RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	rRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000171861	Gene ID	55178	Accession	18485
Symbol	MRM3	Alias	RMTL1;RNMTL1	Full Name	mitochondrial rRNA methyltransferase 3
Status	Confidence	Length	10157 bases	Strand	Plus strand
Position	17 : 782353 - 792509	RNA binding domain	SpoU_methylase
Summary	Efficient translation of mitochondrial-derived transcripts requires proper assembly of the large subunit of the mitochondrial ribosome. Central to the biogenesis of this large subunit is the A-loop of mitochondrial 16S rRNA, which is modified by three rRNA methyltransferases located near mtDNA nucleoids. The protein encoded by this gene methylates G(1370) of 16S rRNA, and this modification is necessary for proper ribosomal large subnit assembly. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000306080	SpoU_methylase	PF00588	5.8e-21	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
MRM3-201	ENST00000304478	1729	420aa	ENSP00000306080
MRM3-204	ENST00000574916	770	No protein	-
MRM3-203	ENST00000574509	727	110aa	ENSP00000458328
MRM3-202	ENST00000571157	572	177aa	ENSP00000460957

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
75296	Diabetes Mellitus, Type 2	4E-6	23300278

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000171861	homo_sapiens	ENSP00000040877	11.351	6.29241	homo_sapiens	ENSP00000306080	43.8095	24.2857
ENSG00000171861	homo_sapiens	ENSP00000481559	31.4448	15.864	homo_sapiens	ENSP00000306080	26.4286	13.3333

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000171861	homo_sapiens	ENSP00000306080	97.8571	95.9524	nomascus_leucogenys	ENSNLEP00000025830	97.8571	95.9524
ENSG00000171861	homo_sapiens	ENSP00000306080	100	99.5238	pan_paniscus	ENSPPAP00000031099	100	99.5238
ENSG00000171861	homo_sapiens	ENSP00000306080	98.5714	96.9048	pongo_abelii	ENSPPYP00000008745	98.5714	96.9048
ENSG00000171861	homo_sapiens	ENSP00000306080	100	99.7619	pan_troglodytes	ENSPTRP00000014527	100	99.7619
ENSG00000171861	homo_sapiens	ENSP00000306080	100	100	gorilla_gorilla	ENSGGOP00000015137	100	100
ENSG00000171861	homo_sapiens	ENSP00000306080	47.619	28.0952	ornithorhynchus_anatinus	ENSOANP00000034789	13.0719	7.71242
ENSG00000171861	homo_sapiens	ENSP00000306080	79.7619	67.619	sarcophilus_harrisii	ENSSHAP00000013599	73.9514	62.6932
ENSG00000171861	homo_sapiens	ENSP00000306080	65.2381	58.3333	notamacropus_eugenii	ENSMEUP00000011131	91.0299	81.3953
ENSG00000171861	homo_sapiens	ENSP00000306080	89.7619	82.381	choloepus_hoffmanni	ENSCHOP00000010075	89.9761	82.5776
ENSG00000171861	homo_sapiens	ENSP00000306080	91.4286	82.381	dasypus_novemcinctus	ENSDNOP00000003311	91.6468	82.5776
ENSG00000171861	homo_sapiens	ENSP00000306080	56.9048	49.2857	erinaceus_europaeus	ENSEEUP00000000558	60.0503	52.0101
ENSG00000171861	homo_sapiens	ENSP00000306080	58.5714	53.0952	echinops_telfairi	ENSETEP00000014502	58.4323	52.9691
