RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000169919	Gene ID	2990	Accession	4696
Symbol	GUSB	Alias	BG;MPS7	Full Name	glucuronidase beta
Status	Confidence	Length	21532 bases	Strand	Minus strand
Position	7 : 65960684 - 65982215	RNA binding domain	N.A.
Summary	This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
GUSB-201	ENST00000304895	2199	651aa	ENSP00000302728
GUSB-209	ENST00000466883	2555	No protein	-
GUSB-205	ENST00000447929	1983	144aa	ENSP00000411262
GUSB-203	ENST00000430730	1859	134aa	ENSP00000411859
GUSB-202	ENST00000421103	1742	505aa	ENSP00000391390
GUSB-206	ENST00000461622	491	No protein	-
GUSB-207	ENST00000462371	820	No protein	-
GUSB-208	ENST00000465785	625	No protein	-
GUSB-213	ENST00000479038	452	No protein	-
GUSB-214	ENST00000489482	519	No protein	-
GUSB-210	ENST00000475316	505	No protein	-
GUSB-211	ENST00000476486	776	No protein	-
GUSB-204	ENST00000446111	933	144aa	ENSP00000416793
GUSB-212	ENST00000478118	571	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
27800	Blood Glucose	5.3950000E-005	-
34988	Platelet Function Tests	2.1311100E-005	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004566	enables beta-glucuronidase activity	2	IBA,TAS	Homo_sapiens(9606)	Function
GO:0005102	enables signaling receptor binding	2	IBA,IPI	Homo_sapiens(9606)	Function
GO:0005576	located_in extracellular region	1	TAS	Homo_sapiens(9606)	Component
GO:0005615	is_active_in extracellular space	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005975	involved_in carbohydrate metabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0006027	involved_in glycosaminoglycan catabolic process	1	TAS	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0019391	involved_in glucuronoside catabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0019904	enables protein domain specific binding	1	IPI	Homo_sapiens(9606)	Function
GO:0030200	involved_in heparan sulfate proteoglycan catabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0030207	involved_in chondroitin sulfate catabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0030214	involved_in hyaluronan catabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0030246	enables carbohydrate binding	1	IBA	Homo_sapiens(9606)	Function
GO:0035578	located_in azurophil granule lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0043202	located_in lysosomal lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0043231	located_in intracellular membrane-bounded organelle	1	IDA	Homo_sapiens(9606)	Component
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:1904813	located_in ficolin-1-rich granule lumen	1	TAS	Homo_sapiens(9606)	Component