENSPVAP0000001508992.96390.8642
ENSG00000172995homo_sapiensENSP0000050692291.853689.7285myotis_lucifugusENSMLUP0000001231796.049493.8272
ENSG00000172995homo_sapiensENSP000005069228.264467.79221vombatus_ursinusENSVURP0001002383580.459875.8621
ENSG00000172995homo_sapiensENSP0000050692235.891431.9953vombatus_ursinusENSVURP0001002375381.283472.4599
ENSG00000172995homo_sapiensENSP0000050692291.145288.902rhinolophus_ferrumequinumENSRFEP0001003292895.544693.1931
ENSG00000172995homo_sapiensENSP0000050692291.263389.1381neovison_visonENSNVIP0000001013595.432193.2099
ENSG00000172995homo_sapiensENSP0000050692295.041391.7355bos_taurusENSBTAP0000006268996.06292.7208
ENSG00000172995homo_sapiensENSP0000050692295.867894.0968heterocephalus_glaber_femaleENSHGLP0000000175595.981194.208
ENSG00000172995homo_sapiensENSP0000050692293.152391.8536rhinopithecus_bietiENSRBIP0000000081598.134396.7662
ENSG00000172995homo_sapiensENSP0000050692289.846587.9575canis_lupus_dingoENSCAFP0002000196295.244193.2416
ENSG00000172995homo_sapiensENSP0000050692292.6891.2633sciurus_vulgarisENSSVLP0000501935996.674995.197
ENSG00000172995homo_sapiensENSP0000050692283.35374.4982phascolarctos_cinereusENSPCIP0000001352785.060276.0241
ENSG00000172995homo_sapiensENSP0000050692278.394374.8524procavia_capensisENSPCAP0000001032882.076678.3684
ENSG00000172995homo_sapiensENSP000005069229.44518.85478nannospalax_galiliENSNGAP0000001534890.909185.2273
ENSG00000172995homo_sapiensENSP0000050692294.923391.6175bos_grunniensENSBGRP0000002789095.942792.6014
ENSG00000172995homo_sapiensENSP0000050692296.458193.7426chinchilla_lanigeraENSCLAP0000001124796.572193.8534
ENSG00000172995homo_sapiensENSP0000050692294.569190.5549cervus_hanglu_yarkandensisENSCHYP0000003571295.243891.201
ENSG00000172995homo_sapiensENSP0000050692292.207889.3743catagonus_wagneriENSCWAP0000002708496.538993.5723
ENSG00000172995homo_sapiensENSP0000050692292.56291.1452ictidomys_tridecemlineatusENSSTOP0000002879796.43394.9569
ENSG00000172995homo_sapiensENSP0000050692292.916291.6175otolemur_garnettiiENSOGAP0000000867596.921295.5665
ENSG00000172995homo_sapiensENSP0000050692294.805294.0968cebus_imitatorENSCCAP0000002986198.891698.1527
ENSG00000172995homo_sapiensENSP0000050692296.458195.0413urocitellus_parryiiENSUPAP0001000615896.458195.0413
ENSG00000172995homo_sapiensENSP0000050692291.499488.0756moschus_moschiferusENSMMSP0000003270396.034792.4411
ENSG00000172995homo_sapiensENSP0000050692299.291698.7013rhinopithecus_roxellanaENSRROP0000002737299.291698.7013
ENSG00000172995homo_sapiensENSP0000050692288.193683.7072mus_pahariMGP_PahariEiJ_P002607992.336287.6391
ENSG00000172995homo_sapiensENSP0000050692294.096893.2704propithecus_coquereliENSPCOP0000001349498.152797.2906
ENSG00000172995homo_sapiensENSP0000050692228.217217.3554caenorhabditis_elegansZK121.2.142.831526.3441
ENSG00000172995homo_sapiensENSP0000050692244.5128.0992drosophila_melanogasterFBpp030541019.41312.2554
ENSG00000172995homo_sapiensENSP0000050692215.46649.79929ciona_intestinalisENSCINP0000003087567.179542.5641
ENSG00000172995homo_sapiensENSP0000050692233.766220.307eptatretus_burgeriENSEBUP0000001700134.624720.8232
ENSG00000172995homo_sapiensENSP0000050692282.998872.6092callorhinchus_miliiENSCMIP0000003067583.293872.8673
ENSG00000172995homo_sapiensENSP0000050692264.698957.1429latimeria_chalumnaeENSLACP0000000760281.185271.7037
ENSG00000172995homo_sapiensENSP0000050692276.151163.9906lepisosteus_oculatusENSLOCP0000000569877.338164.988
ENSG00000172995homo_sapiensENSP0000050692220.779210.7438oncorhynchus_mykissENSOMYP000001299399.84345.08949