ENSG00000171861	homo_sapiens	ENSP00000306080	80.9524	74.0476	callithrix_jacchus	ENSCJAP00000091428	67.4603	61.7063
ENSG00000171861	homo_sapiens	ENSP00000306080	97.381	95	cercocebus_atys	ENSCATP00000016300	97.381	95
ENSG00000171861	homo_sapiens	ENSP00000306080	96.6667	94.0476	macaca_fascicularis	ENSMFAP00000028025	96.6667	94.0476
ENSG00000171861	homo_sapiens	ENSP00000306080	96.4286	93.5714	macaca_mulatta	ENSMMUP00000077046	96.4286	93.5714
ENSG00000171861	homo_sapiens	ENSP00000306080	96.4286	93.8095	macaca_nemestrina	ENSMNEP00000017800	96.4286	93.8095
ENSG00000171861	homo_sapiens	ENSP00000306080	96.6667	94.5238	papio_anubis	ENSPANP00000019465	96.4371	94.2993
ENSG00000171861	homo_sapiens	ENSP00000306080	96.4286	94.5238	mandrillus_leucophaeus	ENSMLEP00000020194	96.4286	94.5238
ENSG00000171861	homo_sapiens	ENSP00000306080	90.4762	81.9048	tursiops_truncatus	ENSTTRP00000003610	89.8345	81.3239
ENSG00000171861	homo_sapiens	ENSP00000306080	90.4762	82.619	vulpes_vulpes	ENSVVUP00000029517	80.1688	73.2067
ENSG00000171861	homo_sapiens	ENSP00000306080	89.5238	80.7143	mus_spretus	MGP_SPRETEiJ_P0029743	89.9522	81.1005
ENSG00000171861	homo_sapiens	ENSP00000306080	90.9524	84.7619	equus_asinus	ENSEASP00005043348	90.9524	84.7619
ENSG00000171861	homo_sapiens	ENSP00000306080	91.4286	83.0952	capra_hircus	ENSCHIP00000030510	91.2114	82.8979
ENSG00000171861	homo_sapiens	ENSP00000306080	90.7143	82.619	loxodonta_africana	ENSLAFP00000013977	90.0709	82.0331
ENSG00000171861	homo_sapiens	ENSP00000306080	89.2857	82.1429	panthera_leo	ENSPLOP00000022946	77.6398	71.4286
ENSG00000171861	homo_sapiens	ENSP00000306080	90.7143	83.8095	ailuropoda_melanoleuca	ENSAMEP00000008781	90.0709	83.2151
ENSG00000171861	homo_sapiens	ENSP00000306080	85.9524	78.0952	oryctolagus_cuniculus	ENSOCUP00000001912	87.4092	79.4189
ENSG00000171861	homo_sapiens	ENSP00000306080	90.2381	84.0476	equus_caballus	ENSECAP00000021875	85.553	79.684
ENSG00000171861	homo_sapiens	ENSP00000306080	90.7143	83.8095	canis_lupus_familiaris	ENSCAFP00845019077	90.0709	83.2151
ENSG00000171861	homo_sapiens	ENSP00000306080	89.2857	82.381	panthera_pardus	ENSPPRP00000015504	89.0736	82.1853
ENSG00000171861	homo_sapiens	ENSP00000306080	90.9524	83.8095	marmota_marmota_marmota	ENSMMMP00000027640	90.9524	83.8095
ENSG00000171861	homo_sapiens	ENSP00000306080	89.7619	80.2381	balaenoptera_musculus	ENSBMSP00010024623	88.7059	79.2941
ENSG00000171861	homo_sapiens	ENSP00000306080	90.7143	84.5238	cavia_porcellus	ENSCPOP00000015960	89.6471	83.5294
ENSG00000171861	homo_sapiens	ENSP00000306080	89.5238	83.0952	felis_catus	ENSFCAP00000001552	77.8468	72.2567
ENSG00000171861	homo_sapiens	ENSP00000306080	90.7143	83.0952	ursus_americanus	ENSUAMP00000017204	90.0709	82.5059
ENSG00000171861	homo_sapiens	ENSP00000306080	79.7619	69.7619	monodelphis_domestica	ENSMODP00000012561	74.7768	65.4018
ENSG00000171861	homo_sapiens	ENSP00000306080	90.4762	82.381	bison_bison_bison	ENSBBBP00000012988	91.7874	83.5749
ENSG00000171861	homo_sapiens	ENSP00000306080	91.1905	82.619	monodon_monoceros	ENSMMNP00015029372	90.5437	82.0331
ENSG00000171861	homo_sapiens	ENSP00000306080	90.4762	82.1429	sus_scrofa	ENSSSCP00000018865	90.0474	81.7536
ENSG00000171861	homo_sapiens	ENSP00000306080	92.1429	85.9524	microcebus_murinus	ENSMICP00000037609	92.1429	85.9524
ENSG00000171861	homo_sapiens	ENSP00000306080	81.4286	74.7619	octodon_degus	ENSODEP00000012713	93.188	85.5586
ENSG00000171861	homo_sapiens	ENSP00000306080	87.381	77.8571	jaculus_jaculus	ENSJJAP00000024840	88.4337	78.7952
ENSG00000171861	homo_sapiens	ENSP00000306080	91.6667	82.619	ovis_aries_rambouillet	ENSOARP00020015710	91.0165	82.0331
ENSG00000171861	homo_sapiens	ENSP00000306080	90.7143	83.3333	ursus_maritimus	ENSUMAP00000013646	90.0709	82.7423
ENSG00000171861	homo_sapiens	ENSP00000306080	60	53.8095	ochotona_princeps	ENSOPRP00000002318	67.9245	60.9164
ENSG00000171861	homo_sapiens	ENSP00000306080	91.1905	82.619	delphinapterus_leucas	ENSDLEP00000010381	90.5437	82.0331
ENSG00000171861	homo_sapiens	ENSP00000306080	90.2381	81.6667	physeter_catodon	ENSPCTP00005007567	72.4665	65.5832
ENSG00000171861	homo_sapiens	ENSP00000306080	89.0476	81.6667	mus_caroli	MGP_CAROLIEiJ_P0028349	89.4737	82.0574
ENSG00000171861	homo_sapiens	ENSP00000306080	89.0476	80.7143	mus_musculus	ENSMUSP00000042882	89.4737	81.1005
ENSG00000171861	homo_sapiens	ENSP00000306080	88.0952	78.5714	dipodomys_ordii	ENSDORP00000007086	89.5884	79.9031
ENSG00000171861	homo_sapiens	ENSP00000306080	77.8571	70	mustela_putorius_furo	ENSMPUP00000013690	89.3443	80.3279
ENSG00000171861	homo_sapiens	ENSP00000306080	94.0476	89.2857	aotus_nancymaae	ENSANAP00000001682	92.0746	87.4126
ENSG00000171861	homo_sapiens	ENSP00000306080	93.3333	88.5714	saimiri_boliviensis_boliviensis	ENSSBOP00000026244	93.7799	88.9952
ENSG00000171861	homo_sapiens	ENSP00000306080	93.0952	84.0476	vicugna_pacos	ENSVPAP00000008721	92.435	83.4515
ENSG00000171861	homo_sapiens	ENSP00000306080	97.1429	95	chlorocebus_sabaeus	ENSCSAP00000010375	97.1429	95
ENSG00000171861	homo_sapiens	ENSP00000306080	90	82.1429	mesocricetus_auratus	ENSMAUP00000020945	90.2148	82.3389
ENSG00000171861	homo_sapiens	ENSP00000306080	90.9524	81.9048	phocoena_sinus	ENSPSNP00000030758	90.3073	81.3239
ENSG00000171861	homo_sapiens	ENSP00000306080	90.4762	81.4286	camelus_dromedarius	ENSCDRP00005019802	82.7887	74.5098
ENSG00000171861	homo_sapiens	ENSP00000306080	92.381	85.7143	carlito_syrichta	ENSTSYP00000005551	92.1615	85.5107
ENSG00000171861	homo_sapiens	ENSP00000306080	88.8095	82.619	panthera_tigris_altaica	ENSPTIP00000025627	88.8095	82.619
ENSG00000171861	homo_sapiens	ENSP00000306080	89.5238	82.1429	rattus_norvegicus	ENSRNOP00000053117	89.9522	82.5359