ENSG00000172995homo_sapiensENSP0000050692288.075680.8737chrysemys_picta_belliiENSCPBP0000001854987.047879.93
ENSG00000172995homo_sapiensENSP0000050692272.727365.8796sphenodon_punctatusENSSPUP0000000948388.888980.5195
ENSG00000172995homo_sapiensENSP0000050692278.748571.1924crocodylus_porosusENSCPRP0000501317386.287278.0078
ENSG00000172995homo_sapiensENSP0000050692288.429781.2279anas_platyrhynchos_platyrhynchosENSAPLP0000003200587.397980.28
ENSG00000172995homo_sapiensENSP0000050692288.665981.2279gallus_gallusENSGALP0001002642286.321879.0805
ENSG00000172995homo_sapiensENSP0000050692288.665981.3459meleagris_gallopavoENSMGAP0000001250186.321879.1954
ENSG00000172995homo_sapiensENSP0000050692287.839481.1098serinus_canariaENSSCAP0000001429787.426680.7286
ENSG00000172995homo_sapiensENSP0000050692288.193680.9917parus_majorENSPMJP0000001561786.258779.2148
ENSG00000172995homo_sapiensENSP0000050692284.297575.0885anolis_carolinensisENSACAP0000001005886.231976.8116
ENSG00000172995homo_sapiensENSP0000050692285.24276.7414podarcis_muralisENSPMRP0000002873586.363677.7512
ENSG00000172995homo_sapiensENSP0000050692287.839481.1098geospiza_fortisENSGFOP0000001858586.011679.422
ENSG00000172995homo_sapiensENSP0000050692287.957581.2279taeniopygia_guttataENSTGUP0000003227287.441380.7512
ENSG00000172995homo_sapiensENSP0000050692258.795747.9339erpetoichthys_calabaricusENSECRP0000002960382.31467.1074
ENSG00000172995homo_sapiensENSP0000050692278.984671.6647salvator_merianaeENSSMRP0000000737987.109479.0365
ENSG00000172995homo_sapiensENSP0000050692287.721480.4014pelodiscus_sinensisENSPSIP0000001033787.206679.9296
ENSG00000172995homo_sapiensENSP0000050692280.519573.0815gopherus_evgoodeiENSGEVP0000501043986.87978.8535
ENSG00000172995homo_sapiensENSP0000050692241.558438.0165chelonoidis_abingdoniiENSCABP000000312318880.5
ENSG00000172995homo_sapiensENSP0000050692281.936275.5608struthio_camelus_australisENSSCUP0000002119187.73780.9102
ENSG00000172995homo_sapiensENSP0000050692288.429781.2279anser_brachyrhynchusENSABRP0000001459387.807780.6565
ENSG00000172995homo_sapiensENSP0000050692278.630572.0189strigops_habroptilaENSSHBP0000502131585.935578.7097
ENSG00000172995homo_sapiensENSP0000050692280.401472.9634terrapene_carolina_triunguisENSTMTP0000003176886.862278.8265
ENSG00000172995homo_sapiensENSP0000050692280.637573.0815terrapene_carolina_triunguisENSTMTP0000002822387.228679.0549
ENSG00000172995homo_sapiensENSP0000050692214.99418.85478ciona_savignyiENSCSAVP0000001018246.520127.4725
ENSG00000172995homo_sapiensENSP0000050692288.311781.9362aquila_chrysaetos_chrysaetosENSACCP0002000166985.97779.7701
ENSG00000172995homo_sapiensENSP0000050692279.69372.7273ficedula_albicollisENSFALP0000002193987.322179.6895
ENSG00000172995homo_sapiensENSP0000050692285.596278.7485coturnix_japonicaENSCJPP0000501814186.722579.7847
ENSG00000172995homo_sapiensENSP0000050692272.491159.1499paramormyrops_kingsleyaeENSPKIP0000002982972.576859.2199
ENSG00000172995homo_sapiensENSP0000050692274.262161.039scleropages_formosusENSSFOP0001505179674.174560.967

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003674enables molecular_function1NDHomo_sapiens(9606)Function
GO:0003676enables nucleic acid binding1IEAHomo_sapiens(9606)Function
GO:0005516enables calmodulin binding1IEAHomo_sapiens(9606)Function
GO:0005575is_active_in cellular_component1NDHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0008150involved_in biological_process1NDHomo_sapiens(9606)Process

Expression