ENSG00000171861	homo_sapiens	ENSP00000306080	92.8571	86.4286	prolemur_simus	ENSPSMP00000001325	92.6366	86.2233
ENSG00000171861	homo_sapiens	ENSP00000306080	90.7143	82.1429	microtus_ochrogaster	ENSMOCP00000021364	90.9308	82.3389
ENSG00000171861	homo_sapiens	ENSP00000306080	81.6667	73.3333	sorex_araneus	ENSSARP00000005596	86.398	77.5819
ENSG00000171861	homo_sapiens	ENSP00000306080	90.4762	82.619	peromyscus_maniculatus_bairdii	ENSPEMP00000026360	90.4762	82.619
ENSG00000171861	homo_sapiens	ENSP00000306080	88.8095	79.5238	mus_spicilegus	ENSMSIP00000029570	89.2345	79.9043
ENSG00000171861	homo_sapiens	ENSP00000306080	90.7143	82.8571	cricetulus_griseus_chok1gshd	ENSCGRP00001013504	90.9308	83.0549
ENSG00000171861	homo_sapiens	ENSP00000306080	90.4762	82.619	pteropus_vampyrus	ENSPVAP00000011038	90.2613	82.4228
ENSG00000171861	homo_sapiens	ENSP00000306080	90.7143	82.619	myotis_lucifugus	ENSMLUP00000001379	90.7143	82.619
ENSG00000171861	homo_sapiens	ENSP00000306080	76.9048	68.8095	vombatus_ursinus	ENSVURP00010011059	73.7443	65.9817
ENSG00000171861	homo_sapiens	ENSP00000306080	89.7619	82.381	rhinolophus_ferrumequinum	ENSRFEP00010015052	90.1914	82.7751
ENSG00000171861	homo_sapiens	ENSP00000306080	90.9524	82.8571	neovison_vison	ENSNVIP00000009053	90.3073	82.2695
ENSG00000171861	homo_sapiens	ENSP00000306080	92.381	84.7619	heterocephalus_glaber_female	ENSHGLP00000013353	91.9431	84.3602
ENSG00000171861	homo_sapiens	ENSP00000306080	95.7143	93.0952	rhinopithecus_bieti	ENSRBIP00000041847	95.4869	92.8741
ENSG00000171861	homo_sapiens	ENSP00000306080	90.7143	83.8095	canis_lupus_dingo	ENSCAFP00020013634	90.0709	83.2151
ENSG00000171861	homo_sapiens	ENSP00000306080	91.6667	84.5238	sciurus_vulgaris	ENSSVLP00005017296	91.6667	84.5238
ENSG00000171861	homo_sapiens	ENSP00000306080	77.619	68.8095	phascolarctos_cinereus	ENSPCIP00000034743	72.6058	64.3653
ENSG00000171861	homo_sapiens	ENSP00000306080	88.8095	80.9524	procavia_capensis	ENSPCAP00000007496	88.5986	80.7601
ENSG00000171861	homo_sapiens	ENSP00000306080	91.1905	85.2381	nannospalax_galili	ENSNGAP00000008266	91.1905	85.2381
ENSG00000171861	homo_sapiens	ENSP00000306080	90.4762	82.381	bos_grunniens	ENSBGRP00000025230	91.7874	83.5749
ENSG00000171861	homo_sapiens	ENSP00000306080	91.4286	83.8095	chinchilla_lanigera	ENSCLAP00000012431	90.3529	82.8235
ENSG00000171861	homo_sapiens	ENSP00000306080	91.1905	82.619	cervus_hanglu_yarkandensis	ENSCHYP00000013534	90.9739	82.4228
ENSG00000171861	homo_sapiens	ENSP00000306080	92.1429	84.7619	ictidomys_tridecemlineatus	ENSSTOP00000014703	92.3628	84.9642
ENSG00000171861	homo_sapiens	ENSP00000306080	91.9048	85.7143	otolemur_garnettii	ENSOGAP00000001209	91.9048	85.7143
ENSG00000171861	homo_sapiens	ENSP00000306080	93.8095	89.0476	cebus_imitator	ENSCCAP00000040623	94.2584	89.4737
ENSG00000171861	homo_sapiens	ENSP00000306080	92.1429	85.2381	urocitellus_parryii	ENSUPAP00010023464	92.3628	85.4415
ENSG00000171861	homo_sapiens	ENSP00000306080	92.1429	83.3333	moschus_moschiferus	ENSMMSP00000016098	91.7062	82.9384
ENSG00000171861	homo_sapiens	ENSP00000306080	95.9524	93.8095	rhinopithecus_roxellana	ENSRROP00000036512	93.9394	91.8415
ENSG00000171861	homo_sapiens	ENSP00000306080	89.2857	81.4286	mus_pahari	MGP_PahariEiJ_P0035090	89.7129	81.8182
ENSG00000171861	homo_sapiens	ENSP00000306080	92.381	86.6667	propithecus_coquereli	ENSPCOP00000004281	92.1615	86.4608
ENSG00000171861	homo_sapiens	ENSP00000306080	26.9048	10.9524	caenorhabditis_elegans	T14B4.1.1	9.22449	3.7551
ENSG00000171861	homo_sapiens	ENSP00000306080	50.4762	36.6667	petromyzon_marinus	ENSPMAP00000001757	61.9883	45.0292
ENSG00000171861	homo_sapiens	ENSP00000306080	56.4286	46.9048	callorhinchus_milii	ENSCMIP00000022093	67.9083	56.447
ENSG00000171861	homo_sapiens	ENSP00000306080	71.1905	56.1905	latimeria_chalumnae	ENSLACP00000008085	65.2838	51.5284
ENSG00000171861	homo_sapiens	ENSP00000306080	57.1429	41.4286	lepisosteus_oculatus	ENSLOCP00000007391	54.4218	39.4558
ENSG00000171861	homo_sapiens	ENSP00000306080	65.2381	48.8095	esox_lucius	ENSELUP00000040807	58.9247	44.086
ENSG00000171861	homo_sapiens	ENSP00000306080	62.8571	46.1905	electrophorus_electricus	ENSEEEP00000003295	61.2529	45.0116
ENSG00000171861	homo_sapiens	ENSP00000306080	67.381	50.2381	oncorhynchus_kisutch	ENSOKIP00005098893	62.7494	46.7849
ENSG00000171861	homo_sapiens	ENSP00000306080	67.619	50	oncorhynchus_mykiss	ENSOMYP00000087315	60.4255	44.6809
ENSG00000171861	homo_sapiens	ENSP00000306080	63.5714	49.0476	salmo_salar	ENSSSAP00000044666	61.0984	47.1396
ENSG00000171861	homo_sapiens	ENSP00000306080	55.9524	42.381	poecilia_reticulata	ENSPREP00000014670	65.8263	49.8599
ENSG00000171861	homo_sapiens	ENSP00000306080	71.4286	53.0952	xenopus_tropicalis	ENSXETP00000048602	72.2892	53.7349
ENSG00000171861	homo_sapiens	ENSP00000306080	61.9048	51.4286	crocodylus_porosus	ENSCPRP00005018075	60.1852	50
ENSG00000171861	homo_sapiens	ENSP00000306080	58.3333	44.7619	laticauda_laticaudata	ENSLLTP00000001398	66.5761	51.087
ENSG00000171861	homo_sapiens	ENSP00000306080	38.5714	31.1905	pseudonaja_textilis	ENSPTXP00000010907	68.9362	55.7447
ENSG00000171861	homo_sapiens	ENSP00000306080	64.2857	51.9048	gallus_gallus	ENSGALP00010044701	66.3391	53.5627
ENSG00000171861	homo_sapiens	ENSP00000306080	62.381	49.7619	meleagris_gallopavo	ENSMGAP00000007052	45.1724	36.0345
ENSG00000171861	homo_sapiens	ENSP00000306080	58.8095	47.619	serinus_canaria	ENSSCAP00000014332	63.0102	51.0204
ENSG00000171861	homo_sapiens	ENSP00000306080	64.7619	54.2857	parus_major	ENSPMJP00000027182	66.6667	55.8824
ENSG00000171861	homo_sapiens	ENSP00000306080	34.7619	27.8571	naja_naja	ENSNNAP00000000552	67.5926	54.1667
ENSG00000171861	homo_sapiens	ENSP00000306080	60.4762	49.2857	podarcis_muralis	ENSPMRP00000037162	70.5556	57.5
ENSG00000171861	homo_sapiens	ENSP00000306080	59.7619	49.0476	geospiza_fortis	ENSGFOP00000017176	62.4378	51.2438
ENSG00000171861	homo_sapiens	ENSP00000306080	65	54.2857	taeniopygia_guttata	ENSTGUP00000007457	62.6147	52.2936
ENSG00000171861	homo_sapiens	ENSP00000306080	40.9524	35.7143	pelodiscus_sinensis	ENSPSIP00000015976	72.5738	63.2911
ENSG00000171861	homo_sapiens	ENSP00000306080	55.7143	46.1905	struthio_camelus_australis	ENSSCUP00000008145	65.1811	54.039
ENSG00000171861	homo_sapiens	ENSP00000306080	64.7619	51.6667	anser_brachyrhynchus	ENSABRP00000012649	67.8304	54.1147
ENSG00000171861	homo_sapiens	ENSP00000306080	64.7619	48.3333	gasterosteus_aculeatus	ENSGACP00000014524	60.5791	45.2116
ENSG00000171861	homo_sapiens	ENSP00000306080	55.7143	42.619	sander_lucioperca	ENSSLUP00000031432	55.8473	42.7208
ENSG00000171861	homo_sapiens	ENSP00000306080	18.3333	12.381	hucho_hucho	ENSHHUP00000031179	31.8182	21.4876
ENSG00000171861	homo_sapiens	ENSP00000306080	64.5238	47.8571	betta_splendens	ENSBSLP00000025318	57.7825	42.8571
ENSG00000171861	homo_sapiens	ENSP00000306080	63.8095	47.381	pygocentrus_nattereri	ENSPNAP00000013611	59.4235	44.1242
ENSG00000171861	homo_sapiens	ENSP00000306080	67.619	50.7143	oncorhynchus_tshawytscha	ENSOTSP00005071094	61.6052	46.2039
ENSG00000171861	homo_sapiens	ENSP00000306080	65.2381	53.5714	aquila_chrysaetos_chrysaetos	ENSACCP00020023417	65.7074	53.9568
ENSG00000171861	homo_sapiens	ENSP00000306080	67.1429	50.2381	cyprinodon_variegatus	ENSCVAP00000015928	62.1145	46.4758
ENSG00000171861	homo_sapiens	ENSP00000306080	57.619	44.7619	denticeps_clupeoides	ENSDCDP00000031569	59.3137	46.0784
ENSG00000171861	homo_sapiens	ENSP00000306080	66.6667	50	takifugu_rubripes	ENSTRUP00000003564	61.2691	45.9519
ENSG00000171861	homo_sapiens	ENSP00000306080	37.1429	32.1429	ficedula_albicollis	ENSFALP00000006047	70.2703	60.8108
ENSG00000171861	homo_sapiens	ENSP00000306080	62.8571	50.7143	coturnix_japonica	ENSCJPP00005020477	65.1852	52.5926
ENSG00000171861	homo_sapiens	ENSP00000306080	52.619	39.7619	sinocyclocheilus_grahami	ENSSGRP00000092959	65.3846	49.4083
ENSG00000171861	homo_sapiens	ENSP00000306080	65.4762	50.2381	tetraodon_nigroviridis	ENSTNIP00000019313	64.554	49.5305
ENSG00000171861	homo_sapiens	ENSP00000306080	68.3333	51.4286	paramormyrops_kingsleyae	ENSPKIP00000032715	61.3248	46.1538

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000451	involved_in rRNA 2-O-methylation	1	TAS	Homo_sapiens(9606)	Process
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005739	located_in mitochondrion	1	IDA	Homo_sapiens(9606)	Component
GO:0005759	located_in mitochondrial matrix	1	TAS	Homo_sapiens(9606)	Component
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0070039	enables rRNA (guanosine-2-O-)-methyltransferase activity	2	EXP,IMP	Homo_sapiens(9606)	Function